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Amniotic membrane transplantation in a patient with impending perforated corneal ulcer caused by Streptococcus mitis: A case report and review of literature

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World Journal of Clinical Cases 2022年第12期10卷 3923-3929页

作者： Fang-Chi Hsiao Yaa-Jyuhn james Meir Lung-Kun yeh Hsin-Yuan Tan Ching-Hsi Hsiao David Hui-Kang Ma Wei-Chi Wu Hung-Chi Chen Department of Ophthalmology Chang Gung Memorial HospitalTaoyuan 333423Taiwan Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33305Taiwan Department of Medicine College of MedicineChang Gung UniversityTaoyuan 33305Taiwan Center for Tissue Engineering Chang Gung Memorial HospitalTaoyuan 333423Taiwan

BACKGROUND Streptococcus mitis(***)is an opportunistic pathogen that can lead to severe ocular *** previous reports,penetrating keratoplasty(PK)was usually adopted for the treatment of persistent corneal *** report describes an unusual case of nonhealing descemetocele caused by *** treated by antibiotics plus amniotic membrane transplantation(AMT).CASE SUMMARY A 63-year-old woman presented with a right persistent corneal ulcer that she had suffered from for the past 9 *** culture of a corneal scraping yielded *** right eye descemetocele decreased in diameter from 3 to 0.8 mm after the continuous administration of topical vancomycin and ceftriaxone for 2 *** to the slow healing,AMT was *** corneal erosion healed and gradually became *** visual acuity recovered from initially counting fingers to 100/200 at the last follow-up,67 mo after *** Antibiotics plus AMT may be an effective alternative treatment other than PK to promote epithelializationand to reduce inflammation in the corneas complicated by S. mitis keratitis.

关键词： Persistent corneal ulcer Amniotic membrane transplantation Streptococcus mitis Case report

α-Vitamin E derivative, RRR-α-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells

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Asian Journal of Andrology 2007年第1期9卷 31-39页

作者： Eugene Chang Jing Ni Yi Yin Chiu-Chun Lin Philip Chang Nadine S. james Sherry R. Chemler Shuyuan yeh Departments of Urology and Pathology University of Rochester Rochester NY 14642 USA Department of Chemistry The State University of New York at Buffalo Buffalo NY 14260 USA

Aim： To investigate the activity of RRR-α-tocopheryloxybutyric acid （TOB）, an ether analog of RRR-α-tocopheryl succinate （VES）, in prostate cancer cells. Methods： VES and TOB were used to treat prostate cancer LNCaP, PC3, and 22Rvl cells and primary-cultured prostate fibroblasts. The proliferation rates were determined by MTT assay, the cell viabilities were determined by trypan blue exclusion assay, and the cell deaths were evaluated by using Cell Death Detection ELISA kit. The protein expression levels were determined by Western blot analysis. Results： The MTT growth assay demonstrated that TOB could effectively suppress the proliferation of prostate cancer cells, but not normal prostate fibroblasts. Mechanism dissections revealed that TOB reduced cell viability and induced apoptosis in prostate cancer cells similar to VES. In addition, both TOB and VES suppressed prostate-specific antigen （PSA） at the transcriptional level leading to reduced PSA protein expression. Furthermore, vitamin D receptor （VDR） expression increased after the addition of TOB. Conclusion： Our data suggests that the VES derivative, TOB, is effective in inhibiting prostate cancer cell proliferation, suggesting that TOB could be used for both chemopreventive and chemotherapeutic purposes in the future.

关键词： α-tocopheryloxybutyric acid α-vitamin E succinate prostate cancer prostate-specific antigen vitamin D receptor LNCaP PC3, 22Rvl

Transplantation tolerance that depends on regulatory T cells induced by TGF-beta-producing regulatory B cells

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Transplantation tolerance that depends on regulatory T cells...

Gronwall-Bihari不等式的统一探讨(英文)

2013中国器官移植大会

作者： Gaoping Zhao Kang Me Lee Ryan Scott Julie SooHoo Liang Moh Moh Lindsey Fitzgerald Ji Lei Heidi yeh Shaoping Deng james Markmann james Kim Department of Surgery Sichuan Provincial People's Hospital & Sichuan Academy of Medical Sciences Department of Surgery Massachusetts General HospitalHarvard Medical School

