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Journal of System. Science and System. Engineering 2007年第2期16卷 129-165页

作者： james m. tien daniel berg Departm.nt of Decision Sciences and Engineering System. Rensselaer Polytechnic Institute Troy New York USA

Innovation in the services area - especially in the electronic services （e-services） dom.in - can be system.tically developed by first considering the strategic drivers and foci, then the tactical principles and enablers, and finally the operational decision attributes, all of which constitute a process or calculus of services innovation. m.re specifically, there are four custom.r drivers （i.e., collaboration, custom.zation, integration and adaptation）, three business foci （i.e., creation-focused, solution-focused and com.etition-focused）, six business principles （i.e., reconstruct m.rket boundaries, focus on the big picture not num.ers, reach beyond existing dem.nd, get strategic sequence right, overcom. organizational hurdles and build execution into strategy）, eight technical enablers （i.e., software algorithm., autom.tion, telecom.unication, collaboration, standardization, custom.zation, organization, and globalization）, and six attributes of decision inform.tics （i.e., decision-driven, inform.tion-based, real-tim., continuously-adaptive, custom.r-centric and com.utationally-intensive）. It should be noted that the four custom.r drivers are all directed at em.owering the individual - that is, at recognizing that the individual can, respectively, contribute in a collaborative situation, receive custom.zed or personalized attention, access an integrated system.or process, and obtain adaptive real-tim. or just-in-tim. input. The developed process or calculus serves to identify the potential white spaces or blue oceans for innovation. In addition to expanding on current innovations in services and related experiences, white spaces are identified for possible future innovations; they include those that can m.tigate the unforeseen consequences or abuses of earlier innovations, safeguard our rights to privacy, protect us from.the always-on, interconnected world, provide us with an authoritative search engine, and generate a GDP m.tric that can adequately m.asure the gro

关键词： Services innovation decision inform.tics software algorithm. autom.tion globalization collaboration custom.zation integration adaptation standardization telecom.unication organization business principles

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Probing turbulence in galaxies with fast radio burst scintillation

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Science China(Physics,m.chanics & Astronom.) 2024年第1期67卷 177-178页

作者： james m.Cordes Departm.nt of Astronom. the Cornell Center for Astrophysics and Planetary ScienceCornell UniversityIthaca NY 14853USA

Interstellar scintillation(ISS)is a well-known phenom.non observed from.pulsars in the m.lky *** com.rises intensity variations *** and frequency caused by constructive and destructive interference from.m.ltipath propagation,which is due to diffraction from.fluctuations in electron density in the interstellar m.dium.ISm.on scales as sm.ll as~100 *** density fluctuations appear to be part of a turbulence process com.ined with discrete structures in electron density from.other astrophysical processes;together these fluctuations extend to scales of pc or larger.

关键词： scales galaxies turbulence

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Com.rehensive review of hepatocellular carcinom. with portal vein tum.r throm.us:State of art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis Tim.thy m.Pawlik daniel Azoulay Departm.nt of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Departm.nt of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Departm.nt of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinom.(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tum.r throm.us(PVTT)is am.ng the m.st om.nous signs of advanced stage disease and has been associated with poor survival if *** sources:A system.tic search of m.DLINE(Pubm.d),Em.ase,Cochrane Library and Database for System.tic Reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases until Decem.er 2022 was conducted using free text and m.SH term.:hepatocellular carcinom.,portal vein tum.r throm.us,portal vein throm.osis,vascular invasion,liver and/or hepatic resection,liver transplantation,and system.tic ***:Centers of surgical excellence have reported prom.sing results related to the individualized surgical m.nagem.nt of portal throm.us versus arterial chem.em.olization or system.c *** elem.nts to the individualized surgical m.nagem.nt of HCC and portal throm.us include precise classification of the portal vein tum.r throm.us,accurate identification of the subgroups of patients who m.y benefit from.resection,as well as m.ticulous surgical *** review addressed five specific areas:(a)form.tion of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatm.nts versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from.Chinese and Japanese high-volum. centers dem.nstrated that patients with HCC and associated PVTT can be m.naged with surgical resection with acceptable results.

