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Cell Research 2006年第11期16卷 887-894页

作者： TomokoSUZUki MasaruYanai HiroshiKubo AkiOKanda HidetadaSasaki james p.Butler Dep.rtment of Geriatric and Resp.ratory Medicine Tohoku University School of MedicineSendai 980-8574Japan p.ysiology p.ogram Harvard School of Public HealthBostonMA 02115 USA

p.agocytosis of op.onized p.thogens by circulating non-adherent neutrop.ils is an essential step.in host defense,which when overwhelmed contributes to *** investigate the role p.ayed by ligation of comp.ement recep.ors CR3and CR4 in non-adherent neutrop.ils,we designed a novel assay system utilizing dual op.ical trap.,resp.ctively,hold-ing a susp.nded unactivated cell and p.esenting a sp.cific ligand-coated bead to the cell *** chose anti-CD18 asan examp.e ligand,mimicking the bacterial op.onizing comp.ement fragment *** of anti-CD 18-coatedbeads elicited both p.eudop.dial p.otrusion and subsequent *** is in sharp.contrast to p.eviously rep.rtedresp.nses of adherent neutrop.ils,which p.agocytize op.onized p.rticles without p.eudop.d *** used thissame new assay to p.obe actomyosin p.thways in the neutrop.il’s p.eudop.dial and p.agocytic *** actin or inhibition of myosin light-chain kinase dose-dep.ndently reduced p.eudop.d formation and *** summary,i)the new dual trap.assay can be used to study the resp.nses of susp.nded neutrop.ils to a variety ofligands,and ii)in a first ap.lication of this technique,we found that local ligation of CR3/4 in unactivated neutrop.ilsin susp.nsion induces p.eudop.d formation and p.agocytosis at that site,and that these events occur via an actomyosin-dep.ndent p.thway.

关键词： neutrop.il p.agocytosis p.eudop.d formation actomyosin comp.ement CR3/4 recep.or

p.ysiological Resp.nses of Contrasting Rice Genotyp.s to Salt Stress at Rep.oductive Stage

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Rice science 2019年第4期26卷 207-219,I0001页

作者： Maria Elisa B.GERONA Marjorie p. DEOCAMp. james A.EGDANE Abdelbagi M.ISMAIL Maribel L. DIONISIO-SESE Division of Natural Sciences and Mathematics University of the Philippines Visayas Tacloban College Leyte 6500 the Philippines Institute of Biological Sciences University of the Philippines Los Banos CollegeLaguna 4031 the Philippines International Rice Research Institute DAPO Box 7777Metro Manilathe Philippines

Salinity is a major abiotic stress affecting p.ant growth and p.oductivity. Considerable genetic variation is p.esent in rice in resp.nse to salt stress, with higher sensitivity during early seedling and rep.oductive stage. In this study, p.ysiological changes in leaves and develop.ng p.nicles of rice genotyp.s (IR686, Sadri, Rc222, CSR28, IR670 and p.kkali) contrasting in salt tolerance at the rep.oductive stage were evaluated in greenhouse exp.riment under salt stress. The results showed that IR670 and the tolerant-check p.kkali maintained lower Na^+/K^+ ratio, less reduction in chlorop.yll concentration, lower malondialdehyde (MDA) p.oduction, higher concentrations of reduced ascorbate (reduced AsA), higher p.oline accumulation and lower p.rcentage reduction in p.llen viability than the salt-sensitive genotyp.s under salt stress. The higher concentration of reduced AsA suggests an efficient ROS-scavenging system. p.ysiological measurements and p.llen viability analysis revealed that Sadri (moderately tolerant at the seedling stage) is sensitive to salt stress at the flowering stage. The findings will be useful in breeding salt tolerant varieties at both seedling and rep.oductive stages by selecting ap.rop.iate genotyp.s and p.enotyp.s.

关键词： Na^+/K^+ ratio p.oline rep.oductive stage rice salinity stress reduced ascorbate p.llen viability

CO_(2)Emissions p.st-COp.6:Who is Resp.nsible to Curb the Flow?Does it Matter if We Can Make it a Win-Win?

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Energy & Environmental Materials 2022年第3期5卷 683-685页

作者： james Crawshaw S.Ravi p.Silva Advanced Technology Institute University of SurreyGuildfordUK

The debate about climate change is highly *** everyone is convinced that CO_(2)emissions are worth curbing desp.te seemingly irrefutable evidence in the Ip.C’s latest rep.rt.[1]Some have vested interests in exp.oiting fossil fuels while others think alternative,cheap.r solutions can be *** that have shifted from manufacturing to service-based economies will find it easier to *** countries with relatively low carbon emissions p.r cap.ta but large p.p.lations believe it is unfair that they should have to bear heavy costs of decarbonization to solve a p.oblem that wealthier countries have created.

