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Tumour Associated Tissue Eosinophilia as a Prognostic Indicator in Squamous Cell Carcinoma of Upper Aerodigestive Tract

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International Journal of Otolaryngology and Head & Neck Surgery 2016年第2期5卷 54-58页

作者： Chandra Bhan Kartikeya Purohit jagdish prasad Purohit Ajay Pratap Singh Bhoopendra Singh Siva Selvaraj Manish Pandey Vineet Kumar Vineet Kumar Department of ENT Head and Neck Surgery MLB Medical College Jhansi India

Immune response is known to develop against malignant tumours. Malignant tumours express newer antigen on their cell surface membrane which elicit immunological reaction in and around tumoural tissue. In early part of immune reaction neutrophil, eosinophil migrates followed by monocyte-macrophage cell. Tumor associated tissue eosinophilia (TATE) is believed to play a significant role in the biological behavior of the carcinoma. Eosinophil infiltrate in association with the head and neck squamous cell carcinoma (SCC) have been reviewed from time-to-time. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of this study was to investigate and evaluate the possible role of the tumour associated tissue eosinophilia (TATE) as a predictive indicator for the grading and establishing prognosis of the upper aerodigestive tract squamous cell carcinoma (SCC).

关键词： Tumour Associated Tissue Eosinophilia (TATE) Squamous Cell Carcinoma (SCC)

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Post-transplant dyslipidemia: Mechanisms, diagnosis and management

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World Journal of Transplantation 2016年第1期6卷 125-134页

作者： Arnav agarwal G V Ramesh prasad Division of Nephrology Department of Medicine University of Toronto Renal Transplant Program St. Michael’s Hospital

Post-transplant dyslipidemia is highly prevalent and presents unique management challenges to the clinician. The two major outcomes to considerwith post-transplant therapies for dyslipidemia are preserving or improving allograft function, and reducing cardiovascular risk. Although there are other cardiovascular risk factors such as graft dysfunction, hypertension, and diabetes, attention to dyslipidemia is warranted because interventions for dyslipidemia have an impact on reducing cardiac events in clinical trials specific to the transplant population. Dyslipidemia is not synonymous with hyperlipidemia. Numerous mechanisms exist for the occurrence of posttransplant dyslipidemia, including those mediated by immunosuppressive drug therapy. Statin therapy has received the most attention in all solid organ transplant recipient populations, although the effect of proper dietary advice and adjuvant pharmacological and nonpharmacological agents should not be dismissed. At all stages of treatment appropriate monitoring strategies for side effects should be implemented so that the benefits from these therapies can be achieved. Clinicians have a choice when there is a conflict between various transplant society and lipid society guidelines for therapy and targets.

关键词： Cholesterol Dyslipidemia Triglycerides Statins Immunosuppression

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小梁切除术中前房注入黏弹剂(2%羟甲基纤维素)的效果

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 34-34页

作者： agarwal H.C. Anuradha V.K. Titiyal J.S. Gupta V. 邢咏新 Department of Ophthalmology Dr. Rajendra Prasad Centre for Ophthalmic Sciences All-India Institute of Medical Sciences New Delhi-110029 IndiaDr.

BACKGROUND AND OBJECTIVE: To evaluate the effect of intraoperative intracamera l injection of 2%hydroxypropyl methylcellulose (HPMC) on anterior chamber depth and intraocular pressure (IOP) following trabeculectomy in eyes with uncontroll ed primary open-angle glaucoma in a prospective randomized manner. PATIENTS AND METHODS: Thirty consecutive eyes with primary open-angle glaucoma scheduled fo r trabeculectomy were randomized to conventional trabeculectomy without HPMC inj ection (group I; n=15) or to intracameral injection of 2%HPMC during trabeculec tomy (group II; n=15). All patients were observed serially on days 1, 3, 5, 7, a nd 14 and months 1, 3, and 6 postoperatively. The main outcome measure was resto ration of anterior chamber depth to preoperative level with IOP of less than 21m mHg with no additional antiglaucoma medication or surgery. RESULTS: The anterior chamber depth decreased from 2.5 ±0.53 to 1.5 ±0.94 mm on postoperative day 1 in group I and increased slightly from 2.4 ±0.43 to 2.5 ±0.36 mm on postopera tive day 1 in group II (P=.04). Overall, the IOP decreased to 5.0 ±2.8 mm Hg in group I (87%reduction) and 9.0 ±4.6 mm Hg in group II (70%reduction). Two ey es developed postoperative flat anterior chamber and related complications in gr oup I, whereas none of the eyes in group II developed such complications. CONCLU SIONS: Intracameral injection of 2%HPMC during trabeculectomy helps to maintain anterior chamber depth and reduces incidence of complications related to shallo w anterior chamber depth following trabeculectomy.

关键词：小梁切除术黏弹剂甲基纤维素前房深度抗青光眼药物浅前房原发性青光眼眼内压

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