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Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National university DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Development of a Powder Extruder System for Dual-pore Tissue-engineering Scaffold Fabrication

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Journal of Bionic Engineering 2019年第4期16卷 686-695页

作者： Nae-un Kang Myoung Wha hong Young Yul kim Young-Sam Cho Seung-jae Lee Department of Mechanical Design Engineering College of EngineeringWonkwang University460 Iksandae-roIks an Jeonbuk570-749Republic of Korea Department of Orthopedics Daejeon StMary's HospitalCatholic University of Korea64Daeheung-i Jung-guDaejeon301-723Republic of Korea

In this study,we developed a powder extruder system that can extrude and deposit powder mixtures to overcome the reported limitations of conventional dualpore scaffold manufacturing *** evaluate the extrusion and deposition capability of the powder extruder system,3D tissue-engineering scaffolds with dual-pore characteristics were fabricated with a PCL/PEO/NaCl(polycaprolactone/polyethylene oxide/sodium chloride)powder *** addition,to evaluate the fabricated scaffolds,their compressive modulus,morphology,and in-vitro cell activity were ***,it was confirmed that the proposed powder extruder system can fabricate dual-pore scaffolds with well-interconnected pores as well as arbitrary 3D shapes shown by the fabrication of a 3D femur-shape scaffold similar to the femur *** results of the cell proliferation and Cell Counting Kit-8(CCK-8)assays,DNA content analysis and viability assays confirm that the dual-pore scaffold fabricated by the powder extruder system improves cell attachment,proliferation,and viability.

关键词： dual-pore scaffold powder extruder system polycaprolactone 3D tissue-engineering scaffold

high mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： hanki kim Bum Jun kim Seungyon Koh hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

high-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Two-dimensional Dirac plasmon-polaritons in graphene,3D topological insulator and hybrid systems

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Light(Science & Applications) 2022年第11期11卷 2602-2616页

作者： Chihun In un Jeong kim h.unyong Choi Department of Physics Freie Universitat BerlinBerlin 14195Germany Department of Physical Chemistry Fritz-Haber-lInstitute of the Max-Planck-SocietyBerlin 14195Germany Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Institute of Applied Physics Seoul National UniversitySeoul 08826Republic of Korea Advanced Sensor Laboratory Samsung Advanced Institute of TechnologySuwonGyeonggido 16419Republic of Korea

Collective oscillations of massless particles in two-dimensional(2D)Dirac materials offer an innovative route toward implementing atomically thin devices based on low-energy quasiparticle *** confinement of nearfield distribution on the 2D surface is essential to demonstrate extraordinary optoelectronic functions,providing means to shape the spectral response at the mid-infrared(IR)*** the dynamic polarization from the linear response theory has successfully accounted for a range of experimental observations,a unified perspective was stll elusive,connecting the state-of-the-art developments based on the 2D Dirac ***,we review recent works on graphene and three-dimensional(3D)topological insulator(TI)plasmon-polariton,where the mid-IR and terahertz(Thz)radiation experiences prominent confinement into a deep-subwavelength scale in a novel optoelectronic *** presenting general light-matter interactions between 2D Dirac plasmon and subwavelength quasiparticle excitations,we introduce various experimental techniques to couple the plasmonpolaritons with electromagnetic *** and optical controls over the plasmonic excitations reveal the hybridized plasmon modes in graphene and 3D Tl,demonstrating an intense near-field interaction of 2D Dirac plasmon within the highly-compressed *** findings can further be applied to invent optoelectronic biomolecular sensors,atomically thin photodetectors,and laser-driven light sources.

关键词： structure Dirac topological

A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong Cho Byeori kim haeh.un Cho Taek-Young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

Superelastic metastable Ti-Mo-Sn alloys with high elastic admissible strain for potential bio-implant applications

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Journal of Materials Science & Technology 2023年第32期163卷 45-58页

作者： Shuanglei Li jae h.kim Seung Won Kang jae ho kim Tae-h.un Nam Jong-Taek Yeom Titanium Alloys Department Metal Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Materials Engineering and Convergence Technology&Research Institute for Green Energy Convergence Technology(RIGET) Gyeongsang National University900 GazwadongJinjuGyeongnam 52828Republic of Korea

The demand for titanium alloys simultaneously having high elastic admissible strain and large recovery strain for bio-implant applications is ***-free Ti-based shape memory alloys are promising candidates for obtaining the required multifunctional *** this study,a wide content range of(0-15)wt%of low-cost,toxicity-free,and high-biocompatible Sn element was added to the Ti-8Mo(wt%)alloy to study its effect on the superelastic recovery and mechanical properties of biomedical Ti-Mo-Sn *** tailoring Sn content,desired multifunctional properties of high elastic admissible strain and room temperature superelasticity were achieved in the studied Ti-Mo-Sn *** was found that the increase in Sn content stabilized theβphase and a singleβphase was obtained at room temperature in Ti-8Mo-(13,15)Sn *** addition of Sn modified the lattice parameters of theα″martensite andβphase and affected the lattice deformation stain ofβ→α″.The lattice deformation strain along the[011]βdirection was found to be decreased by-0.26%/wt%*** room temperature superelasticity with a recovery strain of 3.1%and an elastic admissible strain of 1%was obtained in the Ti-8Mo-13Sn *** Sn content increased to 15 wt%,a high elastic admissible strain of 1.56%and a recovery strain of 2.0%were *** Ti-Mo-Sn alloys with excellent multifunctional properties are promising candidates for bio-implant applications.

关键词： Ti-Mo-Sn alloy Shape memory alloy Elastic admissible strain Elastic modulus Superelasticity

What Causes the Springtime Tropospheric Ozone Maximum over Northeast Asia?

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Advances in Atmospheric Sciences 2010年第3期27卷 543-551页

作者： jae h.kim h.unjin LEE Department of Atmospheric Science Pusan National University

Scientists have long debated the relative importance of tropospheric photochemical production versus stratospheric influx as causes of the springtime tropospheric ozone maximum over northern mid-latitudes. This paper investigates whether or not stratospheric intrusion and photochemistry play a significant role in the springtime ozone maximum over Northeast Asia, where ozone measurements are sparse. We examine how tropospheric ozone seasonalities over Naha （26°N, 128°E）, Kagoshima （31°N, 131°E）, and Pohang （36°N, 129°E）, which are located on the same meridional line, are related to the timing and location of the jet stream. The ozone seasonality shows a gradual increase from January to the maximum ozone month, which corresponds to April at Naha, May at Kagoshima, and June at Pohang. In order to examine the occurrence of stratospheric intrusion, we analyze a correlation between jet stream activity and tropospheric ozone seasonality. From these analyses, we did not find any favorable evidence supporting the hypothesis that the springtime enhancement may result from stratospheric intrusion. According to trajectory analysis for vertical and horizontal origins of the airmass, a gradual increasing tendency in ozone amounts from January until the onset of monsoon was similar to the increasing ozone formation tendency from winter to spring over China's Mainland, which has been observed during the build-up of tropospheric ozone over Central Europe in the winter-spring transition period due to photochemistry. Overall, the analyses suggest that photochemistry is the most important contributor to observed ozone seasonality over Northeast Asia.

关键词： tropospheric ozone photochemistry, stratospheric intrusion, jet stream activity, trajectory