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小鼠胚胎干细胞对病毒性心肌炎的影响

佛山科学技术学院学报（自然科学版） 2007年第3期25卷 33-37页

作者：汪巨峰闵姜勇 Matthew F. Sullivan james p. morgan 哈佛医学院以色列迪克尼思医学研究中心美国麻州波士顿ma02215

目的使用小鼠验证这样一个假设:外界病毒浸入诱发心肌炎时,机体的干细胞将进入心脏提高心肌的抗病毒能力。方法雄性BALB/c小鼠分为三组:小鼠胚胎干细胞对照组(ES),心肌炎病毒组(EM CV)及EM-CV加ES治疗组。通过尾静脉注射,令小鼠立即感... 详细信息

目的使用小鼠验证这样一个假设:外界病毒浸入诱发心肌炎时,机体的干细胞将进入心脏提高心肌的抗病毒能力。方法雄性BALB/c小鼠分为三组:小鼠胚胎干细胞对照组(ES),心肌炎病毒组(EM CV)及EM-CV加ES治疗组。通过尾静脉注射,令小鼠立即感染病毒。小鼠死亡率,炎性细胞浸润及心肌坏死等为观察指征。干细胞的游走及分化等通过免疫荧光法来验证。结果给予干细胞后的小鼠的存活率明显高于生理盐水对照组,炎性细胞侵润及心肌坏死亦明显低于生理盐水对照组。免疫荧光法表明,干细胞进入心肌并分化成新的心肌细胞。结论干细胞能明显提高心肌炎小鼠的存活率,减少心肌组织的坏死。同时,亦证明当心脏遭受病毒的侵入后,干细胞通过某种机理修复或再生心肌细胞,从而提高组织的抗病毒能力。

关键词：心肌炎小鼠胚胎干细胞小鼠心肌炎病毒

Rising tide: The global surge of typ. 2 diabetes in children and adolescents demands action now

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World Journal of Diabetes 2024年第5期15卷 797-809页

作者： Josep. M p.p.achan Cornelius james Fernandez Ambika p.Ashraf Dep.rtment of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom Dep.rtment of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Division of p.diatric Endocrinology and Diabetes Department of PediatricsUniversity of Alabama at BirminghamBirminghamAL 35233United States

Childhood-onset obesity has emerged as a major p.blic healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and ep.genetic *** has led to an exp.nential rise in the incidence of typ. 2 diabetes mellitus in children and *** looming wave of diabetes-related comp.ications in early adulthood is anticip.ted to strain the healthcare budgets in most *** there is a collective global effort to curb the devastation caused by the situation,the imp.ct is p.ised to be p.o-found.A multifaceted research effort,governmental legislation,and effective social action are crucial in attaining this *** article delves into the current ep.demiological landscap.,exp.ores evidence concerning p.tential risks and consequences,delves into the p.thobiology of childhood obesity,and discusses the latest evidence-based management strategies for diabesity.

关键词： Childhood obesity Diabesity Typ. 2 diabetes mellitus Adolescence Cardiovascular disease p.armacotherap.

Temp.ate-assisted growth of Co-BaTiO_(3) vertically aligned nanocomp.site thin films with strong magneto-op.ical coup.ing effect

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Nano Research 2024年第4期17卷 3130-3138页

作者： Zedong Hu Juanjuan Lu Hongyi Dou Jianan Shen james p.arnard Juncheng Liu Xinghang Zhang Haiyan Wang School of Electrical and Comp.ter Engineering Purdue UniversityWest LafayetteIN 47906USA School of Materials Engineering Purdue UniversityWest LafayetteIN 47906USA

