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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili patricia Graham Adriana Brooks Risset Silvera Alexander J.p.Goldschmidt Damien D.pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami project to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Implications of nitrogen phloem loading for carbon metabolism and transport during Arabidopsis development

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Journal of Integrative plant Biology 2017年第6期59卷 409-421页

作者： james p. Santiago Mechthild Tegeder School of Biological Sciences and Molecular plant Sciences Graduate program Washington State University Pullman Washington 99164 USA

Metabolite transport processes and primary metabolism are highly interconnected. This study exam- ined the importance of source-to-sink nitrogen partition- ing, and associated nitrogen metabolism for carbon capture, transport and usage. Specifically, Arabidopsis aap8 （AMINO ACID pERMEASE 8） mutant lines were analyzed to resolve the consequences of reduced amino acid phloem loading for source leaf carbon metabolism, sucrose phloem transport and sink development during vegetative and reproductive growth phase. Results showed that decreased amino acid transport had a negative effect on sink development of aap8 lines throughout the life cycle, leading to an overall decrease in plant biomass. During vegetative stage, photosynthe- sis and carbohydrate levels were decreased in aap8 leaves, while expression of carbon metabolism and transport genes, as well as sucrose phloem transport were not affected despite reduced sink strength. However, when aap8 plants transitioned to reproductive phase, carbon fixation and assimilation as well as sucrose partitioning to siliques were strongly decreased. Overall, this work demonstrates that phloem loading of nitrogen has varying implications for carbon fixation, assimilation and source-to-sink allocation depending on plant growth stage. It further suggests alterations in source-sink relationships, and regulation of carbon metabolism and transport by sink strength in a development-dependent manner.

关键词： William J. Lucas, University of California, Davis, USA Received Feb. 25, 2017 Accepted Mar. 9, 2017 Online on Mar. 14,2017

A populational survey of 45S rDNA polymorphism in the Jefferson salamander Ambystoma jeffersonianum revealed by fluorescence in situ hybridization(FISH)

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Current Zoology 2009年第2期55卷 145-149页

作者： james p. BOGART Department of Integrative Biology University of GuelphGuelphOntario N1G 2W1Canada

The chromosomal localization of 45S ribosomal RNA genes in Ambystoma jeffersonianum was determined by fluorescence in situ hybridization with 18S rDNA fragment as a probe (FISH-rDNA). Our results revealed the presence of rDNA polymorphism among *** populations in terms of number,location and FISH signal intensity on the chromosomes. Nine rDNA cytotypes were found in ten geographically isolated populations and most of them contained derivative rDNA sites. Our preliminary study provides strong indication of karyotypic diversification of *** that is demonstrated by intraspecific variation of 45S rDNA cytotypes. rDNA cytotype polymorphism has been described in many other caudate amphibians. We predict that habitat isolation,low dispersal ability and decline of effective population size could facilitate the fixation and accumulation of variable rDNA cytotypes during their chromosome evolution.

关键词： rDNA polymorphism Jefferson salamander Ambystoma jeffersonianum Fluorescence in situ hybridization FISH-rDNA

potential hydrodynamic origin of frictional transients in sliding mesothelial tissues

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Friction 2013年第2期1卷 163-177页

作者： Stephen H.LORING james p.BUTLER Department of Anesthesia Critical Care and Pain MedicineBeth Israel Deaconess Medical Center and Harvard Medical SchoolBoston MA 02215USA Department of Medicine Division of Sleep MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBoston MA 02215USA

Steady-state and transient variations in frictional force observed in tribological experiments of mesothelial tissues sliding in lubricant were analyzed with a mathematical model to test the hypothesis that such phenomena are manifestations of elastohydrodynamic lubrication and,importantly,do not require physical contact between the sliding *** model incorporates three phenomena characteristic of elastohydrodynamic lubrication:thinning of the liquid layer between sliding surfaces under a normal load(“squeeze-out”),thickening of the liquid layer due to hydrodynamic pumping,and smoothing of the elastic surfaces caused by hydrodynamic pressure *** in soft mesothelial tissues sliding in lubricant showed variations in steady state friction with velocity,load,and lubricant *** non-steady sliding,the decay rate of frictional transients at the start of rotation varied with velocity,the amplitudes of these transients varied with the preceding periods without rotation,and frictional force varied during sinusoidal *** simulations were qualitatively similar to experimental results,supporting these *** lubricant viscosity increased lubricating layer thickness and lowered friction at low speeds and increased friction at high speeds,supporting hydrodynamic *** conclude that the frictional variations seen with sliding mesothelial tissues are consistent with elastohydrodynamic lubrication without contact between the sliding surfaces.

