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Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function

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Cellular & Molecular Immunology 2021年第2期18卷 328-338页

作者： Juan Huang Jian Peng james Alexander Pearson Georgios Efthimiou Youjia Hu Ningwen Tai Yanpeng Xing Luyao Zhang Jianlei Gu Jianping Jiang Hongyu Zhao Zhiguang Zhou F.Susan wong Li Wen National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology(Central South University)Ministry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya HospitalCentral South UniversityChangshaHunanChina Section of Endocrinology Department of Internal MedicineSchool of MedicineYale UniversityNew HavenCTUSA Division of Infection and Immunity School of MedicineCardiff UniversityCardiffUK Department of Microbiology University of HullHullUK Department of Gastrointestinal Surgery of the First Hospital of Jilin University ChangchunJilinChina Department of Biostatistics Data Science&GeneticsYale School of Public HealthNew HavenCTUSA

Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes ***7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains *** our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD *** investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin ***,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T *** addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B *** data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T ***,therapeutically targeting TLR7 may prove beneficial for disease protection.

关键词： Type 1 diabetes Toll-like receptor 7 B cell

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X-reality for phantom limb management for amputees:A systematic review and meta-analysis

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再生工程(英文) 2023年第2期4卷 134-151页

作者： james Chung-Wai Cheung Daphne Sze Ki Cheung Ming Ni Kam-Wai Chen Ye-Jiao Mao Lin Feng Wing-Kai Lam Duo Wai-Chi wong Aaron Kam-Lun Leung Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong KongChina School of Nursing The Hong Kong Polytechnic UniversityHong KongChina Department of Orthopaedics Ruijin HospitalShanghai Jiao Tong UniversityShanghaiChina Department of Prosthetics and Orthotics Queen Mary HospitalHong KongChina Sports Information and External Affairs Centre Hong Kong Sports InstituteHong KongChina Research Institute for Sports Science and Technology The Hong Kong Polytechnic UniversityHong KongChina Department of Rehabilitation Science The Hong Kong Polytechnic UniversityHong KongChina

Phantom limb is a disabling neuropsychiatric condition among amputees resulting in pain and disturbance that impact their functions,quality of life,and *** pharmacological approaches appeared to be ineffec-tive,the emergence and integration of X-reality,including virtual reality,augmented reality,and mixed reality,might elevate the effectiveness of mirror therapy in managing phantom *** objective of this study is to review X-reality for managing phantom pain.A systematic search was conducted on PubMed,Scopus,Web of Science,PsycINFO,Embase,and ***(n=16)studies containing 66 lower-limb and 53 upper-limb amputees were included for the review over the thematic framework of amputee characteristics and intervention designs,while thirteen(n=13)studies were further proceeded for the *** found eleven studies on virtual reality(n=11),four studies on marker-based augmented reality(n=4)and one study on mixed reality(n=1)with a total of 40 game/task themes involving,motor skills,motor control,and ***,all these interventions adopted the movement representation strategies with different ***,the X-reality interventions reduced the pain level of the amputees(mean difference:-2.30,95%CI,-3.38 to-1.22),especially the virtual reality subgroup(mean difference:-2.83,95%CI,-4.43 to-1.22).However,there were substantial heterogeneity and partially explained by the subgroup analysis on publication *** strength of evidence was limited by case reports and case series in this review.

关键词： Extended reality Limb telescoping Phantom pain Phantom sensation

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Butyrate protects against endothelial dysfunction through PPARδ

Butyrate protects against endothelial dysfunction through PP...

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2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：田琴琴 fung Ping Leung Francis M Chen Xiaoyu Tian Wing Tak wong School of Life Sciences The Chinese University of Hong Kong

Endothelium is important in maintaining vascular homeostasis and vessel tone by balancing the production of vasodilator and vasoconstrictor, perturbation of which always leads to impaired vessel relaxation and increased vessel contraction and progresses to atherosclerotic lesion formation and subsequent cardiac ***, a short-chain fatty acid (SCFA) produced primarily by bacterial fermentation of fiber in the colon, has been found to present anti-inflammatory, anti-oxidative and anti-apoptotic ***

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Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy

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Asian Journal of Andrology 2017年第1期19卷 98-102页

作者： Jeremy YC Teoh james HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu Division of Urology Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China Division of Urology Department of Surgery Queen Mary Hospital University of Hong Kong Hong Kong China.

