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Utility of a deep learning model and a clinical model for predicting bleeding after endoscopic submucosal dissection in patients with early gastric cancer

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World Journal of Gastroenterology 2022年第24期28卷 2721-2732页

作者： Ji Eun Na Yeong Chan lee Tae Jun Kim Hyuk lee Hong-Hee won Yang won Min Byung-Hoon Min Jun Haeng lee Poong-Lyul Rhee jae J Kim Department of Internal Medicine Inje University Haeundae Paik HospitalBusan 48108South Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan UniversitySeoul 06351South Korea

BACKGROUND Bleeding is one of the major complications after endoscopic submucosal dissection(ESD)in early gastric cancer(EGC)*** are limited studies on estimating the bleeding risk after ESD using an artificial intelligence *** To derivate and verify the performance of the deep learning model and the clinical model for predicting bleeding risk after ESD in EGC *** Patients with EGC who underwent ESD between January 2010 and June 2020 at the Samsung Medical Center were enrolled,and post-ESD bleeding(PEB)was investigated *** split the entire cohort into a development set(80%)and a validation set(20%).The deep learning and clinical model were built on the development set and tested in the validation *** performance of the deep learning model and the clinical model were compared using the area under the curve and the stratification of bleeding risk after *** A total of 5629 patients were included,and PEB occurred in 325 *** area under the curve for predicting PEB was 0.71(95%confidence interval:0.63-0.78)in the deep learning model and 0.70(95%confidence interval:0.62-0.77)in the clinical model,without significant difference(P=0.730).The patients expected to the low-(leeding rate of 2.2%,3.9%,and 11.6%,respectively,in the deep learning model;4.0%,8.8%,and 18.2%,respectively,in the clinical *** A deep learning model can predict and stratify the bleeding risk after ESD in patients with EGC.

关键词： Clinical model Deep learning model Post-endoscopic submucosal dissection bleeding Stratification of bleeding risk

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Effects of structure and electronic properties of D-π-A organic dyes on photovoltaic performance of dye-sensitized solar cells

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Journal of Energy Chemistry 2021年第3期30卷 208-216页

作者： Min-Woo lee jae-Yup Kim Hyung-Geun lee Hyun Gil Cha Duck-Hyung lee Min jae Ko Bio-Based Chemistry Research Center Advanced Convergent Chemistry DivisionKorea Research Institute of Chemical Technology(KRICT)Ulsan 44429Republic of Korea Department of Chemical Engineering Dankook UniversityYongin 16890Republic of Korea Department of Chemistry Sogang UniversitySeoul 04107Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul 04763Republic of Korea

Herein,we examine the performance of dye-sensitized solar cells containing five D-π-A organic dyes designed by systematic modification of π-bridge size and geometric *** dye has a simple push-pull structure with a triarylamino group as an electron donor,bithiophene-4,4-dimethyl-4 H-cyclopenta 1,2-b:5,4-b’]dithiophene(M11),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophenethiophene(M12),thiophene-4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M13),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene-benzene(M14),and 4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M15)units asπ-bridges,and cyanoacrylic acid as an electron acceptor/*** extension of theπ-bridge linkage favors wide-range absorption but,because of the concomitant molecular volume increase,hinders the efficient adsorption of dyes on the TiO_(2) film ***,higher loadings are achieved for smaller dye molecules,resulting in(i)a shift of the TiO_(2) conduction band edge to more negative values,(ii)a greater photocurrent,and(iii)suppressed charge recombination between the photoanode and the redox couple in the ***,under one-sun equivalent illumination(AM 1.5 G,100 mW/cm^(2)),the highest photovoltage,photocurrent,and conversion efficiency(η=7.19%)are observed for M15,which has the smallest molecular volume among M series dyes.

关键词： Dye-sensitized solar cells Donor-acceptor dyes Electron-rich unit Wide-range absorption Impedance spectroscopy

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Permeability evaluation for artificial single rock fracture according to geometric aperture variation using electrical resistivity

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 787-797页

作者： Hangbok lee Jong-won lee Tae-Min Oh Deep Subsurface Research Center Korea Institute of Geoscience and Mineral ResourcesDaejeon34132Republic of Korea Department of Civil and Environmental Engineering Pusan National UniversityBusan46241Republic of Korea

