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Work conjugate strain of virial stress

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International Journal of Smart and Nano Materials 2016年第1期7卷 39-51页

作者： Leyu Wang Jiaoyan Li james d.lee Center for Collision Safety and Analysis College of ScienceGeorge Mason UniversityFairfaxVAUSA School of Engineering Brown UniversityProvidenceRIUSA department of Mechanical and Aerospace Engineering The George Washington UniversityWashingtonDCUSA

Certain stress tensor and strain tensor form a conjugate pair if there exists a scalar valued strain energy function such that the stress tensor is equal to the derivative of strain energy function with respect to the strain *** stress is widely accepted as the stress measurement in molecular dynamics(Md).However,its conjugate strain is not yet *** atomic logarithmic strain is proposed and numerically verified as the conjugate strain of virial stress at 0 K *** strain energy is calculated by virial stress and the proposed atomic logarithmic strain equals to the interatomic potential energy *** conclusion is numerically verified with(1)Coulomb-Buckingham potential,Lenard-Jones potential,or arbitrary nonlinear pair potential and(2)randomly generated atomic configurations and deformation *** are given in determining the stress–strain relation for magnesium oxide with Md *** result shows that the atomic logarithmic strain is identical to engineer-ing strain when deformation is small.

关键词： Thermodynamic pair conjugacy virial stress atomic logarithmic strain molecular dynamics interatomic potential strain energy magnesium oxide

Work conjugate pair of stress and strain in molecular dynamics

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International Journal of Smart and Nano Materials 2016年第3期7卷 144-178页

作者： Leyu Wang james d.lee Cing-dao Kan Center for Collision Safety and Analysis College of ScienceGeorge Mason UniversityFairfaxVAUSA department of Mechanical and Aerospace Engineering the George Washington UniversityWashingtonDC 20052USA

Certain stress and strain form a thermodynamic conjugate pair such that their strain energy equals to a scalar-valued potential *** atomistic stresses and strains are analytically derived based on the work conjugate *** is numerically verified with both two-body and three-body potentials that the atomistic Kirchhoff stress,first-order Piola–Kirchhoff stress and second-order Piola–Kirchhoff stress are conjugates to atomistic logarithmic strain,deformation gradient and Lagrangian strain,*** stress at 0 K based on original volume is the special form of atomistic Kirchhoff stress for pair *** is numerically verified that Hencky strain is not conjugate to any stress.

关键词： Thermodynamic conjugacy logarithmic strain atomistic stress deformation gradient strain energy interatomic potential Tersoff potential atomistic first-order Piola-Kirchhoff stress atomistic second-order Piola-Kirchhoff stress atomistic Kirchhoff stress virial stress

Multiscale analysis of composite material reinforced by randomly-dispersed particles

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International Journal of Smart and Nano Materials 2012年第1期3卷 2-13页

作者： Jiaoyan Li james d.lee Ken P.Chong The George Washington University WashingtonDC 20052USA National Institute of Standards and Technology GaithersburgMD 20899USA

A multiscale analysis method is presented in which detailed information on the microscopic level is incorporated into macroscopic models capable of simulating damage evolution and ultimate *** composite considered is reinforced by randomly-dispersed particles,which reflects the statistical characteristics of real materials,such as cement-based ***,a three-dimensional material body is decomposed into many unit *** unit cell is reinforced by a cylindrical particle,the orientation of which is characterized by three Euler angles generated by the random number *** on a detailed finite element analysis,the material properties of the representative volume element are *** verification,the properties of the cylindrical particles are set equal to those of the matrix and the computed‘composite’properties reduce exactly to those of the‘isotropic’material,as *** coordinate transformation,the effective material properties of each unit cell are *** assembly of stiffness matrices of all unit cells leads to the stiffness matrix of the whole *** the simple tension loading condition,the initial damaged unit cell can be identified according to the vonMises yield *** stiffness of the damaged unit cell will then be reduced to zero and it will cause stress redistribution and trigger further *** was found that the reinforcement is effective to mitigate and arrest the damage propagation,and therefore prolongs the material’s *** results suggest that the hierarchical coupling approaches used here may be useful for material design and failure protection in composites.