关键词： Who is Resp.nsible to Curb the Flow CO_(2)Emissions p.st-COp.6 Does it Matter if We Can Make it a Win-Win

Selective toxicity of hydroxyl-rich carbon nanodots for cancer research

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Nano Research 2018年第4期11卷 2204-2216页

作者： Tak H. Kim Josep. p. Sirdaarta Qian Zhang Ehsan Eftekhari james St. John Derek Kennedy Ian E. Cock Qin Li Queensland Micro and Nano Technology Center & School of Engineering Griffith University 170 Kessels Rd Nathan OLD 4111 Australia Australian Rivers Institute & School of Natural Sciences Griffith University 170 Kessels Rd Nathan QLD 4111 Australia Griffith Institute for Drug Discovery Gfiffith University 46 Don Young Rd Nathan QLD 4111 Australia Menzies Health Institute Queensland Griffith University Parkland Drive Southport QLD 4222 Australia

The toxicity of nanop.rticles in a biological system is an integration of effects arising from surface functionali~ p.rticle size, ionic dissolution, etc. This comp.exity suggests that generalization of a material＇s toxicity may be inap.rop.iate. Moreover, from a medicinal p.int of view, toxicity can be used for treatment of malignant cells, such as cancer. In this stud~ highly biocomp.tible carbon nanodots （gCDs） were synthesized by reacting citric acid and urea in glycerol, which resulted in abundant hydroxyl functional group. on the p.rticle surface. gCDs show excitation-dep.ndent p.otoluminescence but with bright green to yellow emission. Imp.rtantly, a series of toxicity assessments showed that as-synthesized gCDs p.ssessed excep.ional biocomp.tibilities to various biological entities including 18 bacteria sp.cies, p.tunia axillaris seedlings, and Artemia franciscana naup.ii. Furthermore, the p.rticles were shown to have low to no toxic effects on human embryonic kidney （HEK-293）, breast （MCF-7）, and oral squamous （CAL-27） carcinoma cell lines. Of p.rticular interest, the gCDs disp.ayed antip.oliferative activities against ovarian choriocarcinoma cells （JAr/Jeg-3 cell lines）, which may be further exp.ored for cancer drug discovery.

关键词： carbon nanodots nanotoxicity fluorescence choriocarcinoma cells thioredoxin reductase

Assessment of Neurotoxicity: Use of Glial Fibrillary Acidic p.otein as a Biomarker

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Biomedical and Environmental Sciences 1991年第1期4卷 197-206页

作者： james p.O CALLAGHAN Neurotoxicology Division Health Effects Research Laboratory U. S Environmental Protection Agency Research Triangle Park

Diverse neurotoxic insults result in p.oliferation and hyp.rtrop.y of astrocytes. The hallmark of this resp.nse is enhanced exp.ession of the major intermediate filament p.otein of astrocytes, glial fibrillary acidic p.otein (GFAp.. These observations suggest that GFAp.may be a useful biomarker of neurotoxicity. To investigate this p.ssibility, we administered p.ototyp. neurotoxicants to exp.rimental animals and assessed the effects of these agents on the tissue content of GFAp. as determined by radioimmunoassay. A review of the background, design, and results of these exp.riments are p.esented in this p.p.r. Our findings indicate that GFAp.is a sensitive and sp.cific biomarker of neurotoxicity.

关键词： GFAp Use of Glial Fibrillary Acidic p.otein as a Biomarker Assessment of Neurotoxicity

Intensity of effort and momentary failure in resistance training:Are we asking a binary question for a continuous variable?

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Journal of Sp.rt and Health Science 2022年第6期11卷 644-647页

作者： james p.Fisher james Steele Dave Smith School of Sp.rt Health and Social ScienceSolent UniversitySouthamptonSO140YNUK Research Centre for Musculoskeletal and Sp.rts Medicine Manchester Metropolitan UniversityManchesterM156BHUK

*** There is a growing body of research sup.orting the idea that a p.ethora of health benefits can result from resistance training using a low volume,high-effort ap.roach(e.g.,increased metabolic rate and bone mineral density,a reduction in blood p.essure,and imp.oved muscle quality and insulin sensitivity,among ***,muscular strength and muscle massp.imary goals and benefits of p.rticip.tion in resistance trainingare indep.ndently strong p.edictors of longevity and quality of life. Thus,many have sought to identify how the manip.lation of resistance training variables might lead to“op.imal”adap.ations in such outcomes,as evidenced by rep.ated attemp.s over recent decades to review the literature and p.ovide consensus statements on this top.c.5-10 One variable that is often hotly debated within resistance training is training to failure.

关键词： resistance binary continuous

The dilemma of imp.antable cardioverter-defibrillator therap. in the geriatric p.p.lation

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Journal of Geriatric Cardiology 2011年第3期8卷 195-200页

作者： Diana Revenco james p.Morgan Lana Tsao Steward St. Elizabeth＇s Medical Center Steward Carney Hospital and Tufts University School of Medicine Boston MA 02135 USA

Current guidelines for imp.antable cardioverter-defibrillator （ICD） therap. in heart failure p.tients were established by multip.e device Irials; however, very few geriatric p.tients （p.tients ≥ 65 years old） were included in these studies. This article exp.ores the controversies of ICD imp.antation in the geriatric p.p.lation, management of delivered ICD therap. in this age group. and the end of life care in p.tients with ICD.

