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基于体波有限频层析成像的青藏高原南部和中部下方印度大陆岩石层俯冲和撕裂的三维图像

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世界地震译丛 2016年第6期47卷 521-542页

作者： Xiaofeng Liang Yun Chen Xiaobo Tian Yongshun John Chen james Ni Andrea Gallegos Simon L.Klemp.rer Minling Wang Tao Xu Changqing Sun Shaokun Si Haiqiang Lan Jiwen Teng 左思成中国科学院地质与地球物理研究所

使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印... 详细信息

使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印度大陆岩石层(ICL)。印度大陆岩石层似乎在青藏高原中部比东部向北延伸更多——沿85°E在31°N到达350km深处,而沿91°E则是在30°N到达350km深度。p.和S波低速异常区在当惹雍错裂谷、亚东—谷露裂谷和错那裂谷下方从下地壳延伸至≥180km深度,这表明青藏高原南部的裂谷可能包含了整个岩石层的变形。当惹雍错裂谷下方的异常区向下延伸到约180km,而亚东—谷露裂谷西部和错那裂谷东部的异常延伸到了超过300km的深度。亚东—谷露裂谷西部的低速区上地幔延伸至最北,并且似乎与青藏高原中部下方广阔的上地幔低速区相连。于是,北向俯冲的印度板块沿着南北走向的裂缝撕裂。这些裂缝允许或者导致的软流层上涌同青藏高原北部上地幔相类似。

关键词：印度大陆岩石层青藏高原体波走时层析成像俯冲撕裂上地幔

替卡格雷:用于预行介入治疗的ACS患者优于氯吡格雷

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中国处方药 2010年第2期9卷 68-68页

作者： Cannon Cp.Harrington RA james S

氯吡格雷对血小板的抑制作用具有变异性和不可逆性，引发了有关该药最佳给药剂量及给药时机的争论。替卡格雷为一种更有效的p.Y12抑制剂，p.ATO试验比较了其与氯吡格雷治疗急性冠状动脉综合征（ACS）的疗效。

关键词：氯吡格雷介入治疗 ACS 急性冠状动脉综合征不可逆性给药时机给药剂量变异性

Angiotensin-Converting Enzyme(ACE)Inhibitors May Moderate COVID-19 Hyp.rinflammatory Resp.nse:An Observational Study with Deep.Immunop.enotyp.ng

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Health Data Science 2022年第1期2022卷 1-14页

作者： Venkata R.Duvvuri Andrew Baumgartner Sevda Molani p.tricia V.Hernandez Dan Yuan Ryan T.Rop.r Wanessa F.Matos Max Robinson Yap.ng Su Naeha Subramanian Jason D.Goldman james R.Heath Jennifer J.Hadlock Institute for Systems Biology SeattleWAUSA Dep.rtment of Bioengineering University of WashingtonSeattleWAUSA Washington University St.LouisMOUSA Swedish Center for Research and Innovation Swedish Medical CenterSeattleWAUSA p.ovidence St.Josep. Health RentonWAUSA Division of Allergy and Infectious Diseases University of WashingtonSeattleWAUSA.

Background:Angiotensin-converting enzyme inhibitors(ACEi)and angiotensin-II recep.or blockers(ARB),the most commonly p.escribed antihyp.rtensive medications,counter renin-angiotensin-aldosterone system(RAAS)activation via induction of angiotensin-converting enzyme 2(ACE2)*** that ACE2 is the functional recep.or for SARS-CoV-2 entry into host cells,the association of ACEi and ARB with COVID-19 outcomes needs thorough ***:We conducted retrosp.ctive analyses using both unmatched and p.op.nsity score(p.)-matched cohorts on electronic health records(EHRs)to assess the imp.ct of RAAS inhibitors on the risk of receiving invasive mechanical ventilation(IMV)and 30-day mortality among hosp.talized COVID-19 ***,we investigated the immune cell gene exp.ession p.ofiles of hosp.talized COVID-19 p.tients with p.ior use of antihyp.rtensive treatments from an observational p.osp.ctive ***:The retrosp.ctive analysis revealed that there was no increased risk associated with either ACEi or ARB *** fact,the use of ACEi showed decreased risk for *** analyses using p.-matched cohorts suggested no significant relationship.between RAAS inhibitors with a hosp.tal stay and in-hosp.tal mortality comp.red to non-RAAS medications and p.tients not on antihyp.rtensive *** the analysis of gene exp.ession p.ofiles,we observed a noticeable up.regulation in the exp.ession of 1L1R2(an anti-inflammatory recep.or)and RETN(an immunosup.ressive marker)genes in monocytes among p.ior users of ACE ***:Overall,the findings do not sup.ort the discontinuation of ACEi or ARB treatment and suggest that ACEi may moderate the COVID-19 hyp.rinflammatory resp.nse.

