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Cosmological parameter estimation from large-scale structure deep learning

Science China(Physics,Mechanics & Astronomy) 2020年第11期63卷 36-50页

作者： ShuYang Pan MiaoXin Liu jaime Forero-Romero Cristiano G.Sabiu ZhiGang Li HaiTao Miao Xiao-Dong Li School of Physics and Astronomy Sun Yat-Sen UniversityGuangzhou 510297China Departamento de Física Universidad de los AndesBogotáCP 111711Colombia Department of Astronomy Yonsei UniversitySeoul 03722Korea College of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

We propose a light-weight deep convolutional neural network(CNN)to estimate the cosmological parameters from simulated 3-dimensional dark matter distributions with high *** training set is based on 465 realizations of a cubic box with a side length of 256 h-1 Mpc,sampled with 1283 particles interpolated over a cubic grid of 1283 *** volumes have cosmological parameters varying within the flatΛCDM parameter space of 0.16≤?m≤0.46 and 2.0≤109 As≤*** neural network takes as an input cubes with 32^3 oxels and has three convolution layers,three dense layers,together with some batch normalization and pooling *** the final predictions from the network we find a 2.5%bias on the primordial amplitudeσ8 that cannot easily be resolved by continued *** correct this bias to obtain unprecedented accuracy in the cosmological parameter estimation with statistical uncertainties ofδ?m=0.0015 andδσ8=0.0029,which are several times better than the results of previous CNN *** with a 2-point analysis method using the clustering region of 0-130 and 10-130 h-1 Mpc,the CNN constraints are several times and an order of magnitude more precise,***,we conduct preliminary checks of the error-tolerance abilities of the neural network,and find that it exhibits robustness against smoothing,masking,random noise,global variation,rotation,reflection,and simulation *** effects are well understood in typical clustering analysis,but had not been tested before for the CNN *** work shows that CNN can be more promising than people expected in deriving tight cosmological constraints from the cosmic large scale structure.

关键词： large-scale structure of Universe cosmological parameters dark energy machine learning

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Long-range surface plasmon polaritons at THz frequencies in thin semiconductor layers

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Chinese Optics Letters 2011年第11期 66-68页

作者： Audrey Berrier jaime Gómez Rivas FOM Institute for Atomic and Molecular Physics c/o Philips ResearchHigh-Tech Campus 45656 AE EindhovenThe Netherlands COBRA Research Institute Eindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands

We present a theoretical investigation of THz long-range surface plasmon polaritons propagating on thin layers of *** metallic behavior of doped semiconductors at THz frequencies allows the excitation of surface plasmon polaritons with propagation and confinement lengths that can be actively *** control is achieved by acting on the free carrier density,which can be realized by changing the temperature of InSb.

关键词： InSb THz Long-range surface plasmon polaritons at THz frequencies in thin semiconductor layers

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Management of cancer patients during COVID-19 pandemic at developing countries

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World Journal of Clinical Cases 2020年第16期8卷 3390-3404页

作者： jaime González-Montero Guillermo Valenzuela Mónica Ahumada Olga Barajas Luis Villanueva Department Faculty of MedicineUniversity of ChileSantiago 70058Chile Department Hospital Clinico Universidad de Chile and Clínica DávilaChile Department Hospital Clinico Universidad de Chile and Fundación Arturo López-PérezChile Department Hospital Clínico Universidad de Chile and Fundación Arturo López-PerezChile

Cancer patient care requires a multi-disciplinary approach and multiple medical and ethical *** care during a pandemic health crisis requires prioritising the use of resources for patients with a greater chance of survival,especially in developing *** coronavirus disease 2019 crisis has generated new challenges given that cancer patients are normally not prioritised for admission in critical care ***,the development of new cancer drugs and novel adjuvant/neoadjuvant protocols has dramatically improved the prognosis of cancer patients,resulting in a more complex decision-making when prioritising intensive care in pandemic *** this context,it is essential to establish an effective and transparent communication between the oncology team,critical care,and emergency units to make the best decisions,considering the principles of justice and ***,cancer treatment protocols must be adapted to prioritise according to oncologic response and *** technologies are powerful tools to optimise cancer care during pandemics,and we must adapt quickly to this new scenario of clinical care and *** this new challenging pandemic scenario,multi-disciplinary work and effective communication between clinics,technology,science,and ethics is the key to optimising clinical care of cancer patients.

