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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl james Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI ThALÍA DOMÍNGUEZ BUCIO hAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN ChURChILL james C.GATES james hILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI JENS h.SChMID ILARIA CRISTIANI PAVEL ChEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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聚醚醚酮齐聚物固相增黏及聚合物性质研究

中国塑料 2024年第9期38卷 8-13页

作者：庞馨蕾白瑜王洪学中石化(上海)石油化工研究院有限公司上海201208

以环丁砜为溶剂合成齐聚物,采用齐聚物在双转子密炼机中进一步固相增黏的聚合方式制备了聚醚醚酮(PEEK)。研究了不同增黏时间对PEEK结晶、热学和流动性能等的影响。结果表明,随着聚合时间增加,PEEK结晶度和结晶完善程度逐渐降低,且增黏... 详细信息

以环丁砜为溶剂合成齐聚物,采用齐聚物在双转子密炼机中进一步固相增黏的聚合方式制备了聚醚醚酮(PEEK)。研究了不同增黏时间对PEEK结晶、热学和流动性能等的影响。结果表明,随着聚合时间增加,PEEK结晶度和结晶完善程度逐渐降低,且增黏5 h制得的PEEK的结晶度较齐聚物降低约31.4%;所有聚合物900℃时残炭量仍大于50%,具有优异的热稳定性;PEEK熔体黏度随增黏时间增加逐渐增大,约为齐聚物的13~360倍。

关键词：聚醚醚酮齐聚物固相增黏结晶性能热学性能

Mathematical Modelling and Design of helical Coil heat Exchanger for Production of hot Air for Fluidized Bed Dryer

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Advances in Chemical Engineering and Science 2024年第3期14卷 125-136页

作者： Iniubong james Uwa Uwem Ekwere Inyang Innocent Oseribho Oboh Department of Chemical Engineering Faculty of Engineering University of Uyo Uyo Nigeria

In global industrialization, efforts have been made to increase the rate of heat transfer in heat exchanger, minimizing the size of heat exchanger to reduce cost as well as increasing the effectiveness. helical coil heat exchanger (hChE) has been proven to be effective in improving heat transfer due to its large surface area. In this study, hChE was designed to provide hot air needed for fluidized bed drying processes. The hChE design model was fabricated and evaluated to study the efficiency of the hot air output for a laboratory fluidized bed dryer. The mathematical model for estimation of the final (output) temperature of air, Taf, passing through the hChE was developed and validated experimentally. The drying of bitter kola particulates was carried out with a drying temperature of 50C 3C and a bed height-to-bed diameter ratio (h/D) of 1.5. The time taken to dry bitter kola particulates to 0.4% moisture content was 1 hour 45 minutes. hence, hChE is recommended for use in the production of hot for laboratory-scale fluidized bed dryers.

关键词： helical Coil heat Exchanger Fluidized Bed Dryer heat Transfer Output Air Temperature

扩链条件对聚丁二酸丁二酯-共-对苯二甲酸丁二酯/滑石粉共混物性能的影响

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中国塑料 2024年第6期38卷 1-11页

作者：骆佳伟周炳王洪学贾钦中石化(上海)石油化工研究院有限公司上海201208

将一种多环氧官能团聚合物作为聚丁二酸丁二酯-共-对苯二甲酸丁二酯(PBST)的扩链剂,研究熔体反应挤出过程中的扩链条件对PBST/滑石粉共混物性能的影响。将扩链剂用量、反应温度和螺杆转速作为本研究的主要研究因素,通过方差分析寻找主... 详细信息

将一种多环氧官能团聚合物作为聚丁二酸丁二酯-共-对苯二甲酸丁二酯(PBST)的扩链剂,研究熔体反应挤出过程中的扩链条件对PBST/滑石粉共混物性能的影响。将扩链剂用量、反应温度和螺杆转速作为本研究的主要研究因素,通过方差分析寻找主要影响因素及各因素间交互作用。结果表明,扩链剂用量的影响最为显著,其次是温度,螺杆转速的影响不显著;随着扩链剂用量的增加,熔融温度和结晶温度降低,分子量、熔体黏度和热稳定性增加;同时,随着扩链剂用量的增加,改性PBST强度提高但韧性降低;响应面分析表明扩链剂用量、反应温度和螺杆转速分别为0.66%、200℃和300 r/min时扩链条件最优。

关键词：可生物降解聚酯扩链剂扩链条件聚丁二酸丁二酯-共-对苯二甲酸丁二酯滑石粉

Large polyps:Pearls for the referring and receiving endoscopist

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World Journal of Gastrointestinal Endoscopy 2021年第12期13卷 638-648页

作者： Eric Markarian Brian M Fung Mohit Girotra james h.tabibian Academy of Science and Medicine Crescenta Valley High SchoolLos AngelesCA 91214United States Division of Gastroenterology and hepatology Department of Internal MedicineUniversity of Arizona College of Medicine-PhoenixPhoenixAZ 85006United States Division of Gastroenterology Banner-University Medical Center PhoenixPhoenixAZ 85006United States Section of Gastroenterology and Therapeutic Endoscopy Digestive Health InstituteSwedish Medical CenterSeattleWA 98104United States Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCA 91342United States Vatche and Tamar Manoukian Division of Digestive Diseases David Geffen School of Medicine at UCLALos AngelesCA 90095United States