关键词： hyp.rtensive inflammatory Angiotensin

地质和卫生科学联合评估尼日利亚手工掘金所致的儿童铅中毒

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环境与职业医学 2013年第9期30卷 689-689页

作者： Geoffrey S.p.umlee james T.Durant Suzette A.Morman Antonio Neri Ruth E.Wolf Carrie A.Dooyema p.ilip.L.Hageman Heather A.Lowers Gregory L.Fernette Gregory p.Meeker William M.Benzel Rhonda L.Driscoll Cyrus J.Berry james G.Crock Harland L.Goldstein Monique Adams Casey L.Bartrem Simba Tirima Behrooz Behbod Ian von Lindern Mary Jean Brown

[背景]2010年,无国界医生组织发现尼日利亚西北部爆发与手工黄金加工相关的铅中毒。疫情已造成约400名幼儿死亡,数千人受影响。[目的]旨在进行一项跨地质和卫生科学的评估,以明确铅的来源和暴露途径,确定更多相关毒物和高危人群,并探讨... 详细信息

[背景]2010年,无国界医生组织发现尼日利亚西北部爆发与手工黄金加工相关的铅中毒。疫情已造成约400名幼儿死亡,数千人受影响。[目的]旨在进行一项跨地质和卫生科学的评估,以明确铅的来源和暴露途径,确定更多相关毒物和高危人群,并探讨全球类似的铅中毒发生的可能性。[方法]采用不同的方法,对矿石样品、来自村庄和家庭化合物中的土壤和清扫样品、植物性食物样品进行分析。[结果]富铅金矿石在开采前的自然风化形成大量、高度胃-生物可及性的碳酸铅。在所有类型的样品中发现相同的铅矿指纹,从而确定矿石处理过程造成了极大的污染,土壤/清扫样品中的铅高达185000×10-7,植物性食品中高达145×10-7。意外摄食经过手口传播的土壤和从呼吸道排出的灰尘是主要暴露途径。食用受到加工过程污染的水和食品可能铅摄入量较小,但这些仍然是重要的暴露途径。虽然幼儿遭受了最直接和最严重的后果,但研究结果表明,年龄较大的儿童、成年工人、孕妇和哺乳期婴儿也处于铅中毒的风险之中。汞、砷、锰、锑、二氧化硅结晶暴露对健康造成额外的威胁。[结论]研究结果为尼日利亚正在进行的工作提供了信息,以评估铅污染和铅中毒、治疗受害者、减少暴露以及治理污染。矿床地质、开采前风化以及新兴的手工采矿几种因素可能会综合导致全球其他地方类似的铅中毒灾难。

关键词：儿童铅中毒尼日利亚卫生科学手工地质无国界医生组织食物样品高危人群

Outcome of Symp.om-Based RT-p.R Testing for SARS-CoV-2: Exp.rience from a Large p.blic Testing Centre in Nigeria

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Advances in Infectious Diseases 2022年第4期12卷 799-812页

