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Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling

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分子细胞生物学报:英文版 2012年第2期4卷 118-120页

作者： Gang Ma Lili Li Yuanyu Hu Jenny fung Ling Chau Bi Jin Au Deyong Jia Huijuan Liu james Yeh Lin He Aijun Hao Baojie Li The Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Key Laboratory of the Ministry of Education for Experimental Teratology Shandong University School of MedicineJinan 250012China The Institute of Molecular and Cell Biology Agency for ScienceTechnologyand ResearchSingapore 138632Singapore

Dear Editor,Tumor suppressor p53 is activated in re-sponse to genotoxic stress by Atm and other PI3K-like kinases,which phosphoryl-ate p53 and stabilize p53(Barlow et al.,1997),leading to cell cycle arrest,senes-cence... 详细信息

关键词： Smad1 PI3K damage p53

Financing Alternatives for Chinese Small and Medium Enterprises: The Case for a Small and Medium Enterprise Stock Market

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China & World Economy 2007年第1期15卷 26-42页

作者： Hung-gay fung Qingfeng Liu Jot Yau Dr Y. S. Tsiang Professor College of Business Administration and Center for International Studies University of Missouri St. Louis USA Assistant Professor College of Business James Madison University USA Professor Department of Finance Albers School of Business and Economics Seattle University USA

Financing alternatives for small and medium enterprises in China are discussed in the present study. In particular, we analyze the significant changes and developments m China＇s ＂second board＂ stock market. China ＇s extensive network of regional assets and equity exchanges, which were set up to facilitate private equity transfer, and non-performing loan transactions seem to partially fill the void for small and medium enterprises, which cannot easily obtain approval for listing on the stock exchanges. Foreign investors can identify investment opportunities in non-listed domestic state-owned and private businesses through these regional assets and equity exchanges. At the same time, foreign stock markets are now attracting the young Chinese enterprises to list their stocks on their exchanges.

关键词： Chinese small and medium enterprise financing stock exchange

Effects of ginsenosides on vascular reactivity in rat cerebral and renal arteries

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Effects of ginsenosides on vascular reactivity in rat cerebr...

Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy

两岸三地药理学与临床药理学术会议

作者： wong Wing-tak LEUNG fung-ping YUNG Lai-hang wong Ricky Ngok Shun Department of Physiology Chinese University of Hong Kong Department of Biology Hong Kong Baptist University

Objective To investigate possible mechanisms underlying the antioxidant property(1)and the in vitro vasodilator effects(2)of the two ginsenosides,Rb1 and Rg1,in isolated rat renal and cerebral arter- *** Arterial rings were mounted in a multi-channel myograph for recording of isometric *** examine the antioxidant activity,some rings were exposed to a free radical-generating reaction(hypoxan- thine and xanthine oxidase)with and without pre-treatment with *** calcium antagonistic ef- fects were tested on rings contracted by membrane depolarization in elevated extracellular potassium ions,a condition that promoted Cainflux in vascular smooth muscle *** Ginsenosides protected en- dothelial function(endothelial nitric oxide-dependent relaxation)against oxidative stress;(2)ginsenoside Rbl reduced the high K+-induced contractions of both renal and cerebral arteries while ginsenoside Rgl re- laxed the rat cerebral artery but not the renal *** Ginsenosides are vaso-protective via(1) the antioxidant activity which protects endothelial cell function and(2)the inhibition of Ca2+influx through voltage-sensitive Cachannels in vascular smooth *** vasodilator effects may suggest the potential preventive or therapeutic values of ginsenosides against stroke and renal hypertension.

关键词： ginsenosides endothelial cells relaxation

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World Journal of Gastroenterology 2005年第31期11卷 4865-4868页

作者： Wai K Leung Francis KL Chan Sara SL fung Mei-Yin wong Joseph JY Sung Digestive Diseases Center

AIM: To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule ***: Consecutive patients who underwent capsule endoscopy du ring the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and small bowel transit time, and the small bowel image quality were ***: Twenty-four patients received oral erythromycin whereas 14 patients were not given any prokinetic *** who received erythromycin had a significantly lower gastric transit time than control (16 min vs70 min, P= 0.005),whereas the small bowel transit time was comparable between the two groups (227 min vs183 min, P = 0.18).Incomplete small bowel examination was found in three patients of the control group and in one patient of the erythromycin group. There was no significant difference in the overall quality of small bowel images between the two groups. A marked reduction in gastric transit time was noted in two patients who had repeat capsule endoscopy after oral ***: Use of oral erythromycin significantly reduces the gastric transit time of capsule endoscopy.

