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Successful scleral buckling for long-standing retinal detachment with subretinal proliferation 4-year after strabismus surgery

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1812-1814页

作者： Hyuna Kim In young chung Department of Ophthalmology Gyeongsang National University College of MedicineJinju 52727Korea Institute of Health Science Gyeongsang National UniversityJinju 52727Korea

Dear Editor,We would like to report the case of a patient with longstanding retinal detachment(RD)with subretinal proliferation after strabismus surgery who was successfully treated by scleral *** perforation is a potentially dangerous complication of strabismus surgery that may result in vision loss or even complete blindness and pthisis bulbi[1-2].Because most cases of scleral perforation occurred with handling ocular muscles are limited in superficial in depth and short in length,and produce no complications-its true incidence is not always *** studies have reported an incidence rate of 8%-12.1%of cases[3],whereas more recent studies have reported the rate as 0.13%-2.8%[4].This decrease in the incidence has resulted from improved surgical techniques and the introduction of spatula *** awareness among surgeons may have also contributed to this *** treatment options recommended for globe perforation include observation alone,cryopexy,diathermy,and laser retinopexy[5],however,treatment is still under *** iatrogenic scleral perforation typically causes damage to the immediate adjacent choroid,and there may or may not be damage to the underlying retina,depending on the depth of the needle pass[6].

关键词： needle superficial buckling

A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong Man Yoon young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

Optimal operation of microgrid using hybrid differential evolution and harmony search algorithm

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Frontiers in Energy 2016年第3期10卷 355-362页

作者： S. SURENDER REDDY jae young PARK Chan Mook JUNG Department of Railroad and Electrical Engineering Woosong University Republic of Korea Department of Railroad and Civil Engineering Woosong UniversityRepublic of Korea

This paper proposes the generation scheduling approach for a microgrid comprised of conventional generators, wind energy generators, solar photovoltaie （PV） systems, battery storage, and electric vehicles. The electrical vehicles （EVs） play two different roles： as load demands during charging, and as storage units to supply energy to remaining load demands in the MG when they are plugged into the microgrid （MG）. Wind and solar PV powers are intermittent in nature; hence by including the battery storage and EVs, the MG becomes more stable. Here, the total cost objective is minimized considering the cost of conventional generators, wind generators, solar PV systems and EVs. The proposed optimal scheduling problem is solved using the hybrid differential evolution and harmony search （hybrid DE-HS） algorithm including the wind energy generators and solar PV system along with the battery storage and EVs. Moreover, it requires the least investment.

关键词： battery storage electric vehicles (EVs),microgrid (MG) optimal scheduling solar photovoltaic(PV) system wind energy conversion system

Risk factors for rebleeding after angiographically negative acute gastrointestinal bleeding

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World Journal of Gastroenterology 2009年第32期15卷 4023-4027页

作者： Ijin Joo Hyo-Cheol Kim Jin Wook chung Hwan Jun jae jae Hyung Park Department of Radiology Seoul National University College of Medicine Institute of Radiation Medicine Seoul National University Medical Research Center Clinical Research Institute Seoul National University HospitalSeoul 110-744South Korea

AIM:To identify possible predictive factors for rebleeding after angiographically negative findings in patients with acute non-variceal gastrointestinal ***: From January 2000 to July 2007, 128 patients with acute non-variceal gastrointestinal bleeding had negative f indings after initial angiography. Clinical and laboratory parameters were analyzed ***: Among 128 patients, 62 had no recurrent gastrointestinal bleeding and 66 had recurrent gastrointestinal bleeding within 30 d. As determined by the use of multivariate analysis, an underlying malignancy, liver cirrhosis and hematemesis were significant factors related to recurrent gastrointestinal ***: Clinical factors including underlying malignancy, liver cirrhosis, and hematemesis are important predictors for rebleeding after angiographically negative findings in patients with acute non-variceal gastrointestinal bleeding.

关键词： Angiography Gastrointestinal hemorrhage Predictive factor

Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 952-958页

作者： Yong Wun Cho Yong Seop Han In young chung Seong jae Kim Seong Wook Seo Ji Myong Yoo Jong Moon Park Department of Ophthalmology Gyeongsang National University School of Medicine Gyeongsang Institute of Health Science Gyeongsang National University

AIM: To examine the effect of intravitreal adenoviral vector-mediated tristetraprolin(Ad-TTP) on VEGF m RNA expression in a rat model of laser-induced choroidal ***: Ad-TTP was prepared using a commercial kit. Retinal laser-induced photocoagulation(10 spots per eye) was performed on rats in this experimental choroidal neovascularization(CNV) model. Rats were divided into four groups: control(single intravitreal injection of balanced salt solution, n =10), laser-induced CNV(photocoagulation only, n =20), laser-induced CNV plus Ad-TTP injection(photocoagulation plus a single intravitreal Ad-TTP injection, n =20) and Ad-TTP injection only(n =10). Changes in choroidal morphology were evaluated in ten rats in the laser only and the laser plus Ad-TTP groups. Two weeks after laser injury, the size of CNV was calculated by perfusion with high-molecular-weight fluorescein isothiocyanate(FITC)-dextran. VEGF m RNA expression in retina-choroid tissue from ten rats in each group was measured by reverse transcription polymerase chain reaction(RT-PCR). RESULTS: Two weeks after treatment, the area of laser-induced CNV was reduced by approximately 60% in the rats given the Ad-TTP injection compared with that in the laser-only group. There was a tendency toward decreased VEGF m RNA expression in the Ad-TTP injection ***: A single intravitreal injection of Ad-TTP significantly suppressed CNV size in this experimental laser-induced CNV model. Ad-TTP injection also decreased VEGF m RNA expression compared with that inthe laser-induced CNV group. The present study is meaningful as the first study to investigate the effect of tristetraprolin delivered via intravitreal injection.