Regulatory B cells(Bregs)have been shown to play a critical role in immune homeostasis and in autoimmunity *** have recently demonstrated that combined anti-TIM-1 and anti-CD45RB antibody treatment generates regulatory B cells necessary for long- term mouse islet allograft survival in a full MHC-mismatch donor-recipient pair Lee KM,Kim JI,,Stott R,Soohoo J,O’Connor *** H, Zhao G,Eliades P,Fox C,Cheng N,Deng S,Markmann ***-CD45RB/anti-TIM-1-induced tolerance requires regulatory B cells. Am J Transplantation.2012;12:2072—2078).Here we provide evidence that the induction of tolerance by regulatory B cells requires regulatory T ***,adoptive transfer of Bregs results in an increase in absolute number of Tregs in grafted recipients,and depletion of Tregs abrogates transplant tolerance conferred by adoptive transfer of regulatory B *** hypothesize that Bregs induce

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应用数学 1991年第3期4卷 48-55页

作者： james Conlan 王中烈 Regina大学

本文探讨Gronwall-Bihari不等式的一些n维拓广.我们获得的结论推广了新近建立的一些结果(其中包括Pachpatte、yeh、Hristora、Bainor与Shih等人的结果)的推广.

关键词： G-B不等式 Bihari不等式单调性

Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience

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World Journal of Hepatology 2015年第11期7卷 1460-1483页

作者： Matthew M yeh Raymond S Yeung Smith Apisarnthanarax Renuka Bhattacharya Carlos Cuevas William P Harris Tony Lim Kiat Hon Siddharth A Padia james O Park Kevin M Riggle Sayed S Daoud Department of Pathology University of Washington School of Medicine Department of Medicine University of Washington School of Medicine Northwest Liver Research Program Depart-ment of Surgery University of Washington School of Medicine Department of Radiation Oncology University of Washington School of Medicine Department of Radiology University of Washington School of Medicine Seattle Department of Pathology Singapore General Hospital Department of Pharmaceutical Sciences Washington State University Health Sciences

Hepatocellular carcinoma(HCC) is the most rapidly increasing type of cancer in the United States. HCC is a highly malignant cancer, accounting for at least 14000 deaths in the United States annually, and it ranks third as a cause of cancer mortality in men. One major difficulty is that most patients with HCC are diagnosed when the disease is already at an advanced stage, and the cancer cannot be surgically removed. Furthermore, because almost all patients have cirrhosis, neither chemotherapy nor major resections are well tolerated. Clearly there is need of a multidisciplinary approach for the management of HCC. For example, there is a need for better understanding of the fundamental etiologic mechanisms that are involved in hepatocarcinogenesis, which could lead to the development of successful preventive and therapeutic modalities. It is also essential to define the cellular and molecular bases for malignant transformation of hepatocytes. Such knowledge would:(1) greatly facilitate the identification of patients at risk;(2) prompt efforts to decrease risk factors; and(3) improve surveillance and early diagnosis through diagnostic imaging modalities. Possible benefits extend also to the clinical management of this disease. Because there are many factors involved in pathogenesis of HCC,this paper reviews a multidisciplinary perspective of recent advances in basic and clinical understanding of HCC that include: molecular hepatocarcinogenesis, noninvasive diagnostics modalities, diagnostic pathology, surgical modality, transplantation, local therapy and oncological/target therapeutics.

关键词： Genetic alterations Epigenetic alterations Diagnostic pathology Diagnostic imaging Surgicalmodality Liver transplantation Locoregional therapy Sorafenib Hepatocellular carcinoma Liver resection

Thompson定律在地质学及硅酸盐工学中的重大意义

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硅酸盐学报 1983年第2期 159-164页

作者：叶大年中国科学院地质研究所

当今被地质学家称之为汤普生(Thompson)定律是指,在硅酸盐矿物中低温和高压有利于铝的高配住(六次配位),相反,高温和低压有利于铝的低配位(四次配位)。这个定律是由美国著名矿物学家*** 教授首先提出来的。按照 Thompson定律,本文作者... 详细信息

当今被地质学家称之为汤普生(Thompson)定律是指,在硅酸盐矿物中低温和高压有利于铝的高配住(六次配位),相反,高温和低压有利于铝的低配位(四次配位)。这个定律是由美国著名矿物学家*** 教授首先提出来的。按照 Thompson定律,本文作者讨论了岩浆作用、风化作用和变质作用,特别是板块构造变质作用(双变质作用)中铝的配位数问题,也讨论了陶瓷、水泥、炉渣和铸石工艺学中铝的配位数问题。因此,作者认为,Thompson 定律是自然界一条十分重要的定律,应将它写入一切地质学和硅酸盐工学的教科书中。

关键词：配位数热稳定性铸石热力学性质矿物学家 Thompson 工学地球科学地质学