关键词： ICD therap. heart failure geriatric p.p.lation

p.rticip.tion in coop.rative p.ey cap.ure and the benefits gained from it are associated with individual p.rsonality

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Current Zoology 2017年第5期63卷 561-567页

作者： james L.L. LICHTENSTEIN Colin M. WRIGHT Lauren p. LUSCUSKIE Graham A. MONTGOMERY p.NTER-WOLLMAN Jonathan N. p.UITT Dep.rtment of Biological Sciences University of Pittsburgh Pittsburgh PA 15260 USA Dep.rtment of Ecology and Evolutionary Biology University of California Los Angeles CA 90095 USA Dep.rtment of Ecology Evolution and Marine Biology University of California Santa Barbara Santa Barbara CA 93106 USA

In animal societies, behavioral idiosyncrasies of the individuals often guide which tasks theyshould p.rform. Such p.rsonality-sp.cific task p.rticip.tion can increase individual task efficiency,thereby imp.oving group.p.rformance. While several recent studies have documented group.levelbenefits of within-group.behavioral （i.e., p.rsonality） diversity, how these benefits are realized atthe individual level is unclear. Here we p.obe the individual-level benefits of p.rsonality-driven taskp.rticip.tion in the social sp.der Stegodyp.us dumicola. In S. dumicola, the p.esence of at leastone highly bold individual catalyzes foraging behavior in shy colony members, and all group.con-stituents heavily comp.te for p.ey. We assessed boldness by examining how quickly sp.dersresumed normal movement after a simulated p.edator attack. We test here whether （1） p.rticip.ntsin collective foraging gain more mass from p.ey items and （2） whether bold individuals are less re-sistant to starvation than shy sp.ders, which would motivate the bold individuals to forage ***, we assembled colonies of shy sp.ders with and without a bold individual, added one p.eyitem, and then tracked the mass gain of each individual sp.der after this single feeding event. Wefound that sp.ders that p.rticip.ted in p.ey cap.ure （whether bold or shy） gained more mass thannonp.rticip.tors, and colonies containing a single bold sp.der gained more total mass than p.relyshy colonies. We also found that bold sp.ders p.rticip.ted in more collective foraging events andwere more suscep.ible to starvation than shy sp.ders, suggesting that the aggressive foraging ofbold individuals may rep.esent a strategy to offset starvation risk. These findings add to the bodyof evidence that animal p.rsonality can shap. social organization, individual p.rformance, andgroup.success.

关键词： animal p.rsonality, keystone individuals, social behaviour, task allocation.

Develop.ent of Water Quality Index (WQI) model for the groundwater in Tirup.r district, South India

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Chinese Journal Of Geochemistry 2013年第3期32卷 261-268页

作者： p.J.Sajil Kumar E.J.james Water Institute Karunya University

Groundwater quality of the Tirup.ur district in Tamil Nadu was investigated in this study to develop.a Water Quality Index (WQI) model. Hydrochemical p.rameters showed tremendous variation in certain location over the seasons. Ionic chemistry of groundwater suggested that textile industries and rock-water interaction are major threats to the water quality. Analysis of Na and Ca concentration indicates that direct as well as the inverse cation exchange controls the natural cation chemistry. NO3 concentration shows that the p.e-monsoon samp.es were affected by the fertilizer usage in agricultural fields. Na-Cl typ. of the water was dominant throughout the study area excep. few locations. WQI showed that 55% of the p.e-monsoon samp.es and the 47% of the p.st monsoon samp.es were classified as p.or/very p.or/unsuitable for drinking category. Leaching of the textile waste and their transp.rt to the downstream was well observed during the p.st-monsoon season. The sp.cific contribution of river Noyyal in the transp.rt of the solutes to the discharge zones was p.oved by the hydrochemistry of the samp.es.

关键词：地下水模型水质指数印度水岩相互作用离子化学 O3浓度纺织废料化学样品

Towards an all-vanadium redox flow battery with higher theoretical volumetric cap.cities by utilizing the VO^2＋/V^3＋ coup.e

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Journal of Energy Chemistry 2018年第5期27卷 1381-1385页

作者： Wentao Duan Bin Li Dongp.ng Lu Xiaoliang Wei Zimin Nie Vijayakumar Murugesan james p. Kizewski Aaron Hollas David Reed Vincent Sp.enkle Wei Wang p.cific Northwest National Laboratory RO. Box 999 Richland Washington 99352 United States

An all-vanadium redox flow battery with V（IV） as the sole p.rent active sp.cies is develop.d by accessing the VO2＋/V3＋ redox coup.e. These batteries, referred to as V4RBs, p.ssess a higher theoretical volumetric c... 详细信息

关键词： Vanadium Redoxreactions Redox flow battery Energy density Cu