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Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain

World Journal of Gastroenterology 2014年第5期20卷 1298-1304页

作者： Chunqiu Chen jakub Fichna Moshe Laudon Martin Storr Division of Gas-troenterology University of Calgary Shanghai Tenth People’s Hospital Tongji University School of Medicine Department of Biomolecular Chemistry Medical University of Lodz Neurim Pharmaceuticals LTD Division of Gastroenterology Department of Medicine Ludwig Maximilians University of Munich

AIM: To characterize the antinociceptive action of the novel melatonin receptor (MT) agonists, Neu-P11 and Neu-P12 in animal models of visceral pain. METHODS: Visceral pain was induced by intracolonic (ic) application of mustard oil or capsaicin solution or by intraperitoneal (ip) administration of acetic acid. Neu-P11, Neu-P12, or melatonin were given ip or orally and their effects on pain-induced behavioral responses were evaluated. To identify the receptors involved, the non-selective MT1/MT2 receptor antagonist luzindole, the MT2 receptor antagonist 4-P-PDOT, or the mu-opioid receptor antagonist naloxone were injected ip or intra-cerebroventricularly (icv) prior to the induction of pain. RESULTS: Orally and ip administered melatonin, Neu-P11, and Neu-P12 reduced pain responses in a dose-dependent manner. Neu-P12 was more effective and displayed longer duration of action compared to melatonin. The antinociceptive effects of Neu-P11 or Neu-P12 were antagonized by ip or icv. administered naloxone. Intracerebroventricularly, but not ip administration of luzindole or 4-P-PDOT blocked the antinociceptive actions of Neu-P11 or Neu-P12. CONCLUSION: Neu-P12 produced the most potent and long-lasting antinociceptive effect. Further development of Neu-P12 for future treatment of abdominal pain seems promising. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

关键词： Gastrointestinal tract Melatonin Neu-P11 Neu-P12 Opioid Visceral pain

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Plant-Arthropod Associations from the Lower Miocene of the Most Basin in Northern Bohemia(Czech Republic):A Preliminary Report

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 903-914页

作者： jakub PROKOP Torsten WAPPLER Stanislav KNOR Zlatko KVACEK Department of Zoology Charles UniversityPragueCzech Republic Steinmann Institute Section PalaeontologyUniversity of BonnBonnGermany Institute of Geology and Palaeontology Charles UniversityPragueCzech Republic

Terrestrial plants and insects currently account for the majority of the Earth＇s biodiversity, and approximately haft of insect species are herbivores. Thus, insects and plants share ancient associations that date back more than 400 Myr. However, investigations of their past interactions are at the preliminary stages in Western Europe. Herein, we present the first results of our study of various feeding damage based on a dataset of nearly 3500 examined plant specimens from the Lower Miocene of the Lagerstaette Bflina Mine in the Most Basin, Czech Republic. This site provides a unique view of the Neogene freshwater ecosystems. It has long been studied by scientists working in different branches of sedimentology, paleobotany, and paleozoology. The fossils are preserved in three characteristic horizons overlaying the coal seam （Clayey Superseam Horizon, Delta Sandy Horizon, and Lake Clayey Horizon）, reflecting paleoenvironmental changes in a short time period of development. The trace fossils are classified as functional feeding groups or ＂guilds＂, without searching for a direct cause or a recent analog host relation. Approximately 23% of specimens of dicotyledonous plant leaves were found to be damaged and associated with some leaf ＂morphotypes＂. Deciduous plant-host taxa, and those with a chartaceous texture typical of riparian habitats, were frequently damaged, such as Populus, recorded with two species Populus zaddachii and Populus populina （57.9% and 31% herbivory levels, respectively）, followed by Acer, Alnus, and Carya, averaging almost 30% of damaged leaves/leaflets. There has been evidence of 60 damage types （DT） representing all functional feeding groups recorded at the Bflina Mine, including 12 types of leaf mines and 16 gall- type DT. In total, Lower Miocene of the Lagerstaette Bilina Mine exhibits a high level of external foliage feeding types （23.7%）, and a low level of more specialized DT, such as galls （4.3%） and leaf mines （〈1%）. A broader comparison b

关键词： plant-insect interaction paleoecology climate change Neogene Early Miocene Most Basin BflinaMine Czech Republic

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Fabrication and Significant Photoelectrochemical Activity of Titania Nanotubes Modified with Thin Indium Tin Oxide Film

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Acta Metallurgica Sinica(English Letters) 2017年第12期30卷 1210-1220页

