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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee Su Bin lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Down-scaled regional ocean modeling system (ROMS) for high-resolution coastal hydrodynamics in Korea

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Acta Oceanologica Sinica 2013年第9期32卷 50-61页

作者： lim hak-Soo KIM Chang S PARK Kwang-Soon SHIM jae Seol CHUN Insik Korea Institute of Ocean Science and Technology Konkuk University

A down-scaled operational oceanographic system is developed for the coastal waters of Korea using a re- gional ocean modeling system （ROMS）. The operational oceanographic modeling system consists of at- mospheric and hydrodynamic models. The hydrodynamic model, ROMS, is coupled with wave, sediment transport, and water quality modules. The system forecasts the predicted results twice a day on a 72 h basis, including sea surface elevation, currents, temperature, salinity, storm surge height, and wave information for the coastal waters of Korea. The predicted results are exported to the web-GIS-based coastal informa- tion system for real-time dissemination to the public and validation with real-time monitoring data using visualization technologies. The ROMS is two-way coupled with a simulating waves nearshore model, SWAN, for the hydrodynamics and waves, nested with the meteorological model, WRE for the atmospheric surface forcing, and externally nested with the eutrophication model, CE-QUAL-ICM, for the water quality. The op- erational model, ROMS, was calibrated with the tidal surface observed with a tide-gage and verified with current data observed by bottom-mounted ADCP or AWAC near the coastal waters of Korea. To validate the predicted results, we used real-time monitoring data derived from remote buoy system, HF-radar, and geostationary ocean color imager （GOCI）. This down-scaled operational coastal forecasting system will be used as a part of the Korea operational oceanographic system （KOOS） with other operational oceanographic systems.

关键词： down-scaled operational oceanographic system regional ocean modeling system wave coupledmodel real-time monitoring system

Novel N-doped multichannel carbon nanofiber architecture with porous CoS nanoprisms for high-performance potassium-ion batteries

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Rare Metals 2024年第3期43卷 971-983页

作者： jae Bong lim Seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityGyeonggi-do17546Republic of Korea Department of Intelligence Energy and Industry Chung-Ang UniversitySeoul06974Republic of Korea Western Seoul Center Korea Basic Science InstituteSeoul03759Republic of Korea

Potassium-ion batteries(PIBs)have gained significant attention as an alternative to lithium-ion batteries(LIBs)due to the abundance of potassium(K)and low ***,the difficulty in finding appropriate electrode materials that can efficiently store the larger K ions has hindered their practical ***,we report a novel anode material,N-doped multichannel carbon nanofibers embedded with porous CoS nanoprisms(CSP@NMCNF),for high-performance *** CSP@NMCNF was synthesized using a two-step strategy comprising of the electrospinning of Co acetate hydroxide nanoprism/binary polymer blend and a subsequent heat *** porous CoS nanoprisms with an anisotropic morphology were well aligned along the length axis of the N-doped multichannel carbon nanofibers,thus ensuring their structural stability during the repeated charge-discharge *** addition,numerous pores facilitated the transport of electrons and ***,the CSP@NMCNF anode exhibited excellent electrochemical performance,delivering a high specific capacity of 368 mAh·g^(-1)at 0.5 A·g^(-1)after 200 cycles and excellent rate capability(232 mAh·g^(-1)at 2.0 A·g^(-1)).

关键词： K-ion batteries Cobalt sulfide Multichannel structured composite Electrospinning Nanoprism Porous structure

Targeted therapy in gastric cancer:Personalizing cancer treatment based on patient genome

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World Journal of Gastroenterology 2014年第8期20卷 2042-2050页

作者： Sun Min lim jae Yun lim jae Yong Cho Division of Medical Oncology Department of Internal MedicineSeverance HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Medical Oncology Gangnam Severance HospitalYonsei University College of MedicineSeoul 135-720South Korea

Gastric cancer is the second leading cause of cancerrelated deaths *** cytotoxic chemotherapy has limited efficacy for metastatic gastric cancer,with an overall survival of approximately ten *** advances in high-throughput technologies have enabled the implementation of personalized cancer therapy for high-risk *** use of such high-throughput technologies,including microarray and next generation sequencing,have promoted the discovery of novel targets that offer new treatment strategies for patients lacking other therapeutic *** molecular pathways are currently under investigation as therapeutic targets in gastric cancer,including those related to the epidermal growth factor receptor family,the mesenchymal-epithelial transition factor axis,and the phosphatidylinositol 3-kinase-AKTmammalian target of rapamycin *** in molecular diagnostic tools further support the discovery of new molecular *** exist,however;not all patients can be tested for biomarkers,and numerous challenges hamper implementation of targeted therapy in clinical ***,the scale of tumor genomic profiling is rapidly outpacing our ability to appropriately synthesize all the information in order to optimally refine patient ***,clinicians must continue to educate themselves regarding new tools and frameworks,and to utilize multidisciplinary team science,comprised of oncologists,geneticists,pathologists,biologists and bioinformaticians,to successfully implement this genomic approach therapeutically.