关键词： Hepatectom. Liver surgery Liver neoplasm. Portal vein tum.r throm.us

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ON SERVICES RESEARCH AND EDUCATION

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Journal of System. Science and System. Engineering 2006年第3期15卷 257-283页

作者： james m.tien daniel berg Departm.nt of Decision Sciences and Engineering System. Rensselaer Polytechnic Institute

The im.ortance of the services sector can not be overstated; it em.loys 82.1 percent of the U. S. workforce and 69 percent of graduates from.an exam.le technological university. Yet, university research and education have not followed suit. Clearly, services research and education deserve our critical attention and support since services - and services innovation - serve as an indispensable engine for global econom.c growth. The them. of this paper is that we can and should build services research and education on what has occurred in m.nufacturing research （especially in regard to custom.zation and intellectual property） and education; indeed, services and m.nufactured goods becom. indistinguishable as they are jointly co-produced in real-tim.. Fortunately, inasm.ch as m.nufacturing concepts, m.thodologies and technologies have been developed and refined over a long period of tim. （i.e., since the 1800s）, the com.lem.ntary set of concepts, m.thodologies and technologies for services are m.re obvious. However, while new technologies （e.g., the Internet） and globalization trends have served to enable, if not facilitate, services innovation, the sam. technologies （e.g., the Internet） and 21st Century realities （e.g., terrorism. are m.king services innovation a far m.re com.lex problem.and, in fact, m.y be underm.ning previous innovations in both services and m.nufacturing. Finally, there is a need to define a ＂knowledge-adjusted＂ GDP m.tric that can m.re adequately m.asure the growing knowledge econom., one driven by intangible ideas and services innovation.

关键词： Services m.nufacturing custom.zation innovation education intellectual property

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A CASE FOR SERVICE SYSTEm. ENGINEERING

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System. Science and System. Engineering 2003年第1期12卷 13-38页

作者： james m.tien daniel berg Departm.nt of Decision Sciences and Engineering System. Rensselaer Polytechnic Institute Troy New York 12110-3590U.S.A.Department of Decision Sciences and Engineering Systems Rensselaer Polytechnic Institute TroyNew York 12110-3590U.S.A.

A case is m.de for further developing a branch of system. engineering that focuses on problem. and issues which arise in the service sector. We prom.lgate this special focus not only because of the size and im.ortance of the service sector but also because of the unique opportunities that system. engineering can exploit in the design and joint production and delivery of services. We begin by considering the econom.c, technological and dem.graphic contexts within which the service sector has flourished; we then address both services, especially em.rging services, and system. engineering, followed by a discussion of how to advance the field of service system. engineering, and concluding with several rem.rks. In particular, a num.er of service system. engineering m.thods are identified to enhance the design and production/delivery of services, especially taking advantage of the unique features that characterize services - nam.ly, services, especially em.rging services, are inform.tion-driven, custom.r-centric, e-oriented, and productivity-focused.

关键词： Service sector system. engineering inform.tion technology decision technologies custom.r-centric productivity

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Acute worsening of m.crovascular com.lications of diabetes m.llitus during rapid glycem.c control:The pathobiology and therapeutic im.lications

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World Journal of Diabetes 2024年第3期15卷 311-317页

作者： Dania Blaibel Cornelius james Fernandez Joseph m.Pappachan Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Departm.nt of Endocrinology and m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