关键词：抗生素胃疾病小肠疾病药物胶囊内窥镜检查

Large polyps:Pearls for the referring and receiving endoscopist

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World Journal of Gastrointestinal Endoscopy 2021年第12期13卷 638-648页

作者： Eric Markarian Brian M fung Mohit Girotra james H Tabibian Academy of Science and Medicine Crescenta Valley High SchoolLos AngelesCA 91214United States Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Arizona College of Medicine-PhoenixPhoenixAZ 85006United States Division of Gastroenterology Banner-University Medical Center PhoenixPhoenixAZ 85006United States Section of Gastroenterology and Therapeutic Endoscopy Digestive Health InstituteSwedish Medical CenterSeattleWA 98104United States Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCA 91342United States Vatche and Tamar Manoukian Division of Digestive Diseases David Geffen School of Medicine at UCLALos AngelesCA 90095United States

Polyps are precursors to colorectal cancer,the third most common cancer in the United *** polyps,i.e.,,those with a size≥20 mm,are more likely to harbor *** polyps can be removed through various techniques,with the goal to completely resect and prevent colorectal cancer;however,the management of large polyps can be relatively complex and *** polyps are generally more difficult to remove en bloc with conventional methods,and depending on level of expertise,may consequently be resected piecemeal,leading to an increased rate of incomplete removal and thus polyp *** effectively manage large polyps,endoscopists should be able to:(1)Evaluate the polyp for characteristics which predict high difficulty of resection or incomplete removal;(2)Determine the optimal resection technique(e.g.,snare polypectomy,endoscopic mucosal resection,endoscopic submucosal dissection,etc.);and(3)Recognize when to refer to colleagues with greater *** review covers important considerations in this regard for referring and receiving endoscopists and methods to best manage large colonic polyps.

关键词： Adenoma Endoscopic mucosal resection Endoscopic tattoo Colorectal cancer Polypectomy

COVID-19: A Physical Model

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Open Journal of Biophysics 2020年第2期10卷 88-95页

作者： Kai W. wong Peter C. W. fung Wan K. Chow Department of Physics and Astronomy University of Kansas Lawrence USA Department of Physics Department of Medicine and Centre on Behavioral Health University of Hong Kong Hong Kong China Department of Building Services Engineering The Hong Kong Polytechnic University Hong Kong China

The coronavirus structure is explained as a fractal representation of the Poincare sphere of proteins, dotted with t-spikes having the geometric realization of the SU(3) Lie group for the protein spike, and encompasses an RNA of SU(2) topologies representations, while within the core contains a virus DNA. Through this suggested model, the virus must possess a critical temperature Tc, induced by the EEM mechanism for the completion of the Poincare sphere surface. Thus above Tc it will disintegrate. We then discuss how the virus transmission progresses within the patient’s body, and explain a very fast recent detection method currently used consistent with this model, as well as a corresponding possible cure based on this same principle of the body’s immune system. Hopefully the model can be also used as a guide to finding possible medications, so far is lacking.

关键词： COVID-19 Perelman Mappings Virus Survival Temperature T Virus Multiplication Mechanism

Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation

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Hepatoma Research 2018年第9期4卷 159-170页

作者： james fung Danny Ka-Ho wong Yasuhito Tanaka Regina Lo Tiffany wong Kenneth Siu-Ho Chok AIbert Chi-Yan Chan Tan-To Cheung Wing-Chiu Dai KeIvin Ng Kevin Ng Man Kwan Irene Ng Wai-Kay Seto Ching-Lung Lai Man-fung Yuen Chung-Mau Lo The Liver Transplant Center Queen Mary HospitalHong KongChina Department of Medicine the University of Hong KongHong KongChina State Key Laboratory for Liver Research the University of Hong KongHong KongChina Department of Virology and Liver Unit Graduate School of Medical sciencesNagoya City UniversityNagoya 467-8601Japan Department of Pathology the University of Hong KongHong KongChina Department of Surgery the University of Hong KongHong KongChina

Aim:Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for chronic hepatitis B (CHB) can be associated with reappearance of hepatitis B surface antigen (HBsAg). The current study determined the significance of HBsAg qualitatively and quantitatively using a highly sensitive assay in recurrent HCC after transplantation. Methods:Consecutive patients with HBV-related HCC with LT were included. Oral nucleos(t)ide analogues without hepatitis B immune globulin were used as hepatitis B virus (HBV) prophylaxis. Quantitative HBsAg levels were performed at time of transplant, at 1 month, 3 and 6 months post transplant using a highly sensitive (hs)-HBsAg assay. Results:One hundred and fourteen patients were included, with a median follow-up of 80 months, with 24 cases of HCC recurrence, and a cumulative rate of 20.7% at 5 years. There was significant correlation between time of tumor recurrence and time of HBsAg reappearance (r = 0.551,P = 0.027). Early HCC recurrence was associated with higher median level of hs-HBsAg at the time of transplant (72.85vs. 69.70 IU/mL,P = 0.018). Using a hs-HBsAg cut-off level of 0.0005 IU/mL, patients with levels above this threshold at 3 and 6 months were associated with higher rate of early HCC recurrence (28.6%vs. 3.0% and 26.9%vs. 2.9% respectively, bothP =0.0006). There was no significant difference in HCC recurrence between positive and negative HBsAg using the conventional qualitative HBsAg assay. Conclusion:Serum hs-HBsAg levels of≥ 0.0005 IU/mL at 3 to 6 months after LT is associated with higher rates of early HCC recurrence, and may be useful as an early tumor marker.

