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Clinical outcomes for nasopharyngeal cancer with intracranial extension after taxanebased induction chemotherapy and concurrent chemo-radiotherapy in the modern era

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 25-33页

作者： Sarbani Ghosh-Laskar Avinash Pilar Carlton Johnny Kumar Prabhash Amit Joshi jai prakash agarwal Tejpal Gupta Ashwini Budrukkar Vedang Murthy Monali Swain Vanita Noronha Vijay Maruthi Patil Prathamesh Pai Deepa Nair Devendra Arvind Chaukar Shivakumar Thiagarajan Gouri Pantvaidya Anuja Deshmukh Pankaj Chaturvedi Sudhir Nair Anil D’Cruz Department of Radiation Oncology Tato Memorial HospitalHomi Bhobho National InstituteMumbaiIndia Department of Medical Oncology Tata Memorial HospitalHomi Bhobha Notional InstituteMumbaiIndia Department of Surgical Oncolosy Tota Memorial HospitalHomi Bhabha Notional InstituteMumbait India

Objective:To evaluate the survival outcomes for a cohort of nasopharyngeal cancer with intracranial extension(ICE)treated with induction chemotherapy(ICT)followed by chemo-intensity-modulated radiotherapy(CTRT)at a tertiary cancer ***:We retrospectively analyzed 45 patients with histologically proven,non-metastatic NPC with ICE treated at our institute between October 2008 and October *** were classified as minor ICE or major ICE,based on the extent of *** the patients received 2-3 cycles of a taxane-based ICT regimen followed by *** was delivered with"riskadapted"intensity-modulated radiotherapy(IMRT)technique in all ***:After a median follow up of 45 months(range:8-113 months),the estimated 5-year DFS,LRFS,DMFS,and OS of the entire cohort was 58%,82%,67%and 74%*** multivariate analysis,histological subtype was an independent predictor of LRFS,and age was an independent predictor of *** extent of ICE showed only a trend towards worse DFS(P=0.06).None of the factors significantly predicted for DMFS or ***,N-stage,and response to ICT did not significantly affect any of the *** 2 or worse subcutaneous fibrosis was seen in 22%of patients and grade 2 or worse xerostomia was seen in 24%of patients at last follow ***-three percent of the patients developed clinical hypothyroidism at last follow *** of the patients experienced any neurological or vascular ***:Taxane-based induction chemotherapy followed by chemo-intensity modulated radiotherapy resulted in excellent locoregional control and survival with acceptable toxicities in patients of nasopharyngeal cancer with intracranial *** metastasis continues to be the predominant problem in these patients.

关键词： Nasopharyngeal cancer Intracranial extension Clinical outcomes Induction chemotherapy and intensity-modulated radiotherapy

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Advancements on metal oxide semiconductor photocatalysts in photo-electrochemical conversion of carbon dioxide into fuels and other useful products

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Frontiers in Energy 2024年第2期18卷 187-205页

作者： jai prakash Zhangsen CHEN Shakshi SAINI Gaixia ZHANG Shuhui SUN Department of Chemistry National Institute of Technology HamirpurHamirpur 177005India Institut National de la Recherche Scientifique(INRS) Centre Énergie Matériaux TélécommunicationsVarennes J3X 1P7Canada Department of Chemistry Indian Institute of Technology MandiHimachal PradeshIndia Department of Electrical Engineering École de Technologie SupérieureMontréal H3C 1K3Canada

Due to its fascinating and tunable optoelectronic properties,semiconductor nanomaterials are the best choices for multidisciplinary ***,the use of semiconductor photocatalysts is one of the promising ways to harness solar energy for useful applications in the field of energy and *** recent years,metal oxide-based tailored semiconductor photocatalysts have extensively been used for photocatalytic conversion of carbon dioxide(CO_(2))into fuels and other useful products utilizing solar *** is very significant not only from renewable energy consumption but also from reducing global warming point of *** current research activities are promising for a better future of *** present mini-review is focused on recent developments(2–3 years)in metal oxide semiconductor hybrid photocatalysts-based photo-electrochemical conversion of CO_(2)into fuels and other useful ***,general mechanism of photo-electrochemical conversion of CO_(2)into fuels or other useful products has been ***,various metal oxide-based emerging hybrid photocatalysts including tailoring of their morphological,compositional,and optoelectronic properties have been discussed with emphasis on their role in enhancing photoelectrochemical ***,mechanism of their photo-electrochemical reactions and applications in CO_(2)conversion into fuels/other useful products have been ***,challenges and future prospects have been discussed followed by a summary.

