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Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

Neural Regeneration Research 2024年第2期19卷 331-335页

作者： Seung-Woo Han Jinhee choi Kwon-Yul Ryu Department of Life Science University of SeoulSeoulSouth Korea School of Environmental Engineering University of SeoulSeoulSouth Korea

Many types of plastic products,including polystyrene,have long been used in commercial and industrial *** and nanoplastics,plastic particles derived from these plastic products,are emerging as environmental pollutants that can pose health risks to a wide variety of living organisms,including ***,it is not well understood how microplastics and nanoplastics affect cellular functions and induce stress *** can be exposed to polystyrene-microplastics and polystyrene-nanoplastics through ingestion,inhalation,or skin *** ingested plastics are excreted from the body,but inhaled plastics may accumulate in the lungs and can even reach the brain via the nose-to-brain ***-sized polystyrene-nanoplastics can enter cells by endocytosis,accumulate in the cytoplasm,and cause various cellular stresses,such as inflammation with increased pro-inflammatory cytokine production,oxidative stress with generation of reactive oxygen species,and mitochondrial *** induce autophagy activation and autophagosome formation,but autophagic flux may be impaired due to lysosomal *** permanently exposed to polystyrene-nanoplastics,they can be removed from cells by exocytosis and subsequently restore cellular ***,neurons are very susceptible to this type of stress,thus even acute exposure can lead to neurodegeneration without *** review focuses specifically on recent advances in research on polystyrene-nanoplastic-induced cytotoxicity and ***,in this review,based on mechanistic studies of polystyrene-nanoplastics at the cellular level other than neurons,future directions for overcoming the negative effects of polystyrene-nanoplastics on neurons were suggested.

关键词： autophagy cellular stress cytotoxicity endocytosis exocytosis inflammation microplastics nanoplastics neurotoxicity oxidative stress polystyrene

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Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant

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Horticulture Research 2020年第1期7卷 1536-1547页

作者： Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee jae-pil choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo Hong Jong Bhak Chang-Kug Kim Personal Genomics Institute Genome Research FoundationOsong 28160Korea Genomics Division National Institute of Agricultural Sciences(NAS)Jeonju 54874Korea Theragen Etex Bio Institute Suwon 16229Korea Department of Plant Science Plant Genomics and Breeding Instituteand Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea Department of Industrial Plant Science&Technology Chungbuk National UniversityCheongju 28644Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal ScienceRural Development Administration(RDA)Eumseong 27709Korea Clinomics Inc Ulsan 44919Korea Green Plant Institute Yongin 16954Korea Korean Genomics Center(KOGIC) Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Biomedical Engineering School of Life SciencesUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea

Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical *** grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East *** oleanane-type TSs,platycosides,are a major component of the *** root *** studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy ***,the evolutionary history of platycoside biosynthesis genes remains *** this study,we sequenced the genome of *** and investigated the genes involved in platycoside *** draft genome of *** is 680.1 Mb long and contains 40,017 protein-coding *** analysis revealed that the CYP716 family genes play a major role in platycoside *** CYP716 gene family of *** was much larger than that of other Asterid *** gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in ***,which was confirmed by tissue-specific gene *** these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside *** addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in ***,suggesting that epigenetic modification of these two gene families affects platycoside *** whole-genome,transcriptome,and methylome data of *** provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families.

关键词： properties insight roots

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Data driven computational design of stable oxygen evolution catalysts by DFT and machine learning:Promising electrocatalysts

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Journal of Energy Chemistry 2024年第4期91卷 645-655页

作者： Hwanyeol Park Yunseok Kim Seulwon choi Ho Jun Kim Department of Display Materials Engineering Soonchunhyang UniversityAsanChung-nam 31538Republic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang Uni-versityAsanChungnam 31538Republic of Korea Department of Mechanical Engineering Hanyang University ERICA Campus55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea

The revolutionary development of machine learning(ML),data science,and analytics,coupled with its application in material science,stands as a significant milestone of the scientific community over the last *** active,stable,and cost-efficient catalysts is crucial for oxygen evolution reaction owing to the significance in a range of electrochemical energy co nversion *** this work,we have demonstrated an efficient approach of high-throughput screening to find stable transition metal oxides under acid condition for high-performance oxygen evolution reaction(OER)catalysts through density functional theory(DFT)calculation and a machine learning algorithm.A methodology utilizing both the Materials Project database and DFT calculations was introduced to assess the acid stability under specific reaction *** upon this,OER catalytic activity of acid-stable materials was examined,highlighting potential OER catalysts that meet the required *** identified IrO_(2),Fe(SbO_(3))_(2),Co(SbO_(3))_(2),Ni(SbO_(3))_(2),FeSbO_(4),Fe(SbO_(3))4,MoWO_(6),TiSnO_(4),CoSbO_(4),and Ti(WO_(4))_(2)as promising catalysts,several of which have already been experimentally discovered for their robust OER performance,while others are novel for experimental exploration,thereby broadening the chemical scope for efficient OER *** of the bond length of TM-O and the first ionization energy were used to unveil the OER activity *** the calculated results,guidance has been derived to effectively execute advanced high-throughput screenings for the discovery of catalysts with favorable ***,the intrinsic correlation between catalytic performance and various atomic and structural factors was elucidated using the ML *** these approaches,we not only streamline the choice of the promising electrocatalysts but also offer insights for the design of varied catalyst models and the discovery of superior c

关键词： Transition metal oxides Oxygen evolution reaction High-throughput screening First-principles calculation Machine learning

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Recent Advances in Patterning Strategies for Full‑Color Perovskite Light‑Emitting Diodes

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Nano-Micro Letters 2024年第3期16卷 99-137页

作者： Gwang Heon Lee Kiwook Kim Yunho Kim Jiwoong Yang Moon Kee choi Graduate School of Semiconductor Materials and Devices Engineering Center for Future Semiconductor Technology(FUST)Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea

Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with remarkably narrow bandwidths,high quantum yield,and solution *** recent advances have pushed the luminance efficiency of monochromic perovskite light-emitting diodes(PeLEDs)to their theoretical limits,their current fabrication using the spincoating process poses limitations for fabrication of full-color *** integrate PeLEDs into full-color display panels,it is crucial to pattern red–green–blue(RGB)perovskite pixels,while mitigating issues such as cross-contamination and reductions in luminous ***,we present state-of-the-art patterning technologies for the development of full-color ***,we highlight recent advances in the development of efficient ***,we discuss various patterning techniques of MPHs(i.e.,photolithography,inkjet printing,electron beam lithography and laserassisted lithography,electrohydrodynamic jet printing,thermal evaporation,and transfer printing)for fabrication of RGB pixelated *** patterning techniques can be classified into two distinct approaches:in situ crystallization patterning using perovskite precursors and patterning of colloidal perovskite *** review highlights advancements and limitations in patterning techniques for PeLEDs,paving the way for integrating PeLEDs into full-color panels.

关键词： Perovskite Light-emitting diode Full-color display High-resolution patterning Electroluminescence

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ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

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Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO choi JOO DONG PARK SEUNG HEE choi EUN-SU KO HYE JUNG JANG KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

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Comparison of commercial silicon-based anode materials for the design of a high-energy lithium-ion battery

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Nano Research 2024年第6期17卷 5270-5277页

作者： Minhong choi Eunhan Lee jaekyung Sung Namhyung Kim Minseong Ko Division of Convergence Materials Engineering Pukyong National UniversityBusan 48547Republic of Korea Department of Materials Engineering and Convergence Technology Gyeongsang National University501 Jinju-daeroJinju 52828Republic of Korea Department of Materials System Engineering Pukyong National UniversityBusan 48547Republic of Korea

Silicon(Si)is considered a potential alternative anode for next-generation Li-ion batteries owing to its high theoretical capacity and ***,the commercial use of Si anodes is hindered by their large volume expansion(~300%).Numerous efforts have been made to address this *** these efforts,Si-graphite co-utilization has attracted attention as a reasonable alternative for high-energy anodes.A comparative study of representative commercial Si-based materials,such as Si nanoparticles,Si suboxides,and Si−Graphite composites(SiGC),was conducted to characterize their overall performance in high-energy lithium-ion battery(LIB)design by incorporating conventional ***-Si was found to exhibit poor electrochemical performance,with severe volume expansion during *** suboxide provided excellent cycling stability in a full-cell evaluation with stable volume variation after 50 cycles,but had a large irreversible capacity and remarkable volume expansion during the first *** displayed a good initial Coulombic efficiency and the lowest volume change in the first cycle owing to the uniformly distributed nano-Si layer on graphite;however,its long-term cycling stability was relatively *** complement each disadvantage of Si suboxide and SiGC,a new combination of these Si-based anodes was suggested and a reasonable improvement in overall battery performance was successfully achieved.

