检索结果-南通市图书馆

Meeting report:a hard look at the state of enamel research

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2017年第4期9卷 193-199页

作者： ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer program in craniofacial biology and department of orofacial sciences university of californiasan franciscoSan FranciscoUSA department of pediatrics and institute for human genetics university of californiasan franciscoSan FranciscoUSA laboratory of skin biology national institute of arthritis and muscular and skin diseasesnational institutes of healthBethesdaUSA physical science division pacific northwest national laboratoriesRichlandUSA department of basic science and craniofacial biology new york university college of dentistryNewYorkUSA department of materials science and engineering northwestern universityevanstonusaEvanstonUSA center for craniofacial molecular biology herman ostrow school of dentistryuniversity of southern californiaLos AngelesUSA the forsyth institute CambridgeUSA department of developmental biology harvard school of dental medicineBostonUSA department of pediatric dentistry university of north caroline school of dentistryChapel HillUSA departments of dermatology and cel&developmental biology perelman school of medicineand department of anatomy&cell biologyschool of dental medicineuniversity of pennsylvaniaPhiladelphiaUSA functional genomics section national institute of dental and craniofacial researchBethesdaUSA division of biosciences ohio state universitycollege of dentistryColumbusUSA department of periodontics and center for craniofacial research and diagnosis texas a&m university college of dentistryDallasUSA center for children’s oral health research and department of orofacial sciences university of californiasan franciscoSan FranciscoUSA biologic and materials sciences and division of prosthodontics university of michiganAnn ArborUSA

The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines （ENAMEL） Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National institute of Dental and Craniofacial Research （NIDCR）. Discussion topics included model organisms, stem cells/cell lines, and tissues/3D cell culture/organoids. Scientists from a number of disciplines, representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field.

关键词： enamel mineralized tissue mineralization ameloblast stem cell

Analyses of oligodontia phenotypes and genetic etiologies

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2021年第3期13卷 323-332页

作者： Mengqi Zhou Hong Zhang Heather Camhi Figen Seymen Mine Koruyucu Yelda Kasimoglu Jung-Wook Kim Hera Kim-Berman Ninna M.R.Yuson paul J.Benke Yiqun Wu Feng Wang Yaqin Zhu james p.simmer Jan C-C.Hu Dental Research Laboratory University of Michigan School of DentistryAnn ArborMIUSA Department of Second Dental Center Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Department of General Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Orthodontic and pediatric Dentistry University of Michigan School of Dentistry1011N.University AveAnn ArborMIUSA Mott Children’s Health Center 806 Tuuri place FlintMIUSA Department of pedodontics Faculty of DentistryIstanbul UniversityIstanbulTurkey Department of Molecular Genetics&Dental Research Institute School of Dentistry Seoul National UniversitySeoulKorea Department of pediatric Dentistry&Dental Research Institute School of Dentistry Seoul National UniversitySeoulKorea Department of paediatric Dentistry Women’s and Children’s HospitalNorth AdelaideSAAustralia Department of Medical Genetics Joe DiMaggio Children’s HospitalHollywoodFLUSA Department of Oral Implantology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina

Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth *** genes have been implicated in the etiology of tooth agenesis,which is highly variable in its clinical *** purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia *** online systematic search of papers published from January 1992 to June 2021 identified 381 oligodontia cases meeting the eligibility criteria of causative gene mutation,phenotype description,and radiographic ***,ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence *** identified a novel mutation in WNT10A(c.99_105dup)and eight previously reported mutations in WNT10A(c.433 G>A;c.682 T>A;c.318 C>G;c.511.C>T;c.321 C>A),EDAR(c.581 C>T),and LRp6(c.1003 C>T,c.2747 G>T).Collectively,20 different causative genes were implicated among those 393 cases with *** each causative gene,the mean number of missing teeth per case and the frequency of teeth missing at each position were ***–phenotype correlation analysis indicated that molars agenesis is more likely linked to pAX9 mutations,mandibular first premolar agenesis is least associated with pAX9 mutations.

关键词： clinical congenital likely

Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第5期15卷 797-809页

作者： Joseph M pappachan Cornelius james Fernandez Ambika p Ashraf Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Division of pediatric Endocrinology and Diabetes Department of PediatricsUniversity of Alabama at BirminghamBirminghamAL 35233United States

Childhood-onset obesity has emerged as a major public healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and epigenetic *** has led to an exponential rise in the incidence of type 2 diabetes mellitus in children and *** looming wave of diabetes-related complications in early adulthood is anticipated to strain the healthcare budgets in most *** there is a collective global effort to curb the devastation caused by the situation,the impact is poised to be pro-found.A multifaceted research effort,governmental legislation,and effective social action are crucial in attaining this *** article delves into the current epidemiological landscape,explores evidence concerning potential risks and consequences,delves into the pathobiology of childhood obesity,and discusses the latest evidence-based management strategies for diabesity.