关键词： Cancer Oncology Pandemic COVID-19 SARS-CoV-2

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Estimating traffic volume on Wyoming low volume roads using linear and logistic regression methods

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第6期3卷 493-506页

作者： Dick Apronti Khaled Ksaibati Kenneth Oerow jaime Jo Hepner Department of Civil and Architectural Engineering University of WyomingLaramieWY 82071USA Department of Statistics University of WyomingLaramieWY 82071USA

Traffic volume is an important parameter in most transportation planning applications. Low volume roads make up about 69% of road miles in the United States. Estimating traffic on the low volume roads is a cost-effective alternative to taking traffic counts. This is because traditional traffic counts are expensive and impractical for low priority roads. The purpose of this paper is to present the development of two alternative means of cost- effectively estimating traffic volumes for low volume roads in Wyoming and to make recommendations for their implementation. The study methodology involves reviewing existing studies, identifying data sources, and carrying out the model development. The utility of the models developed were then verified by comparing actual traffic volumes to those predicted by the model. The study resulted in two regression models that are inexpensive and easy to implement. The first regression model was a linear regression model that utilized pavement type, access to highways, predominant land use types, and population to estimate traffic volume. In verifying the model, an R^2 value of 0.64 and a root mean square error of 73.4% were obtained. The second model was a logistic regression model that identified the level of traffic on roads using five thresholds or levels. The logistic regression model was verified by estimating traffic volume thresholds and determining the percentage of roads that were accurately classified as belonging to the given thresholds. For the five thresholds, the percentage of roads classified correctly ranged from 79% to 88%. In conclusion, the verification of the models indicated both model types to be useful for accurate and cost-effective estimation of traffic volumes for low volume Wyoming roads. The models developed were recommended for use in traffic volume estimations for low volume roads in pavement management and environmental impact assessment studies.

关键词： Traffic volume estimation Low volume road Wyoming county roads Transportation planning Regression analysis

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Dietary carbohydrate-to-protein ratio influences growth performance,hepatic health and dynamic of gut microbiota in atlantic salmon(Salmo salar)

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Animal Nutrition 2022年第3期10卷 261-279页

作者： Alejandro Villasante Carolina Ramírez Hector Rodríguez Patricio Dantagnan Adrian Hernandez Elías Figueroa jaime Romero Facultad de Medicina Veterinaria y Agronomía Universidad de Las AmericasSantiagoChile Laboratorio de Biotecnología de Alimentos Unidad de AlimentosInstituto de Nutricion y Tecnología de Los Alimentos(INTA)Universidad de ChileSantiagoChile Programa de Anatomía y Biología Del Desarrollo Facultad de MedicinaUniversidad de ChileSantiagoChile Núcleo de Investigacion en Produccion Alimentaria Facultad de Recursos NaturalesUniversidad Catolica de TemucoTemucoChile