作者： Katarzyna Siuzdak Mariusz Szkoda jakub Karczewski Jacek Ryl Kazimierz Darowicki Katarzyna Grochowska Centre for Plasma and Laser Engineering The Szewalski Institute of Fluid-Flow Machinery Polish Academy of Sciences Fiszera 14 80-231 Gdansk Poland Department of Chemistry and Technology of Functional Materials Chemical Faculty Gdańsk University of Technology Narutowicza 11/12 80-233 Gdansk Poland Faculty of Applied Physics and Mathematics Gdansk University of Technology Narutowicza 11/12 80-233 Gdafisk Poland Department of Electrochemistry Corrosion and Materials Engineering Gdansk University of Technology Narutowicza 11/12 80-233 Gdafisk Poland

Ordered titanium dioxide nanotubes （TiOaNTs） modified with indium tin oxide （ITO） films were obtained via magnetron sputtering, in which ITO plate was used as a target, onto the as-anodized titania support followed by the calcination process. The morphology of fabricated material with deposited oxide was investigated using scanning electron microscopy. Raman and UV-Vis spectroscopies were utilized to characterize crystalline phase and optical properties of prepared samples, whereas X-ray photoelectron spectroscopy allowed determining the binding energy of present elements. In the case of titanium, three various oxidation states were identified and also the presence of indium and tin was confirmed. The electrochemical test carried out when the sample was exposed to light allows for selection of the most photoactive material. The highest photocurrent was registered when only 5-nm ITO layer was sputtered, and it equals 256 and 133 μA cm^-2 for the electrode material immersed in 0.5 M KOH and K2SO4 electrolytes, respectively, that is accordingly 3.5 and 4.4 times higher than the one observed for pristine titania. Furthermore, ITO-modified titania exhibits excellent photostability upon prolonged illumination that is of key importance for possible application in light-driven processes.

关键词： Titania nanotubes Indium tin oxide Photoactivity Anodization Magnetron sputtering Electrochemical activity

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Subcellular Localization and In Vivo Interactions of the Arabidopsis thaliana Ethylene Receptor Family Members

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Molecular Plant 2008年第2期1卷 308-320页

作者： Christopher Grefen Katrin Stadele Kamil Ruzicka Petr Obrdlik Klaus Hatter jakub Horak Zentrum fur Molekularbiologie der Pflanzen Pflanzenphysiologie Universitat Tubingen Auf der Morgenstelle 1 72076 Tubingen Germany Zentrum for Molekularbiologie der Pflanzen Entwicklungsgenetik Universit&t Tubingen Auf der Morgenstelle 3 72076 Tubingen Germany IonGate Biosciences GmbH Industriepark Hochst D 528 65926 Frankfurt am Main Germany

The gaseous phytohormone ethylene regulates many developmental processes and responses to environmental conditions in higher plants. In Arabidopsis thaliana, ethylene perception and initiation of signaling are mediated by a family of five receptors which are related to prokaryotic two-component sensor histidine kinases. The transient ex- pression of fluorescence-tagged receptors in tobacco （Nicotiana benthamiana） epidermal leaf cells demonstrated that all ethylene receptors are targeted to the ER endomembrane network and do not localize to the plasmalemma. In support of in planta overlay studies, the ethylene receptors form homomeric and heteromeric protein complexes at the ER in living plant cells, as shown by membrane recruitment assays. A comparable in vivo interaction pattern was found in the yeast mating-based split-ubiquitin system. The overlapping but distinct expression pattern of the ethylene receptor genes suggests a differential composition of the ethylene receptor complexes in different plant tissues. Our findings may have crucial functional implications on the ethylene receptor-mediated efficiency of hormone perception, induction of signaling, signal attenuation and output.

关键词： Subcellular Localization Vivo Interactions Arabidopsis thaliana Ethylene Receptor Family Members

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Antipredatory reaction of the leopard gecko Eublepharis macularius to snake predators

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Current Zoology 2016年第5期62卷 439-450页

作者： Eva LANDOVA Veronika MuslLovA jakub POLAK Kristyna SEDLACKOVA Daniel FRYNTA Department of Zoology Faculty of Science Charles University Vinicna 7 128 44 Prague Czech Republic National Institute of Mental Health Topolova 748 250 67 Klecany Czech Republic