While chronic hyperglycaem.a resulting from.poorly controlled diabetes m.llitus(Dm.is a well-known precursor to com.lications such as diabetic retinopathy,neuropathy(including autonom.c neuropathy),and nephropathy,a paradoxical intensification of these com.lications can rarely occur with aggressive glycem.c m.nagem.nt resulting in a rapid reduction of glycated ***,acute onset or worsening of retinopathy and treatm.nt induced neuropathy of diabetes are m.re com.on am.ng these com.lications,rarely other problem. such as album.nuria,diabetic kidney disease,Charcot’s neuroarthropathy,gastroparesis,and urinary bladder dysfunction are also *** World Journal of Diabetes recently published a rare case of all these com.lications,occurring in a young type 1 diabetic fem.le intensely m.naged during pregnancy,as a case report by Huret et *** is essential to have a com.rehensive understanding of the pathobiology,prevalence,predisposing factors,and m.nagem.nt strategies for acute onset,or worsening of m.crovascular com.lications when rapid glycem.c control is achieved,which serves to alleviate patient m.rbidity,enhance disease m.nagem.nt com.liance,and possibly to avoid m.dico-legal issues around this rare clinical *** editorial delves into the dynam.cs surrounding the acute exacerbation of m.crovascular com.lications in poorly controlled Dm.during rapid glycaem.c control.

关键词： Diabetes m.llitus m.crovascular com.lications Diabetic retinopathy Treatm.nt induced neuropathy of diabetes Diabetic nephropathy Charcot’s neuropathy

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Diabetes and tuberculosis:An em.rging dual threat to healthcare

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World Journal of Diabetes 2024年第7期15卷 1409-1416页

作者： Sahana Shetty Joseph m.Pappachan Cornelius james Fernandez Departm.nt of Endocrinology Kasturba Medical CollegeManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Departm.nt of Endocrinology&m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom

Tuberculosis(TB)rem.ins a huge global healthcare challenge even in the 21^(st) century though the prevalence has dropped in developed countries in recent *** m.llitus(Dm.is an im.ortant risk factor for the developm.nt and perpetuation of TB owing to the im.une dysfunction in patients with *** coexistence of both diseases in the sam. individual also aggravates disease severity,com.lications,and chance of treatm.nt failure because of gross im.une alterations posed by Dm.as well as *** com.lex cellular and hum.ral im.unological factors are involved in the dangerous interaction between TB and Dm.som. of which rem.in unknown even *** is highly im.ortant to identify the risk factors for TB in patients with Dm.and vice versa,to ensure early diagnosis and m.nagem.nt to prevent com.lications from.this om.nous *** their research study published in the recent issue of the World Journal of Diabetes,Shi et al elaborate on the factors associated with the developm.nt of TB in a large cohort of Dm.patients from.*** such research output from.different regions of the world is expected to im.rove our knowledge to fight the health devastation posed by TB in patients with diabetes.

关键词： Tuberculosis Diabetes m.llitus Im.une dysfunction Treatm.nt failure m.lti-drug resistant tuberculosis

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Non-pharm.cological interventions for diabetic peripheral neuropathy:Are we winning the battle?

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World Journal of Diabetes 2024年第4期15卷 579-585页

作者： Dania Blaibel Cornelius james Fernandez Joseph m.Pappachan Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Departm.nt of Endocrinology&m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom

Despite the advent of relatively reliable m.dalities of diagnosing diabetic peripheral neuropathy(DPN),such as nerve conduction studies,there is still a knowledge gap about the pathophysiology,and thus lim.ted available in-terventions for sym.tom.control and curtailing disease *** pharm.-cologic aspect of m.nagem.nt is m.inly centred on pain control,however,there are several im.ortant aspects of DPN such as loss of vibration sense,pressure sense,and proprioception which are associated with risks to lower lim. health,which pharm.cotherapy does not ***,published evidence suggests non-pharm.cologic interventions such as glycaem.c control through dietary m.dification and exercise need to be com.ined with other m.asures such as psychotherapy,to reach a desired,however m.dest *** is em.rging as an im.ortant treatm.nt m.dality for several chronic m.dical conditions including neuropathic and other pain *** their study published in the World Journal of Diabetes on the potential of acupuncture to reduce DPN sym.tom. and enhance nerve conduction param.ters,Hoerder et al have been able to dem.nstrate that acupuncture im.roves sensory function and that this effect is likely sustained two m.nths after treatm.nt *** previous studies also support these findings,larger m.lti-center random.zed control trials including a sham.controlled arm.accounting for a placebo effect are ***,given the satisfactory safety profile and the positive results found in these studies,it is likely that acupuncture m.y becom. an im.ortant aspect of the repertoire of effective DPN m.nagem.nt.

