检索结果-南通市图书馆

Comparison of Energy Harvesting Systems for Wireless Sensor Networks

在线全文

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2008年第4期5卷 334-347页

作者： james m.Gilbert Farooq Balouchi Department of Engineering University of Hull

Wireless sensor networks (WSNs) offer an attractive solution to many environmental,security,and process monitoring ***,one barrier to their fuller adoption is the need to supply electrical power over extended periods of time without the need for dedicated *** harvesting provides a potential solution to this problem in many *** paper reviews the characteristics and energy requirements of typical sensor network nodes,assesses a range of potential ambient energy sources,and outlines the characteristics of a wide range of energy conversion *** then proposes a method to compare these diverse sources and conversion mechanisms in terms of their normalised power density.

关键词： Energy harvesting energy scavenging wireless sensor networks (WSNs) energy management

Vertebrate pesticide risk assessment by indigenous communities in New Zealand

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2010年第1期5卷 37-43页

作者： Shaun C.OGILVIE james m.ATARIA james WAIWAI james DOHERTY Aroha mILLER james G.ROSS Charles T.EASON Ecology Department Lincoln UniversityLincolnCanterburyNew Zealand Landcare Research LincolnCanterburyNew Zealand Lake Waikaremoana Hapu Restoration Trust TuaiNew Zealand Tuhoe Tuawhenua Trust MuruparaNew Zealand

In New Zealand,the vertebrate pesticide sodium fluoroacetate(Compound 1080)is aerially applied in baits for control of the brush-tailed possum Trichosurus vulpecula(Kerr,1792).maori,the indigenous people of New Zealand,have raised concerns about 1080 impacts on culturally-important ***,we outline two steps taken to help maori assess 1080 ***,field research was undertaken to determine if naturally-occurring plants utilized by a maori community for food and medicine would take up 1080 from *** baits were placed at the base of individual plants of two species,pikopiko(Asplenium bulbiferum)and karamuramu(Coprosma robusta).Plants were sampled at various times up to 56 days,and samples were analyzed for 1080 *** 1080 was detected in any of the pikopiko samples,whereas 1080 was detected in karamuramu,at a maximum concentration of 5 ppb after seven days,and 2.5 ppb after 14 *** concentration decreased to 0 at 28 days,indicating that 1080 was not *** results of the present study suggest there is negligible risk of humans being poisoned by consum-ing plants that have taken up 1080 from *** allay community concerns that minute concentrations of 1080 might influence the medicinal properties of plants,it is suggested that a withholding period of 30 days after 1080 control operations could be ***,after further consultation we undertook a review of the scientific literature relating to 1080 impacts on additional non-target species of cultural importance to *** information was presented on an interactive foodweb database that allowed the collection and presentation of a large volume of complex information about 1080 in a holistic and pictorial *** database was presented to many maori communities throughout New Zealand,and feedback was overwhelmingly *** database is likely to play a key role in informing these communities about 1080,and is seen as an important new tool to help these communities

关键词： 1080 indigenous communities maori risk assessment sodium fluoroacetate

Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第18期23卷 3240-3251页

作者： james D Lord Donna m Shows Translational Research Program Benaroya Research Institute Gastroenterology Division Virginia Mason Medical Center

To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in *** thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease (IBD) therapy for decades, but their mechanism of action in vivo remains obscure. Although thiopurines are lymphotoxic at high doses, and have been reported to cause T cell apoptosis in vitro, their ability to control IBD at lower doses suggests that they may selectively deplete particular lymphocyte populations. Blood cells from 19 IBD patients on a thiopurine, 19 IBD patients not on a thiopurine, and 38 matched healthy control subjects were analyzed by multiple multi-color flow cytometry panels to quantify the immune cell subsets contained therein, both as a percent of cells, and as an absolute cell count. Similar analyses were performed on colon biopsies from 17 IBD patients on a thiopurine, 17 IBD patients not on a thiopurine, and 49 healthy screening colonoscopy *** blood counts revealed lower lymphocyte, but not monocyte or granulocyte, counts in IBD patients who were taking thiopurines at the time of sampling. This reduction was restricted to CD3-negative lymphocytes, wherein both natural killer (NK) and B cells were significantly reduced among thiopurine recipients. Among CD19+ B cells, the transitional B cells were particularly depleted, being nearly absent in both blood and colon biopsies of thiopurine recipients. No differences were associated with thiopurine use in CD8+ T cells, mucosa-associated invariant T (mAIT) cells, invariant natural killer T (iNKT) cells, gamma/delta T cells, Th1, Th17, regulatory T cells (Tregs) or naïve CD4+ T cells. However, patients with IBD had significantly more circulating FOXP3+, Helios+ Tregs and fewer iNKT and mAIT cells than healthy *** use is associated with reduced B and NK cell, but not T cell, subpopulations in the blood of IBD patients.