Ability to recognize a risk of predation and react with adaptive antipredatory behavior can enhance fitness, but has some costs as well. Animals can either specifically react on the most dangerous predators （threat-sensitive avoidance） or they have safe but costly general wariness avoiding all potential predators. The level of threat may depend on the predator＇s foraging ecology and distri- bution with the prey with sympatric and specialist species being the most dangerous. We used 2 choice trials to investigate antipredatory behavior of captive born and wild-caught leopard geckos confronted with different snake predators from 2 families （Colubridae, Boidae） varying in foraging ecology and sympatric/allopatric distribution with the geckos. Predator-na＇ive subadult individuals have general wariness, explore both chemically and visually, and perform antipredatory postures toward a majority of snake predators regardless of their sympatry/allopatry or food specialization. The most exaggerated antipredatory postures in both subadult and adult geckos were toward 2 sympatric snake species, the spotted whip snake Hemorrhois ravergieri, an active forager, and the red sand boa Eryxjohnii, a subterranean snake with a sit-and-wait strategy. In contrast, also subter- ranean but allopatric the Kenyan sand boa Eryx colubrinus did not elicit any antipredatory reaction. We conclude that the leopard gecko possesses an innate general antipredatory reaction to different species of snake predators, while a specific reaction to 2 particular sympatric species can be observed. Moreover, adult wild caught geckos show lower reactivity compared with the captive born ones, presumably due to an experience of a real predation event that can hardly be simulated under laboratory conditions.

关键词： allopatric antipredation lizard posture sympatric 2 choice trial.

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Dielectric behaviors at microwave frequencies and Mossbauer effects of chalcedony, agate, and zultanite

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Chinese Physics B 2015年第5期24卷 649-655页

作者： Levent Paral? Israfil Sabikoglu Jiri Tucek Jiri Pechousek Petr Novak jakub Navarik Celal Bayar University Departments of Electronics and Automation Celal Bayar University Faculty of Arts and Sciences Department of Physics Muradiye Regional Centre of Advanced Technologies and Materials Department of Experimental Physics Faculty of SciencePalacky University

In this study, dielectric properties within 8-12 GHz microwave frequencies, inductively coupled plasma-atomic emis- sion spectrometry, Fourier transform infrared spectrometry, synchronized two thermal analyses, and 57Fe Mossbauer spectroscopy analysis of chalcedony, agate, and zultanite samples from Turkey are presented. Agate and chalcedony show the same nine vibrational absorption peaks obtained unlike zultanite from FTIR spectra in the 350 cm-1 to 4000 cm-1 range, ε＇ values of chalcedony, agate and zultanite derived at 10.5 GHz were 4.67, 4.41, and 7.34, respectively, eI and e~ values of the studied samples at the microwave frequencies are related to the percentage weight of their constituent parts in their chemical compositions. 57Fe Mossbauer spectroscopy results confirm the existence of iron-containing islands in the crystal structure of zultanite, agate, and chalcedony samples, equipped them with magnetic features typical for magnetic nanoparticles including superparamagnetism. The presence of iron-containing islands significantly affects the magnetic, dielectric, and optical properties of studied samples that are not observed for pure minerals without any foreign inclusions.

关键词： zultanite agate chalcedony microwave dielectric properties Mossbauer effects

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CMTJ:Simulation package for analysis of multilayer spintronic devices

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npj Computational Materials 2023年第1期9卷 1804-1813页

作者： jakub Mojsiejuk Sławomir Ziętek Krzysztof Grochot Witold Skowroński Tomasz Stobiecki Institute of Electronics AGH University of Science and TechnologyAl.Mickiewicza 30Kraków 30-059Poland Faculty of Physics and Applied Computer Science AGH University of Science and TechnologyAl.Mickiewicza 30Kraków 30-059Poland

We present CMTJ—a simulation package for large-scale macrospin analysis of multilayer spintronics *** from conventional simulations,such as magnetoresistance and magnetisation hysteresis loops,CMTJ implements a mathematical model of dynamic experimental techniques commonly used for spintronics devices characterisation,for instance:spin diode ferromagnetic resonance,pulse-induced microwave magnetometry,or harmonic Hall voltage *** find that macrospin simulations offer a satisfactory level of agreement,demonstrated by a variety of *** a unified simulation package,CMTJ aims to accelerate wide-range parameter search in the process of optimising spintronics devices.

关键词： multilayer analysis hysteresis

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LIVESPORT办公空间

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现代装饰 2024年第3期 42-49页

作者： jakub Heidler(设计) Jan Kacer(设计) Marek Svoboda(设计) Lukas Baksi(设计) Jachym Bondy(设计) Jurij Lyzhanov(设计) Barbora Lickova(设计) Tomas PlocLukas Kral(设计) Studio Flusse(摄影) 舒禹(编译) 不详

Livesport的新办公室建在以前的楼层上,一个将体育与现代技术融为一体的空间。设计灵感来自于训练中的艰苦努力,准备过程中的自我提升。健身房空间由方块地毯表示,无缝天花板上分布规则的聚光灯网格。三个主要元素进一步增强空间,分别... 详细信息