Polyps are precursors to colorectal cancer,the third most common cancer in the United *** polyps,i.e.,,those with a size≥20 mm,are more likely to harbor *** polyps can be removed through various techniques,with the goal to completely resect and prevent colorectal cancer;however,the management of large polyps can be relatively complex and *** polyps are generally more difficult to remove en bloc with conventional methods,and depending on level of expertise,may consequently be resected piecemeal,leading to an increased rate of incomplete removal and thus polyp *** effectively manage large polyps,endoscopists should be able to:(1)Evaluate the polyp for characteristics which predict high difficulty of resection or incomplete removal;(2)Determine the optimal resection technique(e.g.,snare polypectomy,endoscopic mucosal resection,endoscopic submucosal dissection,etc.);and(3)Recognize when to refer to colleagues with greater *** review covers important considerations in this regard for referring and receiving endoscopists and methods to best manage large colonic polyps.

关键词： Adenoma Endoscopic mucosal resection Endoscopic tattoo Colorectal cancer Polypectomy

Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastrointestinal Endoscopy 2021年第6期13卷 161-169页

作者： Simcha Weissman Mohamed Ahmed Matthew R Baniqued Dean Ehrlich james h.tabibian Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States UCLA Vatche and Tamar Manoukian Division of Digestive Diseases Los AngelesCA 91342United States Director of Endoscopy Division of GastroenterologyDepartment of MedicineOlive View-UCLA Medical CenterSylmarCA 91342United States

Acute pancreatitis is of one the most common gastroenterology-related indications for hospital admissions *** the widespread reliance on endoscopic retrograde cholangiopancreatography(ERCP)for the management of pancreaticobiliary conditions,post-ERCP pancreatitis(PEP)has come to represent an important etiology of acute *** many studies aiming to better understand the pathogenesis and prevention of this iatrogenic disorder,findings have been heterogeneous,and considerable variation in clinical practice ***,we review the literature regarding PEP with the goal to raise awareness of this entity,discuss recent data,and present evidence-based best *** believe this manuscript will be useful for gastrointestinal endoscopists as well as other specialists involved in the management of patients with PEP.

关键词： Post-endoscopic retrograde cholangiopancreatography pancreatitis Endoscopic retrograde cholangiopancreatography Pancreatitis Practice guidelines Pharmacology Prevention

Foreign object ingestion and esophageal food impaction:An update and review on endoscopic management

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World Journal of Gastrointestinal Endoscopy 2019年第3期11卷 174-192页

作者： Brian M Fung Seth Sweetser Louis M Wong Kee Song james h.tabibian UCLA-Olive View Internal Medicine Residency Program Division of Gastroenterology and hepatology Mayo Clinic Division of Gastroenterology Olive View-UCLA Medical Center

Foreign body ingestion encompasses both foreign object ingestion(FOI) and esophageal food impaction(EFI) and represents a common and clinically significant scenario among patients of all ages. The immediate risk to the patient ranges from negligible to life-threatening, depending on the ingested substance,its location, patient fitness, and time to appropriate therapy. This article reviews the FOI and EFI literature and highlights important considerations and implications for pediatric and adult patients as well as their providers. Where published literature is insufficient to provide evidence-based guidance, expert opinion is included to supplement the content of this comprehensive review.

关键词： Foreign bodies Endoscopy Gastrointestinal emergency Medical management Dysphagia

Comprehensive study of protein phosphorylation， acetylation， ubiquitination and S-nitrosylation profiles in pre- and post-rigor meat

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Food Science and human Wellness 2024年

作者： Chi Ren Yuqiang Bai Yejun Zhang Chengli hou Li Chen james D.Morton Xin Li Zhenyu Wang Dequan Zhang Institute of Food Science and Technology， Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality & Safety in harvest， Storage， Transportation， Management and Control， Ministry of Agriculture and Rural Affairs Faculty of Agriculture and Life Sciences， Lincoln University Lincoln 7647， New Zealand

This study investigated the integrated atlas of protein phosphorylation， acetylation， ubiquitination and S-nitrosylation in pre-rigor (0.5 h) and post-rigor (5 d) lamb to interpret the roles of protein post-translational modifications (PTMs) during meat aging. The results showed that the most common PTMs in postmortem meat were phosphorylated proteins. PTMs regulation during the postmortem period altered proteins involved in metabolic pathways and muscle contraction. The phosphorylation and ubiquitination of proteins located in mitochondria and nuclear changed significantly between 0.5 h and 5 d postmortem. Gene set enrichment analysis (GSEA) revealed possible roles of total PTMs proteins， with a general downregulation of phosphorylation， acetylation and ubiquitination. There was a weak correlation in the lysine PTM of acetylation and ubiquitination at the same site in postmortem meat. Multiple PTMs of proteins in glycolysis， TCA cycle， muscle contraction and the calcium signaling pathway cooperatively regulate meat quality development from pre-rigor to post-rigor.

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