We investigated the association of time to prostate-specific antigen nadir （TTPN） and logarithm of prostate-specific antigen velocity after progression Log（PSAVAP） in metastatic prostate cancer with prior primary androgen deprivation therapy （ADT）. All metastatic prostate cancer patients treated with primary ADT from 2000 to 2009 were reviewed. Patients who developed disease progression were included in the subsequent analyses. Patients were categorized into three groups according to their TTPN： TTPN of 〈3 months, 3-17 months, and 〉17 months. We compared the Log（PSAVAP） between the different TTPN groups using Mann-Whitney U-test and Kruskal-Wallis test. Further multiple linear regression analyses on Log（PSAVAP） were performed to adjust for other potential confounding factors. Among 419 patients who were treated with primary ADT, 306 patients developed disease progression with a median follow-up of 28 months, Longer TTPN was associated with lower Log（PSAVAP）（P = 0.008） within all subgroup analyses （TTPN of 〈3 vs 3-17 months, P = 0.020; TTPN of 3-17 vs 〉17 months, P = 0.009; and TTPN of 〈3 vs 〉17 months, P = 0.001）. Upon multiple linear regression analyses, baseline PSA （regression coefficient 0.001, P = 0.045）, PSA nadir （regression coefficient 0.002, P = 0.040）, and TTPN （regression coefficient -0.030, P = 0.001） were the three factors that were significantly associated with Log（PSAVAP）. In conclusion, a longer TTPN was associated with lower Log（PSAVAP） in metastatic prostate cancer patients following primary ADT. TTPN cut-offs at 3 months and 17 months appeared to have prognostic significance in predicting Log（PSAVAP）. TTPN may serve as a good prognostic indicator in deciding the treatment strategy in patients with disease progression.

关键词： androgen deprivation therapy prostate cancer prostate-specific antigen velocity after progression ti me to prostate-specific antigen nadir

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China＇s Outward Direct and Portfolio Investments

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China & World Economy 2007年第6期15卷 53-68页

作者： Hung-Gay fung Qingfeng wilson Liu Erin H. C. Kao Professor College of Business Administration ＆ Center for International Studies University of Missouri-St. Louis USA. Department of Finance and Business Law College of Business James Madison University USA. Department of Finance Ling Tung University Taiwan.

This paper analyzes developments and trends related to China＇s outward direct and financial investments by examining Chinese firms＇ overseas acquisitions, China＇s holdings of US Treasury securities, and the recently formally launched Qualified Domestic Institutional Investor programs. Strategies should be developed to reach optimal decisions for both direct and por（folio investments. We argue that China should have a longer-term view for both direct and portfolio investments, enabling China to become the leader in Asia while maintaining its sustainable growth objective. China should invest heavily in the development of the Asian bond market and the Asian Currency Fund when making both por（folio and direct investment decisions.

关键词： outward direct investments portfolio investments qualified domestic institu-tional investor

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Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5085-5095页

作者： Ye Peng Lin Zhang Chris K.P.Mok Jessica Y.L.Ching Shilin Zhao Matthew K.L.wong Jie Zhu Chunke Chen Shilan Wang Shuai Yan Biyan Qin Yingzhi Liu Xi Zhang Chun Pun Cheung Pui Kuan Cheong Ka Long Ip Adrian C.H.fung Kenneth K.Y.wong David S.C.Hui Francis K.L.Chan Siew C.Ng Hein M.Tun Microbiota I-Center(MaglC) Hong KongChina Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina Centre for Gut Microbiota Research The Chinese University of Hong KongHong KongChina

The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be *** this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytokine and chemokines were measured and associated with the gut microbiota and metabolome composition.

关键词： vaccine immunity vaccines

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Are Meta-analyses of Chinese Herbal Medicine Trials Trustworthy and Clinically Applicable?A Cross-sectional Study

Are Meta-analyses of Chinese Herbal Medicine Trials Trustwor...

