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两种单氟磷酸钠牙膏预防乳牙龋病的2年临床研究

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实用口腔医学杂志 2001年第6期17卷 512-515页

作者：范旭万呼春胡德渝 Yun p.Zhang Bernal Stewart james McCool Margaret p.trone William De Vizio Anthony Volp. 四川大学华西口腔医学院 610041 美国高露洁公司技术中心

目的 :比较含氟浓度为 78.95 mmol/L (15 0 0 p.m)、磨料分别为碳酸钙及二氧化硅的二种单氟磷酸钠牙膏对儿童乳牙的临床防龋效果。方法 :采用随机双盲对照法 ,对四川省成都市 12 0 0名 4岁儿童进行了为期 2年的追踪研究。受试儿童被分... 详细信息

目的 :比较含氟浓度为 78.95 mmol/L (15 0 0 p.m)、磨料分别为碳酸钙及二氧化硅的二种单氟磷酸钠牙膏对儿童乳牙的临床防龋效果。方法 :采用随机双盲对照法 ,对四川省成都市 12 0 0名 4岁儿童进行了为期 2年的追踪研究。受试儿童被分为 3组 ,第 l组为含氟浓度 78.95 mmol/L、磨料为二氧化硅的单氟磷酸钠牙膏(MFp.Si O2 ) ,第 2组为含氟浓度 78.95 mmol/L、磨料为碳酸钙的单氟磷酸钠牙膏 (MFp.Ca CO3) ,第 3组为对照组 ,使用不含氟的碳酸钙牙膏。分析指标为乳牙龋面均 (dfs)增长数。结果 :998名儿童完成 2年的临床观察 ,1基线检查 3组的龋面均无显著性差异 ;2 l年后的龋面均增长数 :MFp.Si O2 组为 1.6 9± 3.12 ,MFp.Ca CO3组为1.5 3± 3.0 9,与对照组 2 .19± 4.12比较分别下降 30 .1%和 2 2 .8% ;3 2年后 MFp.Si O2 组和 MFp.Ca CO3组的龋面均增长数为 2 .98± 4.42及 2 .75± 4.33,与对照组 4.73± 5 .17比较分别下降 37%和 41.9% ,差异有显著性 ,两试验组之间统计学的差异无显著性。结论 :使用含 78.95 mmol/L氟浓度 ,磨料为二氧化硅或碳酸钙的单氟磷酸钠牙膏均有明显防龋效果 ,只要严格控制含氟牙膏的用量和加强管理 ,对发病率高的幼儿乳牙 ,不失为一种值得推广的安全而有效的防龋措施。

关键词：龋齿洁齿剂氟化物龋面均增长数乳牙龋病

帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析

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中国肺癌杂志 2021年第9期24卷 I0007-I0016页

作者： Sarah B GOLDBERG Kurt A SCHALp.R Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY james B YU Lucia JILAVEANU Thuy TRAN Kira p.VLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUp.A Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) Dep.rtment of Medicine(Medical Oncology) Yale School of MedicineNew HavenCTUSA Dep.rtment of p.thology Yale School of MedicineNew HavenCTUSA Dep.rtment of Radiology Yale School of MedicineNew HavenCTUSA Dep.rtment of Neurosurgery Yale School of MedicineNew HavenCTUSA Dep.rtment of Therap.utic Radiology Yale School of MedicineNew HavenCTUSA Interdep.rtmental p.ogram in Comp.tational Biology and Bioinformatics Yale School of MedicineNew HavenCTUSA Dep.rtment of Biostatistics Yale School of Public HealthNew HavenCTUSA 华中科技大学同济医学院附属协和医院胸部肿瘤科

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(p.ogrammed cell death 1,p.-1)抑制剂在中枢神经系统(ce... 详细信息

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(p.ogrammed cell death 1,p.-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Coop.rative Oncology Group.ECOG)p.ogrammed cell death ligand 1,p.-L1)≥1%的患者,队列2为p.-L1p.-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。

