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Scalable nanolaminated SERS multiwell cell culture assay

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Microsystems & Nanoengineering 2020年第1期6卷 916-926页

作者： Xiang Ren Wonil Nam Parham Ghassemi Jeannine S.Strobl Inyoung kim Wei Zhou Masoud Agah Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVA 24061USA Department of Statistics Virginia TechBlacksburgVA 24061USA

This paper presents a new cell culture platform enabling label-free surface-enhanced Raman spectroscopy(SERS)analysis of biological *** platform integrates a multilayered metal-insulator-metal nanolaminated SERS substrate and polydimethylsiloxane(PDMS)multiwells for the simultaneous analysis of cultured *** cell lines,including breast normal and cancer cells and prostate cancer cells,were used to validate the applicability of this unique *** cell lines were cultured in different *** Raman spectra of over 100 cells from each cell line were collected and analyzed after 12h of introducing the cells to the *** unique Raman spectra of each cell line yielded biomarkers for identifying cancerous and normal cells.A kernel-based machine learning algorithm was used to extract the high-dimensional variables from the Raman ***,the nonnegative garrote on a kernel machine classifier is a hybrid approach with a mixed nonparametric model that considers the nonlinear relationships between the higher-dimension *** breast cancer cell lines and normal breast epithelial cells were distinguished with an accuracy close to 90%.The prediction rate between breast cancer cells and prostate cancer cells reached 94%.Four blind test groups were used to evaluate the prediction power of the SERS *** peak intensities at the selected Raman shifts of the testing groups were selected and compared with the training groups used in the machine learning *** blind testing groups were correctly predicted 100% of the time,demonstrating the applicability of the multiwell SERS array for analyzing cell populations for cancer research.

关键词： laminated culture prediction

Ischemic colitis during interferon-ribavirin therapy for chronic hepatitis C:A case report

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World Journal of Gastroenterology 2012年第31期18卷 4233-4236页

作者： Su Jung Baik Tae Hun kim Kwon Yoo Il Hwan Moon Min-Sun Cho Department of Gastroenterology Health Promotion CenterYonsei University Gangnam Severance HospitalSeoul 158-050South Korea Department of Internal Medicine Ewha Medical Research InstituteEwha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea Department of Pathology Ewha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea

Ischemic colitis is a rare complication of interferon *** 9 cases in 6 reports have been described *** report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C,and includes a review of the relevant literature.A 48-year-old woman was treated with pegylated interferon-2a and ribavirin for chronic hepatitis C,genotype *** 19 wk of treatment,the patient complained of severe afebrile abdominal pain with *** signs were stable and serum white blood cell count was within the normal *** computed tomography showed diffuse colonic wall thickening from the splenic flexure to the proximal sigmoid colon,which is the most vulnerable area for the development of ischemic *** revealed an acute mucosal hyperemic change,with edema and ulcerations extending from the proximal descending colon to the sigmoid *** mucosal biopsy revealed acute exudative *** chain reaction and culture for Mycobacterium tuberculosis were negative and the cultures for cytomegalovirus,Salmonella and Shigella species were *** discontinuation of interferon and ribavirin therapy,abdominal pain and hematochezia subsided and,following colonoscopy showed improvement of the mucosal *** colitis cases during interferon therapy in patients with chronic hepatitis C reported so far have all involved the descending *** colitis is a rarely encountered complication of interferon administration in patients with chronic hepatitis C and should be considered when a patient complains of abdominal pain and hematochezia.