关键词： Thiopurine Azathioprine mercaptopurine Lymphocyte Natural killer cell Transitional B cell Inflammatory bowel disease

Perspectives on the clinical development of mmunotherapy in prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2018年第3期20卷 253-259页

作者： Lisa m Cordes james L Gulley Ravi A madan Clinical Center National Institutes of Health Bethesda MD 20892 USA Genitourinary malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20892 USA

Despite impressive survival benefits with immunotherapy in patients with various solid tumors, the full potential of these agents in prostate cancer has yet to be realized. SipuleuceI-T demonstrated a survival benefit in this population, indicating that prostate cancer is an immunoresponsive disease; however, these results have not been matched by other agents. A large trial with ipilimumab in prostate cancer failed to meet its primary objective, and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response. However, several late-stage clinical trials are underway with other vaccines in prostate cancer. Reports of clinical benefit with immunotherapies, particularly when used in combination or a select population, have provided the framework to develop sound clinical trials. Understanding immunogenic modulation, antigen spread, biomarkers, and DNA-repair defects will also help mold future strategies. Through rational patient selection and evidence-based combination approaches, patients with prostate cancer may soon derive durable survival benefits with immunotherapies.

关键词： checkpoint inhibitor immunotherapy prostate cancer therapeutic vaccine

Flu channel drug resistance:a tale of two sites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2010年第3期1卷 246-258页

作者： Rafal m.Pielak james J.Chou Department of Biological Chemistry and molecular Pharmacology Harvard Medical SchoolBostonMA 02115USA Program in Biological and Biomedical Sciences Harvard Medical SchoolBostonMA 02115USA

The m2 proteins of influenza A and B virus,Am2 and Bm2,respectively,are transmembrane proteins that oligomerize in the viral membrane to form proton-selective *** conductance of the m2 proteins is required for viral replication;it is believed to equilibrate pH across the viral membrane during cell entry and across the trans-Golgi membrane of infected cells during viral *** addition to the role of m2 in proton conductance,recent mutagenesis and structural studies suggest that the cytoplasmic domains of the m2 proteins also play a role in recruiting the matrix proteins to the cell surface during virus *** viral ion channels of minimalist architecture,the membrane-embedded channel domain of m2 has been a model system for investigating the mechanism of proton ***,as a proven drug target for the treatment of influenza A infection,m2 has been the subject of intense research for developing new anti-flu ***2 is the target of two anti-influenza A drugs,amantadine and rimantadine,both belonging to the adamantane class of ***,resistance of influenza A to adamantane is now widespread due to mutations in the channel domain of *** review summarizes the structure and function of both Am2 and Bm2 channels,the mechanism of drug inhibition and drug resistance of Am2,as well as the development of new m2 inhibitors as potential anti-flu drugs.

关键词： m2 Bm2 influenza proton channel amantadine rimantadine

SnO2-reduced graphene oxide nanoribbons as anodes for lithium ion batteries with enhanced cycling stability

在线全文

学校读者我要写书评

暂无评论

Nano Research 2014年第9期7卷 1319-1326页

作者： Lei Li Anton Kovalchuk james m. Tour Department of Chemistry Rice University 6 I00 Main Street Houston Texas 77005 USA Richard E. Smalley Institute for Nanoscale Science and Technology Rice University 6100 Main Street Houston Texas 77005 USA Department of materials Science and NanoEngineering Rice University 6100 Main Street Houston Texas 77005 USA

A nanocomposite material of SnO2-reduced graphene oxide nanoribbons has been developed. In this composite, the reduced graphene oxide nanoribbons are uniformly coated by nanosized SnO2 that formed a thin layer of SnO2 on the surface. When used as anodes in lithium ion batteries, the composite shows outstanding electrochemical performance with the high reversible discharge capacity of 1,027 mAh/g at 0.1 A/g after 165 cycles and 640 mAh/g at 3.0 A/g after 160 cycles with current rates varying from 0.1 to 3.0 A/g and no capacity decay after 600 cycles compared to the second cycle at a current density of 1.0 A/g. The high reversible capacity, good rate performance and excellent cycling stability of the composite are due to the synergistic combination of electrically conductive reduced graphene oxide nanoribbons and SnO2, The method developed here is practical for the large-scale development of anode materials for lithium ion batteries.