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第十四届全国中药和天然药物学术研讨会

作者： Robin ST Ho Wu Xinyin Vincent CH Chung Daisy fung Samuel YS wong Justin CW Wu JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong Institute of Integrative Medicine The Chinese University of Hong Kong

＜正＞Background Meta-analysis（MA）on Chinese herbal medicine（CHM）trials is increasingly published and indexed in major international databases but their trustworthiness is *** aimed to assess the bibliographical c...

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粤派扬琴的调音对七平均律的启示

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星海音乐学院学报 2018年第4期 128-136页

作者：谢俊仁黄振丰香港中文大学音乐系香港思科系统公司

通过测音研究,显示七律扬琴低音部分的音律类似传统十二律制,中高音部分则接近七平均律,但各音程稍有参差,不是完全平均,令正线旋律仍有传统律制的影子。据丘鹤俦《琴学新编》,七律扬琴能在"四盆"之间转换,苦喉即士工线。文章分析了苦... 详细信息

通过测音研究,显示七律扬琴低音部分的音律类似传统十二律制,中高音部分则接近七平均律,但各音程稍有参差,不是完全平均,令正线旋律仍有传统律制的影子。据丘鹤俦《琴学新编》,七律扬琴能在"四盆"之间转换,苦喉即士工线。文章分析了苦喉与士工线的关系,推论当其他不固定音高乐器与扬琴合奏时,可能会因应乐曲的调式而把乐音微调。如果士工线旋律倾向传统羽调,其他乐器可以把正线的"乙"(即士工线的"上")奏得稍低;如果旋律属苦喉(或"特殊的羽调"),可以把正线的"乙"奏得稍高。这活的律制没有什么理论根据,只是约定俗成,不适宜强称为"七平均律",简单称为"粤乐七律"可能更好。这并不贬低其艺术意义,反而令粤乐更具地区色彩。

关键词：扬琴粤乐七律七平均律苦喉士工线丘鹤俦《琴学新编》

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Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

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Engineered Regeneration 2022年第2期3卷 121-130页

作者： james Chung-Wai Cheung Ming Ni Andy Yiu-Chau Tam Tim Tin-Chun Chan Alyssa Ka-Yan Cheung Ocean Yu-Hong Tsang Chi-Bun Yip Wing-Kai Lam Duo Wai-Chi wong Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Research Institute for Smart Ageing The Hong Kong Polytechnic UniversityHong Kong 999077China Jockey Club Smart Ageing Hub Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Orthopaedics Pudong New Area People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 201299China Social Service Department Yan Chai HospitalHong Kong 999077China C2 Innovations and Research Limited Hong Kong 999077China Department of Kinesiology Shenyang Sport UniversityShenyang 110102China Sports Information and External Affairs Centre Hong Kong Sports InstituteHong Kong 999077China

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social *** reality(VR)could deliver a nascent application that is more engaging and *** objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen *** measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded ***-after effects of each group were evaluated using separated Wilcoxon Signed-rank *** sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning *** generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls *** appeared to be a significant confounder on the training *** work may consider developing artificial intelligence to customize programs depending on IQ level.

关键词： Mental retardation Intellectual development X-reality Immersive rehabilitation Metaverse

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某年仲夏

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城市住宅 1998年第12期5卷 34-41页

作者： Sammy T.K.wong Jolons fung 蓝海谧 Lotus Interior Ltd

面积:121平方米(建筑面积)间隔:二层别墅阳光、水分,泥地里柔柔轻渗,是你播种又灌溉,春风里生。房子是个复式单元,连接上下两层的楼梯有很宽敞空间,浓浓的漫着一份校园气息,叫人不由得想起某年仲夏的一部电视剧主题曲,化不开的师生挚情... 详细信息

面积:121平方米(建筑面积)间隔:二层别墅阳光、水分,泥地里柔柔轻渗,是你播种又灌溉,春风里生。房子是个复式单元,连接上下两层的楼梯有很宽敞空间,浓浓的漫着一份校园气息,叫人不由得想起某年仲夏的一部电视剧主题曲,化不开的师生挚情,直让人如沐春风。

关键词：居室室内装饰别墅二层 120m^2

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