Atlantic salmon(Salmo salar)fed a carbohydrate-rich diet exhibit suboptimal growth performance,along with other metabolic *** is well known that gut microbes play a pivotal role in influencing metabolism of the host,and these microbes can be modified by the *** main goal of the present study was to determine the effect of feeding graded levels of digestible carbohydrates to Atlantic salmon on the distal intestine digesta microbiota at 3 sampling times(i.e.,weeks 4,8 and 12),during a 12-week trial.A low carbohydrate-to-high protein diet(LC/HP,0%wheat starch),a medium carbohydrate-tomedium protein diet(MC/MP,15%wheat starch)or a high carbohydrate-to-low protein diet(HC/LP,30%wheat starch)was fed to triplicate fish tanks(27 to 28 fish per tank).We performed an in-depth characterization of the distal intestine digesta ***,growth parameters,liver histology and the expression of genes involved in hepatic neolipogenesis in fish were *** fed a HC/LP diet showed greater hepatosomatic and viscerosomatic indexes(P=0.026 and P=0.018,respectively),lower final weight(P=0.005),weight gain(P=0.003),feed efficiency(P=0.033)and growth rate(P=0.003)compared with fish fed the LC/HP ***,feeding salmon a high digestible carbohydrate diet caused greater lipid vacuolization,steatosis index(P=0.007)and expression of fatty acid synthase(fas)and delta-6 fatty acyl desaturase(d6fad)(P=0.001 and P=0.001,respectively)in the liver compared with fish fed the LC/HP ***,the major impact of feeding a carbohydrate-rich diet to Atlantic salmon in beta diversity of distal intestine digesta microbiota was observed at week 4(HC/LP vs MC/MP and HC/LP vs LC/HP;P=0.007 and P=0.008,respectively)and week 8(HC/LP vs MC/MP;P=0.04),no differences between experimental groups were detected after 12 weeks of ***,at the end of the trial,there was a negative correlation between lactic acid bacteria(LAB)members,including Leuconostoc and Lactobacil

关键词： Microbiota Microbiome Atlantic salmon Steatosis Lactic acid bacteria Probiotics

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Submicroscopic 11p13 deletion including the elongator acetyltransferase complex subunit 4 gene in a girl with language failure, intellectual disability and congenital malformations: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5296-5303页

作者： jaime Toral-Lopez Luz María González Huerta Olga Messina-Baas Sergio A Cuevas-Covarrubias Departamento de Genética Medica Centro Medico EcatepecISSEMYMEcatepec 55000México Programa de Maestría y Doctorado en Ciencias Médicas Odontológicas y de la Salud/Hospital Infantil de MéxicoUniversidad Nacional Autónoma de MéxicoMéxico 06720México Departamento de Biología Molecular Hospital General de MéxicoCuauhtémoc 06720México Departamento de Oftalmología Hospital General de MéxicoCuauhtémoc 06720México Genetica Hospital General de MéxicoCuauhtémoc 06726Mexico Sergio A Cuevas-CovarrubiasPrograma de Maestría y Doctorado en Ciencias MédicasOdontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoMéxico 06720Mexico

BACKGROUND We described the main features of an infant diagnosed with facial dysmorphic,language failure,intellectual disability and congenital malformations to strengthen our understanding of the ***,treatment is only rehabilitation and surgery for cleft lip and *** SUMMARY The proband was a 2-years-8-months-old *** history was negative for congenital malformations or intellectual *** patient had microcephaly,upward-slanting palpebral fissures,depressed nasal bridge,bulbous nose and bilateral cleft lip and *** magnetic resonance imaging showed cortical atrophy and band *** motor and intellectual development is delayed.A submicroscopic deletion in 11p13 involving the elongator acetyltransferase complex subunit 4 gene(ELP4)and a loss of heterozygosity in Xq25-q26.3 were *** There is no treatment for the ELP4 deletion caused by a submicroscopic 11p3 *** describe a second case of deletion of the ELP4 gene without aniridia,which confirms the association between ELP4 gene with several defects and absence of this ocular *** clinical data in the deletion of the ELP4 gene as cleft palate,facial dysmorphism,and changes at level brain could be associated to this gene or be part of the effect of the recessives genes involved in the loss of heterozygosity region of Xq25-26.3.

关键词： Submicroscopic 11p13 deletion Elongator acetyltransferase complex subunit 4 gene Language failure Intellectual disability Congenital malformations Case report

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New approach to assess sperm DNA fragmentation dynamics： Fine-tuning mathematical models

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Journal of Animal Science and Biotechnology 2017年第3期8卷 592-600页

作者： Isabel Ortiz Jesus Dorado Jane Morrell jaime Gosalvez Francisco Crespo Juan M.Jimenez Manuel Hidalgo Veterinary Reproduction Group Department of Animal Medicine and Surgery Faculty of Veterinary Medicine University of Cordoba 14071 Cordoba Spain Department of Clinical Sciences Division of Reproduction Swedish University of Agricultural Sciences Box 7054 SE-75007 Uppsala Sweden Department of Biology Universidad Aut6noma de Madrid 28049 Madrid Spain Department of Reproduction Centro Militar de Cria Caballar (FESCCR-Ministry of Defense) 05005 Avila Spain Department of Chemistry and Physics of Materials University of Salzburg Hellbrunner StraBe 34/111 A-5020 Salzburg Austria