关键词： silicon-based anode high-energy comparison lithium ion battery blended electrode

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Synaptic a-Si:H/a-Ga_(2)O_(3) phototransistor inspired by the phototaxis behavior of organisms with all-optical and all-electrical stimulation modes

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Nano Research 2024年第8期17卷 7631-7642页

作者： Youngbin Yoon Youngki Kim Soowon choi Jungdae Kwon Myunghun Shin School of Electronics and Information Engineering Korea Aerospace UniversityGoyang10540Republic of Korea Nano Materials Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea

To improve neuromorphic computing performance,neuromorphic system components should mimic the behaviors of organic *** this study,a synaptic a-Si:H/a-Ga_(2)O_(3)phototransistor featuring all-optical and-electrical emulation is fabricated in a manner advantageous for complementary metal-oxide-semiconductor process *** phototransistor exhibits excitatory and inhibitory synaptic behaviors under stimulation by both optical and electrical *** mimics several essential synaptic functions,including excitatory postsynaptic current,inhibitory postsynaptic current,short-term memory,long-term memory,pairedpulse facilitation,and spike-timing-dependent *** optical and electrical modulation mechanisms are confirmed to arise from the a-Si:H/a-Ga_(2)O_(3) heterojunction structure and interface effects,and the device is shown to operate at low power in both optical and electrical *** all-optical weight modulation function is applied to the wavelength-differential behavior response of zebrafish,successfully mimicking the color perception process of the ***,to verify the translation of the optoelectrical-derived synaptic behaviors of the phototransistor into artificial neuromorphic computation,handwritten digit image recognition of the Modified National Institute of Standards and Technology dataset is performed by a convolutional neural network,with a demonstrated average learning accuracy of 98.46%.These findings verify the applicability of the synaptic a-Si:H/a-Ga_(2)O_(3) phototransistor in neuromorphic computing.

关键词： synaptic phototransistor artificial synapse phototaxis neuromorphic computing interface charge state optoelectronic synaptic device

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电沉积Mo和Mo-Co合金纳米线用于互联电阻的电阻率改性

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Engineering 2024年第1期32卷 127-137页

作者： Jun Hwan Moon Taesoon Kim Youngmin Lee Seunghyun Kim Yanghee Kim jae-Pyoung Ahn Jungwoo choi Hyuck Mo Lee Young Keun Kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and EngineeringDaejeon 34141Republic of Korea Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Research Resources Division Korea Institute of Science and TechnologySeoul 02792Republic of Korea

Achieving historically anticipated improvement in the performance of integrated circuits is challenging,due to the increasing cost and complexity of the required technologies with each new *** overcome this limitation,the exploration and development of novel interconnect materials and processes are highly desirable in the microelectronics ***(Mo)is attracting attention as an advanced interconnect material due to its small resistivity size effect and high cohesive energy;however,effective processing methods for such materials have not been widely ***,we investigate the electrochemical behavior of ions in the confined nanopores that affect the electrical properties and microstructures of nanoscale Mo and Mo-Co alloys prepared via template-assisted *** in an electrolyte allow the deposition of extremely pure metal materials,due to their interac-tion with metal ions and *** this study,boric acid and tetrabutylammonium bisulfate(TBA)were added to an acetate bath to inhibit the hydrogen evolution *** accelerated the reduction of Mo at the surface by inducing surface conduction on the *** Mo nanowires with a 130 nm diameter synthesized through high-aspect-ratio nanopore engineering exhibited a resistivity of(63.0±17.9)μΩ*** also evaluated the resistivities of Mo-Co alloy nanowires at various compo-sitions toward replacing irreducible conventional barrier/liner *** intermetallic compound formed at a Mo composition of 28.6 at%,the resistivity of the Mo-Co nanowire was(58.0±10.6)μΩcm,indicat-ing its superior electrical and adhesive properties in comparison with those of conventional barriers such as TaN and ***,density functional theory and non-equilibrium Green's function calcula-tions confirmed that the vertical resistance of the via structure constructed from Mo-based materials was 21%lower than that of a conventional Cu/Ta/TaN structure.

