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急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark Gregory W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler james C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul G. nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent n. Thijs Gotz Thomalla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeImagingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeImagingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Academy Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国

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活体中共焦显微镜下的角膜后沉着物

美国医学会眼科杂志（中文版） 2005年第3期17卷 191-191页

作者： Michael S. Wertheim William D. Mathers Stephen J. Planck Tammy M .Martin Eric B. Suhler Justine R. Smith james T. Rosenbaum 许珂（译）

目的：在活体中用共焦显微镜（IVCM）观察不同葡萄膜炎亚型的角膜后沉着物（KP）成分。方法：用扫描共焦显微镜观察患者（n=33）的KP，这些患者来自第三级转诊的葡萄膜炎门诊部，患有免疫介导或感染性的葡萄膜炎，包括HIJA-B27相关的葡... 详细信息

目的：在活体中用共焦显微镜（IVCM）观察不同葡萄膜炎亚型的角膜后沉着物（KP）成分。方法：用扫描共焦显微镜观察患者（n=33）的KP，这些患者来自第三级转诊的葡萄膜炎门诊部，患有免疫介导或感染性的葡萄膜炎，包括HIJA-B27相关的葡萄膜炎、结节病、Vogt—Koyanagi—Harada综合征，青少年慢性关节炎，Fuchs异色性虹膜腱状体炎，巨细胞病毒性视网膜炎、眼部带状疱疹、眼部弓形体病和先天葡萄膜炎。图像被采集并行实时数字化处理。

关键词：角膜显微镜检查电子扫描/仪器和设备

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh n nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick nicholson Vikram Huded nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera james E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug neurology RadiologyBoston Medical CenterBostonMassachusettsUSA neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA neurology National Hospital Organization Osaka National HospitalOsakaJapan neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of neurology Xinqiao HospitalChongqingChina neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance neurology Hospital Geral de FortalezaFortalezaBrazil Interventional neuroradiology Hospital Geral de FortalezaFortalezaBrazil neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional neurovascular Unit University Hospital CareggiFirenzeToscanaItaly neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional neuroradiology Lahore General HospitalLahorePakistan neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional neuroradiology Institut National de NeurologieTunisTunisia neurology Boston Medical CenterBostonMassachusettsUSA neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pn of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,pncrease in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

肝纤维化组织学分期的MR弹性成像和（31）P-MRS比较

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国际医学放射学杂志 2013年第1期 100-100页

作者： E.M.Godfrey A.J.Patterson A.n.Priest S.E.Davies I.Joubert A.S.Krishnan 李琼 Department of Radiology St James' HospitalBeckett StreetLeeds LS9 7TFUK

目的常规的成像技术对肝纤维化不敏感。本研究评估MR弹性成像(MRE)的硬度值和31P-MRS测量的磷酸单酯(PME)/磷酸二酯(PDE)比值对于组织学肝纤维化分期的诊断准确性。方法单位伦理委员会批准了这项双盲的前瞻性研究。共77例临床怀疑肝纤... 详细信息

目的常规的成像技术对肝纤维化不敏感。本研究评估MR弹性成像(MRE)的硬度值和31P-MRS测量的磷酸单酯(PME)/磷酸二酯(PDE)比值对于组织学肝纤维化分期的诊断准确性。方法单位伦理委员会批准了这项双盲的前瞻性研究。共77例临床怀疑肝纤维化的病人[男55例,(49±11.5)岁]在同一天进行了肝脏活检和MRI检查。采用1.5T全身成像系统进行MRE和31P-MRS检查。肝活检的分期采用慢性肝炎的Ishak评分和脂肪肝的修订的nAS纤维化评分。结果 MRE硬度值与纤维化分期呈正相关(Spearman系数=0.622,Pn系数=-0.041,P=0.741)。MRE硬度值的曲线下面积较高(范围0.75～0.97)。PME/PDE的诊断实用性并不好(范围0.44～0.58)。结论 MRE的肝脏硬度值随纤维化分期而增加,并且能区分纤维化分组。没有发现31P-MRS与纤维化分期之间的联系。

