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Portal vein embolization failure:Current strategies and future perspectives to improve liver hypertrophy before major oncological liver resection

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2088-2096页

作者： Gianluca Cassese Ho-Seong Han Boram Lee jai young cho Hae Won Lee Boris Guiu Fabrizio Panaro Roberto Ivan Troisi Clinical Medicine and Surgery Federico II UniversityNaples 80131Italy Department of Surgery Seoul National University College of MedicineSeongnam 13620South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Medical Imaging and Interventional Radiology St-Eloi University HospitalMontpellier 34295France Digestive Surgery and Transplantation CHU de MontpellierMontpellier 34295France

Portal vein embolization(PVE)is currently considered the standard of care to improve the volume of an inadequate future remnant liver(FRL)and decrease the risk of post-hepatectomy liver failure(PHLF).PHLF remains a significant limitation in performing major liver surgery and is the main cause of mortality after *** degree of hypertrophy obtained after PVE is variable and depends on multiple *** to 20%of patients fail to undergo the planned surgery because of either an inadequate FRL growth or tumor progression after the PVE procedure(usually 6-8 wk are needed before surgery).The management of PVE failure is still debated,with a lack of consensus regarding the best clinical *** additional techniques have been proposed,such as sequential transarterial chemoembolization followed by PVE,segment 4 PVE,intra-portal administration of stem cells,dietary supplementation,and hepatic vein *** aim of this review is to summarize the up-to-date strategies to overcome such difficult situations and discuss future perspectives on improving FRL hypertrophy.

关键词： Portal vein embolization Portal vein embolization failure Rescue associating liver partition and portal vein ligation Hepatic vein embolization Liver venous deprivation Segment 4 portal vein embolization

Immunotherapy for hepatocellular carcinoma:A promising therapeutic option for advanced disease

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World Journal of Hepatology 2022年第10期14卷 1862-1874页

作者： Gianluca Cassese Ho-Seong Han Boram Lee Hae Won Lee jai young cho Fabrizio Panaro Roberto Ivan Troisi Department of Clinical Medicine and Surgery Division of Minimally Invasive and Robotic HPB SurgeryFederico II UniversityNaples 80131Italy Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Division of HBP Surgery and TransplantationMontpellier University Hospital-School of MedicineMontpellier 34000France

Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide,and its incidence continues to *** improvements in both medical and surgical therapies,HCC remains associated with poor outcomes due to its high rates of recurrence and *** 50% of patients require systemic therapies that traditionally consist of tyrosine kinase ***,however,immune checkpoint inhibitors have revolutionized HCC management,providing new therapeutic *** these major advances,the different factors involved in poor clinical responses and molecular pathways leading to resistance following use of these therapies remain *** strategies,such as adoptive T cell transfer,vaccination,and virotherapy,are currently under *** of immunotherapies with other systemic or local treatments are also being investigated and may be the most promising opportunities for HCC *** aim of this review is to provide updated information on currently available immunotherapies for HCC as well as future perspectives.

关键词： Hepatocellular Carcinoma Immunotherapy Hepatocellular Carcinoma management Hepatocellular Carcinoma therapy Molecular targeted therapy

Laparoscopic anatomical versus non-anatomical liver resection for hepatocellular carcinoma in the posterosuperior segments:a propensity score matched analysis

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 824-834,I0001页

作者： Boram Lee jai young cho Ho-Seong Han Yoo-Seok Yoon Hae Won Lee Jun Suh Lee Moonhwan Kim Yeongsoo Jo Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnamKorea

Background:Since laparoscopic anatomical resection(LAR)for tumors,especially located in the posterosuperior(PS)segments of the liver remains difficult,laparoscopic non-anatomical resection(LNAR)are generally *** compare the clinical outcomes between LAR and LNAR for hepatocellular carcinoma(HCC)located in the PS ***:We retrospectively reviewed the data for 1,029 patients who underwent hepatectomy for HCC between 2004 and *** 167 patients who underwent laparoscopic hepatectomy for HCC in PS segments,64 underwent LNAR and 103 underwent *** were matched one-to-one using propensity score matching(46:46).Results:LNAR was associated with significantly shorter operation time(P=0.001),lower estimated blood loss(P=0.001),lower transfusion rate(P=0.006)and shorter hospital stay(P=0.012)than *** respective 1-,3-,and 5-year overall survival rates(LAR:95.3%,87.1%,and 77.8%;LNAR:96.7%,91.6%,and 85.0%;P=0.262)and recurrence-free survival rates(LAR:75.7%,70.3%,and 68.9%;LNAR:81.8%,58.3%,and 55.3%;P=0.879)were *** intrahepatic recurrence rate was significantly higher in LNAR group than in LAR group(78.6%vs.57.1%,P=0.023),but the post-recurrence treatments differed significantly between the two groups(P=0.016);the re-resection rate was much greater in the LNAR group(45.0%vs.0%)*** respective 1-,3-,and 5-year post-recurrence survival rates were similar in the LAR and LNAR groups(P=0.212).After recurrence,survival in re-resection group was significantly greater than not(P=0.026).Conclusions:LNAR is safe and feasible for HCC located in PS segments,and provided acceptable oncologic outcomes that are comparable to those of *** can be considered for patient with tumor located in PS segment when LAR is not feasible.

关键词： Laparoscopy hepatectomy carcinoma,hepatocellular recurrence

Intra-arterial lipo-prostaglandin E1 infusion for arterial spasm in liver transplantation:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8153-8157页

作者： Moonhwan Kim Hae Won Lee Chang Jin Yoon Boram Lee Yeongsoo Jo jai young cho Yoo-Seok Yoon Jun Suh Lee Ho-Seong Han Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam-si 13620Gyeonggi-doSouth Korea Department of Radiology Seoul National UniversitySeongnam 463-707South Korea

BACKGROUND Hepatic artery obstruction is a critical consideration in graft outcomes after living donor liver *** report a case of diffuse arterial vasospasm that developed immediately after anastomosis and was managed with an intra-arterial infusion of lipo-prostaglandin E1(PGE1).CASE SUMMARY A 57-year-old male with hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma underwent ABO-incompatible living donor liver *** grafted hepatic artery was first anastomosed to the recipient’s right hepatic artery ***,the arterial pulse immediately *** a new anastomosis was performed using the right gastroepiploic artery,the patient’s arterial pulse rate remained *** attempted angiographic intervention immediately after the operation;it showed diffuse arterial vasospasms like‘beads on a string’.We attempted continuous infusion of lipo-PGE1 overnight via an intra-arterial *** next day,arterial flow improved without any spasms or *** patient had no additional arterial complications or related sequelae at the time of writing,1-year post-liver *** Angiographic evaluation is helpful in cases of repetitive arterial obstruction,and intra-arterial infusion of lipo-PGE1 may be effective in treating diffuse arterial spasms.

关键词： Liver transplantation Hepatic artery Vasospasm Prostaglandin E1 Intervention Case report

Tidal effects based on a GUP-induced effective metric

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Communications in Theoretical Physics 2024年第9期76卷 65-74页

作者： Soon-Tae Hong Yong-Wan Kim young-jai Park Center for Quantum Spacetime and Department of Physics Sogang University Department of Physics and Research Institute of Physics and Chemistry Jeonbuk National University Department of Physics Sogang University

In this paper, we study tidal forces in the Schwarzschild black hole, whose metric explicitly includes a generalized uncertainty principle(GUP) effect. We also investigate interesting features of the geodesic equations and tidal effects that are dependent on the GUP parameter αrelated to a minimum length. Then, by solving the geodesic deviation equations explicitly with appropriate boundary conditions, we show that α in the effective metric affects both the radial and angular components of the geodesic equation, particularly near the singularities.