关键词： Ischemia Hepatitis C Interferon

The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation

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International Journal of Oral Science 2022年第1期14卷 71-79页

作者： Muhammad Irfan Ji-Hyun kim Hassan Marzban David AReed Anne George Lyndon FCooper Seung Chung Department of Oral Biology University of Illinois at ChicagoChicagoUSA Department of Human Anatomy and Cell Science University of ManitobaWinnipegCanada

Therapeutic dentin regeneration remains difficult to achieve,and a majority of the attention has been given to anabolic strategies to promote dentinogenesis directly,whereas,the available literature is insufficient to understand the role of inflammation and inflammatory complement system on *** aim of this study is to determine the role of complement C5a receptor(C5aR)in regulating dental pulp stem cells(DPSCs)differentiation and in vivo dentin *** DPSCs were subjected to odontogenic differentiation in osteogenic media treated with the C5aR agonist and C5aR *** vivo dentin formation was evaluated using the dentin injury/pulp-capping model of the C5a-deficient and wildtype *** vitro results demonstrate that C5aR inhibition caused a substantial reduction in odontogenic DPSCs differentiation markers such as DMP-1 and DSPP,while the C5aR activation increased these key odontogenic genes compared to control.A reparative dentin formation using the C5a-deficient mice shows that dentin regeneration is significantly reduced in the C5a-deficient *** data suggest a positive role of C5aR in the odontogenic DPSCs differentiation and tertiary/reparative dentin *** study addresses a novel regulatory pathway and a therapeutic approach for improving the efficiency of dentin regeneration in affected teeth.

关键词： C5a vivo inflammation

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水瓶座金字塔首尔某影视明星私宅

室内设计与装修 2022年第7期 46-50页

作者： [韩国]承孝相 Jong Oh kim(摄影) jae Min Lee(摄影) 不详

本项目位于首尔,是为韩国影视明星C所设计的私人住宅。她在这座20世纪70年代建造的房子里度过童年,并成长为银幕上的主角,之后又饰演过无数人的生活状态,或许这个场所对她来说是唯的现实,也是重要的归宿。但是弘大地区的商业发展使得周... 详细信息

本项目位于首尔,是为韩国影视明星C所设计的私人住宅。她在这座20世纪70年代建造的房子里度过童年,并成长为银幕上的主角,之后又饰演过无数人的生活状态,或许这个场所对她来说是唯的现实,也是重要的归宿。但是弘大地区的商业发展使得周边的风景骤变,坚持了40多个春秋的这栋老楼也要迎来新的变化。

关键词：私人住宅影视明星金字塔首尔新的变化

Characterisation of undigested components throughout the gastrointestinal tract of broiler chickens fed either a wheat-or maizebased diet

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Animal Nutrition 2022年第1期8卷 153-159页

作者： Eunjoo kim Natalie K.Morgan Amy F.Moss Lily Li Peter Ader Mingan Choct School of Environmental and Rural Science University of New EnglandArmidaleNSW2351Australia BASF South East Asia038987Singapore BASF SE 68623LampertheimGermany

This study was to characterise the undigested nutrients present along the gastrointestinal tract of birds offered common wheat-or maize-based diets,with the goal of optimising utilisation of enzymes to enhance digestive ***-and maize-based diets were offered to 240 mixed-sex broilers(10 birds/pen;n=12)from 1 to 35 d *** of dry matter,starch,crude protein and nonstarch polysaccharides(NSP)were measured in the crop,gizzard,duodenum,jejunum,ileum,caeca and excreta at d 12 and 35 *** of nutrient levels in the excreta presented that more than 30%of nutrients provided in the feed was wasted,irrespective of wheat or maize diet *** average,92 g/kg crude protein,92 g/kg insoluble NSP and 14 g/kg oligosaccharides were not utilised by birds at d 12 *** quantity of water-insoluble NSP in the small intestine at d 12 was lower in birds offered the wheat-based diet compared to those fed the maize-based diet(P<0.05),with the reverse being true for water-soluble NSP(P<0.001).On average,84 g/kg crude protein,79 g/kg insoluble NSP and 9 g/kg oligosaccharides remained in the excreta at 35 d of *** this time period,accumulation of feed in the gizzard was noted for birds offered both diets,but was more pronounced in those offered the maize-based diet(P<0.001).Birds offered the maize-based diet demonstrated improved utilisation of oligosaccharides compared to those fed the wheat-based diet at both d 12 and 35(P=0.087 and P=0.047,respectively).Protein utilisation in the jejunum and ileum was greater in birds offered the wheat-based diet compared to those fed the maize-based diet(P=0.004 and P<0.001,respectively).Thus,while both diets supported standard growth performance of birds,the degree and flow of nutrient disappearance along the gastrointestinal tract was influenced by cereal type and bird age.