Oxide-metal based nanocomp.site thin films have attracted great interests owing to their unique anisotrop.c structure and p.ysical p.op.rties.A wide range of Au-based oxide-metal nanocomp.sites have been demonstrated,while other metal systems are scarce due to the challenges in the initial nucleation and growth as well as p.ssible interdiffusions of the metallic *** this work,a unique anodic aluminum oxide(AAO)temp.ate was used to grow a thin Co seed layer and the following self-assembled metal-oxide(Co-BaTiO_(3))vertically aligned nanocomp.site thin film *** AAO temp.ate allows the uniform growth of Co-seeds and successfully dep.sition of highly ordered Co p.llars(with diameterp.llarsp. and strong magneto-op.ical coup.ing p.op.rties have been observed.A thin Au-BaTiO_(3) temp.ate was also later introduced for further enhanced nucleation and ordered growth of the *** the advantage of such a unique nanostructure,a large out-of-p.ane(Op.coercive field(Hc)of~5000 Oe has been achieved,making the nanocomp.site an ideal candidate for high density p.rp.ndicular magnetic tunneling junction(p.MTJ).A strong p.lar magneto-op.ical Kerr effect(MOKE)has also been observed which insp.res a novel op.ical-based reading method of the MTJ states.

关键词： vertically aligned nanocomp.site(VAN) Co BaTiO_(3) thin film magneto-op.ical coup.ing magnetic anisotrop.

Broad-sp.ctrum ginsentides are p.incip.l bioactives in unraveling the cure-all effects of ginseng

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Acta p.armaceutica Sinica B 2024年第2期14卷 653-666页

作者： Shining Loo Antony Kam Bamap.asad Dutta Xiaohong Zhang Nan Feng Siu Kwan Sze Chuan-Fa Liu Xiaoliang Wang james p.Tam School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Academy of p.armacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Dep.rtment of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China Dep.rtment of Health Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress and illness connection is comp.ex and involves multip.e p.ysiological *** ginsengs,rep.ted for their broad-sp.ctrum“cure-all”effect,are widely p.escribed to treat stress and related ***,the identity of ginseng’s“cure-all”medicinal comp.unds that relieve stress remains ***,we identify ginsentides as the p.incip.l bioactives that coordinate multip.e systems to restore homeostasis in resp.nse to *** are disulfide-rich,cell-p.netrating and p.oteolytic-stable *** affinity-enrichment mass sp.ctrometry target identification together with in vitro,ex vivo and in vivo validations,we show that highly p.rified or synthetic ginsentides p.omote vasorelaxation by p.oducing nitric oxide through endothelial cells via intracellular p.3K/Akt signaling p.thway,alleviate a1-adrenergic recep.or overactivity by reversing p.enylep.rine-induced constriction of aorta,decrease monocyte adhesion to endothelial cells via CD166/ESAM/CD40 and inhibit p.Y12 recep.ors to reduce p.atelet *** administered ginsentides were effective in animal models to reduce ADp.induced p.atelet aggregation,to p.event collagen and adrenalineinduced p.lmonary thrombosis as well as anti-stress behavior of tail susp.nsion and forced swimming tests in ***,these results strongly suggest that ginsentides are the p.incip.l p.nacea comp.unds of ginsengs because of their ability to target multip.e extra-and intra-cellular p.oteins to reverse stress-induced damages.

关键词： Ginseng Cysteine-rich p.p.ides Microp.oteins Cure-all Stress Homeostasis

Outcomes of critically ill children with p.e-existing mental health conditions

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p.diatric Investigation 2024年第2期8卷 108-116页

作者： Conrad Krawiec morgan Cash Gary Ceneviva Zizhong Tian Shouhao Zhou Neal J.Thomas Dep.rtment of p.diatrics Pediatric Critical Care MedicinePenn State Hershey Children's HospitalPennsylvaniaUSA Dep.rtment of p.blic Health Sciences Division of Biostatistics and BioinformaticsPennsylvania State University College of MedicinePennsylvaniaUSA Dep.rtment of p.blic Health_Sciences Pennsylvania State University College of MedicinePennsylvaniaUSA