关键词： Gastric cancer Targeted therapy Biomarker Microarray Sequencing

Diurnal Variation of Tropical Convection during TOGA COARE IOP

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Advances in Atmospheric Sciences 2005年第5期22卷 685-702页

作者： jae-Young BYON Gyu-Ho lim School of Earth and Environmental Sciences Seoul National University Seoul South KoreaSchool of Earth and Environmental Sciences Seoul National University Seoul South Korea

Diurnal variation of tropical convection and kinematic and thermodynamic conditions was investigated for different large-scale environments of the convectively active and inactive periods by using satellite observations and surface measurements during the Intensive Observation Period （IOP） of the Tropical Ocean Global Atmosphere/Coupled Ocean-Atmosphere Response Experiment （TOGA/COARE）. During the convectively active period, the features of nocturnal convection appear in vertical profiles of convergence, vertical velocity, heat source, and moisture sink. The specific humidity increases remarkably in the middle troposphere at dawn. On the other hand, the altitude of maximum convergence and that of the upward motion is lower during the convectively inactive period. The specific humidity peaks in the lower troposphere in the daytime and decreases in the middle troposphere. Spectral analyses of the time series of the infrared （IR） brightness temperature （TBB） and amounts of rainfall suggest multiscale temporal variation with a prominent diurnal cycle over land and oceanic regions such as the Intensive Flux Array （IFA） and the South Pacific Convergence Zone （SPCZ）. Over land, the daily maximum of deep convection associated with cloud top temperature less than 208 K appears at midnight due to the daytime radiative heating and the sea-land breeze. Over the ocean, convection usually tends to occur at dawn for the convectively active period while in the afternoon during the inactive period. Comparing the diurnal variation of convection with large-scale variables, the authors inferred that moisture in the middle troposphere contributes mostly to the development of nocturnal convection over the ocean during the convectively active period.

关键词： diurnal variation tropical convection rainfall large-scale environment

Improvement of uniformity in cultivation environment and crop growth rate by hybrid control of air flow devices

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Journal of Central South University 2015年第12期22卷 4702-4708页

作者： BAEK Min-Seon KWON Sook-Youn lim jae-Hyun Department of Computer Science and Engineering Kongju National University Green Energy Technology Research Center Kongju National University

A complete control type plant factory has high efficiency in terms of cultivation area by constructing vertical multiple layered cultivation ***,it has a problem of irregular crop growth due to temperature deviation at upper and lower beds and increases in energy consumption by a prolonged cultivation *** this work,air flow rate inside a facility was improved by a hybrid control of air flow devices like air conditioning and air circulation fan with an established wireless sensor network to minimize temperature deviations between upper and lower beds and to promote crop *** performance of proposed system was verified with an experimental environment or Case A wherein air conditioning device was operated without a control algorithm and Case B wherein air conditioning and circulation fans were alternatively operated based on the hybrid control *** planting leafy vegetables under each experimental condition,crops were cultivated for 21 *** a result,Case B wherein AC(air conditioning) and ACF(air-circulation fan) were alternatively operated based on the hybrid control algorithm showed that fresh mass,number of leaves,and leaf length for the crops grown were increased by 40.6%,41.1%,and 11.1%,respectively,compared to Case A.