关键词： multiscale analysis random response finite element method representative volume element Euler angle damage propagation

Alphabet strategy for diabetes care:A checklist approach in the time of COVId-19 and beyond

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World Journal of diabetes 2021年第4期12卷 407-419页

作者： Rajeev Upreti james d lee Satyan Kotecha Vinod Patel department of Endocrinology George Eliot HospitalNuneaton CV107DJUnited Kingdom

Chronic disease management requires achievement of critical individualised targets to mitigate again long-term morbidity and premature mortality associated with diabetes *** responsibility for this lies with both the patient and health care *** plans have been introduced in many healthcare settings to provide a patient-centred approach that is both evidence-based to deliver positive clinical outcomes and allow individualised *** Alphabet strategy(AS) for diabetes is based around such a care plan and has been evidenced to deliver high clinical standards in both well-resourced and underresourced *** patient educational resources include special care plans for those people with diabetes undertaking fasting during Ramadan,Preconception Care, Prevention and Remission of *** Strategy and Care Plan has facilitated evidence-based,cost-efficient multifactorial intervention with an improvement in the National diabetes Audit targets for blood pressure,cholesterol levels and glycated *** of these attainments were of the standard seen in intensively treated cohorts of key randomized controlled trials in diabetes care such as the Steno-2 and United Kingdom Prospective diabetes *** is despite working in a relatively under-resourced service within the United Kingdom National Health *** AS for diabetes care is a useful tool to consider for planning care, education of people with diabetes and healthcare *** the time of the coronavirus disease 2019 pandemic the risk factors for the increased mortality observed have to be addressed *** AS has the potential to help with this aspiration.

关键词： Alphabet strategy COVId-19 Care planning Chronic disease diabetes care Multifactorial interventions Patient care

Alphabet Strategy for diabetes care: A multi-professional, evidence-based, outcome-directed approach to management

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World Journal of diabetes 2015年第6期6卷 874-879页

作者： james d lee Ponnusamy Saravanan Vinod Patel diabetes and Endocrinology Centre George Eliot Hospital NHS Trust Warwick Medical School University of Warwick CV4 7AL Coventry United Kingdom

With the rising global prevalence in diabetes, healthcare systems are facing a growing challenge to provide efficient and effective diabetes care management in the face of spiralling treatment costs. diabetes is a major cause of premature mortality and associated with devastating complications especially if managed poorly. Although diabetes care is improving in England and Wales, recent audit data suggests care remains imperfect with wide geographical variations in quality. diabetes care is expensive with a sizeable amount of available expenditure used for treating the complications of diabetes. A target driven, long-term, multifactorial intervention in patients with type 2 diabetes has been shown to reduce mortality and morbidity. The alphabet strategy is a novel approach to effective diabetes care provision, aiming to address patient education and empowerment, provide consistent comprehensive care delivered in a timely fashion, and allowing multidisciplinary team work.

关键词： Alphabet strategy diabetes care management Checklist Multifactorial intervention Chronicdisease management

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固体力学中的无网格法

国外科技新书评介 2007年第11期 15-16页

作者：陈友平 james d．lee 邓守春 Giogia Washinton Unversity USA Azim Eskandafian 中国科学院力学研究所助理研究员

在过去的数十年中，有限元方法（FEM）已经成为了计算力学中的主要方法，它对工程应用和科学研究已经作出了巨大的贡献。然而，有限元法并不能处理所有的问题，如由于大变形引起的网格扭曲、移动的不连续边界（如裂纹的复杂路径扩展）... 详细信息

在过去的数十年中，有限元方法（FEM）已经成为了计算力学中的主要方法，它对工程应用和科学研究已经作出了巨大的贡献。然而，有限元法并不能处理所有的问题，如由于大变形引起的网格扭曲、移动的不连续边界（如裂纹的复杂路径扩展）、结构优化中的网格重划分或多物理问题等。

关键词：无网格法固体力学有限元方法不连续边界网格重划分计算力学科学研究有限元法

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi james d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics