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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger barbara Schaedl james Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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The Beijing 2022 Winter Olympics:An opportunity to promote physical activity and winter sports in Chinese youth

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Journal of Sport and Health Science 2022年第1期11卷 3-5页

作者： barbara E.Ainsworth james F.Sallis School of Kinesiology Shanghai University of SportShanghai 200438China College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Mary MacKillop Institute for Health Research Australian Catholic UniversityMelbourneVIC 3000Australia Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoSan DiegoCA 92093USA

TagedPIn February and March 2022,China will host the Beijing 2022 Olympic and Paralympic Winter *** vision for this landmark event promises a“joyful rendezvous upon pure ice and snow uniting the passion of hundreds of millions for winter sports”.1 Themes have been developed to create a positive environmental impact with new development for the northern region of the country and to promote winter sports and improve the health and well-being of the Chinese *** key messages for the winter games include inspiring youth with the Olympic spirit and encouraging millions to embrace winter ***,the Chinese government aims to mobilize at least 300 million of its citizens to engage in winter sports as an outcome of hosting the Winter Olympic Games.

关键词： winter sports hundreds

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杏仁核内去甲肾上腺素在应激激素调控记忆保持过程中的作用(英文)

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Acta Pharmacologica Sinica 2000年第6期21卷 3-15页

作者： barbara FERRY,james L McGAUGH Center for the Neurobiology of Learning and Memory Center for the Neurobiology of Learning and Memory Department of Psychobiology University of California Irvine CA 92697-3800 USA

There is extensive evidence indicating that the noradrenergic system of the amygdala, particularly the baso-lateral nucleus of the amygdala (BLA), is involved in memory consolidation. This article reviews the central hypothesis that stress hormones released during emotionally arousing experiences activate noradrenergic mechanisms in the BLA, resulting in enhanced memory for those events. Findings from experiments using rats have shown that the memory-modulatory effects of the adreno-cortical stress hormones epinephrine and glucocorticoids involve activation of β-adrenoceptors in the BLA. In addition, both behavioral and microdialysis studies have shown that the noradrenergic system of the BLA also mediates the influences of other neuromodulatory systems such as opioid peptidergic and GABAergic systems on memory storage. Other findings indicate that this stress hormone-induced activation of noradrenergic mechanisms in the BLA regulates memory storage in other brain regions.

关键词：去甲肾上腺素杏仁核学习记忆肾上腺皮质激素应激 α肾上腺素受体类 β肾上腺素受体

Memmler's Structure and Function of the Human Body 9th ed.

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Maternal Smoking During Pregnancy and Sudden Infant Death Using the National Maternal and Infant Health Survey: A Case-Case Study

2009年

作者： Cohen, barbara Janson/ Taylor, Jason james

ISBN: (纸本)9780781765886

Based on Memmler's The Human Body in Health and Disease , this text is an excellent primer that focuses on normal anatomy and physiology. With a new design and a robust new multimedia electronic ancillary package, this Ninth Edition will be even more engaging and understandable for students with diverse learning styles. This edition's new artwork includes real dissection photographs from Rohen's Color Atlas of Anatomy, Sixth Edition. New A&P in Action case scenarios integrated throughout each chapter show how content is applied to real-life situations. Icons direct students to relevant electronic materials. The new PASSport to Success online student ancillary package includes a learning styles assessment that guides students to the interactive activities best suited to their individual learning style. Eleven different types of visual, auditory, and kinesthetic activities are presented on the PASSport Website and on a bound-in CD-ROM. LiveAdvise one-to-one online tutoring is also included.

关键词： Physiology.

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International Journal of Clinical Medicine 2011年第3期2卷 318-324页

作者： Kathleen F Brookfield james D Wilkinson barbara Luke Kristopher Arheart Eleni Sfakianaki 不详

We utilized data from the National Maternal and Infant Health Survey (NMHIS) to analyze the risk of SIDS and other infant deaths among women who smoke during pregnancy adjusting for potentially modifiable risk factors such as secondhand smoke exposure and breastfeeding. The following variables were assessed with respect to risk for SIDS and other infant deaths: smoking exposure, level of education, infant and maternal age, infant and maternal birthweight, maternal BMI, gender, secondhand smoke exposure, breast feeding, prenatal vitamins, WIC, multiple gestation, sleep apnea monitor prescription, sleep apnea incidents and maternal alcohol use. Univariate analysis and multivariate logistic regression were performed to identify variables significantly associated with the odds of mortality from SIDS. Analysis utilized weighted estimates using SUDAAN 9.0.0 to adjust for design effects. A p-value <0.01 was considered statistically significant. Women who smoked during pregnancy were 1.83 times more likely to give birth to an infant that died from SIDS versus some other cause of death, OR (95%) = 1.83(1.33, 2.51). Other Race infants and Black infants were more likely to suffer SIDS mortality than White infants, but the result was not significant in the final model. Other modifiable risk factors, such as secondhand smoke exposure and breast feeding, were not significant predictors of SIDS mortality. Independent of sociodemographic variables and other potential risk factors for SIDS death, maternal smoking was associated with an increased risk of SIDS death versus other death. This study highlights the importance of screening all pregnant women for tobacco use and emphasizes the importance of smoking cessation to decrease the risk of infant death from SIDS.

关键词： Sudden Infant Death Smoking Pregnancy Passive Smoking Breastfeeding

Rapid,high-resolution detection of environmental change over continental scales from satellite data–the Earth Observation Data Cube

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International Journal of Digital Earth 2016年第1期9卷 106-111页

作者： Adam Lewis Leo Lymburner Matthew B.J.Purss Brendan Brooke Ben Evans Alex Ip Arnold G.Dekker james R.Irons Stuart Minchin Norman Mueller Simon Oliver Dale Roberts barbara Ryan Medhavy Thankappan Rob Woodcock Lesley Wyborn Geoscience Australia CanberraAustralia National Computational Infrastructure Australian National UniversityCanberraAustralia Commonwealth Scientific and Industrial Research Organisation CanberraAustralia NASA Goddard Space Flight Center GreenbeltMDUSA Research School of Finance Actuarial Studies and Applied StatisticsANUCanberraAustralia The Group on Earth Observations Secretariate GenevaSwitzerland

The effort and cost required to convert satellite Earth Observation(EO)data into meaningful geophysical variables has prevented the systematic analysis of all available *** overcome these problems,we utilise an integrated High Performance Computing and Data environment to rapidly process,restructure and analyse the Australian Landsat data *** this approach,the EO data are assigned to a common grid framework that spans the full geospatial and temporal extent of the observations–the EO Data *** approach is pixel-based and incorporates geometric and spectral calibration and quality assurance of each Earth surface reflectance *** demonstrate the utility of the approach with rapid time-series mapping of surface water across the entire Australian continent using 27 years of continuous,25 m resolution *** preliminary analysis of the Landsat archive shows how the EO Data Cube can effectively liberate high-resolution EO data from their complex sensor-specific data structures and revolutionise our ability to measure environmental change.

关键词： Earth Observation Data Cube HPD HPC surface water Landsat Australia

High Dose Rate (HDR) Brachytherapy for Mycosis Fungoides of the Wrist

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International Journal of Clinical Medicine 2015年第3期6卷 154-157页

作者： Gaurav Shukla Virginia Lockamy james Keller Joya Sahu barbara Pro Onder Alpdogan Wenyin Shi Department of Radiation Oncology Thomas Jefferson University Philadelphia PA USA Department of Dermatology Thomas Jefferson University Philadelphia PA USA Department of Medical Oncology Thomas Jefferson University Philadelphia PA USA

Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma accounting for approximately half of all cutaneous T-cell lymphomas. Radiation therapy is an effective treatment for early stage MF and has been shown to result in long-term disease-free intervals, with even curative potential. Radiation is also effective as palliative treatment for the localized lesion resistant to the topic or other treatments. In the current study, we report using high dose rate (HDR) radiation treatment for a patient with resistant mycosis fungoides involving the wrist. We report a convenient treatment with an ideal radiation dose distribution, and a excellent clinical outcome.

关键词： Mycosis Fungoides Cutaneous T-Cell Lymphoma Radiation Therapy High Dose Rate (HDR)

Phosphorus features in FT-IR spectra of natural organic matter

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Acta Geochimica 2006年第S1期 259-260页

作者： C. Wayne Honeycutt Tsutomu Ohno james F. Hunt barbara J. Cade-Menun USDA-ARS New England Plant Soil and Water Laboratory Orono ME 04469 USA Dept. of Plant Soil and Environmental Sciences Univ. of Maine Orono ME 04469 USA Geol. & Environ. Sci. Dept. Stanford University Stanford CA 94305 USA

Phosphorus features in FT-IR spectra of natural organic matter

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Chinese Journal Of Geochemistry 2006年第B8期25卷 259-260页

作者： Zhongqi HE C. Wayne Honeycutt Tsutomu Ohno james F. Hunt barbara J. Cade-Menun USDA-ARS New England Plant Soil and Water Laboratory Orono ME 04469 USA Dept. of Plant Soil and Environmental Sciences Univ. of Maine Orono ME 04469 USA Geol. ＆ Environ. Sci. Dept. Stanford University Stanford CA 94305 USA