关键词： Molybdenum Molybdenum-cobalt Interconnect Microstructure Electrodeposition Density functional theory

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Health risks of pest control and disinfection workers after the COVID-19 outbreak in South Korea

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Journal of Environmental Sciences 2024年第5期139卷 350-363页

作者： Yun-Hee choi Da-An Huh Lita Kim Sang ji Lee Kyong Whan Moon Department of Health and Safety Convergence Science Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea BK21 FOUR R&E Center for Learning Health System Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea Institute of Sciences Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea Department of Health and Environmental Science Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea

The exposure patterns of pest control and disinfection workers have changed after the coronavirus disease 2019(COVID-19)outbreak,but the health risks of chemical exposure have not been *** identified these workers’chemical exposure patterns and risks before and after the COVID-19 *** used data conducted between 2018(pre-pandemic)and 2021(post-pandemic)from three-year cross-sectional surveys on pest control and disinfection *** and dermal exposure concentrations were estimated using equations based on a biocidal product risk assessment model from the Korean National Institute of Environmental *** non-carcinogenic and carcinogenic risks of chemicals were calculated using the United States Environmental Protection Agency risk assessment *** found that the annual work frequency(50^(th)percentile)of foggers using disinfectants increased the most among all the work types,from 140 uses/year to 176 uses/year after the COVID-19 ***,all chemicals’non-carcinogenic and carcinogenic risks increased regardless of exposure *** the worst scenario(95^(th)percentile),the margin of exposure for citric acid,benzethonium chloride,benzyl-C12-16-alkyldimethyl chlorides,and sodium chlorite of inhalation exposure,and isopropyl alcohol and benzyl-C12-16-alkyldimethyl chlorides of dermal exposure were acceptable(>100)before the COVID-19outbreak but became unacceptable(10^(-6))before and after the COVID-19 outbreak but comparatively high after the COVID-19 ***,significantly more workers experienced health symptoms after the COVID-19outbreak(p<0.05),with the most common being muscle lethargy(31%),skin/face stinging(28.7%),and breath shortness/neck pain(24.1%).

关键词： Biocide Disinfection Health risk assessment Occupational exposure Pest control

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Particle morphology control for spherical powder fabrication using the ball milling process with DEM simulation

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Particuology 2024年第7期90卷 41-50页

作者： Battsetseg Jargalsaikhan Khulan Uranchimeg Amgalan Bor Kyung Sung Kim Heekyu choi Research Institute of Future Convergence Changwon National UniversityChangwonGyoungnam 641-773Republic of Korea Graduate School of Material Science Engineering Changwon National UniversityChangwonGyoungnam 641-773Republic of Korea Department of Chemical and Biological Engineering School of Engineering and Applied SciencesNational University of MongoliaUlaanbaatar 14200Mongolia Department of Mechatronics Convergence Engineering College of Future ConvergenceChangwon National UniversityChangwonGyoungnam 641-773Republic of Korea Graduate School of Convergence on Culture Technology Changwon National UniversityChangwonGyoungnam 641-773Republic of Korea

Characteristics of spherical particles on copper powder and changing sizes were studied in a ball mill under various experimental conditions,such as different ball diameters,high rotation speeds,and milling times,using a discrete element method(DEM)*** experiment has investigated the characteristics of spherical particle morphology evolution involved in the mechanical alloying of copper *** morphological evolution of the copper particle was analyzed using scanning electron microscopy(SEM).A spherical copper particle was shown with a roundness value using imageJ *** DEM was used to simulate the ball motion in a planetary ball mill,and the impact energy and shear energy generated during the collision were analyzed to estimate the contact number between the ball and the ball ***,as the size of the ball decreased,the number of ball-to-ball and ball-to-wall contacts increased accordingly,and the spherical shape of the copper powder changed.

关键词： Planetary ball mill DEM simulation Spherical particle morphology Copper powder Ball diameter

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