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Early stage colon cancer

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world Journal of Gastroenterology 2013年第46期19卷 8468-8473页

作者： Hugh james Freeman Department of Medicine University of British Columbia

Evidence has now accumulated that colonoscopy and removal of polyps,especially during screening and surveillance programs,is effective in overall risk reduction for colon *** resection of malignant pedunculated colon polyps or early stage colon cancers,long-term repeated surveillance programs can also lead to detection and removal of asymptomatic high risk advanced adenomas and new early stage metachronous *** stage colon cancer can be defined as disease that appears to have been completely resected with no subsequent evidence of involvement of adjacent organs,lymph nodes or distant *** differs from the clinical setting of an apparent"curative"resection later pathologically upstaged following detection of malignant cells extending into adjacent organs,peritoneum,lymph nodes or other distant sites,including *** highly selected early stage colon cancer group remains at high risk for subsequent colon polyps and metachronous colon *** staging is important,not only for assessing the need for adjuvant chemotherapy,but also for patient selection for continued *** advanced stages of colon cancer and a more guarded outlook,repeated surveillance should be *** future,novel imaging technologies(e.g.,confocal endomicroscopy),coupled with increased pathological recognition of high risk markers for lymph node involvement(e.g.,"tumor budding")should lead to improved staging and clinical care.

关键词： Colon cancer Node-negative colon cancer Staging of colon cancer Nodal micrometastases Follow-up and surveillance of early colon cancer

structures:new solutions and uncommon characteristics james Kirby,Shiwei Zhou,

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Acta Mechanica Sinica 2022年第6期38卷 128-140,I0003页

作者： james Kirby Shiwei Zhou Yi Min Xie Centre for Innovative Structures and Materials School of EngineeringRMIT UniversityMelbourne 3001Australia

To investigate the characteristics of optimal fail-safe structures subjected to single and multi-member damage scenarios,we con-sider a pin-jointed cantilever truss with all members directly connected from the load point to the *** problem formu-lations are considered—minimizing the compliance with a volume constraint and minimizing the volume with stress *** these formulations produce equivalent structures for traditional truss design problems,we find that this is not always the case in the fail-safe *** solutions are developed for a three-bar truss under both problem *** is modelled as the complete removal of any one member,and a minmax problem is constructed to minimize the compliance or volume of the structure for the worst-case damage *** new analytical solutions provide much needed benchmarks for numerical fail-safe *** problems are extended to n-bar systems with damage to multiple *** show that as the structural complexity(the number of members in a system)increases,the optimum fail-safe structure tends towards a variation of the nominal two-bar design with overlapping *** these observations,we then approach the idea of full redundancy through the introduction of parallel substructures into a more complex truss *** compare our fully redundant truss design with a benchmark fail-safe solution and show that the fully redundant design has significantly better performance and with fewer ***,this suggests that fully redundant structural designs are highly efficient and have the additional benefit of only requiring the computation of the nominal solution.

关键词： Fail-safe optimization Minimum compliance Minimum volume,

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粉末冶金铁基材料的温压与温-模压制

粉末冶金技术 2013年第6期31卷 463-468,474页

作者： james w Brian Narasimhan K S Hoeganaes公司 Cinnaminson NJ美国

自温压工艺（ANCORDENSE）用于大量生产迄今已有20年,采用一次压制工艺可将中等-大型尺寸的铁基零件压制到生坯密度7.3g/cm3.本文回顾了温压的应用与最近温压技术的改进.鉴于并非所有零件生产厂家都希望对粉末与压制模具二者进行加热,... 详细信息

自温压工艺（ANCORDENSE）用于大量生产迄今已有20年,采用一次压制工艺可将中等-大型尺寸的铁基零件压制到生坯密度7.3g/cm3.本文回顾了温压的应用与最近温压技术的改进.鉴于并非所有零件生产厂家都希望对粉末与压制模具二者进行加热,在利用原先温压工艺经验的基础上,开发出了温-模压制（AncorMax 200）工艺.并将温-模压制用的预混合粉进行了改性,使用的润滑剂含量只有0.4％（质量分数,下同）,从而将生坯密度提高到了7.4g/cm3.温-模压制工艺的改进进一步促进了预混合粉的开发,使用的润滑剂含量已减少至0.2％～0.3％,可达到的生坯密度接近7.5g/cm3.本文概述了温压工艺的基本原理以及温压与温-模压制工艺二者的最新改进.

关键词：粉末冶金温压温-模压制

Bayesian Deep Learning for Dynamic Power System State Prediction Considering Renewable Energy Uncertainty

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 913-922页

作者： Shiyao Zhang james J.Q.Yu Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Department of Computer Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Modern power systems are incorporated with distributed energy sources to be environmental-friendly and ***,due to the uncertainties of the system integrated with renewable energy sources,effective strategies need to be adopted to stabilize the entire power ***,the system operators need accurate prediction tools to forecast the dynamic system states *** this paper,we propose a Bayesian deep learning approach to predict the dynamic system state in a general power ***,the input system dataset with multiple system features requires the data pre-processing ***,we obtain the dynamic state matrix of a general power system through the Newton-Raphson power flow ***,by incorporating the state matrix with the system features,we propose a Bayesian long short-term memory(BLSTM)network to predict the dynamic system state variables *** results show that the accurate prediction can be achieved at different scales of power systems through the proposed Bayesian deep learning approach.