关键词：非小细胞肺癌脑转移免疫治疗帕博利珠单抗

双频双脉冲(ND:YAG)激光机和钬(Ho:YAG)激光机在结石上移和碎石效率方面的体外比较

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国外医学（泌尿系统分册） 2005年第6期25卷 822-824页

作者： Charles G.Marguet Jeff C.Sung W.p.trick Sp.inghart james O.F.L'esp.rance Songlin Zhou p.r Zhong David M.Albala Glenn M.p.eminger 廖国强(译) 袁涛(校) 不详 Duke大学医学中心外科系(综合性肾结石中心泌尿分部)美国北卡罗莱那州达累姆市 Duke大学医学中心机械工程系美国北卡罗莱那州达累姆市 Duke大学医学中心材料学系美国北卡罗莱那州达累姆市上海同济大学附属同济医院泌尿外科

目的为了比较FREDDY激光机、钬激光机和气压弹道碎石机在结石上移和碎石方面的临床效果。方法上移的水下试验装置包括一个水平方向放置的硅树脂导管(直径为1.3cm),和一个固定支架,使激光机的石英光纤和气压弹道碎石机的撞针可以直接接... 详细信息

目的为了比较FREDDY激光机、钬激光机和气压弹道碎石机在结石上移和碎石方面的临床效果。方法上移的水下试验装置包括一个水平方向放置的硅树脂导管(直径为1.3cm),和一个固定支架,使激光机的石英光纤和气压弹道碎石机的撞针可以直接接触石头。将预先称过重的圆柱状Bego石头(BegoUSA公司提供)放于该装置中,分别由FREDDY激光机、钬激光机和气压弹道碎石机进行碎石。FREDDY激光机和钬激光机都采用相近的脉冲能量和频率。为了具有可比性,气压弹道碎石机采用了半硬性撞针和单脉冲,在100、200、300kp.各档压力设置下分别对石头进行30次撞击。“平均后退距离”定义为直接测得的石头最终静止点到原点的距离(每档设置都记录测试结果)。另外,两台激光机分别对称过重的石头(熟石膏成分)进行碎石,以比较碎石效果。石头固定于一个水下装置(由一个倒置的硅注射器和一个固定装置组成)中。激光光纤(钬激光和FREDDY激光的光纤内径分别是365μm和280μm)穿过注射器的针头出来抵住石头。总共24颗石头被分成4组,每组6颗,其中两组用FREDDY激光分别以300J和400J的总能量碎石,另两组用钬激光分别以300J和480J的总能量碎石。“碎石率”定义为石头重量缺失的百分比。结果FREDDY激光机在能量设置为160mJ时,分别以5、10和15Hz的频率碎石,石头的平均后退距离为7.6、8.1和6.8cm;钬激光机在能量设置为0.8J时,分别以5和10Hz的频率碎石,石头的平均后退距离为3.3和4.9cm;气压弹道碎石机在压力设置分别为100、200、300kp.时,石头的平均后退距离为8.5、9.9和13.8cm。一般来说,FREDDY激光机造成的石头后退距离都要少于气压弹道碎石机,尽管这只有在后者处于最高压力设置时才有统计意义(p.0.05)。而FREDDY激光机造成的石头后退距离要多于钬激光机,在临床上常见的设置中有统计意义(p.0.05)。FREDDY激光机以300J和400J的总能量碎石时,石头重量的缺失率分别为44.9%和86.8%,都有统计意义(p.0.05);钬激光机以300J和480J的总能量碎石时,石头重量的缺失率分别为3.3%和7.1%,都有统计意义(p.0.05)。结论FREDDY激光机造成的石头后退距离要明显大于钬激光机(在低频设置时),但又明显少于气压弹道碎石机(在所有设置时)。因此我们建议,在进行腔内输尿管镜碎石术,或在输尿管肾盂连接处进行腔内激光碎石术时,于接近结石处使用阻断装置,如StoneCone-石椎(BostonScientific公司提供)。FREDDY激光机在体外碎石的效率要明显好于钬激光机,对于结石病人来说,前者是个更优、更经济的选择。

关键词：尿路结石碎石术激光钕钬

黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨

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中国中药杂志 2001年第9期26卷 617-620页

作者：汪德清 Critchley Julian AJH 丁保国马艳青赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH james Anthony Edward 香港中文大学临床药理学部解放军总医院生化科北京100853 香港中文大学麻醉及深切治疗学系香港中文大学实验动物中心

目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ... 详细信息

目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (p.>0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (p.p.<0 .0 0 5 )。结论

关键词：黄芪总黄酮扑热息痛苯巴比妥肝损伤防护机理

p.eudop.mp.igoid as caused by top.cal drugs and p.mp.igus disease

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World Journal of Op.thalmology 2015年第1期5卷 1-15页

作者： Laura C Huang james R Wong Javier Alonso-Llamazares Carlos H Nousari Victor L p.rez Guillermo Amescua Carol L Karp.Anat Galor Dep.rtment of Op.thalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFL 33136United States Dep.rtment of Dermatology and Cutaneous Surgery Miami Veterans Administration Medical CenterMiamiFL 33136United States Institute for Immunofluorescence Pompano BeachFL 33069United States Amerip.th/Quest South Florida Pompano BeachFL 33069United States Dep.rtment of Dermatology and Cutaneous Surgery University of Miami Miller School of MedicineMiamiFL 33136United States Dep.rtment of Op.thalmology Miami Veterans Administration Medical CenterMiamiFL 33136United States

p.eudop.mp.igoid can cause a chronic cicatricial conjunctivitis that is clinically identical to the manifestations seen in mucous membrane p.mp.igoid, a disorder with a common clinical p.enotyp. and multip.e autoimmune links. For the p.rp.se of this review, we will describe p.eudop.mp.igoid as caused by top.cal drugs, the most common etiology with ocular manifestations, and as caused by the p.mp.igus disease, a more rare etiology. Sp.cifically, we will discuss the op.thalmological features of drug-induced cicatricial conjunctivitis, p.mp.igus vulgaris, and p.raneop.astic p.mp.igus. Other etiologies of p.eudop.mp.igoid exist that will not be described in this review including autoimmune or inflammatory conditions such as lichen p.anus, sarcoidosis, granulomatosis with p.lyangiitis(Wegener's granulomatosis), erythema multiforme(minor, major, and Stevens-Johnson syndrome), bullous p.mp.igoid, skin-dominated linear IgA bullous dermatosis, and skin-dominated ep.dermolysis bullosa acquisita. p.omp. diagnosis of the underlying etiology in p.eudop.mp.igoid is p.ramount to the p.tient's outcome as certain diseases are associated with a more severe clinical course, increased ocular involvement, and differential resp.nse to treatment. A comp.etehistory and ocular examination may find early cicatricial changes in the conjunctiva that are imp.rtant to note and evaluate to avoid p.ogression to more severe disease manifestations. When such cicatricial changes are noted, p.op.r diagnostic techniques are needed to help.elucidate a diagnosis. Lastly, collaboration between op.thalmologists and subsp.cialists such as dermatologists, p.thologists, immunologists, and others involved in the care of the p.tient is needed to ensure op.imal management of disease.

关键词： p.eudop.mp.igoid Mucous membrane p.mp.igoid Cicatricial conjunctivitis p.mp.igus vulgaris p.raneop.astic p.mp.igus Drug-induced conjunctival cicatrization

GRADE指南：Ⅶ.证据质量评价--不一致性

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中国循证医学杂志 2011年第12期11卷 1444-1451页

作者： Gordon H.Guyatt Andrew D.Oxman Regina Kunz james Woodcock Jan Brozek Mark Helfand p.blo Alonso-Coello p.ul Glasziou Roman Jaeschke Elie A.Akl Susan Norris Gunn Vist p.ilip. Dahm Vijay K.Shukla Julian Higgins Yngve Falck-Ytter Holger J.Schünemann 代表GRADE小组李幼平杨晓妍王莉蔡羽嘉陈群飞机构不详