关键词： Hepatitis B hepatocellular carcinoma transplantation hepatitis B surface antigen recurrence

The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis:a report of two cases

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Chinese Neurosurgical Journal 2021年第4期7卷 306-312页

作者： Peter Y.M.Woo Ben C.F.Ng June H.M.wong Oliver K.S.Ng Timothy S.K.Chan Ngai-fung Kwok Kwong-Yau Chan Department of Neurosurgery Kwong Wah HospitalHong KongHong KongChina Department of Internal Medicine Caritas Medical CenterHong KongHong KongChina Department of Pathology Kwong Wah Hospital25 Waterloo RoadYaumateiHong KongHong KongChina Department of Neurosurgery Queen Elizabeth HospitalHong KongHong KongChina

Background:IgG4-related hypertrophic pachymeningitis is a relative newly recognized and rare manifestation of IgG4-related disease,an immune-mediated fibroinflammatory tumefactive *** than 80 patients have been reported in the literature,and it can mimic common neurosurgical *** describe the clinical presentation of two patients that were initially considered to have a subdural collection,tuberculous meningitis,and a cervical spinal meningioma,but were eventually diagnosed with this *** presentation:Two ethnic Chinese men,86 and 62 years old,experienced a 4-week history of *** patients had a history of autoimmune disease,namely glomerulonephritis and Grave’s disease,*** resonance brain imaging revealed diffuse dural thickening with the latter patient exhibiting homogeneous and intense gadolinium-contrast *** the 86-year-old patient also had progressive bilateral visual loss,giant cell arteritis was suspected and a 2-week course of glucocorticoid therapy was prescribed,but his symptoms failed to *** 62-year-old patient also had accompanying low-grade fever and was treated empirically as having tuberculous meningitis although there were no confirmatory microbiological *** patient further developed right hemiparesis,and additional imaging revealed a C4/5 intradural-extramedullary contrast-enhancing lesion resembling a meningioma causing cord *** patients underwent neurosurgical intervention with the former undergoing a dural biopsy and the latter having the cervical lesion *** final diagnosis was IgG4-related hypertrophic pachymeningitis with the hallmark histological features of lymphoplasmacytic infiltration of IgG4+plasma cells,storiform fibrosis,and obliterative *** addition,their serum IgG4 levels were elevated(i.e.,>135 mg/dL).Both patients received at least 6 months of glucocorticoid therapy while the latter also had *** symptom

关键词： Hypertrophic pachymeningitis IgG4-related disease IgG4-related sclerosing disease Central nervous system

Axon degeneration： make the Schwann cell great again

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Neural Regeneration Research 2017年第4期12卷 518-524页

作者： Keit Men wong Elisabetta Babetto Bogdan Beirowski Hunter james Kelly Research Institute Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Department of Biochemistry Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA

Axonal degeneration is a pivotal feature of many neurodegenerative conditions and substantially accounts for neurological morbidity. A widely used experimental model to study the mechanisms of axonal degeneration is Wallerian degeneration （WD）, which occurs after acute axonal injury. In the peripheral nervous system （PNS）, WD is characterized by swift dismantling and clearance of injured axons with their myelin sheaths. This is a prerequisite for successful axonal regeneration. In the central nervous system （CNS）, WD is much slower, which significantly contributes to failed axonal regeneration. Although it is well documented that Schwann cells （SCs） have a critical role in the regenerative potential of the PNS, to date we have only scarce knowledge as to how SCs ＇sense＇ axonal injury and immediately respond to it. In this regard, it remains unknown as to whether SCs play the role of a passive bystander or an active director during the execution of the highly orchestrated disintegration program of axons. Older reports, together with more recent studies, suggest that SCs mount dynamic injury responses minutes after axonal injury, long before axonal breakdown occurs. The swift SC response to axonal injury could play either a pro degenerative role, or alternatively a supportive role, to the integrity of distressed axons that have not yet committed to degenerate. Indeed, supporting the latter concept, recent 昀ndings in a chronic PNS neurodegeneration model indicate that deactivation of a key molecule promoting SC injury responses exacerbates axonal loss. If this holds true in a broader spectrum of conditions, it may provide the grounds for the development of new glia-centric therapeutic approaches to counteract axonal loss.

关键词： Wallerian degeneration neurodegeneration glia oligodendrocytes myelin dedifferentiation