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Studies on Enzyme Kinetics by Microchip and Related Techniques

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高等学校化学学报 2004年第Z1期25卷 165-166页

作者： james j. Bao WANG Huai-Feng ZHOU Da-Wei Ken R. Wehmeyer College of Pharmaceuticals Tianjin University Tianjin 300072 China College of Pharmaceuticals Tianjin University Tianjin 300072 China College of Pharmaceuticals Tianjin University Tianjin 300072 China Procter & Gamble Pharmaceuticals 8700 Mason-Montgomery Road Mason OH 45040 USA

Both conventional and microchip-based capillary electrophoresis(CE) technologies have been used for the analysis of enzymes. Practical procedures of using CE to determine the Km and Vmax values of an enzyme have been developed. By studying the inhibition to the enzyme, it is possible to select a suitable drug candidate. When compared with the conventional CE method, single lane microchip-based method can improve the speed for the assay three times. By using multiple lane-based microchip, the speed can be further increased.

关键词： Enzyme Enzyme kinetics Inhibition Enzyme activity

Optimization of huff-n-puff gas inj.ction in shale oil reservoirs

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Petroleum 2017年第4期3卷 431-437页

作者： james j.Sheng Texas Tech University P.O.Box 43111LubbockTX 79409USA Southwest Petroleum University Chengdu 610500China

Earlier studies show that huff-n-puff inj.ction is preferred to continuous gas flooding to improve liquid oil production in shale oil *** to gas flooding,huff-n-puff has more operational parameters to optimize so that liquid oil production can be *** paper is to discuss the optimum huff-n-puff times,number of cycles and soaking time under practical operational and reservoir *** operational and reservoir conditions dictate the maximum inj.ction and production rates,and the maximum inj.ction pressure and minimum production *** numerical simulation results and discussions show that the optimum huff time is so long that the pressure near the wellbore reaches the set maximum inj.ction pressure during the huff period;and the optimum puff time is the time required for the pressure near the wellbore to reach the set minimum production pressure during the puff *** benefits of soaking may not compensate the loss in inj.ction and production due to the time lost in the soaking ***,soaking may not be necessary during the huff-n-puff gas inj.ction in shale oil *** number of huff-n-puff cycles is determined when an economic rate cut-off is reached.

关键词： shale reservoirs inj.ction

Status of surfactant EOR technology

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Petroleum 2015年第2期1卷 97-105页

作者： james j.Sheng Texas Tech University P.O.Box 43111LubbockTX 79409United States

Surfactant enhanced oil recovery(EOR)includes surfactant flooding and surfactant *** main functions of surfactants are to reduce interfacial tension and wettability *** paper is to review the EOR technology related to surfactant *** reviewed topics include the following:Surfactant EOR mechanismsFactors affecting interfacial tension Trapping numberScreening criteriaLaboratory work Numerical simulation work Summary of pilot and large-scale applications Surfactants used Salinity gradientSurfactant EOR in carbonate reservoirs Surfactant EOR in shale reservoirs.

关键词： Surfactant flooding Surfactant EOR Review Enhanced oil recovery Chemical EOR

Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride

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Protein & Cell 2016年第4期7卷 300-304页

作者： Linlin Zhao Shuqing Wang Lingyu Du j.oti Dev Liuj.an Zhou Zhij.n Liu james j. Chou Bo OuYang National Center for Protein Science State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 China Tianj.n Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) School of Pharmacy Tianjin Medical University Tianjin 300070 China Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA 02115 USA Shanghai Science Research Center Chinese Academy of Sciences. Shanahai 201204. China

Dear Editor, Hepatitis C virus （HCV） infection, which causes hepatitis C and can chronically lead to serious and life-threatening dis- eases including liver cirrhosis and hepatocellular carcinoma （Lauer and Walker, 2001）, is a rising global health problem. More than 170 million people are infected by HCV worldwide and 3-4 million people are infected each year. No effective vaccines are available to prevent HCV infection. Moreover, HCV is a fast mutating RNA virus with seven distinct genotypes and many subtypes within each genotype. The high degree of genetic diversity can lead to further viral resistance to the current therapies within individual patients （Li et al., 2012）. Hence, there remains a strong desire in the medical community to explore new therapeutic opportunities.