关键词： Broiler chicken Nutrient digestibility Undigested dietary component

Ruptured splenic artery aneurysms in pregnancy and usefulness of endovascular treatment in selective patients:A case report and review of literature

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World Journal of Clinical Cases 2022年第25期10卷 9057-9063页

作者： Sang Hun Lee Songsoo Yang Inkyu Park Yeong Cheol Im Gyu Yeol kim Department of Obstetrics and Gynecology Ulsan University and Ulsan University HospitalUlsan 44033South Korea Department of Surgery Ulsan University and Ulsan University HospitalUlsan 44033South Korea

BACKGROUND The rupture of a splenic artery aneurysm(SAA)in pregnancy is an uncommon ***,it is associated with high mortality rates in pregnant women and fetuses even after surgical *** the endovascular treatment of SAAs is currently preferred as it can improve the outcomes even in emergent cases,the endovascular treatment of a ruptured SAA during pregnancy has not been reported until *** SUMMARY We report a case of a 33-year-old woman with the sudden onset of epigastric pain due to a ruptured SAA at the mid-portion of the splenic artery at 18 wk of *** emergent initial resuscitation,the patient was diagnosed with a ruptured SAA through digital *** upon diagnosis,she underwent emergent endovascular embolization of the splenic artery for the rupture on the ***,surgery was performed to remove the hematoma under stable *** the fetus was found to be dead during resuscitation,the woman recovered without complications and was discharged 15 d *** Endovascular treatment might be a valuable alternative to surgery/lead to safer surgery for selected pregnant patients with ruptured SAAs.

关键词： Splenic artery Aneurysm Pregnancy Endovascular treatment Case report

HID灯镇流器中UniFET Ⅱ MOSFET的性能和效率

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电子产品世界 2013年第2期20卷 15-20页

作者： jae-Eul Yeon Won-Hwa Lee Kyu-Min Cho Hee-Jun kim 韩国富川市飞兆半导体韩国分公司HVPCIA部门消费电子电源系统团队韩国富川市柳韩大学信息与通信工程系韩国安山市汉阳大学电子与计算机工程学院

先进的单元结构和寿命控制技术已同时增强了功率MOSFET的导通电阻和反向恢复性能。本文介绍一种新开发的平面MOSFET—UniFETTM Ⅱ MOSFET—具有显著提高的体二极管特性,另外还介绍了其性能和效率。根据寿命控制的集中程度,UniFET Ⅱ MOS... 详细信息

先进的单元结构和寿命控制技术已同时增强了功率MOSFET的导通电阻和反向恢复性能。本文介绍一种新开发的平面MOSFET—UniFETTM Ⅱ MOSFET—具有显著提高的体二极管特性,另外还介绍了其性能和效率。根据寿命控制的集中程度,UniFET Ⅱ MOSFET可分为普通FET、FRFET和Ultra FRFET MOSFET,其反向恢复时间分别为传统MOSFET的70%、25%和15%左右。为了验证全新MOSFET的性能和效率,用带混频逆变器的150W HID灯镇流器进行了实验。结果证明,两个UniFET Ⅱ MOSFET可取代两个传统MOSFE和四个附加FRD,并且无MOSFET故障。

关键词： UniFET Ⅱ FRFET Ultra FRFET MOSFET故障混频逆变器和HID镇流器

Systematic review on the surgical treatment for T1 gallbladder cancer

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World Journal of Gastroenterology 2011年第2期17卷 174-180页

作者： Seung Eun Lee Jin-Young Jang Chang-Sup Lim Mee Joo Kang Sun-Whe kim Department of Surgery Chung-Ang University College of Medicine Department of Surgery Seoul National University College of Medicine