Livesport的新办公室建在以前的楼层上,一个将体育与现代技术融为一体的空间。设计灵感来自于训练中的艰苦努力,准备过程中的自我提升。健身房空间由方块地毯表示,无缝天花板上分布规则的聚光灯网格。三个主要元素进一步增强空间,分别是地板线条、运动器材和电子笔,它们是从设计元素中抽象出来的,线条划分办公室不同区域,运动器材增强使用体验,电子笔则是导航系统,帮助新来的运动员快速融入团队与比赛。

关键词：运动器材办公空间自我提升健身房聚光灯设计元素电子笔导航系统

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A comparison of the microstructure-dependent corrosion of dual-structured Mg-Li alloys fabricated by powder consolidation methods:Laser powder bed fusion vs pulse plasma sintering

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Journal of Magnesium and Alloys 2022年第12期10卷 3553-3564页

作者： Anna Dobkowska Łukasz Zrodowski Monika Chlewicka Milena Koralnik Bogusława Adamczyk-Cieslak jakub Ciftci Bartosz Moronczyk Mirosław Kruszewski jakub Jaroszewicz Dariusz Kuc Wojciech Swieszkowski Jarosław Mizera Faculty of Materials Science and Engineering Warsaw University of Technology141 Woloska02-507 WarsawPoland Institute of Materials Engineering Silesian University of TechnologyKrasinskiego 840-019 KatowicePoland

In this study, powder metallurgy methods were used to fabricate Mg-7.5Li-3Al-Zn alloys from repowdered extruded alloys. Extruded alloys were powdered using ultrasonic atomization, and then laser powder bed fusion(LPBF) and pulse plasma sintering(PPS) were used to consolidate the bulk materials. A comparison of the properties of the fabricated alloys with those of a conventionally extruded one was carried out using methods that characterized the microstructure and corrosion resistance. When compared to their conventionally extruded counterpart, LPBF and PPS materials exhibited refined microstructures with low enrichment in Al Li and coarse Al, Zn, Mn precipitates. The main drawback of the LPBF alloy, printed for the needs of this study, was its porosity, which had a negative effect on its corrosion. The presence of unrecrystallized particle boundaries in the PPS alloy was also unbeneficial with regard to corrosion. The advantage of the LPBF and PPS processes was the ability to change the proportion of α(Mg) to β(Li), which when the complete consolidation of the material is achievable, may increase the corrosion resistance of dual-structured Mg-Li alloys. The results show that powder metallurgy routes have a wide potential to be used for the manufacture of Mg-Li based alloys.

关键词： Additive manufacturing Laser Powder Bed Fusion(LPBF) Pulse Plasma Sintering(PPS) Corrosion Mg-Li alloys

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Fine-tuning of mechanical properties in a Zn-Ag-Mg alloy via cold plastic deformation process and post-deformation annealing

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Bioactive Materials 2021年第10期6卷 3424-3436页

作者： Maria Wątroba Wiktor Bednarczyk jakub Kawałko Piotr Bała AGH University of Science and Technology Faculty of Metals Engineering and Industrial Computer ScienceAl.A.Mickiewicza 3030-059 KrakowPoland AGH University of Science and Technology Academic Centre for Materials and NanotechnologyAl.A.Mickiewicza 3030-059 KrakowPoland

In recent years,Zn-based materials have been extensively investigated as potential candidates for biodegradable implant *** introduction of alloying elements providing solid-solution strengthening and second phase strengthening seems crucial to provide a suitable platform for the thermo-mechanical strengthening of Zn *** this study,a systematic investigation of the microstructure,crystallographic texture,phase composition,and mechanical properties of a Zn-3Ag-0.5Mg(wt%)alloy processed through combined hot extrusion(HE)and cold rolling(CR),followed by short-time heat treatment(CR+HT)at 200◦C was ***,the influence of different annealing temperatures on the microstructure and mechanical properties was *** adequate combination of processing conditions during CR and HT successfully addressed brittleness obtained in the high-strength HE Zn-3Ag-0.5Mg *** controlling the microstructure,the most promising results were obtained in the sample subjected to 50%CR reduction and 5-min annealing,which were:ultimate tensile strength of 432 MPa,yield strength of 385 MPa,total elongation to failure of 34%,and Vickers microhardness of 125 *** obtained properties clearly exceed the mechanical benchmarks for biodegradable implant *** on the conducted investigation,brittle multi-phase Zn alloys’mechanical performance can be substantially enhanced to provide sufficient plasticity by grain refinement through cold deformation process,followed by short-time annealing to restore proper strength.

关键词： Zinc alloys Cold rolling Heat treatment Mechanical properties Grain refinement

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