关键词： metal-oxide semiconductors nanohybrid photocatalysts photo-electrochemical CO_(2)conversion tailoring morphology fuels challenges and future prospects

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Techno-economic and environmental impact analysis of electric two-wheeler batteries in India

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Clean Energy 2024年第3期8卷 147-156页

作者： Aman Gupta Ditipriya Bose Sandeep Tiwari Vikrant Sharma jai prakash Department of Green Energy and Sustainable Development Zakir Husain College of Engineering and Technology Aligarh Muslim UniversityUttar Pradesh-202002India Battery Testing Facility National Institute of Solar EnergyGurugram-Faridabad RoadGwal PahariGurugram-122003HaryanaIndia

This paper presents a comprehensive techno-economic and environmental impact analysis of electric two-wheeler batteries in *** technical comparison reveals that sodium-ion(Na-ion)and lithium-ion(Li-ion)batteries outperform lead-acid batteries in various parameters,with Na-ion and Li-ion batteries exhibiting higher energy densities,higher power densities,longer cycle lives,faster charge rates,better compactness,lighter weight and lower self-discharge *** economic comparison,Na-ion batteries were found to be~12-14%more expensive than Li-ion ***,the longer lifespans and higher energy densities of Na-ion and Li-ion batteries can offset their higher costs through improved performance and long-term ***-acid batteries have the highest environmental impact,while Li-ion batteries demonstrate better environmental performance and potential for ***-ion batteries offer promising environmental advantages with their abundance,lower cost and lower toxic and hazardous material *** recycling processes can further enhance the environmental benefits of Na-ion ***,this research examines the potential of Na-ion batteries as a cheaper alternative to Li-ion batteries,considering India’s abundant sodium resources in regions such as Rajasthan,Chhattisgarh,Jharkhand and others.

关键词： electric two-wheelers environmental impact assessment lead-acid batteries lithium-ion batteries sodium-ion batteries techno-economic analysis

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Finite size effect on dissociation and diffusion of chiral partners in Nambu-Jona-Lasinio model

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Chinese Physics C 2022年第4期46卷 114-122页

作者： Paramita Deb Sabyasachi Ghosh jai prakash Santosh Kumar Das Raghava Varma Department of Physics Indian Institute of Technology BombayPowaiMumbai-400076India Indian Institute of Technology Bhilai GEC CampusSejbaharRaipur-492015ChhattisgarhIndia School of Physical Sciences Indian Institute of Technology GoaPonda-403401GoaIndia

The masses of pion and sigma meson modes,along with their dissociation in the quark medium,provide detailed spectral structures of the chiral *** has been observed in pA and pp systems both at LHC and *** this research,we studied the restoration of chiral symmetry by investigating the finite size effect on the detailed structure of chiral partners in the framework of the Nambu-Jona-Lasinio *** diffusion and conduction have been studied using this dissociation *** is determined that the masses,widths,diffusion coefficients,and conductivities of chiral partners merge at different temperatures in the restoration phase of chiral ***,merging points are shifted to lower temperatures when finite size effect is introduced into the *** strengths of diffusions and conductions are also reduced once the finite size is introduced in the calculations.

关键词： heavy-ion collisions quark gluon plasma effective QCD

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Si–Ge based vertical tunnel field-effect transistor of junction-less structure with improved sensitivity using dielectric modulation for biosensing applications

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Chinese Physics B 2023年第12期32卷 644-651页

作者： Lucky agarwal Varun Mishra Ravi prakash Dwivedi Vishal Goyal Shweta Tripathi School of Electronics Engineering Vellore Institute of TechnologyChennai 600127India Department of Electronics and Communication Engineering Graphic Era(deemed to be University) DehradunUttarakhand 248002India Department of Electronics and Communication Engineering GLA UniversityMathura 281406India Department of Electronics and Communication Engineering Motilal Nehru National Institute of TechnologyAllahabad 211004India

A dielectric modulation strategy for gate oxide material that enhances the sensing performance of biosensors in junction-less vertical tunnel field effect transistors(TFETs)is *** junction-less technique,in which metals with specific work functions are deposited on the source region to modulate the channel conductivity,is used to provide the necessary doping for the proper functioning of the *** simulation studies of the proposed structure and junction structure have been compared,and showed an enhanced rectification of 10^(4) *** proposed structure is designed to have a nanocavity of length 10 nm on the left-and right-hand sides of the fixed gate dielectric,which improves the biosensor capture area,and hence the *** considering neutral and charged biomolecules with different dielectric constants,TCAD simulation studies were compared for their *** off-state current IOFFcan be used as a suitable sensing parameter because it has been observed that the proposed sensor exhibits a significant variation in drain ***,it has been investigated how positively and negatively charged biomolecules affect the drain current and threshold *** explore the device performance when the nanogaps are fully filled,half filled and unevenly filled,extensive TCAD simulations have been *** proposed TFET structure is further benchmarked to other structures to show its better sensing capabilities.