AIM:To evaluate the efficacy of simple and extended cholecystectomy for mucosa(T1a) or muscularis(T1b) gallbladder(GB) cancer. METHODS:Original studies on simple and extended cholecystectomy for T1a or T1b GB cancer were searched from MEDLINE(PubMed) ,Cochrane Library,EMBase,and CancerLit using the search terms of GB,cancer/carcinoma/tumor/neoplasm. RESULTS:Twenty-nine out of the 2312 potentially relevant publications met the eligibility *** the 1266 patients with GB cancer included in the publications,706(55.8%) and 560(44.2%) had T1a and T1b GB cancer,*** cholecystectomy for T1a and T1b GB cancer was performed in 590(83.6%) and 375(67.0%) patients,respectively(P<0.01) .In most series,the treatment of choice was simple cholecystectomy for T1a GB cancer patients with a 5-year survival rate of 100%.Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8%of the T1a GB cancer patients,respectively(P<0.01) .Eight patients(1.1%) with T1a GB cancer and 52 patients(9.3%) with T1b GB cancer died of recurrent GB cancer(P<0.01) . CONCLUSION:Simple cholecystectomy represents the adequate treatment of T1a GB *** is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer.

关键词： Gallbladder Cancer Cholecystectomy Simple Extended

Foaming supramolecular surfactants for gas mobility control in naturally fractured carbonate reservoirs at high temperature,salinity,and hardness

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Petroleum Science 2022年第6期19卷 3134-3148页

作者： Enrique Soto-Castruita Raúl Hern andez-Altamirano Eduardo Buenrostro-González Erick-Emanuel Luna-Rojero Sung jae Ko-kim Violeta-Yasmín Mena-Cervantes Mirna Pons-Jiménez Jorge-Francisco Ramírez-Pérez David-Aaσn Nieto-Alvarez Ricardo Cerón-Camacho Jos e-Ernesto Parra Raúl Oviedo-Roa Jos e-Manuel Martínez-Magadán Rodolfo Cisneros-Dévora Luis-S.Zamudio-Rivera Instituto Mexicano del Petr oleo Eje Central Lazaro Cardenas Norte 152Col.San Bartolo AtepehuacanCiudad de Mexico07730Mexico CONACy T-Instituto Mexicano del Petroleo Eje Central Lazaro Cardenas Norte 152Col.San Bartolo AtepehuacanCiudad de Mexico07730Mexico Centro Mexicano para la Produccion mas Limpia Instituto Politecnico NacionalAvenida Acueducto s/nCol.La Laguna TicomanCiudad de Mexico07340Mexico Centro de Tecnologías para Exploracion y Produccion Camino de Terracería 800Col.San Jose NovilleroBoca delRíoVeracruz94286Mexico

Oil production and mainte nance are essential issues in naturally fractured reservoirs because they are the largest and most productive on ***,they present early water and gas channeling but could be remediated by using foaming agents to control these phenomena through blocking channeling *** Mexico these reservoirs have pressure up to 5,500 psi,high temperature up to 200℃,salinity up to400,000 ppm,and hardness up to 250,000 ppm;due to these thermodynamic conditions,there has been no available technology to form stable enough *** this work,a foaming supramolecular surfactant with the capability to chelate Ca^(2+)ions is *** a result,surfactant monomers are bridged by captured Ca^(2+)cations leading to the formation of high-molecular-weight oligomers,which significantly increment the viscosity of the solution improving the foam stability,and since at this manner the Ca2+cations are no longer available to precipitate as components of solid salts,the foaming supramolecular surfactant also performs as *** observations are explained through quantum theoretical *** foam is stable,effectively blocking the gas channels,whereas in presence of oil the foam is broken leading the oil to pass into the *** characteristic rheological properties of the foam allow its injection into the formation at a range of flow rates,foam qualities,and shear stress to achieve the flooding and the blocking of a variety of fractured carbonate formations,and the change of the wettability of the matrix,which is a desirable behavior in a huff and puff process,as reported in a previous publication about a successful pilot test of this foam.

关键词： Calcium chelation Foaming composition Supramolecular surfactant Molecular design Gas mobility control Flow assurance Improved oil recovery Conformance control