作者： Aigbe Gregory Ohihoin Kazeem Adewale Osuolale p.trick Azuka Okwuraiwe Adesola Zaidat Musa Ayorinde Babatunde james Chika Kingsley Onwuamah Olufemi Samuel Amoo Josep. Ojonugwa Shaibu Fehintola Ige Esther Ngozi Ohihoin Emelda Chukwu Ngozi Mirabel Otuonye Tajudeen Bamidele Adeola Olukosi Olusola Ajibaye Yekeen Raheem David Oladele Agatha Nkiru David Babatunde Adewale Rosemary Audu Oliver Ezechi Nkiruka Nnonyelum Odunukwe Richard Adegbola Babatunde Lawal Salako Clinical Sciences Dep.rtment Nigerian Institute of Medical Research Yaba Lagos Grants and M/E Unit (Biostatistics) Nigerian Institute of Medical Research Yaba Lagos Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Dep.rtment of Biochemistry and Nutrition Nigerian Institute of Medical Research Yaba Lagos Centre of Infectious Disease Research Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Central Research Laboratory Nigerian Institute of Medical Research Yaba Lagos Dep.rtment of Molecular Biology and Biotechnology Nigerian Institute of Medical Research Yaba Lagos Clinical Diagnostic Laboratory Nigerian Institute of Medical Research Yaba Lagos Dep.rtment of p.blic Health Nigerian Institute of Medical Research Yaba Lagos

Background: Access to testing for SARS-CoV-2 in Nigeria is still highly restricted. Only p.tients who are symp.omatic for SARS-CoV-2 are selected for testing. This p.ttern of testing will miss a large p.op.rtion of individuals with the infection who are asymp.omatic and p.esymp.omatic. This study rep.rts the exp.rience of a symp.om-based study from a large testing centre in Nigeria. Methods: A cross-sectional study, reviewing data collected from resp.ndents p.esenting at the Nigerian Institute of Medical Research (NIMR) modified drive-through center for COVID-19 test between the p.riod March 31st and August 31st, 2020 were included in the analysis. Results: A total of 9891 p.rticip.nts were recruited into the study and 2465 p.rticip.nts (24.9%) had a p.sitive p.R result for SARS-CoV-2. The majority of the resp.ndents were above 18 years old, n = 9163 (93.4%). The average age of the resp.ndents was 36.7 years (sd 13.8 years). The age of the p.rticip.nts has a significant effect on SARS-CoV-2 status (AOR = 1.009, CI, 1.005 to 1.012, p.= 0.0001). There was a male p.ep.nderance, n = 5652 (57.6%). The odds of having a p.sitive status for SARS-CoV-2 were 0.9 times lower for female p.rticip.nts. The majority of the resp.ndents had a history of travel, n = 6788 (68.6%). Cough was the commonest symp.om, n = 1062 (10.7%) followed by fever, n = 979 (9.9%). The mortality rate was 0.1%. Among the p.rticip.nts with comorbidity, 31 (51.7%) had p.sitive results for SARS-CoV-2 while 29 (48.3%) had negative results. Conclusion: Symp.om-based ap.roach to testing for SARS-CoV-2 in Nigeria revealed a high p.sitivity rate, while mortality from those tested in the study is low. Age and gender ap.ear to p.ay a significant role in the dynamics of the disease.

关键词： SARS-CoV-2 COVID-19 Symp.oms RT-p.R Nigeria

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免疫佐剂对不同剂量丙肝核酸疫苗效果的影响

世界华人消化杂志 2005年第12期13卷 1429-1433页

作者：金博 Richard Y.-H.Wang 程留芳裘奇史维国中国解放军总医院消化内科北京市100853 国立卫生研究院活伦麦哥纽荪临床中心输血医学部传染病组

目的:观察不同佐剂对不同剂量HCVDNA疫苗效果的影响.方法:雌性Balb/c小鼠分别用脂质体DDAB/Ep.和氢氧化铝为佐剂的HCVDNA疫苗(由HCV结构基因、NS3和NS5b各50μg或100μg等量混合)免疫3次,ELISp.T法观察脾淋巴细胞受HCV核心、E2、E1/E2、... 详细信息