关键词： Hexamethylene Rimantadine Chemical Shift Perturbation Nuclear Overhauser Enhancement Channel Cavity

WHO SURRENDERED TO CLAUDIUS AT CAMULODUNUM IN A.D. 43?

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j.urnal of Ancient Civilizations 2003年 97-101页

作者： james j. Stewart Southern Illinois University at Carbondale

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Spring

山东师范大学外国语学院学报（基础英语教育） 2006年第2期8卷 91-92页

作者： james j. Kilpatrick

Springs are not always the same. In some years, April bursts upon our Virginia hills in one prodigious leap—and all the stage is filled at once, whole choruses of tulips, arabesques of forsythia, cadenzas of flowering plum. The trees grow leaves *** other years, spring tiptoes in. It pauses, overcome by shyness, like my grandchild at the door, peeping in, ducking out of sight, giggling in the hallway. “I know you’re out there,” I cry. “Come in!” And April slips into our *** dogwood bud, pale green, is inlaid with russet markings. Within the perfect cup a score of clustered seeds are nestled. One examines the bud in awe: Where were those seeds a month ago? The apples display their milliner’s scraps of ivory silk, rose-tinged. All the sleeping things wake up—primrose, baby iris, blue phlox. The earth warms—you can smell it, feel it, crumble April in your *** dark Blue Ridge Mountains in which I dwell, great-hipped, big-breasted, slumber on the western sky. And then they stretch and gradually awaken. A warm wind, soft as a girl’s hair, moves sailboat clouds in gentle skies. The rains come—good rains to sleep by—and fields that were dun as oatmeal turn to pale green, then to Kelly green.

关键词：读者 Spring

The wings of the dove

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Low Cost, High Efficiency, Gain Flattened L Band EDFA Using FBGs as C Band Seed Generators

作者： Henry james edited by j. Donald Crowley and Richard A. Hocks.

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光学学报 2003年第S1期23卷 271-272页

作者： j.j. Pan james Guo Lightwaves 2020 Inc. 1323 Great Mall Drive Milpitas CA 95035 USALightwaves 2020 Inc. 1323 Great Mall Drive Milpitas CA 95035 USA

A low cost, coolerless 980nm diode pumped, gain flattened L band EDFA with fast transient control, high pump efficiency and gain clamping effect was realized by using FBGs as C band seed generators.

关键词： EDFA in as with Gain Flattened L Band EDFA Using FBGs as C Band Seed Generators High Efficiency Low Cost

Recent Advancements in Optical Harmonic Generation Microscopy: Applications and Perspectives

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Biomedical Engineering Frontiers 2021年第1期2卷 65-88页

作者： Darian S.james Paul j.Campagnola Department of Biomedical Engineering University of Wisconsin-Madison1550 Engineering DrMadisonWI 53706USA

Second harmonic generation(SHG)and third harmonic generation(THG)microscopies have emerged as powerful imaging modalities to examine structural properties of a wide range of biological *** SHG and THG arise from very different contrast mechanisms,the two are complimentary and can often be collected simultaneously using a modified multiphoton *** this review,we discuss the needed instrumentation for these modalities as well as the underlying theoretical principles of SHG and THG in tissue and describe how these can be leveraged to extract unique structural *** provide an overview of recent advances showing how SHG microscopy has been used to evaluate collagen alterations in the extracellular matrix and how this has been used to advance our knowledge of cancers,fibroses,and the cornea,as well as in tissue engineering *** examples using polarization-resolved approaches and machine learning algorithms are ***,we review how THG has enabled developmental biology and skin cancer studies due to its sensitivity to changes in refractive index,which are ubiquitous in all cell and tissue ***,we offer perspectives and outlooks on future directions of SHG and THG microscopies and present unresolved questions,especially in terms of overall miniaturization and the development of microendoscopy instrumentation.

关键词： harmonic resolved directions