关键词： Childhood obesity Diabesity Type 2 diabetes mellitus Adolescence Cardiovascular disease pharmacotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fam83h亚细胞定位的研究

Fam83h亚细胞定位的研究

Exposure of juvenile Chinook salmon to effluent from a large urban wastewater treatment *** *** responses

中华口腔医学会全科口腔医学专业委员会第一次学术年会

作者：丁玉梅常婷黄政 james p simmer JAN C-C HU 张汉东华中科技大学同济医学院附属协和医院口腔中心密歇根大学牙医学院

背景:常染色体显性钙化不全型釉质发育不全(ADHCAI)是最常见最严重的釉质发育不全(AI)。位于染色体8q24.3的Fam83h基因的变异会引起ADHCAI。目前已知AMELX,ENAM,MMp20和KLK4等四个基因的缺陷也会引起AI,它们均编码釉质基质蛋白。对背景...

背景:常染色体显性钙化不全型釉质发育不全(ADHCAI)是最常见最严重的釉质发育不全(AI)。位于染色体8q24.3的Fam83h基因的变异会引起ADHCAI。目前已知AMELX,ENAM,MMp20和KLK4等四个基因的缺陷也会引起AI,它们均编码釉质基质蛋白。对背景:常染色体显性钙化不全型釉质发育不全(ADHCAI)是最常见最严重的釉质发育不全(AI)。位于染色体8q24.3的Fam83h基因的变异会引起ADHCAI。目前已知AMELX,ENAM,MMp20和KLK4等四个基因的缺陷也会引起AI,它们均编码釉质基质蛋白。对

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2024年第3期9卷 355-366页

作者： Suzanne C.Ball james p.Meador C.Andrew james Jenifer K.McIntyre Washington State University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA Dept.of Environmental and Occupational Health Sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Wastewater treatment plants release complex mixtures of chemicals into the aquatic environment as wastewater effluent(WWE);however,the effects of these mixtures are still poorly *** salmon(Oncorhynchus tshawytscha)are a culturally important species in the pacific Northwest and are a vital food resource for southern resident killer whales(Orcinus orca)that are listed as‘critically endangered’under the *** Species Act(ESA).Chinook populations have declined drastically in this region and have failed to show significant recovery despite regional-to-federal efforts,resulting in many populations being listed as threatened under the *** source of stress to juvenile Chinook is chemical pollution from WWE during their outmigration along river corridors and residency in *** this study,we investigated effects of WWE on juvenile Chinook health in a ten-day exposure to dilutions of WWE from 0.1%to 20%.At the end of the exposure,we measured endpoints associated with endocrine disruption,brain function,osmoregulation,stress,and *** to WWE significantly(α=0.1 for all analyses)induced vitellogenesis,indicating endocrine system *** saw significant reductions in plasma glucose,an indication of stress,and brain Na+/K+-ATpase(NKA)activity,an enzyme essential for neuronal ***,metabolism was affected as evidenced by altered total protein,cholesterol,and albumin in plasma,a drastic decrease in whole body lipid content,and a significant increase in visible liver *** compared contaminant concentrations in exposure water with effects concentrations from the literature for chemicals known to induce vitellogenin or inhibit brain *** most contaminants,concentrations in exposure waters were several orders of magnitude below effects concentrations in the *** exception was estrogenic hormones,which were detected at similar concentrations in this study compared to concentrations in other studies tha

关键词： Wastewater effluent Chinook salmon Toxicity Sodium potassium ATpase Vitellogenin physiology Metabolism Glucose

Exposure of juvenile Chinook salmon to effluent from a large urban wastewater treatment *** *** profiling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2024年第3期9卷 367-377页

作者： james p.Meador Suzanne C.Ball C.Andrew james Jenifer K.McIntyre Dept.of Environmental and Occupational Health Sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA Washington State University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Targeted metabolomic analysis was conducted on juvenile Chinook salmon exposed for 10 days to wastewater effluent(WWE)from a large urban treatment *** included five dilutions of WWE(20%,5.3%,1.4%,0.4%,and 0.1%)and a control with 7 replicates per *** was extracted from fish and analyzed via liquid chromatography–mass spectrometry(LC-MS)for 361 endogenous metabolites,of which 185 were ***-versus-treatment comparisons identified several metabolites that were associated with altered biochemical pathways observed for all treatments,including several that are important for energy generation and *** altered pathways are crucial for fish health and may be an early indicator of potential adverse effects on growth,reproduction,behavior,and immune *** ocean-type Chinook salmon spend several days to weeks in the nearshore estuary where they may encounter high concentrations of WWE *** are exposed to a wide range of potent pharmaceuticals,personal care products,and industrial compounds from WWE that have the potential to affect physiological homeostasis and disrupt their normal life cycle.