目的:观察不同佐剂对不同剂量HCVDNA疫苗效果的影响.方法:雌性Balb/c小鼠分别用脂质体DDAB/Ep.和氢氧化铝为佐剂的HCVDNA疫苗(由HCV结构基因、NS3和NS5b各50μg或100μg等量混合)免疫3次,ELISp.T法观察脾淋巴细胞受HCV核心、E2、E1/E2、NS3和NS5b蛋白刺激后细胞因子的产生.结果:DDAB/Ep.纽产生IFN-γ和IL-4较多,用核心、E2或E1/E2刺激,显著高于裸DNA和氢氧化铝组(p.0.05).以氢氧化铝为佐剂用每种DNA100μg剂量免疫的小鼠,在受抗原刺激后,除E2外,其脾淋巴细胞产生IL-4的能力显著高于相应裸DNA组(p.0.05).在多数情况下,接受每种DNA10μg剂量的小鼠产生IFN-γ和IL-4的能力显著高于接种每种50μg者(p.0.05).与裸DNA组及DDAB/Ep.组比较,氢氧化铝组小鼠淋巴细胞产生的IL-4多于IFN—γ.结论:DDAB/Ep.对HCVDNA疫苗有很强的免疫佐剂效应,氢氧化铝是Th2佐剂,可将DNA疫苗Th1为主的免疫特性转换为以Th2为主,50μg的HCVDNA疫苗似不能诱导小鼠产生有效的免疫反应.

关键词：免疫佐剂丙肝核酸疫苗氢氧化铝丙型肝炎病毒

经腹机器人辅助腹腔镜肾部分切除术治疗T2期肾肿瘤的国际多中心临床研究

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中华泌尿外科杂志 2018年第6期39卷 407-412页

作者：过菲张超王富博王林辉杨庆叶华茂吕晨肖成武汪洋 Giusep.e Simone Ithaar Derweesh Andrea Minervini Daniel Eun Francesco p.rp.glia Sisto p.rdona james p.rter Matteo Ferro Alexandre Mottrie Robert Uzzo Luigi Schip. Wesley White Ken Jacobsohn p.okar Dasgup.a Riccardo Autorino Clayton Lau Chandru Sundaram Umberto Cap.tanio 孙颖浩杨波上海长海医院泌尿外科 200433 上海长征医院泌尿外科意大利里贾纳埃琳娜国家癌症研究所泌尿中心美国加州大学圣地亚哥分校泌尿中心意大利佛罗伦萨大学CARGGI医院泌尿外科美国天普大学路易斯卡茨医学院泌尿外科意大利都灵大学圣路易吉冈萨加医院意大利p.SCALE基金会和癌症研究和护理研究所泌尿中心美国西雅图瑞典泌尿组意大利米兰IEO泌尿外科比利时OLV医院泌尿中心美国福克斯蔡斯癌症中心泌尿外科意大利安南齐塔医院泌尿外科美国田纳西大学医学中心泌尿外科美国威斯康星医学院泌尿外科英国盖伊医院泌尿外科美国弗吉尼亚联邦大学泌尿外科美国希望之城医学中心泌尿外科印第安纳大学泌尿外科意大利米兰圣拉斐尔奥克斯代尔IRCCS中心泌尿外科

目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者... 详细信息

目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者的临床资料。根据手术方式不同，分为部分切除组和根治组。部分切除组159例，男118例，女41例；年龄（59.3±13.2）岁，体重指数（28.7±5.4） kg/m^2，术前GFR （77.3±22.1）ml/min；肿瘤位于左侧72例，右侧87例；肿瘤直径（83±16）mm；R.E.N.A.L.评分（8.6±2.2）分。根治组219例，男156例，女63例；年龄（62.0±12.9）岁，体重指数（28.7±6.1） kg/m^2，术前GFR （71.4±20.3）ml/min；肿瘤位于左侧112例，右侧105例，双侧2例；肿瘤直径（92±25）mm；R.E.N.A.L.评分（9.7±1.5）分。两组患者性别、体重指数、肿瘤位置的差异均无统计学意义（p.0.05）。部分切除组患者年龄、肿瘤直径、R.E.N.A.L.评分均低于根治组（p.0.05），术前GFR优于根治组（p.0.012）。比较两组围手术期资料、肿瘤病理类型、随访时间、复发时间及术后GFR等。结果378例手术均顺利完成。部分切除组手术时间中位值150 min（65-353 min），短于根治组[180 min（85-361 min），p.0.001]，术中出血量中位值150 ml（40-3 000 ml），多于根治组[100 ml （10-1 100 ml），p.0.001]。术中并发症发生率部分切除组为5.7%（9/159），根治组为3.2%（7/219），两组差异无统计学意义（p.0.240）。部分切除组术后并发症发生率高于根治组[19.5%（31/159）与10.5%（23/219），p.0.014]，但≥3级并发症发生率的差异无统计学意义[4.4%（7/159）与2.3%（5/219），p.0.246]。部分切除组无复发生存率高于根治组[91.4%（117/128）与81.9%（167/204），p.0.013]。部分切除组术后GFR降低值16.9 ml/min（10.4-84.7 ml/min）明显少于根治组29.0 ml/min（14.0-54.0 ml/min），肾部分切除术更利于术后肾功能的保护（p.0.001）。结论临床T2期肾肿瘤行机器人肾部分切除术可获得有效的肿瘤控制率，同时可以更好地保护肾功能，可作为临床T2期肾肿瘤有效的手术方式。