A convenient approach was proposed by which to evaluate and monitor the permeability of a rock fracture by verifying the quantitative correlation between the electrical resistivity and permeability at laboratory *** this purpose,an electrical resistivity measurement system was applied to the laboratory experiments using artificial cells with the shape of a single rock *** experiments were conducted using rock fractures according to the geometry,aperture sizes,wavelengths,and roughness *** overall negative relationship between the normalized electrical resistivity values and the aperture sizes directly linked with the permeability,was well fitted by the power-law function with a large determination coefficient(≈0.86).The effects of wavelength and roughness amplitude of the rock fracture on the electrical resistivity were also *** showed that the electrical resistivity was slightly increased with decreasing wavelength and increasing roughness *** empirical model for evaluating the permeability of a rock fracture was proposed based on the experimental *** the field,if the electrical resistivity of pore groundwater could be measured in advance,this empirical model could be applied effectively for simple,quick monitoring of the fracture *** uncertainty may be associated with the permeability estimation due to the limited control parameters considered in this research,this electrical resistivity approach could be helpful to monitor the rock permeability in deep underground facilities such as those used for radioactive waste repositories or forms of energy storage.

关键词： Permeability Rock fracture Electrical resistivity Fracture geometry Long-term monitoring

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Integrating Ontology-Based Approaches with Deep Learning Models for Fine-Grained Sentiment Analysis

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Computers, Materials & Continua 2024年第10期81卷 1855-1877页

作者： Longgang Zhao Seok-won lee The Knowledge-Intensive Software Engineering(NiSE)Research Group Department of Artificial IntelligenceAjou UniversitySuwon City16499Republic of Korea Department of Software and Computer Engineering Ajou UniversitySuwon City16499Republic of Korea

Although sentiment analysis is pivotal to understanding user preferences,existing models face significant challenges in handling context-dependent sentiments,sarcasm,and nuanced *** study addresses these challenges by integrating ontology-based methods with deep learning models,thereby enhancing sentiment analysis accuracy in complex domains such as film reviews and restaurant *** framework comprises explicit topic recognition,followed by implicit topic identification to mitigate topic interference in subsequent sentiment *** the context of sentiment analysis,we develop an expanded sentiment lexicon based on domainspecific corpora by leveraging techniques such as word-frequency analysis and word ***,we introduce a sentiment recognition method based on both ontology-derived sentiment features and sentiment *** evaluate the performance of our system using a dataset of 10,500 restaurant reviews,focusing on sentiment classification *** incorporation of specialized lexicons and ontology structures enables the framework to discern subtle sentiment variations and context-specific expressions,thereby improving the overall sentiment-analysis *** results demonstrate that the integration of ontology-based methods and deep learning models significantly improves sentiment analysis accuracy.

关键词： Deep learning ontology fine-grained sentiment analysis online reviews

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Unilateral versus bilateral Y-type stent-in-stent metal stent insertions in inoperable malignant hilar biliary strictures:A multicenter retrospective study

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 561-567页

作者： Ik Hyun Jo Chang-Nyol Paik Dae Bum Kim jaesin lee Jong Yul lee jae Hyuck Chang Kyu-Hyun Paik won-Suk Park Department of Internal Medicine College of MedicineSt.Vincent’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineIncheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineBucheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineDaejeon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea

Background:To date,there is controversy regarding unilateral versus bilateral stent placement in patients with malignant hilar biliary strictures(MHBSs).The aim of this study was to compare the clinical outcomes and complications of unilateral and bilateral(stent-in-stent method)stent placements for these ***:We conducted a multicenter retrospective analysis of patients with inoperable MHBS who underwent endoscopic self-expandable metal stent(SEMS)placement from January 2009 to December *** groups classified according to the stent procedure method were compared for demographic,procedural,and postprocedure *** analysis for patency loss and overall survival was also ***:A total of 236 subjects were included.A superior technical success rate was found in the unilateral stent group(98.8%vs.82.5%,P<0.001),whereas the clinical success rate was higher in the bilateral group(85.7%vs.70.5%,P=0.028).There was no significant difference with respect to complications or patency loss,and the bilateral group had better overall survival(P<0.01).In the Cox proportional hazard model,MHBSs from lymph node compression were associated with a higher risk of death(HR=9.803,P=0.003).In contrast,bilateral SEMS insertion showed reduced postprocedural mortality(HR=0.316,P=0.001).Conclusions:Y-type stent-in-stent bilateral SEMSs are technically difficult but demonstrated more favorable overall survival for palliative bile drainage of inoperable MHBS patients compared to unilateral insertions.

