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Effect of Ipomea carnea Jacq. flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats

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Chinese Journal of Natural Medicines 2014年第3期12卷 161-166页

作者： jain smita Patil U.K. Department of Pharmacognosy VNS Institute of Pharmacy Department of Pharmaceutical Sciences Dr. H.S. Gour Central University

AIM： To investigate the active chloroform fraction of the ethanol extract oflpomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD： Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diiso- cyanate （TDI） for 7 days. One week after second sensitization, all of the rats were provoked with 5 ~tL of 5% TDI to induce airway hypersensitivity. After the last challenge, blood and bronchoalvelor lavage （BAL） fluid were collected and subjected to total and differential leucocytes count. Flash chromatography was performed on the most active chloroform fraction to isolate an individual component. RESULTS： Treatment with the ethanolic extract and its chloroform fraction at an oral dose of 200 mg·kg^ -1 showed a significant decrease in circulating neutrophil and eosinophil in blood and BAL as compared with standard dexamethasone （DEXA）. The structure of the compound obtained from chloroform fraction oflpomea carnea was elucidated as stigmast-5, 22-dien-3β-ol on the basis of spectral data analysis. CONCLUSION： The chloroform fraction was found to be more effective to suppress airway hyper reactivity symptoms, and de- creased count of both total and differential inflammatory cells.

关键词： Ipomea carnea Toluene diisocyanate Bronchoalvelor lavage Neutrophils Stigmasterol

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BACE1 inhibitors:A promising therapeutic approach for the management of Alzheimer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 369-381页

作者： Richa Arya smita jain Sarvesh Paliwal Kirtika Madan Swapnil Sharma Achal Mishra Prashant Tiwari Sunil Kumar Kadiri Banasthali University Banasthali-304022(Raj.)India Department of Pharmacy Guru Ghasidas VishwavidyalayaBilaspurChhattisgarh-495009India Department of Pharmacology College of Pharmaceutical SciencesDayananda Sagar UniversityBengaluru-560111India

Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta(Aβ)aggregates,resulting from mutations in the amyloid precursor *** enzymeβ-secretase,also known asβ-site amyloid precursor protein cleaving enzyme 1(BACE1),plays a crucial role in generating Aβ*** no targeted therapy available for Alzheimer’s disease,inhibiting BACE1 aspartic protease has emerged as a primary treatment *** 1999,compounds demonstrating potential binding to the BACE1 receptor have advanced to human *** optimization of synthetically derived compounds,coupled with computational approaches,has offered valuable insights for developing highly selective leads with drug-like *** review highlights pivotal studies on the design and development of BACE1 inhibitors as anti-Alzheimer’s disease *** summarizes computational methods employed in facilitating drug discovery for potential BACE1 inhibitors and provides an update on their clinical status,indicating future directions for novel BACE1 *** promising clinical results of Elenbecestat(E-2609)catalyze the development of effective,selective BACE1 inhibitors in the future.

关键词： BACE1 inhibitors Amyloid precursor protein β-secretase Structure-based drug design 3D-QSAR β-amyloid precursor protein

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The Perfect Man:Perspectives on Masculinities Within Heterogeneous Traditions of Early India

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Sociology Study 2018年第7期8卷 336-344页

作者： smita Sahgal Lady Shri Ram College University of Delhi India

There is no manual on masculinity in early India and yet the idea of perfect man runs through Sanskrit,Pali,and Prakrit *** the Sanskrit traditions should construct an image of perfect man is *** is thrust on virility and procreation;procreation of a son who would inherit land and carry the lineage *** and healthy men were needed to protect society and for the purpose of *** this is understandable in a tradition that emphasizes life of a householder,one does find the concept of a complete man a little paradoxical in literature of monastic traditions that promote celibate existence for their *** monks were also kept away from both productive activities as well as from the responsibility of providing security to *** focus was clearly on acquisition of knowledge and spiritual *** what could push the construction of the notion of a perfect man?A closer exploration of Buddhist and jain texts makes the complexity comprehensible as would be revealed by the study.

关键词： Masculinity Buddhism jainism relational construction sexual deviants

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Ophthalmic manifestations in seropositive dengue fever patients during epidemics caused by predominantly different dengue serotypes

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Advances in Ophthalmology Practice and Research 2022年第2期2卷 18-24页

作者： Ajeet M.Wagle smita R.Hegde Srinivasan Sanjay Kah-Guan Au Eong International Eye Cataract Retina Centre Mount Elizabeth Medical CentreSingapore International Eye Cataract Retina Centre Farrer Park Medical CentreSingapore Khoo Teck Puat Hospital Singapore Alexandra Hospital Singapore Shree Shantinath Medical Trust-jain Hospital MumbaiIndia Narayana Nethralaya BangaloreIndia Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore

Purpose:Dengue fever(DF)epidemics in Singapore in 2005–2006 and 2007 were caused predominantly by dengue virus serotypes 1(DENV-1)and 2(DENV-2)*** investigated the prevalence of ophthalmic manifestations during these consecutive ***:Seropositive DF patients admitted to the hospital during two separate dengue epidemics were enrolled from June 2005 to December ***,ophthalmic,and laboratory data were *** primary outcome measures were differences in ophthalmic and laboratory features across the two *** associated with increased risk of developing various DF-related ophthalmic manifestations were the secondary outcome ***:Of the 115 patients enrolled,109(94.7%;33 in 2005–2006 and 76 in 2007)completed the eye screening *** of patients were Chinese(65,59.6%)and males(81,74.3%).The mean age was 40.8 years(range,18–87).Colour vision impairment(12 vs 14[36.4%vs 18.7%];P?0.04),cotton wool spots(10 vs 3[30.3%vs 3.9%];P<0.001),bleeding diathesis(7 vs 3[21.2%vs 3.9%];P?0.004)and abnormal liver function(mean alanine amino-transferase[150.2 U/L vs 68.28 U/L;P?0.001],mean aspartate amino-transferase[196.86 U/L vs 99.53 U/L;P?0.002],total protein[68.43 g/L vs 72.27 g/L;P?0.016],serum albumin[36.86 g/L vs 40.5 g/L;P?0.001])were noted more often in DF epidemics predominantly caused by DENV-1 compared to ***:A higher prevalence of colour vision impairment,cotton wool spots,bleeding diathesis,and abnormal liver function was found in DF epidemics predominantly caused by DENV-1 compared to DENV-2.

关键词： Dengue fever Ophthalmic manifestations Serotype Epidemic Singapore

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