关键词： lithium ion battery tin oxide graphene oxide nanoribbons energy storage

High energy neutron and pion-decay gamma-ray emissions from solar flares

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Astronomy and Astrophysics 2009年第1期9卷 11-40页

作者： Edward L.Chupp james m.Ryan Physics Department and Space Science Center in the Institute for the Study of Earth Oceans and Space University of New Hampshire

Solar flare gamma-ray emissions from energetic ions and electrons have been detected and measured to GeV energies since 1980. In addition, neutrons produced in solar flares with 100 meV to GeV energies have been observed at the Earth. These emissions are produced by the highest energy ions and electrons accelerated at the Sun and they provide our only direct （albeit secondary） knowledge about the properties of the accelerator（s） acting in a solar flare. The solar flares, which have direct evidence for pion-decay gamma-rays, are unique and are the focus of this paper. We review our current knowledge of the highest energy solar emissions, and how the characteristics of the acceleration process are deduced from the observations. Results from the RHESSI, INTEGRAL and CORONAS missions will also be covered. The review will also cover the solar flare capabilities of the new mission, FERmI GAmmA RAY SPACE TELESCOPE, launched on 2008 June II. Finally, we discuss the requirements for future missions to advance this vital area of solar flare physics.

关键词： Sun -- Flares -- Particle Acceleration-meson Production

Tight Rock Wettability and Its Relationship to Other Petrophysical Properties： A montney Case Study

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2017年第2期28卷 381-390页

作者： Ali Javaheri Hassan Dehghanpour james m.Wood University of Alberta Edmonton AB T6G 2R3 Canada Encana Corporation Calgary AB T2P 2S5 Canada

Understanding and modelling the wettability of tight rocks is essential for designing fracturing and treatment fluids. In this paper, we measure and analyze spontaneous imbibition of water and oil into five twin core plugs drilled from the cores of a well drilled in the montney Formation, an unconventional oil and gas play in the Western Canadian Sedimentary Basin. We characterize the samples by measuring the mineralogy using XRD（x-ray diffraction）, total organic carbon content, porosity, and permeability. Interestingly, the equilibrated water uptake of the five samples is similar, while, their oil uptake increases by increasing the core porosity and permeability. We define two wettability indices for the oil phase based on the slope and equilibrium values of water and oil imbibition curves. Both indices increase by increasing porosity and permeability, with the slope affinity index showing a stronger correlation. This observation suggests that part of the pore network has a stronger affinity to oil than to water. We also observe that the two indices decrease by increasing neutron porosity and gamma ray parameters measured by wireline logging tools. The samples with higher gamma ray and neutron porosity are expected to have greater clay content, and thus less effective porosity and permeability.

关键词： spontaneous imbibition wettability petrophysics gamma ray log

Diagnosis and management of testosterone deficiency

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第2期17卷 177-186,I0006页

作者： james A mcBride Culley C Carson Robert m Coward Department of Urology University of North Carolina School of Medicine NC USA.

Testosterone supplementation therapy （TST） use has dramatically increased over the past decade, due to the availability of newer agents, aggressive marketing, and an increasing incidence of testosterone deficiency （TD）. Despite the increase in TST, a degree of ambiguity remains as to the exact diagnostic criteria of TD, and administration and monitoring of TST. One explanation for this phenomenon is the complex role testosterone plays in multiple physiologic pathways. Numerous medical co-morbidities and medications can alter testosterone levels resulting in a wide range of nonspecific clinical signs and symptoms of TD. The diagnosis is also challenging due to the lack of a definitive serum total testosterone level that reliably correlates with symptoms. This observation is particularly true in the aging male and is exacerbated by inconsistencies between different laboratory assays. Several prominent medical societies have developed guideline statements to clarify the diagnosis, but they differ from each other and with expert opinion in several ways. Aside from diagnostic dilemmas, there are numerous subtle advantages and disadvantages of the various testosterone agents to appreciate. The available TST agents have changed significantly over the past decade similar to the trends in the diagnosis of TD. Therefore, as the usage of TST increases, clinicians will be challenged to maintain an up-to-date understanding of TD and TST. The purpose of this review is to provide a clear description of the current strategies for diagnosis and management of TD.

关键词： androgens erectile dysfunction hormones hypogonadism testosterone