关键词： Cholestasis Extrahepatic neoplasm Cholangiopancreatography Endoscopy Self-expandable metal stents

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Characteristics of bifurcation and buckling load of space truss in consideration of initial imperfection and load mode

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 206-218页

作者： Su-deok SHON Seung-jae lee Kang-guk lee School of Architectural Engineering Korea University of Technology and Education1800 ChungjeolroCheonan ChungnamRepublic of Korea Research Center for Urban Affair Kyungil UniversityGyeongsan-city GyeongbukRepublic of Korea

This study investigated characteristics of bifurcation and critical buckling load by shape imperfection of space truss,which were sensitive to initial *** critical point and buckling load were computed by the analysis of the eigenvalues and determinants of the tangential stiffness *** two-free-nodes example and star dome were selected for the case study in order to examine the nodal buckling and global buckling by the sensitivity to the eigen buckling mode and the analyses of the influence,and characteristics of the parameters as defined by the load ratio of the center node and surrounding node,as well as rise-span ratio were *** sensitivity to the imperfection of the initial shape of the two-free-nodes example,which occurs due to snapping at the critical point,resulted in bifurcation before the limit point due to the buckling mode,and the buckling load was reduced by the increase in the amount of *** two sensitive buckling patterns of the numerical model are established by investigating the displaced position of the free nodes,and the asymmetric eigenmode greatly influenced the behavior of the imperfection shape whether it was at limit point or ***,the sensitive mode of the two-free-nodes example was similar to the in-extensional basis mechanism of a simplified *** star dome,which was used to examine the influence among several nodes,indicated that the influence of nodal buckling was greater than that of global buckling as the rise-span ratio was ***,global buckling is occurred with reaching bifurcation point as the value of load ratio was higher,and the buckling load level was about 50%-70% of load level at limit point.

关键词： Space truss Geometric nonlinearity Initial imperfection Snap-through Bifurcation Global buckling

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Genomic organization and transcriptional modulation in response to endocrine disrupting chemicals of three vitellogenin genes in the self-fertilizing fish Kryptolebias marmoratus

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Journal of Environmental Sciences 2016年第4期28卷 187-195页

作者： Bo-Mi Kim Min Chul lee Hye-Min Kang jae-Sung Rhee jae-Seong lee Department of Biological Science College of ScienceSungkyunkwan University Department of Marine Science College of Natural SciencesIncheon National University

Vitellogenin（Vtg）is the precursor of egg yolk proteins,and its expression has been used as a reliable biomarker for estrogenic contamination in the aquatic *** examine the biomarker potential of the self-fertilizing killifish Kryptolebias marmoratus Vtgs（Km-Vtgs）,full genomic DNAs of Km-Vtgs-Aa,Km-Vtgs-Ab,and Km-Vtgs-C were cloned,sequenced,and *** Vtg genes in *** are tandemly placed in a550 kb section of the same *** silico analysis of promoter regions revealed that both the Km-Vtgs-Aa and Km-Vtgs-Ab genes had an estrogen response element（ERE）,but the Km-Vtgs-C gene did ***,all three Km-Vtgs genes had several ERE-half sites in their promoter *** analysis demonstrated that the three deduced amino acid residues were highly conserved with conventional Vtgs protein,forming distinctive clades within teleost *** tissue showed the highest expression of Km-Vtg transcripts in all tested tissues（brain/pituitary,eye,gonad,intestine,skin,and muscle）in response to endocrine disrupting chemical（EDC）-exposed ***-Vtg transcripts were significantly increased in response to 17β-estradiol（E2）,tamoxifen（TMX）,4-n-nonylphenol（NP）,bisphenol A（BPA）,and octylphenol（OP）over 24 hr *** Km-Vtg-A gene was highly expressed compared to the control in response to NP and ***-induced modulatory patterns of Km-Vtg gene expression were different depending on tissue,gender,and isoforms.

关键词： Kryptolebias marmoratus Vitellogenin Endocrine disrupting chemical

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Comparison of mesophilic and thermophilic anaerobic digestions of thermal hydrolysis pretreated swine manure: Process performance,microbial communities and energy balance

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Journal of Environmental Sciences 2023年第4期126卷 222-233页

作者： Xiaohui Liu Changmin lee jae Young Kim Department of Civil and Environmental Engineering Seoul National UniversitySeoul 08826Korea