Background： Sperm DNA fragmentation（sDF） has been proved to be an important parameter in order to predict in vitro the potential fertility of a semen sample. Colloid centrifugation could be a suitable technique to select those donkey sperm more resistant to DNA fragmentation after thawing. Previous studies have shown that to elucidate the latent damage of the DNA molecule, sDF should be assessed dynamically, where the rate of fragmentation between treatments indicates how resistant the DNA is to iatrogenic damage. The rate of fragmentation is calculated using the slope of a linear regression equation. However, it has not been studied if s DF dynamics fit this model. The objectives of this study were to evaluate the effect of different after-thawing centrifugation protocols on sperm DNA fragmentation and elucidate the most accurate mathematical model（linear regression, exponential or polynomial） for DNA fragmentation over time in frozen-thawed donkey ***： After submitting post-thaw semen samples to no centrifugation（UDC）, sperm washing（SW） or single layer centrifugation（SLC） protocols, sD F values after 6 h of incubation were significantly lower in SLC samples than in SW or *** of determination（R-2） values were significantly higher for a second order polynomial model than for linear or exponential. The highest values for acceleration of fragmentation（aSDF） were obtained for SW, fol owed by SLC and ***： SLC after thawing seems to preserve longer DNA longevity in comparison to UDC and SW. Moreover,the fine-tuning of models has shown that sDF dynamics in frozen-thawed donkey semen fit a second order polynomial model, which implies that fragmentation rate is not constant and fragmentation acceleration must be taken into account to elucidate hidden damage in the DNA molecule.

关键词： Colloid centrifugation Dynamics Fine-tuning Mathematical models Sperm DNA fragmentation

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Spread of common native and invasive grasses and ruderal trees following anthropogenic disturbances in a tropical dry forest

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Ecological Processes 2017年第1期6卷 394-407页

作者： Xavier A.jaime Skip J.Van Bloem Frank H.Koch Stacy A.C.Nelson Department of Ecosystem Science and Management Texas A&M University2138 TAMUCollege StationTX 77843-2138USA Belle W.Baruch Institute of Coastal Ecology and Forest Science Clemson UniversityPO Box 596GeorgetownSC 29442USA USDA Forest Service Southern Research Station3041 East Cornwallis RoadResearch Triangle ParkNC 27709USA Center for Geospatial Analytics Department of Forestry and Environmental ResourcesNorth Carolina State UniversityRaleighNC 27695USA.

Introduction:A fundamental challenge to the integrity of tropical dry forest ecosystems is the invasion of nonnative grass *** grasses compete for resources and fuel anthropogenic *** 2012,a bulldozer from the Puerto Rico Electric Power Authority cleared a 570-m trail from a state road into a mature dry forest section of Guánica Forest to control a *** monitored colonization by a non-native invasive grass(Megathyrsus maximus),a highly invasive tree(Leucaena leucocephala),and a native grass(Uniola virgata),as well as natural regeneration,along the bulldozer *** determined whether bulldozing facilitated colonization by these species into the forest and the extent of ***:Distance from propagule source and temporal variations strongly influenced colonization by our three focal *** maximus invaded along the trail from source populations by the state *** establishment of new colonies of *** seedlings went as far as 570 m inside the forest(i.e.,at the end of the bulldozer trail),but we found most new colonies within 270 m of the *** leucocephala exhibited a similar spreading *** disturbance,Uniola virgata was distributed widely across the forest,but the highest densities were found in areas near the latter portion(>401 m)of the bulldozer ***,the species formed new clumps along more than half of the trail(250 to 570 m),apparently colonizing from undisturbed patches ***:Bulldozing facilitated the invasion of non-native *** projected community assemblage will be more fire-prone than before since *** carries fire across the landscape better than ***,emphasizing the capacity of invasive plant colonization to alter local ecological processes after only a single wildfire and bulldoze *** results provide a valuable baseline for short-term vegetation response to anthropogenic disturbances in tropical semi-deciduous dry forests.