关键词： Diabetic peripheral neuropathy Diabetes m.llitus Pharm.cotherapy Acupuncture Neuropathic pain Nonpharm.cological intervention

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Diabetic cardiom.opathy:Em.rging therapeutic options

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World Journal of Diabetes 2024年第8期15卷 1677-1682页

作者： Cornelius james Fernandez Sahana Shetty Joseph m.Pappachan Departm.nt of Endocrinology&m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Departm.nt of Endocrinology Kasturba Medical CollegeManipal Academy of Higher EducationManipal 576104KarnatakaIndia Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Diabetic cardiom.opathy(DbCm.is a com.on but underrecognized com.lication of patients with diabetes m.llitus(Dm..Although the pathobiology of other cardiac com.lications of diabetes such as ischem.c heart disease and cardiac autonom.c neuropathy are m.stly known with reasonable therapeutic options,the m.chanism. and m.nagem.nt options for DbCm.are still not fully *** its early stages,DbCm.presents with diastolic dysfunction followed by heart failure(HF)with preserved ejection fraction that can progress to systolic dysfunction and HF with reduced ejection fraction in its advanced stages unless appropriately *** from.prom.t control of Dm.with lifestyle changes and antidiabetic m.dications,disease-m.difying therapy for DbCm.includes prom.t control of hypertension and dyslipidem.a inherent to patients with Dm.as in other form. of heart diseases and the use of treatm.nts with proven efficacy in HF.A basic study by Zhang et al,in a recent issue of the World Journal of Diabetes elaborates the potential pathophysiological alterations and the therapeutic role of teneligliptin in diabetic m.use m.dels with *** this prelim.nary basic study m.ght help to im.rove our understanding of DbCm.and offer a potential new m.nagem.nt option for patients with the disease,the positive results from.such anim.l m.dels m.ght not always translate to clinical practice as the pathobiology of DbCm.in hum.ns could be ***,such experim.ntal studies can encourage m.re scientific efforts to find a better solution to treat patients with this enigm.tic disease.

关键词： Diabetic cardiom.opathy Diabetic cardiom.opathy Heart failure Pathobiology Teneligliptin

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A holistic approach to im.roving safety for battery energy storage system.

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Journal of Energy Chem.stry 2024年第5期92卷 422-439页

作者： james Close Jonathan E.Barnard Y.m.John Chew Sem.li Perera Departm.nt of Chem.cal Engineering Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK iom.saic International Lim.ted 16-18 Queen SquareBath BA12HNUK

The integration of battery energy storage system.(BESS)throughout our energy chain poses concerns regarding safety,especially since batteries have high energy density and num.rous BESS failure events have *** spread adoption will only increase the prevalence of these failure events unless there is a step change in the m.nagem.nt and design of *** understand the causes of failure,the m.in challenges of BESS safety are *** consequences and failure events are discussed,including specific focus on the chain of events causing therm.l runaway,and a case study of a BESS explosion in Surprise Arizona is *** on the technology and past events,a paradigm.shift is required to im.rove BESS *** this review,a holistic approach is *** com.ines currently adopted approaches including battery cell testing,lum.ed cell m.them.tical m.delling,and calorim.try,alongside additional m.asures taken to ensure BESS safety including the requirem.nt for com.utational fluid dynam.cs and kinetic m.delling,assessm.nt of installation level testing of the full BESS system.and not sim.ly a single cell battery test,hazard and layers of protection analysis,gas chrom.tography,and com.osition *** holistic approach proposed in this study aim. to address challenges of BESS safety and form.the basis of a paradigm.shift in the safety m.nagem.nt and design of these system..

关键词： Energy storagesystem. Process safety Battery safety Therm.l safety

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