Anaerobic digestion (AD) of swine manure (SM) commonly shows low biogas output and unsatisfactory economic performance. In this study, thermophilic AD (TAD, 50±1℃) was combined with thermal hydrolysis pretreatment (THP, 170℃/10 bar), to investigate its potential for maximizing biogas yield, securing successful digestion and microbial diversity, as well as improving energy balance. Four lab-scale continuously stirred tank reactors were operated for 300 days and compared with each other, i.e., reactor 1 (raw SM fed in mesophilic AD:RSM-MAD), reactor 2 (THP-treated SM fed in MAD:TSM-MAD), reactor 3 (RSM-TAD),and reactor 4 (TSM-TAD). The results showed that THP was efficient to increase methane production of SM, TSM-TAD mode led to the highest methane yield (129.8±40.5 mL-CH_(4)/gVS/day) among the tests (p 700 mg/L) or volatile fatty acids (> 6000 mg/L) accumulation compared with MAD in start-up phase, TSM-TAD treatment mode behaved a sustainable digestion process in a long-term operation. For TSM-TAD scenario, higher Shannon–Weaver (3.873) and lower Simpson index (0.061) indicated this mode ensured and enlarged the diversity of bacteria communities. Phylum Bathyarchaeota was dominant (59.3%-90.0%) in archaea community,followed by Euryarchaeota in the four reactors. RSM-MAD treatment mode achieved the highest energy output (4.65 GJ/day), TSM-TAD was less effective (-17.38 GJ/day) due to increased energy demands. Thus improving the energetic efficiency of THP units is recommended for the development of TSM-TAD treatment mode.

关键词： Thermal hydrolysis pretreatment Digestion temperature Process performances Microbial communities Energy balance

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Nanoparticle Exsolution on Perovskite Oxides:Insights into Mechanism,Characteristics and Novel Strategies

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Nano-Micro Letters 2024年第2期16卷 312-346页

作者： Yo Han Kim Hyeongwon Jeong Bo‑Ram won Hyejin Jeon Chan‑ho Park Dayoung Park Yeeun Kim Somi lee jae‑ha Myung Department of Materials Science and Engineering Incheon National UniversityIncheon 22012Republic of Korea

Supported nanoparticles have attracted considerable attention as a promising catalyst for achieving unique properties in numerous applications,including fuel cells,chemical conversion,and *** demonstrate high activity by expanding the number of active sites,but they also intensify deactivation issues,such as agglomeration and poisoning,*** for bottomup synthesis of supported nanoparticles has emerged as a breakthrough technique to overcome limitations associated with conventional *** are uniformly exsolved from perovskite oxide supports and socketed into the oxide support by a one-step reduction *** uniformity and stability,resulting from the socketed structure,play a crucial role in the development of novel ***,tremendous research efforts have been dedicated to further controlling exsolution *** effectively address exsolution at a more precise level,understanding the underlying mechanism is *** review presents a comprehensive overview of the exsolution mechanism,with a focus on its driving force,processes,properties,and synergetic strategies,as well as new pathways for optimizing nanocatalysts in diverse applications.

关键词： Supported nanoparticle Exsolution In situ growth Mechanism Perovskite oxide Catalyst

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Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients

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World Journal of Gastroenterology 2017年第28期23卷 5196-5205页

作者： Jung won Park Jin Ha lee Ye Hyun Park Soo Jung Park jae Hee Cheon won Ho Kim Tae Il Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Cancer Prevention Center Yonsei University College of Medicine

To assess factors associated with the higher effect of metformin on mortality in diabetic colorectal cancer (CRC) patients, since the factors related to the effectiveness of metformin have not been identified *** January 2000 and December 2010, 413 patients diagnosed with both stage 3/4 CRC and diabetes mellitus were identified. Patients’ demographics and clinical characteristics were analyzed. The effect of metformin on CRC-specific mortality and the interactions between metformin and each adjusted factor were *** follow-up duration was median 50 mo (range: 1-218 mo). There were 85 deaths (45.9%) and 72 CRC-specific deaths (38.9%) among 185 patients who used metformin, compared to 130 total deaths (57.0%) and 107 CRC-specific deaths (46.9%) among 228 patients who did not use metformin. In multivariate analysis, survival benefit associated with metformin administration was identified (HR = 0.985, 95%CI: 0.974-0.997, P = 0.012). Interaction test between metformin and sex after adjustment for relevant factors revealed that female CRC patients taking metformin exhibited a significantly lower CRC-specific mortality rate than male CRC patients taking metformin (HR = 0.369, 95%CI: 0.155-0.881, P = 0.025). Furthermore, subgroup analysis revealed significant differences in CRC-specific mortality between the metformin and non-metformin groups in female patients (HR = 0.501, 95%CI: 0.286-0.879, P = 0.013) but not male patients (HR = 0.848, 95%CI: 0.594-1.211, P = 0.365). There were no significant interactions between metformin and other adjusted factors on CRC-specific *** showed a strong sex-dependent difference in the effect of metformin on CRC-specific mortality in advanced stage CRC patients with diabetes.

关键词： Colorectal cancer Metformin Survival Sex

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