关键词： Tropical dry forest Grass invasions Bulldozing Wildfire Leucaena leucocephala Megathyrsus(Panicum)maximus Uniola virgata

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Sarcomatoid carcinoma of the pancreas—a rare tumor with an uncommon presentation and course:A case report and review of literature

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World Journal of Clinical Cases 2021年第15期9卷 3716-3725页

作者： Paulina F Toledo Zoltan Berger Laura Carreño Gonzalo Cardenas jaime Castillo Omar Orellana Department of Gastroenterology Hospital Clinico Universidad de ChileSantiago 834456IndependenciaChile Department of Internal Medicine Section GastroenterologyHospital Clinico Universidad de ChileSantiago 834456IndependenciaChile Department of Pathology Hospital Clínico de la Universidad de ChileSantiago 834456IndependenciaChile Department of Radiology Hospital Clínico Universidad de ChileSantiago 834456IndependenciaChile Department of Surgery Hospital Clínico Universidad de ChileSantiago 834456IndependenciaChile

BACKGROUND Sarcomatoid carcinoma of the pancreas(SCP)is a rare type of pancreatic neoplasm,and only a few cases have been described in the ***,it is composed mostly of atypical spindle cells with apparent sarcomatous *** SUMMARY This is a report of a 61-year-old Chilean woman who underwent medical investigation for acute abdominal *** tomography identified a solid tumor in the tail of the pancreas with features suspicious of ***-bloc distal pancreatectomy and splenectomy were performed to excise the *** and immunohistochemistry were confirmatory of sarcomatoid carcinoma with lymphovascular *** surgery,the patient did not receive *** studies indicate a poor prognosis for this type of ***,our patient has survived for 35 mo with no recurrence to *** The case presented herein is a patient with an SCP with a rare presentation and long-term survival after surgery despite not receiving adjuvant chemotherapy.

关键词： Pancreatic neoplasms Sarcomatoid carcinoma Pancreatic ductal carcinoma Survival Abdominal pain Case report

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Ionic Species Affect the Self-Propulsion of Urease-Powered Micromotors

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Research 2020年第1期2020卷 349-362页

作者： Xavier Arque Xavier Andres Rafael Mestre Bernard Ciraulo jaime Ortega Arroyo Romain Quidant Tania Patino Samuel Sanchez Institute for Bioengineering of Catalonia(IBEC) The Barcelona Institute of Science and Technology(BIST)Baldiri i Reixac 10-1208028 BarcelonaSpain Institute of Photonic Sciences(ICFO) The Barcelona Institute of Science and TechnologyCarl Friedrich Gauss 308860 CastelldefelsBarcelonaSpain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Pg.Lluís Companys 2308010 BarcelonaSpain Chemistry Department University of RomeTor VergataVia della Ricerca Scientifica00133 RomeItaly

Enzyme-powered motors self-propel through the catalysis of in situ bioavailable fuels,which makes them excellent candidates for biomedical ***,fundamental issues like their motion in biological fluids and the understanding of the propulsion mechanism are critical aspects to be tackled before a future application in ***,we investigated the physicochemical effects of ionic species on the self-propulsion of urease-powered *** showed that the presence of PBS,NaOH,NaCl,and HEPES reduced self-propulsion of urease-powered micromotors pointing towards iondependent mechanisms of *** studied the 3D motion of urease micromotors using digital holographic microscopy to rule out any motor-surface interaction as the cause of motion decay when salts are present in the *** order to protect and minimize the negative effect of ionic species on micromotors’performance,we coated the motors with methoxypolyethylene glycol amine(mPEG)showing higher speed compared to noncoated motors at intermediate ionic *** results provide new insights into the mechanism of urease-powered micromotors,study the effect of ionic media,and contribute with potential solutions to mitigate the reduction of mobility of enzyme-powered micromotors.

关键词： holographic salts catalysis

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