关键词： laser-induced choroidal neovascularization tristetraprolin adenoviral vectors

Tailored eradication vs empirical bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: A comparative,open trial

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World Journal of Gastroenterology 2019年第46期25卷 6743-6751页

作者： Youn I Choi Jun Won chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon jae Kim Ja young Seo Department of Gastroenterology Gil Medical CenterGachon UniversityIncheon 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityIncheon 21565South Korea

BACKGROUND Few studies have compared the efficacy and safety profile of a tailored eradication(TR)strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy(EBQT)for first-line eradication of Helicobacter pylori(***)in Korean *** To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for *** This is an open-label,comparative study in which we prospectively enrolled patients over 18 years of age with *** infection and retrospectively reviewed their ***-positive patients diagnosed by rapid urease test,Giemsa staining,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR)were enrolled from May 2016 to September 2018 at Gil Medical *** with *** infection received either a TR regimen or the EBQT *** the tailored therapy group that underwent DPO-PCR testing,patients with A2142G and/or A2143G point mutations were treated with a bismuth-containing quadruple *** eradication rate,patient-reported side effect rate,and *** eradication success rate were evaluated and compared between the *** A total of 150 patients were assigned to the TR(n=50)or EBQT group(n=100).The first-line eradication rate of *** did not differ between the groups(96.0%vs 95.7%,P=0.9).The rate of eradication-related side effects for TR was 12.0%,which differed significantly from that of EBQT(43.0%)for first-line treatment(P<0.001).CONCLUSION DPO-PCR-based TR for *** eradication may be equally efficacious,with less treatment-related complications,compared to EBQT in Korea,where clarithromycin resistance is high.

关键词： Helicobacter pylori Eradication Tailored Empirical Quadruple

Bowel preparations as quality indicators for colonoscopy

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World Journal of Gastroenterology 2014年第11期20卷 2746-2750页

作者： jae young Jang Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineCollege of MedicineKyung Hee UniversitySeoul 130-701South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

Colonoscopy is the principal investigative procedure for colorectal neoplasms because it can detect and remove most precancerous *** effectiveness of colonoscopy depends on the quality of the *** preparation is an essential part of high-quality colonoscopies because only an optimal colonic cleansing allows the colonoscopist to clearly view the entire colonic mucosa and to identify any polyps or other *** bowel preparation not only prolongs the overall procedure time,decreases the cecal intubation rate,and increases the costs associated with colonoscopy but also increases the risk of missing polyps or adenomas during the ***,a repeat examination or a shorter colonoscopy follow-up interval may be suitable strategies for a patient with suboptimal bowel preparation.

关键词： Colonoscopy Colorectal neoplasm Bower preparation Quality

Efficacy of Helicobacter pylori eradication for the prevention of metachronous gastric cancer after endoscopic resection for early gastric cancer

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World Journal of Gastroenterology 2014年第11期20卷 2760-2764页

作者： jae young Jang Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineCollege of MedicineKyung Hee UniversitySeoul 136-705South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

Helicobacter pylori(***)plays an important role in gastric carcinogenesis,as the majority of gastric cancers develop from ***-infected gastric *** rate of early gastric cancer diagnosis has increased in Japan and Korea,where *** infection and gastric cancer are highly *** intestinal-type gastric cancer without concomitant lymph node metastasis is usually treated by endoscopic *** metachronous gastric cancers often develop because atrophic mucosa left untreated after endoscopic treatment confers a high risk of gastric *** efficacy of *** eradication for the prevention of metachronous gastric cancer remains ***,in patients who undergo endoscopic resection of early gastric cancer,*** eradication is recommended to suppress or delay metachronous gastric *** and regularly scheduled endoscopy should be performed to detect minute metachronous gastric cancer after endoscopic resection.

关键词： Helicobacter pylori Gastric cancer Endoscopic resection Metachronous cancer

Comparison of laser iridotomy using short duration532-nm Nd: YAG laser (PASCAL) vs conventional laser in dark irides

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 288-291页

作者： Hye Jin chung Hae-young Park Su-young Kim HanGil Eye Hospital Department of Ophthalmology and Visual Science College of Medicine the Catholic University of Korea

AIM: To evaluate the outcome of laser iridotomy using532-nm Nd: YAG laser(PASCAL) with short pulse duration and Nd: YAG laser compared to conventional combined laser ***: Retrospective, nonrandomized, comparative case series. Forty-five eyes of 34 patients underwent laser iridotomy. Twenty-two eyes underwent iridotomy using short duration PASCAL and Nd: YAG laser, and 23 eyes underwent iridotomy using conventional combined laser method. The average settings of PASCAL were60 μm and 700-900 m W with a short duration of 0.01 s to reduce the total applied energy. The conventional laser was 50 μm and 700-900 m W for 0.1s. After photocoagulation with these laser, the Nd: YAG laser was added in each group. Endothelial cell counts of preiridotomy and 2mo after iridotomy were measured and ***: All eyes completed iridotomy *** total energy used in the PASCAL group was 1.85 ±1.17 J. Compared to conventional laser 13.25 ±1.67 J, the energy used was very small due to the short exposure time of PASCAL. Endothelial cell counts were reduced by0.88% in the PASCAL group and 6.72% in the conventional laser group(P =0.044). The change in corneal endothelial cell counts before and after iridotomy was significant in conventional combined laser iridotomy group(P =0.004).CONCLUSION: Combined PASCAL and Nd:YAG laseriridotomy is an effective and safe technique in the dark brown irides of Asians. Furthermore, the short duration of exposure in PASCAL offers the advantages of reducing the total energy used and minimizing the corneal damage.

关键词： endothelium laser iridotomy 532-nm Nd: YAG laser