关键词： effective metric generalized uncertainty principle geodesic deviation equation

Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo young cho Dong Hae Ho Sae Byeok Jo Jeong Ho cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

Advancements in hemostatic strategies for managing upper gastrointestinal bleeding: A comprehensive review

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World Journal of Gastroenterology 2024年第15期30卷 2087-2090页

作者： Ah young Lee Joo young cho Division of Gastroenterology Department of Internal MedicineCha Gangnam Medical CenterCha University College of MedicineSeoul 06135Korea

Upper gastrointestinal(GI)hemorrhage presents a substantial clinical *** management typically involves resuscitation and endoscopy within 24 h,although the benefit of very early endoscopy(<12 h)for high-risk patients is *** goals include stopping acute bleeding,preventing rebleeding,and using a multimodal approach encompassing endoscopic,pharmacological,angiographic,and surgical *** agents such as vasopressin,prostaglandins,and proton pump inhibitors are effective,but the increase in antithrombotic use has increased GI bleeding *** hemostasis,particularly for nonvariceal bleeding,employs techniques such as electrocoagu-lation and heater probes,with concerns over tissue injury from monopolar *** methods such as Hemospray and Endoclot show promise in creating mechanical tamponades but have ***,the first-line therapy includes thermal probes and hemoclips,with over-the-scope clips emerging for larger ulcer *** gold probe,combining bipolar electrocoagulation and injection,offers targeted coagulation but has faced device-related *** advancements involve combining techniques and improving endoscopic imaging,with studies exploring combined approaches showing *** research is crucial for developing standardized and effective hemorrhage management strategies.

关键词： Upper gastrointestinal bleeding Hemostasis Endoscopy Probe Spray Clip

Clinical diagnostic advances in intestinal anastomotic techniques:Hand suturing,stapling,and compression devices

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1231-1234页

作者： Ah young Lee Joo young cho Division of Gastroenterology Department of Internal MedicineCha Gangnam Medical CenterCha University College of MedicineSeoul 06135South Korea

The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical *** methods aim to prevent leakage and minimize tissue fibrosis,which can lead to stricture *** healing process involves various phases:hemostasis and inflammation,proliferation,and *** staplers and sutures can cause inflammation and fibrosis due to the release of profibrotic *** anastomosis devices,including those made of nickel-titanium alloy,offer a minimally invasive option for various surgical challenges and have shown safety and ***,despite advancements,anastomotic techniques are evaluated based on leakage risk,with complications being a primary *** devices like Magnamosis use magnetic rings for compression anastomosis,demonstrating greater strength and patency compared to *** technology is also being explored for other medical *** there are promising results,particularly in animal models,the realworld application in humans is limited,and further research is needed to assess their safety and practicality.

关键词： Anastomoses Diagnostic advances,Anastomotic techniques Technique Intestine

Pre-operative factors that can predict neoplastic polypoid lesions of the gallbladder

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World Journal of Gastroenterology 2011年第17期17卷 2216-2222页

作者： Byung Hyo Cha Jin-Hyeok Hwang Sang Hyub Lee Jang Eon Kim jai young cho Haeryoung Kim So Yeon Kim Department of Internal Medicine Cheju Halla General HospitalCheju-siCheju-do 690-766South Korea Departments of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam-siGeonggi-do 463-707South Korea Department of Surgery Seoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Radiology Seoul National University College of Medicine

AIM:To investigate the preoperative factors that can predict neoplastic polypoid lesions of the gallbladder(PLGs) as well as malignant ***:A retrospective analysis was conducted on the 210 consecutively enrolled patients who underwent cholecystectomy due to a PLG larger than 10 mm,as was determined by preoperative trans-abdominal ultrasonography or endoscopic *** ana-lyzed the medical,laboratory,radiologic data and the pathologic ***:In 210 cases,146 had non-neoplastic polyps(69.5%) and 64 cases were neoplastic polyps(30.5%).An older age(≥ 65 years),the presence of diabetes mellitus(DM) and the size of polyp(≥ 15 mm) were revealed to be independent predictive variables for neoplastic polyps with odd ratios(OR) of 2.27(P = 0.044),2.64(P = 0.021) and 4.94(P cholecystectomy.

关键词：胆囊息肉肿瘤胆囊炎糖尿病外科手术前的因素