关键词：肝纤维化 MRE 硬度值肝疾病 MR P-MRS 弹性成像组织学显微解剖学解剖学

心肌细胞移植的多模态分子成像:第二部分.骨髓基质细胞在猪体内的PET/CT和MR成像

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国际医学放射学杂志 2016年第6期 680-680页

作者： n.Parashurama B.C.Ahn K.Ziv K.Ito R.Paulmurugan J.K.Willmann 华明辉 Department of Radiology James Clark CenterMolecular Imaging Program at Stanford

摘要目的运用临床PET报告基因成像和MR预标记细胞成像来定量确定猪心肌细胞治疗(CCT)后骨髓基质细胞(MSC)可检测的极限值。方法动物研究由动物实验制度

关键词：骨髓基质细胞基因成像报告基因基质(细胞) 分子成像 PET/CT MR 多模态

Z0011试验:是术前评估乳腺癌病人进行腋窝超声检查的终点吗?

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国际医学放射学杂志 2015年第6期 598-598页

作者： T.P.J.Farrell n.C.Adams M.Stenson P.A.Carroll M.Griffin E.M.Connolly 于静 Department of Radiology St James ’s Hospital

摘要目的 Z0011试验质疑前哨淋巴结(SLn)阳性≤2个的乳腺癌病人术前分期进行腋窝超声(Ax US)检查的意义。本研究旨在对Ax US发现的异常淋巴结数目与最终淋巴

关键词：腋窝超声乳腺癌乳腺肿瘤淋巴结淋巴组织病人

新斯的明降低分娩期患者A控硬膜外镇痛（PCEA）的布比卡因用量：一项随机对照研究

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麻醉与镇痛 2011年第5期7卷 22-29页

作者： Vernon H. Ross, MD Peter H. Pan, MD Medge D. Owen, MD Melvin H. Seid, MD Lynne Harris, Rn Brittany Clyne, MD Misa Voltaire, MD james C. Eisenach, MD 房丽丽（译） Departments of Anesthesiology Wake Forest University School of Medidne North Carolina Obstetrics and Gynecology Wake Forest University School of Medidne North Carolina 不详

背景鞘内注射新斯的明产生镇痛作用的同时可能导致重度恶心。相反，硬膜外注射新斯的明可以增强阿片类药物和局部麻醉药的镇痛作用而不产生恶心呕吐。以往的研究只针对单次硬膜外注射新斯的明，而对连续硬膜外注射新斯的明和母婴安全性... 详细信息

背景鞘内注射新斯的明产生镇痛作用的同时可能导致重度恶心。相反，硬膜外注射新斯的明可以增强阿片类药物和局部麻醉药的镇痛作用而不产生恶心呕吐。以往的研究只针对单次硬膜外注射新斯的明，而对连续硬膜外注射新斯的明和母婴安全性未进行评估。因此，本研究拟验证在分娩期患者中新斯的明复合布比卡因硬膜外注射是否减少布比卡因用量。方法12例择期剖宫产的健康产妇随机分组，分别接受40μg（n=6）和80μg（n=6）新斯的明单次注射，监测20分钟胎心率（fetalheartrate，FHR）和宫缩。然后，另外40例健康的分娩期产妇随机分组，分别接受布比卡因1．25mg／ml或联合新斯的明4μg／ml产妇自控硬膜外镇痛（patient—controlledepiduralanalgesia，PCEA）。主要观察指标为每小时布比卡因用量。结果硬膜外新斯的明单次注射未导致FHR基础值改变，未诱导宫缩或产生恶心。硬膜外新斯的明的使用可使全部产妇的布比卡因用量减少19％，P〈0．05（使用4小时以上产妇用量减少达25％，P〈0．05），但可能导致轻度镇静。两组产妇的分娩方式、恶心发生率和FHR异常情况均相似。结论以上数据显示硬膜外使用新斯的明可降低PCEA中布比卡因每小时需要量的19％-25％。单次给药和连续注射新斯的明均不会诱发恶心、诱导宫缩或FHR异常，但可能导致轻度镇静。

关键词：自控硬膜外镇痛新斯的明布比卡因随机对照研究分娩期用量患者硬膜外注射

neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys

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Zoological Research 2020年第1期41卷 3-19页