关键词： biomolecules high-k dielectric junction-less vertical tunnel field effect transistor(TFET)

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Camelina sativa,a short gestation oilseed crop with biofuel potential:Opportunities for Indian scenario

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Oil Crop Science 2021年第3期6卷 114-121页

作者： Ankur agarwal Om prakash Madhu Bala Defence Institute of Bio-Energy Research Defence R&D OrganizationGoraparaoP.O.ArjunpurHaldwaniUttarakhand263139India

Camelina is an oilseed crop which is being commercially produced globally as feedstock for *** a non-edible oil bearing low input crop owing to its low fertilizer and water requirement,fits well for biofuel *** India,targets for biofuel blending has been set by New Biofuel Policy-2018 and to meet these targets efforts are being made to harness the potential of available feedstock in the *** these feedstock,contribution of short gestation oilseed bearing crop has been very *** has been introduced in India during 2009–10 as experimental crop by DIBER,*** then various efforts have made to standardize the production technology of this crop under various agro-climatic regions of the country,crop improvement,oil quality analysis and development of high energy *** has various advantages to offer for Indian biofuel *** paper reviews the potential of this crop for Indian Biofuel scenario.

关键词： Camelina False flax Production Agro-technology Crop improvement Economics

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Role of spleen tyrosine kinase in liver diseases

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World Journal of Gastroenterology 2020年第10期26卷 1005-1019页

作者： Dhadhang Wahyu Kurniawan Gert Storm jai prakash Ruchi Bansal Department of Biomaterials Science and Technology Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschede 7500the Netherlands Department of Pharmacy Universitas Jenderal SoedirmanPurwokerto 53132Indonesia Department of Pharmaceutics University of UtrechtUtrecht 3454the Netherlands Department of Pharmacokinetics Toxicology and TargetingGroningen Research Institute of PharmacyUniversity of GroningenEnschede 7500the Netherlands

Spleen tyrosine kinase (SYK),a non-receptor tyrosine kinase,is expressed in most hematopoietic cells and non-hematopoietic cells and play a crucial role in both immune and non-immune biological *** mediate diverse cellular responses via an immune-receptor tyrosine-based activation motifs (ITAMs)-dependent signalling pathways,ITAMs-independent and ITAMs-semidependent signalling *** liver,SYK expression has been observed in parenchymal (hepatocytes) and non-parenchymal cells (hepatic stellate cells and Kupffer cells) and found to be positively correlated with the disease *** implication of SYK pathway has been reported in different liver diseases including liver fibrosis,viral hepatitis,alcoholic liver disease,non-alcoholic steatohepatitis and hepatocellular *** of SYK pathway using kinase inhibitors have shown to attenuate the progression of liver diseases thereby suggesting SYK as a highly promising therapeutic *** review summarizes the current understanding of SYK and its therapeutic implication in liver diseases.

关键词： Spleen tyrosine kinase Liver diseases Inflammation Targeted therapeutics Spleen tyrosine kinase inhibitors

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Global Dynamics of a Multi-group SEIR Epidemic Model with Infection Age

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Chinese Annals of Mathematics,Series B 2021年第6期42卷 833-860页

作者： Vijay Pal BAJIYA jai prakash TRIPATHI Vipul KAKKAR Jinshan WANG Guiquan SUN Department of Mathematics Central University of RajasthanBandar Sindri-305817KishangarhAjmerRajasthanIndia Complex Systems Research Center Shanxi UniversityTaiyuan 030006China Department of Mathematics North University of ChinaTaiyuan 030051China Complex Systems Research Center Shanxi UniversityTaiyuan 030006China.

Consider the heterogeneity(e.g.,heterogeneous social behaviour,heterogeneity due to different geography,contrasting contact patterns and different numbers of sexual partners etc.)of host population,in this paper,the authors propose an infection age multigroup SEIR epidemic *** model system also incorporates the feedback variables,where the infectivity of infected individuals may depend on the infection *** the direction of mathematical analysis of model,the basic reproduction number R_0 has been *** global stability of disease-free equilibrium and endemic equilibrium have been established in the term of R_(0).More precisely,for R_(0)≤1,the disease-free equilibrium is globally asymptotically stable and for R_(0)>1,they establish global stability of endemic equilibrium using some graph theoretic techniques to Lyapunov function *** considering a numerical example,they investigate the effects of infection age and feedback on the prevalence of the *** result shows that feedback parameters have different and even opposite effects on different ***,by choosing an appropriate value of feedback parameters,the disease could be eradicated or maintained at endemic ***,the infection age of infected individuals may also change the behaviour of the disease,global stable to damped oscillations or damped oscillations to global stable.