关键词： Bayesian deep learning data analytics NewtonRaphson power flow renewable energy source system state

Evolving HDI Beyond Microvias

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印制电路信息 2013年第4期21卷 234-236页

作者： james w.Fuller Endicott Interconnect Technologies

The advent of HDI through the use of microvias was a critical development in extending the utility of copper interconnect systems. Evolving HDI beyond microvias will be equally important in continuing this extension.

关键词：《印制电路信息》期刊编辑工作发行工作

Future challenges in the in vitro and in vivo evaluation of biomaterial biocompatibility

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Regenerative Biomaterials 2016年第2期3卷 73-77页

作者： james M.Anderson Case western Reserve University 2103 Cornell RoadWRB 5105ClevelandOH 44106-7288USA

As the science and engineering of biomaterials continues to expand with increased emphasis on the development of nanomaterials and tissue engineering scaffolds,emphasis also must be placed on appropriate and adequate approaches to the in vivo and in vitro evaluation of biomaterial biocompatibility/biological response *** article presents six topic areas that should be addressed by investigators as they move forward in the development of new systems for regenerative *** certainly,there are other areas that require attention to detail and a more complete understanding of the strengths and weaknesses of various experimental approaches to biomaterial/biological response *** small number of issues addressed in this article is only meant to bring to the attention of prospective investigators and authors,the importance of the development of adequate and appropriate evaluation techniques that address the unique features of biomaterials utilized in the development of new medical devices.

关键词： biomaterials nanomaterials tissue engineering

Refinement of reduced-models for dynamic systems

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Progress in Natural Science:Materials International 2008年第8期18卷 993-997页

作者： Sau-Lon james Hu Department of Ocean Engineering University of Rhode Island Narragansett RI 02882-1197 USA

A refinement procedure for the reduced models of structural dynamic systems is presented in this article. The refinement procedure is to "tune"the parameters of a reduced model, which could be obtained from any traditional model reduction scheme, into an improved reduced model. Upon the completion of the refinement, the improved reduced model matches the dynamic characteristics-the chosen structural frequencies and their mode shapes-of the full order model. Mathematically, the procedure to implement the model refinement technique is an application of the recently developed cross-model cross-mode (CMCM) method for model updating. A numerical example of reducing a 5-DOF (degree-of-freedom) classical mass-spring (or shear-building) model into a 3-DOF generalized mass-spring model is demonstrated in this article.

关键词： Model reduction Model re?nement Finite element method Modal analysis Structural dynamics

The onset of surface-enhanced Raman scattering for single-particle detection of submicroplastics

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Journal of Environmental Sciences 2022年第11期34卷 58-64页

作者： Cheng-Hao Lee james Kar-Hei Fang Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina Research Institute for Future Food The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong SARChina

Microplastics represent an emerging environmental problem worldwide, raising ecological and food safety concerns. Compared to microplastics, there is growing evidence of an even higher abundance of submicro-and nanoplastics in the environment, but a reliable monitoring method for detecting these smaller-sized plastics is lacking. Herein we presented the application of surface-enhanced Raman scattering(SERS) for this purpose. Particles of polystyrene(PS;600 nm) were used as the probe analyte. Gold nanourchins(Au NU;50 nm),i.e. urchin-shaped nanoparticles with irregular spikes around the core, were used as the SERS-active substrate. The effectiveness of SERS on PS was evaluated at a single-particle level with different numbers of Au NU in order to determine the minimum conditions required for the onset of the SERS effect. Our findings suggest that SERS of a single particle of PS can be induced by as few as 1–5 particles of Au NU, and that the use of excitation wavelength at 785 nm is appropriate to meet the red-shifted surface plasmon resonance of Au NU upon aggregation. These specifications provide additional information for the development of SERS-based tools for detecting plastic particles < 1 μm in food and environmental samples.

关键词： Microplastics Nanoplastics Gold nanourchins SERS Food contamination

A new direction for Alzheimer's research

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Neural Regeneration Research 2018年第2期13卷 190-193页

作者： james D.weinstein Marshall University School of Medicine Medical Center

Despite decades of research, at present there is no curative therapy for Alzheimer＇s disease. Changes in the way new drugs are tested appear to be necessary. Three changes are presented here and will be discussed. The first change is that Alzheimer＇s disease must be considered a disease of four major pathological processes, not one. The four processes are： 1） vascular hy- poperfusion of the brain with associated mitochondrial dysfunction, 2） destructive protein inclusions, 3） uncontrolled oxidative stress, and 4） proinflammatory immune processes second- ary to microglial and astrocytic dysfunction in the brain. The second change recommended is to alter the standard cognitive measurement tools used to quantify mental decline in test patients. Specifically the Dementia Severity Rating Scale （DSRS） should supersede Mini-Mental State Examination （MMSE） and other popular tests, and a measurement scale developed in research should be used to produce a linear and non-irregular baseline. Finally, accepting the concept that four etiologies cause Alzheimer＇s disease leads to the last necessary change, that new thera- pies must be employed directed against all four causes, likely as a combination. There are drugs ready to be employed in such a combinations which are available and used clinically for other purposes so can be used ＂offlabel＂ and one such combination is suggested.

关键词： Alzheimer's disease etiologies combination therapy cognitive testing failed research off-label use Dementia Severity Rating Scale