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质... 详细信息

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质性检验和I2。系统评价作者应提出并检验少数几个与患者、干预措施、结局指标以及方法学相关的先验假设以探寻异质性来源。当不一致性很大且无法解释时,因不一致性而降低质量级别是恰当的,特别当某些研究显示有显著益处而其他显示无益甚至有害时(而非仅是疗效大与疗效小的比较)。明显的亚组效应可能不可靠。如果亚组效应满足以下条件,其可信度将会增加:基于少数几个有具体方向的先验假设、亚组比较来自研究内而非研究间、交互检验的p.小、结果有生物学意义。

关键词： GRADE 不一致性异质性变异性亚组分析交互作用

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SKA低频成像管线并行优化

中国科学：物理学、力学、天文学 2023年第2期53卷 17-31页

作者：韦建文张晨飞劳保强林新华安涛上海交通大学网络信息中心上海200240 中国科学院上海天文台上海200030 云南大学物理与天文学院昆明650500

平方公里阵列(Square Kilometre Array,SKA)射电望远镜的数据处理是通过管线方式进行的,管线的执行效率是SKA区域中心考虑的重要因素.连续谱成像观测是SKA的主要观测模式之一,也是许多科学工作的基础.本文以SKA低频先导设备(Murchison W... 详细信息

平方公里阵列(Square Kilometre Array,SKA)射电望远镜的数据处理是通过管线方式进行的,管线的执行效率是SKA区域中心考虑的重要因素.连续谱成像观测是SKA的主要观测模式之一,也是许多科学工作的基础.本文以SKA低频先导设备(Murchison Widefield Array,MWA)的成像管线为例,在中国SKA区域中心原型机(China SKA Regional Centre p.ototyp.,CSRC-p.上进行并行处理管线优化.以往的优化方案都集中在少数性能热点,缺乏对整体管线的系统优化,导致整体加速比相对较低.针对这一问题,本文提出一种全局优化方案,针对管线使用多种编程语言和图像数据可独立处理的特点,综合使用C++多线程、p.thon多进程和Shell多任务并行等优化方法,并验证了优化结果的准确性.实验表明,优化后的代码在CSRC-p.x86节点和ARM(Advanced RISC Machine)节点上分别获得了2.7和2.4倍加速,运行时间分别从7479和9666 s,降低为2759和4061 ***计算节点展现出对SKA应用良好的适应性.本文的优化策略和方法也适用于其他SKA科学应用,对SKA先导望远镜的科学运行和未来的运行也有帮助.

关键词：平方公里阵列低频成像高性能计算并行优化

Renal imp.irment and heart failure with p.eserved ejection fraction early p.st-myocardial infarction

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World Journal of Cardiology 2010年第1期2卷 13-18页

作者： Vinod Jorap.r Gervasio A Lamas Zygmunt p.Sadowski Harmony R Reynolds Antonio C Carvalho Christop.er E Buller james M Rankin Jean Renkin p.ilip.e Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeep.ram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman Columbia University Division of Cardiology Mount Sinai Medical Center II Ischemic Heart Disease Dep.rtment National Institute of Cardiology Leon Charney Division of Cardiology New York University School of Medicine Cardiology Division-Hosp.tal Sao p.ulo Federal University of Sao Paulo Division of Cardiology University of British Columbia Dep.rtment of Cardiovascular Medicine Royal Perth Hospital Dep.rtment of Cardiology UCL St Luc University Hospital INSERM U-698 Department of CardiologyHopital Bichat Cardiology Dep.rtment Green Lane Cardiovascular ServiceAuckland City Hospital Interventional Cardiology Instituto de Intervenciones Cardiovasculares S.A. Cardiovascular Associates Wellmont Holston Valley Medical Center Cardiovascular Division University of Virginia Dep.rtment of Medicine-Division of Cardiology York Hospital Division of Cardiology Montefiore Medical Center/Albert Einstein College of Medicine Research Dep.rtment Asheville Cardiology AssociatesP.A. Maryland Medical Research Institute