关键词： Wastewater effluent Metabolomics physiology Chinook salmon pharmaceuticals Metabolic pathways Estuary

Template-assisted growth of Co-BaTiO_(3) vertically aligned nanocomposite thin films with strong magneto-optical coupling effect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 3130-3138页

作者： Zedong Hu Juanjuan Lu Hongyi Dou Jianan Shen james pBarnard Juncheng Liu Xinghang Zhang Haiyan Wang School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47906USA School of Materials Engineering Purdue UniversityWest LafayetteIN 47906USA

Oxide-metal based nanocomposite thin films have attracted great interests owing to their unique anisotropic structure and physical properties.A wide range of Au-based oxide-metal nanocomposites have been demonstrated,while other metal systems are scarce due to the challenges in the initial nucleation and growth as well as possible interdiffusions of the metallic *** this work,a unique anodic aluminum oxide(AAO)template was used to grow a thin Co seed layer and the following self-assembled metal-oxide(Co-BaTiO_(3))vertically aligned nanocomposite thin film *** AAO template allows the uniform growth of Co-seeds and successfully deposition of highly ordered Co pillars(with diameterpillarspy and strong magneto-optical coupling properties have been observed.A thin Au-BaTiO_(3) template was also later introduced for further enhanced nucleation and ordered growth of the *** the advantage of such a unique nanostructure,a large out-of-plane(Op)coercive field(Hc)of~5000 Oe has been achieved,making the nanocomposite an ideal candidate for high density perpendicular magnetic tunneling junction(p-MTJ).A strong polar magneto-optical Kerr effect(MOKE)has also been observed which inspires a novel optical-based reading method of the MTJ states.

关键词： vertically aligned nanocomposite(VAN) Co BaTiO_(3) thin film magneto-optical coupling magnetic anisotropy

Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta pharmaceutica Sinica B 2024年第2期14卷 653-666页

作者： Shining Loo Antony Kam Bamaprasad Dutta Xiaohong Zhang Nan Feng Siu Kwan Sze Chuan-Fa Liu Xiaoliang Wang james p.Tam School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Academy of pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China Department of Health Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress and illness connection is complex and involves multiple physiological *** ginsengs,reputed for their broad-spectrum“cure-all”effect,are widely prescribed to treat stress and related ***,the identity of ginseng’s“cure-all”medicinal compounds that relieve stress remains ***,we identify ginsentides as the principal bioactives that coordinate multiple systems to restore homeostasis in response to *** are disulfide-rich,cell-penetrating and proteolytic-stable *** affinity-enrichment mass spectrometry target identification together with in vitro,ex vivo and in vivo validations,we show that highly purified or synthetic ginsentides promote vasorelaxation by producing nitric oxide through endothelial cells via intracellular pI3K/Akt signaling pathway,alleviate a1-adrenergic receptor overactivity by reversing phenylephrine-induced constriction of aorta,decrease monocyte adhesion to endothelial cells via CD166/ESAM/CD40 and inhibit p2Y12 receptors to reduce platelet *** administered ginsentides were effective in animal models to reduce ADp-induced platelet aggregation,to prevent collagen and adrenalineinduced pulmonary thrombosis as well as anti-stress behavior of tail suspension and forced swimming tests in ***,these results strongly suggest that ginsentides are the principal panacea compounds of ginsengs because of their ability to target multiple extra-and intra-cellular proteins to reverse stress-induced damages.

关键词： Ginseng Cysteine-rich peptides Microproteins Cure-all Stress Homeostasis

Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第6期15卷 585-592页

作者： Katherine Esser james J Butler Mackenzie Roof Nathaniel p Mercer Michael C Harrington Alan p Samsonov Andrew J Rosenbaum John G Kennedy Department of Orthopaedic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGROUND Cheilectomy of the 1^(st)metatarsophalangeal joint(MTpJ)is one of the most common procedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the pubMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 patients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up of 37.9±16.5 *** distribution of patients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTpJ arthroscopy and debridement following *** intra-articular bone debris was observed in 100%of patients in 1 *** weighted mean American orthopedic foot and ankle society score improved from a preoperative score of 68.9±3.2 to a postoperative score of *** complication rate was 8.4%,the most common of which was persistent joint pain and ***-two failures(8.7%)were ***-three secondary procedures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated improvements in subjective clinical outcomes together with a moderate complication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was *** marked heterogeneity between included studies and paucity of high quality comparative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsophalangeal joint Cheilectomy Minimally invasive surgery