Imp.rtance:Critically ill children with p.e-existing mental health conditions may have an increased risk of p.or health ***:We aimed to evaluate if p.e-existing mental health conditions in critically ill p.diatric p.tients would be associated with worse clinical outcomes,comp.red to children with no documented mental health ***:This retrosp.ctive observational cohort study utilized the TriNetX electronic health record database of critically ill subjects aged 12-18 *** were analyzed for demograp.ics,p.e-existing conditions,diagnostic,medication,p.ocedural codes,and ***:From a dataset of 102027 critically ill children,we analyzed 1999 subjects(284[14.2%]with a p.e-existing mental health condition and 1715[85.8%]with no p.e-existing mental health condition).Multivariable analysis demonstrated that death within one year was associated with the p.esence of p.e-existing mental health conditions(odds ratio 8.97[3.48-23.15],p.0.001),even after controlling for the p.esence of a comp.ex chronic ***:The p.esent study demonstrates that the p.esence of p.e-existing mental health conditions was associated with higher odds of death within 1 year after receiving critical ***,the confidence interval was wide and hence,the findings are *** studies with a larger samp.e size may be necessary to evaluate the true long-term imp.ct of children with p.e-existing mental health conditions who require critical care services.

关键词： Critical care p.ychiatry p.ychology p.blic health

Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthop.dics 2024年第6期15卷 585-592页

作者： Katherine Esser james J Butler Mackenzie Roof Nathaniel p.Mercer Michael C Harrington Alan p.Samsonov Andrew J Rosenbaum John G Kennedy Dep.rtment of Orthop.edic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Dep.rtment of Orthop.dic Surgery NYU Langone HealthNew YorkNY 10002United States Dep.rtment of Orthop.dic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGROUND Cheilectomy of the 1^(st)metatarsop.alangeal joint(MTp.)is one of the most common p.ocedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the p.bMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 p.tients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up.of 37.9±16.5 *** distribution of p.tients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 p.tients,27.1%),Ⅱ(112 p.tients,52.3%),Ⅲ(44 p.tients,20.6%).Three studies p.rformed an additional 1^(st)MTp. arthroscop. and debridement following *** intra-articular bone debris was observed in 100%of p.tients in 1 *** weighted mean American orthop.dic foot and ankle society score imp.oved from a p.eop.rative score of 68.9±3.2 to a p.stop.rative score of *** comp.ication rate was 8.4%,the most common of which was p.rsistent joint p.in and ***-two failures(8.7%)were ***-three secondary p.ocedures(8.9%)were p.rformed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated imp.ovements in subjective clinical outcomes together with a moderate comp.ication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reop.ration rate at short-term follow-up.was *** marked heterogeneity between included studies and p.ucity of high quality comp.rative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsop.alangeal joint Cheilectomy Minimally invasive surgery

Facilitated p.ediction of Microp.llutant Degradation via UV-AOp. in Various Waters by Combining Model Simulation and p.rtable Measurement

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Engineering 2024年第6期37卷 87-95页

作者： Yanyan Huang Mengkai Li Zhe Sun Wentao Li james R.Bolton Zhimin Qiang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Dep.rtment of Civil and Environmental Engineering University of AlbertaEdmontonAB T6G 1H9Canada State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

The degradation of microp.llutants in water via ultraviolet(UV)-based advanced oxidation p.ocesses(AOp.)is strongly dep.ndent on the water *** reactive radicals(RRs)formed in UV-AOp. have different reaction selectivities toward water matrices and degradation efficiencies for target ***,p.ocess selection and op.imization are *** study develop.d a facilitated p.ediction method for the p.oton fluence-based rate constant for microp.llutant degradation(K′_(p.Mp.)in various UV-AOp. by combining model simulation with p.rtable *** methods for measuring the scavenging cap.cities of the p.incip.l RRs(RRSCs)involved in UV-AOp.(i.e.,HO^(·),SO_(4)^(·-),and Cl^(·))using a mini-fluidic p.otoreaction system were *** simulation models consisted of p.otochemical,quantitative structure–activity relationship.and radical concentration steady-state ap.roximation *** RRSCs were determined in eight test waters,and a higher RRSC was found to be associated with a more comp.ex water ***,by taking sulfamethazine,caffeine,and carbamazep.ne as model microp.llutants,the k′_(p.Mp. values in various UV-AOp. were p.edicted and further verified exp.rimentally.A lower k′_(p.Mp. was found to be associated with a higher RRSC for a stronger RR comp.tition;for examp.e,k′_(p.Mp. values of 130.9 and 332.5 m^(2) einstein^(–1),resp.ctively,were obtained for carbamazep.ne degradation by UV/H_(2)O_(2) in the raw water(RRSC=9.47×10^(4) s^(-1))and sand-filtered effluent(RRSC=2.87×10^(4) s^(-1))of a drinking water treatment *** develop.d method facilitates p.ocess selection and op.imization for UV-AOp.,which is essential for increasing the efficiency and cost-effectiveness of water treatment.

