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A study of scientific publications on the greater cane rat (Thryonomys swinderianus, Temminck 1827)

Animal Models and Experimental Medicine 2020年第1期3卷 40-46页

作者： Oluwaseun Ahmed Mustapha Ebunoluwa Elizabeth Teriba Oluwaseun Samuel Ezekiel Ayokunle Matthew Olude Adebayo Koyuum Akinloye james olukayode olopade Department of Veterinary Anatomy College of Veterinary MedicineFederal University of AgricultureAbeokutaNigeria Department of Veterinary Anatomy Faculty of Veterinary MedicineUniversity of IbadanIbadanNigeria Department of Animal Production and Health Federal University of Technology AkureAkureNigeria

Background:The greater cane rat(GCR),reputed to be African's second largest rodent,is a precocial hystricomorph with an uncommon phenotype and life *** and socio-economic interests in the GCR have led to heightened research efforts targeted towards a better understanding of its biology and exploration of its economic and translational ***:Records of all online scientific publications on the GCR from Google,Google Scholar,PubMed,***,Ebscohost and Worldwide science,with the exception of research theses,proceedings,unpublished projects and abstracts,were collated and analyzed using descriptive ***:A total of 146 published scholarly articles spanning about six decades were retrieved,with 98%of the GCR publications originating from African *** boasts the highest number of publications(58.22%)followed by Ghana(21.23%)and South Africa(5.48%)while Senegal contributed the least(0.69%).Publications were sorted into ten field *** field with the highest number of articles(41.78%)was animal breeding and management recording,closely followed by anatomy(37.67%).Lesser contributions were made by parasitology(5.48%),biochemistry/hematology(4.8%),pharmacology/toxicology(4.11%),pathology(2.06%),and surgery/anesthesia and physiology(1.37%apiece).The fields with fewest contributions were microbiology and developmental biology(0.69%each).Conclusion:This study chronicles the spectrum of knowledge available on the GCR,highlighting the knowledge gap that still exists in various fields in order to provide advocacy for new frontiers in research efforts on this *** suggest the need for a clearly defined and well integrated national/regional policy aimed at establishing Africa's foremost micro-livestock rodent,the greater cane rat,on the world's scientific radar.

关键词： African rodent grasscutter greater cane rat micro-livestock review wildlife

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Folic Acid Reverses the Effects of Cannabis on the Brain of New Born Wistar Rats

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Neuroscience & Medicine 2019年第3期10卷 213-223页

作者： Olakunle Olutoye Osinubi Silas Kalu Onwuka james olukayode olopade Ayo M. Olude Department of Veterinary Anatomy University of Ibadan Ibadan Nigeria Department of Veterinary Anatomy Federal University of Agriculture Abeokuta Nigeria

There are conflicting reports on the effect of Cannabis on brain cells, some reports support damage to brain cells while others do not. This work was carried out at the neuroscience unit of the Department of Veterinary Anatomy, University of Ibadan Oyo State, Nigeria. It investigated the neurodegenerative effect of extract of Cannabis sativa plant on brain regions in newborn Wistar rats exposed to Cannabis in utero and also combining the antioxidant and cell proliferative properties of folic acid to reverse these changes particularly in the Purkinje layer of the cerebellum in the group that received folic acid and cannabis. Four groups of pregnant Wistar rats were treated from Day 5 to 20 of pregnancy as follows: group A received 2ml of normal saline solution per os, group B received 2.0 mg /kg body weight of ethanolic extract of Cannabis sativa plant dissolved in normal saline per os, group C received 2.0 mg /kg body weight of Cannabis sativa extract and 40 mg/kg body weight of folic acid tablets (Emzor®) and group D received 2 mg/kg body weight of folic acid per os. The rat pups from group B showed deficit in locomotor function with spongiosis and astrogliosis in the corpus callosum, cerebellum and hippocampal regions of the brain. While pups from group A showed normal locomotor activities with no visible lesions in regions of the brain such as the cerebrum, cerebellum and the hippocampus. Group C pups were presented with normal locomotor activities with congestion of vessels in cerebrum and meninges and scattered areas of cell loss in the cerebrum, cerebellum hippocampus and corpus callosum and group D pups showed normal locomotor function, with vascular congestion in the meninges and cerebrum. We, therefore, concluded that folic acid which is a crucial factor in cell division, neurotransmitter production and an antioxidant in the nervous system could have a reversal of behavioural and locomotor deficits on nervous tissues exposed to Cannabis sativa extract

关键词： Ethanolic Extract of Cannabis sativa Folic Acid Transplacental Administration Locomotor Deficit

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