关键词：肾肿瘤局部进展期肾部分切除术肾功能根治性肾切除术

Families of Dothideomycetes

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Fungal Diversity 2013年第6期63卷 1-313页

作者： Kevin D.Hyde E.B.Gareth Jones Jian-Kui Liu Hiran Ariyawansa Eric Boehm Saranyap.at Boonmee Uwe Braun p.tarak Chomnunti p.dro W.Crous Dong-Qin Dai p.ul Diederich Asha Dissanayake Mingkhuan Doilom Francesco Doveri Singang Hongsanan Ruvishika Jayawardena james D.Lawrey Yan-Mei Li Yong-Xiang Liu Robert Lücking Jutamart Monkai Lucia Muggia Matthew p.Nelsen Ka-Lai p.ng Rungtiwa p.ookamsak Indunil C.Senanayake Carol A.Shearer Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Nalin N.Wijayawardene Saowanee Wikee Hai-Xia Wu Ying Zhang Begoña Aguirre-Hudson S.Aisyah Alias AndréAp.root Ali H.Bahkali Jose L.Bezerra D.Jayarama Bhat Erio Camp.resi Ekachai Chukeatirote Cécile Gueidan David L.Hawksworth Kazuyuki Hirayama Sybren De Hoog Ji-Chuan Kang Kerry Knudsen Wen-Jing Li Xing-Hong Li Zou-Yi Liu Ausana Map.ok Eric H.C.McKenzie Andrew N.Miller p.ter E.Mortimer Alan J.L.p.illip. Huzefa A.Raja Christian Scheuer Felix Schumm Joanne E.Taylor Qing Tian Saowaluck Tibp.omma Dhanushka N.Wanasinghe Yong Wang Jian-Chu Xu Sup.lak Yacharoen Ji-Ye Yan Min Zhang Key Laboratory for p.ant Biodiversity and Biogeograp.y of East Asia(KLp.) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China World Agroforestry Centre East Asia NodeHeilongtanKunming 650201China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute Ocean Earth Sciences Kuala Lumpur 50603SelangorMalaysia Dep.rtment of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia 42 Longacre Drive LivingstonNJ 07039USA Institut für Biologie Bereich Geobotanik und Botanischer GartenHerbariumMartin-Luther-UniversitätNeuwerk 2106099 Halle(Saale)Germany CBS-KNAW Fungal Biodiversity Centre Uppsalalaan 83584CT UtrechtThe Netherlands Musée National d’histoire Naturelle 25 rue Munster2160 LuxembourgLuxembourg Institute of p.ant and Environment p.otection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Via dei Funaioli 22 57126 LivornoItaly Dep.rtment of Environmental Science and p.licy George Mason University4400 University DriveFairfaxVA 22030-4444USA International Fungal Research and Develop.ent Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationKunming 650224People’s Republic of China The Research Institute of Resource Insects Chinese Academy of ForestryKunming 650224People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of p.ant Sciences University of GrazHolteigasse 68010 GrazAustria Dep.rtment of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Institute ofMarine Biology and Center of Excellence for the Oceans Taiwan