作者： Pei Zhang Jie-Si Chen Qi-Ye Li Long-Xiang Sheng Yi-Xing Gao Bing-Zheng Lu Wen-Bo Zhu Xiao-Yu Zhan Yuan Li Zhi-Bing Yuan Gang Xu Bi-Tao Qiu Min Yan Chun-Xue Guo You-Qiong Wang Yi-Jun Huang Jing-Xia Zhang Fu-Yu Liu Zhong-Wei Tang Sui-Zhen Lin David nCooper Huan-Ming Yang Jian Wang Yu-Qi Gao Wei Yin Guo-Jie Zhang Guang-Mei Yan State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China BGI-Shenzhen ShenzhenGuangdong 518083China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine of People's Liberation Army Chongqing 400038China Key Laboratory of High Altitude Environmental Medicine Third Military Medical UniversityMinistry of EducationChongqing 400038China School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006China Guangzhou Cellprotek Pharmaceutical Co.Ltd. GuangzhouGuangdong 510663China Institute of Medical Genetics School of MedicineCardiff UniversityCardiff CF144XNUK james D.Watson Institute of Genome Sciences HangzhouZhejiang 310058China Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China China national Genebank BGI-ShenzhenShenzhenGuangdong 518120China

Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment.

关键词： Acute hypobaric hypoxia Cynomolgus monkeys Brain injury neuroprotectant Gene regulatory networks

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吉兰-巴雷综合征诊治的10个步骤(Diagnosis and management of Guillain-Barrésyndrome in ten steps全译)

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中华诊断学电子杂志 2023年第3期11卷 198-211页

作者： Sonja E Leonhard Melissa R Mandarakas Francisco AA Gondim Kathleen Bateman Maria LB Ferreira David R Cornblath Pieter A van Doorn Mario E Dourado Richard AC Hughes Badrul Islam Susumu Kusunoki Carlos A Pardo Ricardo Reisin james J Sejvar nortina Shahrizaila Cristiane Soares Thirugnanam Umapathi 王玉忠 Eppie M Yiu Hugh J Willison Bart C Jacobs 伊拉斯姆斯大学医疗中心神经内科鹿特丹市3015 CE 福塔莱萨联邦大学沃尔特·坎迪奥大学医院塞阿拉州60430-370 开普敦大学格鲁特·舒尔医院开普敦市7925 累西腓市康复医院神经内科伯南布哥州52171-011 约翰·霍普金斯大学医学院神经病学系马里兰州21218 北里奥格兰德州联邦大学奥诺弗雷卢佩斯医院综合医学部纳塔尔市59012-300 伦敦大学学院皇后广场神经病学研究所伦敦市WC1N 3BG 国际腹泻病研究中心达卡市1212 金代大学医学院大阪市589-8511 不列颠医院布宜诺斯艾利斯市C1280AEB 亚特兰大市疾病预防控制中心乔治亚州30329 马来亚大学神经病学系吉隆坡市50603 埃斯塔多联邦医院里约热内卢市20221-903 国家神经科学研究所新加坡308433 济宁医学院附属医院神经内科济宁272029 墨尔本皇家儿童医院神经内科维多利亚州3052 默多克儿童研究所神经科学研究组维多利亚州3052 墨尔本大学儿科学系维多利亚州3052 格拉斯哥大学医学、兽医学与生命科学学院格拉斯哥市G611QH 伊拉斯姆斯大学医疗中心免疫科鹿特丹市3015 GD

吉兰-巴雷综合征(GBS)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBS通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBS的临床... 详细信息

吉兰-巴雷综合征(GBS)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBS通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBS的临床表现和病程多种多样,其诊疗存在一定的复杂性,而目前尚无可用的国际性临床诊疗指南。本文作者撰写了一份适用于全球的GBS诊疗指南,特别是在疾病暴发期间,以期为临床医生提供指导。本指南根据当前文献和专家共识撰写而成,采用10步式结构,以便在临床实践中更好地应用。本文首先介绍了GBS的诊断标准、临床变异和鉴别诊断;其次,通过10个步骤介绍了GBS的早期识别和诊断、收治重症监护室的指征、治疗指征和选择、疾病进展的监测和处理、临床病程和结局的预测,以及并发症和后遗症的处理。

关键词：吉兰-巴雷综合征诊断治疗