关键词： air flow devices hybrid control cultivation environment uniformity growth rate

Survival analysis based on human epidermal growth factor 2 status in stage Ⅱ-Ⅲ gastric cancer

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World Journal of Gastroenterology 2017年第41期23卷 7407-7414页

作者： Jang Ho Cho jae Yun lim jae Yong Cho Division of Medical Oncology Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

AIM To investigate human epidermal growth factor 2(HER2) overexpression and validate its prognostic effect in stage Ⅱ-Ⅲ gastric *** We reviewed the data of patients who were diagnosed with gastric cancer between March 2008 and October 2013 at the Yonsei University Medical Center. Among these patients, 384 patients who met the inclusion criteria were analyzed retrospectively. RESULTS Thirty-two(8.3%) of the 384 stage Ⅱ-Ⅲ gastric cancer patients exhibited HER2 overexpression. The median follow-up duration was 26.0 mo. HER2-negative patients had superior recurrence-free survival(RFS) compared to HER2-positive patients(HR = 0.52, 95%CI: 0.30-0.89; P = 0.015). The median overall survival(OS) was significantly prolonged in the HER2-negative group compared with the HER2-positive group(55.0 mo vs 38.0 mo, HR = 0.43, 95%CI: 0.21-0.88, P = 0.021). OS was also prolonged in HER2-negative patients who received adjuvant chemotherapy compared to HER2-positive patients(55.0 vs 38.0mo, HR = 0.42, 95%CI: 0.18-1.00, P = 0.051). In patients who did not receive adjuvant chemotherapy,the median RFS was prolonged in the HER2-negative group compared to the HER2-positive group(not reached vs 12.0 mo, HR = 0.17, 95%CI: 0.06-0.49, P= 0.001). In a multivariate analysis, HER2 status(HR= 0.421, 95%CI: 0.206-0.861, P = 0.018) and Eastern Cooperative Oncology Group performance status(HR = 2.002, 95%CI: 1.530-2.618, P < 0.001) were independent predictors of *** Our findings showed that HER2-positive patients had inferior OS and RFS. Stage Ⅱ-Ⅲ HER2-positive patients might be potential candidates for targeted therapies involving trastuzumab.

关键词： Trastuzumab Gastric neoplasm Human epidermal growth factor 2

Real-Time Demand Response Management for Controlling Load Using Deep Reinforcement Learning

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Computers, Materials & Continua 2022年第12期73卷 5671-5686页

作者： Yongjiang Zhao jae Hung Yoo Chang Gyoon lim Department of Computer Engineering Chonnam National UniversityYeosu59626Korea

With the rapid economic growth and improved living standards,electricity has become an indispensable energy source in our ***,the stability of the grid power supply and the conservation of electricity is *** following are some of the problems facing now:1)During the peak power consumption period,it will pose a threat to the power *** and improving the power distribution infrastructure requires high maintenance costs.2)The user’s electricity schedule is unreasonable due to personal behavior,which will cause a waste of *** load as a vital part of incentive demand response(DR)can achieve rapid response and improve demand-side *** load by manually formulating rules,some devices are selective to be adjusted during peak power ***,it is challenging to optimize methods based on manual *** paper uses SoftActor-Critic(SAC)as a control algorithm to optimize the control *** results show that through the coordination of the SAC to control load in CityLearn,realizes the goal of reducing both the peak load demand and the operation costs on the premise of regulating voltage to the safe limit.

关键词： Demand response controlling load SAC CityLearn

A New Approach for Manufacturing a High Porosity Ti-6Al-4V Scaffolds for Biomedical Applications

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Journal of Materials Science & Technology 2008年第6期24卷 931-935页

作者： Montasser DEWIDAR H.Fouad MOHAMED jae-Kyoo lim Department of Mechanical Design and Materials High Institute of EnergySouth Valley University AswanEgypt Biomedical Engineering Department Faculty of EngineeringHelwan UniversityEgypt Automobile Hi-Technology Research Institute Faculty of Mechanical & Aerospace System Eng.Chonbuk National UniversityDuckjin 1-664-14JeonjuJB 561-756South Korea

Titanium and its alloys are currently considered as one of the most important metallic materials used in the biomedical applications, due to their excellent mechanical properties and superior biocompatibility. In the present study, a new effective method for fabricating high porosity titanium alloy scaffolds was developed. Porous Ti-6Al-4V scaffolds are successfully fabricated with porosities ranging from 30% to 70% using spaceholder and powder sintering technique. Based on its acceptable properties, spherical carbamide particles with different diameters （0.56, 0.8, and 1mm） were used as the space-holder material in the present investigation. The Ti-6Al-4V scaffolds porosity is characterized by using scanning electron microscopy. The results show that the scaffolds spherical-shaped pores are depending on the shape, size and distribution of the space-holder particles. This investigation shows that the present new manufacturing technique is promising to fabricate a controlled high porosity and high purity Ti-6Al-4V scaffolds for hard tissue replacement.

关键词： Ti-6Al-4V Porous material Powder metallurgy Space-holder