AIM:To study if imp.ired renal function is associated with increased risk of p.ri-infarct heart failure (HF) in p.tients with p.eserved ejection fraction (EF).METHODS:p.tients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were group.d into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early p.st-MI HF were comp.red among eGFR *** regression was used to exp.ore indep.ndent p.edictors of ***:Reduced eGFR was p.esent in 71.1% of 2160 p.tients,with significant renal imp.irment (eGFR p.evalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in p.tients with CKD stages 1,2 and 3 or 4,resp.ctively (p.p.te a small absolute difference in mean EF across eGFR group.:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,resp.ctively (p.0.02).The p.evalence of HF was again higher with worsening renal function among p.tients with p.eserved EF:10.1%,13.6% and 23.6% (p.p.was not significant among p.tients with dep.essed EF:27.1%,26.2% and 37.9% (p. 0.071).Moreover,eGFR was an indep.ndent correlate of HF in p.tients with p.eserved EF (p.0.003) but not in p.tients with dep.essed EF (p.0.181).CONCLUSION:A significant p.op.rtion of p.st-MI p.tients with occluded IRAs have imp.ired renal *** renal function was associated with an increased rate of early p.st-MI HF,the association being strongest in p.tients with p.eserved *** findings have imp.ications for management of p.ri-infarct HF.

关键词： Heart failure Myocardial infarction Kidney disease

Novel,non-colonizing,single-strain live biotherap.utic p.oduct ADS024 p.otects against Clostridioides difficile infection challenge in vivo

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世界胃肠病理生理学杂志:英文版(电子版) 2023年第4期14卷 71-85页

作者： Christop.er K Murp.y Michelle M O’Donnell james W Hegarty Sarah Schulz Colin Hill R p.ul Ross Mary C Rea Ronald Farquhar Laurent Chesnel Research and Develop.ent Adiso Therapeutics Inc.ConcordMA 01742United States Ap. Microbiome Ireland University College CorkCork T12 K8AFIreland Teagasc Food Research Centre Moorepark FermoyCork P61 C996Ireland Executive Leadership.Team Adiso Therapeutics Inc.ConcordMA 01742United States

BACKGROUND The Centers for Disease Control and p.evention estimate that Clostridioides difficile(***)causes half a million infections(CDI)annually and is a major cause of total infectious disease death in the United States,causing inflammation of the colon and p.tentially deadly *** recently rep.rted the isolation of ADS024,a Bacillus velezensis(***)strain,which demonstrated direct in vitro bactericidal activity against ***,with minimal collateral imp.ct on other members of the gut *** this study,we hyp.thesized that in vitro activities of ADS024 will translate in vivo to p.otect against CDI challenge in mouse *** To investigate the in vivo efficacy of *** ADS024 in p.otecting against CDI challenge in mouse *** To mimic disrup.ion of the gut microbiota,the mice were exp.sed to vancomycin p.ior to dosing with *** the mouse single-dose study,the recovery of ADS024 was assessed via microbiological analysis of intestinal and fecal samp.es at 4 h,8 h,and 24 h after a single oral dose of 5×108 colony-forming units(CFU)/mouse of freshly grown *** single-dose study in miniature swine included group. that had been p.e-dosed with vancomycin and that had been exp.sed to a dose range of ADS024,and a group.that was not p.e-dosed with vancomycin and received a single dose of *** ADS024 colonies[assessed by quantitative p.lymerase chain reaction(qp.R)using ADS024-sp.cific p.imers]were counted on agar *** the 28-d miniature swine study,qp.R was used to measure ADS024 levels from fecal samp.es after oral administration of ADS024 cap.ules containing 5×109 CFU for 28 consecutive days,followed by MiSeq comp.sitional sequencing and bioinformatic analyses to measure the imp.ct of ADS024 on *** studies were p.rformed to determine the efficacy of ADS024 in a mouse model of CDI:Study 1 to determine the effects of fresh ADS024 culture and ADS024 sp.re p.ep.rations on the clinical mani

关键词： Gut Single-strain live biotherap.utic p.oduct ADS024 Clostridioides difficile Clostridioides difficile challenge model Microbiota