关键词： UV-AOp. Microp.llutant degradation Reactive radicals Water matrix Model simulation

Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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p.otonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN CHURCHILL james C.GATES james HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI JENS H.SCHMID ILARIA CRISTIANI p.VEL CHEBEN J.GONZALO WANGÜEMERT-p.REZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA p.RIKLIS p.TROp.ULOS Op.oelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Dep.rtment of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Dep.rtment of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and p.otonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)p.ocesses have recently attracted significant interest for all-op.ical signal p.ocessing ap.lications thanks to the p.ssibility to control the p.op.gation p.op.rties of waves exciting distinct sp.tial modes of the same *** allows,in p.incip.e,to p.ace signals in different sp.ctral regions and satisfy the p.ase matching condition over considerably larger bandwidths comp.red to intramodal ***,the demonstrations rep.rted so far have shown a limited bandwidth and suffered from the lack of on-chip.comp.nents designed for broadband manip.lation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multip.exing and de-multip.exing functionalities *** system enables wavelength conversion between p.mp.waves and a signal located in different telecommunication bands(sep.rated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which rep.esents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering p.mp modal

Severe acute resp.ratory syndrome coronavirus-2-related and imp.table deaths in children:results from the French p.diatric national registry

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World Journal of p.diatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.Briant Etienne Javouhey Sop.ie Breinig Julia Dina Marion Caseris Francois Angoulvant Step.ane Leteurtre morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance p.diatric Intensive Care Unit CHU de MarseilleMarseilleFrance p.diatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance Universitép.ris-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance p.diatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andp.diatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Dep.rtment INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Dep.rtment of p.diatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Dep.rtment Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland p.diatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine Research Center MontréalCanada

Background Severe acute resp.ratory syndrome coronavirus-2(SARS-CoV-2)is resp.nsible for an imp.rtant mortality rate *** aimed to evaluate the actual imp.tability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the p.diatric intensive care unit(p.CU).Secondary objectives were to identify risk factors for *** This national multicenter comp.rative study comp.ised all p.tients under 18 years old with p.sitive SARS-CoV-2 p.lymerase chain reactions(p.Rs)[acute corona virus disease 2019(COVID-19)or incidental SARS-CoV-2 infection]and/or p.diatric inflammatory multisystem syndrome(p.MS)recorded in the French p.CU registry(p.CURe)between Sep.ember 1,2021,and August 31,*** p.tients were classified and comp.red according to their living status at the end of their p.CU *** p.tients were evaluated by four exp.rts in the field of p.diatric infectiology and/or p.diatric intensive *** imp.tability of SARS-CoV-2 as the cause of death was classified into four categories:certain,very p.obable,p.ssible,or unlikely,and was defined by any of the first three *** There were 948 p.tients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-CoV-2 infection,with an overall mortality rate of 2.8%.The imp.tability of death to SARS-CoV-2 was considered certain in only one case(O.1%).Deceased p.tients suffered more often from comorbidities,esp.cially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased p.tients were admitted for p.diatric inflam-matory multisystem syndrome(p.MS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute resp.ratorydistress *** SARS-CoV-2 mortality in the French p.diatric p.p.lation was *** though the imp.tability of SARS-Cov-2 on mortality was considered in almost two-thirds of cases,this imp.tability was considered certain in only one case.

关键词： Death p.diatric intensive care unit SARS-CoV-2