关键词： Multi-group model Infection age Feedback Graph-theoretic approach Lyapunov function

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Effect of irrigation schedule on growth and seed yield of camelina(Camelina sativa L.)in Tarai region of central Himalaya

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Oil Crop Science 2021年第1期6卷 8-11页

作者： Ankur agarwal Om prakash Madhu Bala Defence Institute of Bio-Energy Research Defence R&D OrganizationGoraparaoP.OArjunpurHaldwaniUttarakhand263139India

Camelina(Camelina sativa)has emerged as a potential biofuel crop globally with its suitability even as a jet fuel source with 75–80%less greenhouse gas emissions compared to common petroleum *** crop has originated from Mediterranean region and belongs to Brassicaceae ***,DRDO has made initial and pioneer efforts in successful introduction of this crop to India and its agro-technology *** a short duration crop with lesser input requirement,it fits well in the cropping pattern of hilly states of Indian *** areas experience fallow land due to shortage of irrigation water for growing other *** present study revealed that irrigation at flowering stage is more *** at this stage(if only one irrigation is available)exhibited grain yield of 1.004 kg·m^(-2)which was 21 and 80%higher over pod setting and rosette stage irrigation,*** maximum seed yield was observed under treatment where irrigation was provided at all three crop growth stages(2.044 kg·m^(-2)).It was 50%higher over T6 treatment(where two irrigations were given at rosette and flowering stage)and 104%higher over T3(where only one irrigation was given at flowering stage).

关键词： Irrigation scheduling Water requirement Water deficit Biofuel crop False flax

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Hunting of hunted:an ensemble modeling approach to evaluate suitable habitats for caracals in India

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Ecological Processes 2022年第1期11卷 744-757页

作者： Ashish Kumar Jangid Chandra prakash Singh jai Singh Parihar Jasbir Singh Chauhan Rajnish Kumar Singh prakash Kumar Verma Amritanshu Singh Shantanu Sharma Shekhar Kolipaka Wildlife Institute of India DehradunUttarakhand 248001India Space Applications Centre Indian Space Research OrganisationAhmedabadGujarat 380015India Madhya Pradesh State Forest Department Madhya Pradesh Tiger Foundation SocietyKuno National ParkBhopalMadhya Pradesh 462001India Leo Foundation WageningenThe Netherlands

Background:Large-scale hunting and various anthropogenic pressures in the recent past have pushed the Asiatic caracal(Caracal caracal schmitzi),an elusive medium-sized and locally threatened felid species towards local extinction in *** widely distributed historically,it has been sparsely reported from several regions of central and northern states in India till twentieth ***,the species distribution became confined only to the states of Rajasthan,Gujarat and Madhya Pradesh,which have had reported sightings in the twenty-first *** order to highlight the potentially suitable habitats for Asiatic caracals in India,we targeted forth-filtering of the spatial model ensemble by creating and utilizing the validated and spatially thinned species presence information(n=69)and related ecological variables(aridity,NDVI,precipitation seasonality,temperature seasonality,terrain ruggedness),filtered with anthropological variable(nightlight).Results:Out of eight spatial prediction models,the two most parsimonious models,Random Forest(AUC 0.91)and MaxEnt(AUC 0.89)were weighted and *** ensemble model indicated several clustered habitats,covering 1207.83 km^(2)areas in Kachchh(Gujarat),Aravalli mountains(Rajasthan),Malwa plateau(Rajasthan and Madhya Pradesh),and Bundelkhand region(Madhya Pradesh)as potentially suitable habitats for *** probabilities of pixels were further regressed with converted vegetation height data within selected highly potential habitats,i.e.,Ranthambore Kuno Landscape(RKL)(suitability~0.44+0.03(vegetation height)^(**),R^(2)=0.27).The regression model inferred a significant positive relation between vegetation height and habitat suitability,hence the lowest ordinal class out of three classes of converted vegetation height was masked out from the RKL,which yielded in an area of 567 km^(2) as potentially highly suitable habitats for caracals,which can be further proposed as survey areas and conservation priority are

关键词： Medium-sized cat Caracal caracal schmitzi Potentially suitable habitat Drylands Potential survey area

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