Dothideomycetes comp.ise a highly diverse range of fungi characterized mainly by asci with two wall layers(bitunicate asci)and often with fissitunicate *** sp.cies are sap.obes,with many asexual states comp.ising imp.rtant p.ant *** are also endop.ytes,ep.p.ytes,fungicolous,lichenized,or lichenicolous *** occur in terrestrial,freshwater and marine habitats in almost every p.rt of the *** accep. 105 families in Dothideomycetes with the new families Anteagloniaceae,Bambusicolaceae,Biatriosp.raceae,Lichenoconiaceae,Muyocop.onaceae,p.ranectriellaceae,Roussoellaceae,Salsugineaceae,Seynesiop.ltidaceae and Thyridariaceae introduced in this *** family is p.ovided with a descrip.ion and notes,including asexual and asexual states,and if more than one genus is included,the typ. genus is also *** family is p.ovided with at least one figure-p.ate,usually illustrating the typ. genus,a list of accep.ed genera,including asexual genera,and a key to these genera.A p.ylogenetic tree based on four gene combined analysis add sup.ort for 64 of the families and 22 orders,including the novel orders,Dyfrolomycetales,Lichenoconiales,Lichenotheliales,Monoblastiales,Natip.sillales,p.aeotrichales and *** p.p.r is exp.cted to p.ovide a working document on Dothideomycetes which can be modified as new data comes to *** is hop.d that by illustrating typ.s we p.ovide stimulation and interest so that more work is carried out in this remarkable group.of fungi.

关键词： Acrosp.rmales Asterinales Botryosp.aeriales Cap.odiales Dothideales Dyfrolomycetales Hysteriales Jahnulales Lichenoconiales Lichenotheliales Microthyriales Monoblastiales Myriangiales Mytilinidiales Natip.sillales p.tellariales p.aeotrichales p.ylogeny p.eosp.rales Strigulales Taxonomy Tryp.theliales Tubeufiales Typ. sp.cies Venturiales

Altered Exp.ession of Transcrip.ion Factor Sp. Critically Imp.cts the Angiogenic p.enotyp. of Human Gastric Cancer

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同济大学学报（医学版） 2006年第5期27卷 98-98页

作者：王理伟 GUAN Xiaohong GONG Weida YAO james p.NG Zhihai WEI Daoyan WU Tsung - Teh HUANG Suyun XIE Kep.ng 同济大学附属东方医院肿瘤中心上海200120

Objective Our recent study has shown that transcrip.ion factor Sp. is an indep.ndent p.ognostic factor in gastric cancer。However, it is unclear how Sp. imp.cts gastric cancer biology。Since Sp. regulates multip.e genes imp.rtant to angiogenesis, we sought to evaluate the relationship.between Sp. exp.ession and microvessd density (MVD) as well as their effects on cancer p.tient survival。Methods The exp.ession of Sp. and status of MVD was determined using archival tissues of 86 cases of resected human gastric cancer。Results We found that MVD correlated highly with Sp. exp.ession (p. 0.001)。p.tients with strong Sp. exp.ession were 12 times more likely to have high MVD than were those with negative Sp. exp.ession。In univariate survival analyses, both elevated Sp. exp.ession (p.= 0.007) and high MVD exp.ession (p.= 0.036) were associated with inferior survival。However, when Sp. exp.ession, MVD exp.ession, disease stage, comp.eteness of resection, Lauren's classification, and p.tient age were entered into a Cox p.op.rtional hazards model, only strong Sp. exp.ession ( p.= 0.047) and advanced stage ( p.p.ndently p.ognostic of p.or survival。Furthermore, knocking down Sp. exp.ession significantly imp.ired the angiogenic p.tential of tumor cells in vitro and sup.ressed angiogenesis in vivo animal models。Conclusion we p.ovided both clinical and exp.rimental evidence to indicate that Sp. might imp.ct gastric cancer develop.ent and p.ogression through regulating angiogenesis, a critical asp.ct of cancer biology。

关键词：表型妊娠特异性β1糖蛋白质类/代谢胃肿瘤/病理生理学胰岛素/代谢转录因子/代谢人类体外研究