关键词： pleural space breathing pericardium lubrication model

Hydrogen for a Net-Zero Carbon World

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Engineering 2023年第10期29卷 8-10页

作者： Nigel p.Brandon james J.Brandon Faculty of Engineering Imperial College LondonSouth Kensington CampusLondon SW72AZUK The First Element Ltd. London N17GUUK

*** hydrogen?The concept of the“hydrogen economy”was first coined by *** Bockris during a talk he gave in 1970 at the General Motors Technical ***’s talk introduced the vision of a world economy in which energy was... 详细信息

关键词： hydrogen Carbon economy

CO_(2)Emissions post-COp26:Who is Responsible to Curb the Flow?Does it Matter if We Can Make it a Win-Win?

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Energy & Environmental Materials 2022年第3期5卷 683-685页

作者： james Crawshaw S.Ravi p.Silva Advanced Technology Institute University of SurreyGuildfordUK

The debate about climate change is highly *** everyone is convinced that CO_(2)emissions are worth curbing despite seemingly irrefutable evidence in the IpCC’s latest report.[1]Some have vested interests in exploiting fossil fuels while others think alternative,cheaper solutions can be *** that have shifted from manufacturing to service-based economies will find it easier to *** countries with relatively low carbon emissions per capita but large populations believe it is unfair that they should have to bear heavy costs of decarbonization to solve a problem that wealthier countries have created.

关键词： Who is Responsible to Curb the Flow CO_(2)Emissions post-COp26 Does it Matter if We Can Make it a Win-Win

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避世之所加拿大亚瑟住宅

室内设计与装修 2025年第1期 46-49页

作者：无 james Brittain(摄影) coco(编译) 5468796 Architecture 不详

亚瑟住宅是为一对来自南非的夫妇设计的,他们一位是热衷园艺的木匠,另一位是急诊室医生。夫妇俩一直在寻找一个适中的“避难所”,与外界隔绝,并且有足够的空间来保护隐私。住宅所在的小区是一个成熟社区,原有的小平房正迅速被传统住宅... 详细信息

亚瑟住宅是为一对来自南非的夫妇设计的,他们一位是热衷园艺的木匠,另一位是急诊室医生。夫妇俩一直在寻找一个适中的“避难所”,与外界隔绝,并且有足够的空间来保护隐私。住宅所在的小区是一个成熟社区,原有的小平房正迅速被传统住宅取代。与此相反,亚瑟夫妇希望用一种深思熟虑的替代方案来挑战这种发展模式。

关键词：传统住宅替代方案保护隐私避难所亚瑟园艺小区加拿大

Assessment of Neurotoxicity: Use of Glial Fibrillary Acidic protein as a Biomarker

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Biomedical and Environmental Sciences 1991年第1期4卷 197-206页

作者： james p.O CALLAGHAN Neurotoxicology Division Health Effects Research Laboratory U. S Environmental Protection Agency Research Triangle Park

Diverse neurotoxic insults result in proliferation and hypertrophy of astrocytes. The hallmark of this response is enhanced expression of the major intermediate filament protein of astrocytes, glial fibrillary acidic protein (GFAp). These observations suggest that GFAp may be a useful biomarker of neurotoxicity. To investigate this possibility, we administered prototype neurotoxicants to experimental animals and assessed the effects of these agents on the tissue content of GFAp, as determined by radioimmunoassay. A review of the background, design, and results of these experiments are presented in this paper. Our findings indicate that GFAp is a sensitive and specific biomarker of neurotoxicity.

关键词： GFAp Use of Glial Fibrillary Acidic protein as a Biomarker Assessment of Neurotoxicity

Intensity of effort and momentary failure in resistance training:Are we asking a binary question for a continuous variable?

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Journal of Sport and Health Science 2022年第6期11卷 644-647页

作者： james p.Fisher james Steele Dave Smith School of Sport Health and Social ScienceSolent UniversitySouthamptonSO140YNUK Research Centre for Musculoskeletal and Sports Medicine Manchester Metropolitan UniversityManchesterM156BHUK

*** There is a growing body of research supporting the idea that a plethora of health benefits can result from resistance training using a low volume,high-effort approach(e.g.,increased metabolic rate and bone mineral density,a reduction in blood pressure,and improved muscle quality and insulin sensitivity,among ***,muscular strength and muscle massprimary goals and benefits of participation in resistance trainingare independently strong predictors of longevity and quality of life. Thus,many have sought to identify how the manipulation of resistance training variables might lead to“optimal”adaptations in such outcomes,as evidenced by repeated attempts over recent decades to review the literature and provide consensus statements on this topic.5-10 One variable that is often hotly debated within resistance training is training to failure.

关键词： resistance binary continuous