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Advances in Atmospheric Sciences 2005年第2期22卷 230-237页

作者： jae-jin kim Jong-jin BAIK Climate Environment System Research Center Seoul National University Seoul 151-742 KoreaSchool of Earth and Environmental Sciences Seoul National University Seoul 151-742 Korea

The effects of street bottom heating and inflow turbulence on urbanstreet-canyon flow are experimentally investigated using a circulating water channel. Threeexperiments are carried out for a street canyon with a street aspect ratio of 1. Results from eachexperiment with bottom heating or inflow turbulence are compared with those without bottom heatingand appreciable inflow turbulence. It is demonstrated that street bottom heating or inflowturbulence increases the intensity of the canyon vortex. A possible explanation on how street bottomheating or inflow turbulence intensifies the canyon vortex is given from a fluid dynamicalviewpoint.

关键词： urban street-canyon flow street bottom heating inflow turbulence circulating water channel

Effects of a Building’s Density on Flow in Urban Areas

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Advances in Atmospheric Sciences 2009年第1期26卷 45-56页

作者： jae-jin kim Do-Yong kim Department of Environmental Atmospheric Sciences Pukyong National University Busan Korea Center for Atmosphere Science and Earthquake Research Korea Meteorological Administration Busan Korea

The effects of a building＇s density on urban flows are investigated using a CFD model with the RNG k - ε turbulence closure scheme. Twenty-seven cases with different building＇s density parameters （e.g., building and street-canyon aspect ratios） are numerically simulated. As the building＇s density parameters vary, different flow regimes appear. When the street canyon is relatively narrow and high, two counterrotating vortices in the vertical direction are generated. The wind speed along streets is mainly affected by the building＇s length. However, it is very difficult to find or generalize the characteristics of the street-canyon flows in terms of a single building＇s density parameter. This is because the complicated flow patterns appear due to the variation of the vortex structure and vortex number. Volume-averaged vorticity magnitude is a very good indicator to reflect the flow characteristics despite the strong dependency of flows on the variation of the building＇s density parameters. Multi-linear regression shows that the volume-averaged vorticity magnitude is a strong function of the building＇s length and the street-canyon width. The increase in the building＇s length decreases the vorticity of the street-canyon flow, while, the increase in the street- canyon width increases the vorticity.

关键词： urban flow characteristics building's density parameter volume-averaged vorticity CFD model

Effects of Street-Bottom and Building-Roof Heating on Flow in Three-Dimensional Street Canyons

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Advances in Atmospheric Sciences 2010年第3期27卷 513-527页

作者： jae-jin kim Jong-jin BAIK Department of Environmental Atmospheric Sciences Pukyong National University School of Earth and Environmental Sciences Seoul National University

Using a computational fluid dynamics （CFD） model, the effects of street-bottom and building-roof heating on flow in three-dimensional street canyons are investigated. The building and street-canyon aspect ratios are one. In the presence of street-bottom heating, as the street-bottom heating intensity increases, the mean kinetic energy increases in the spanwise street canyon formed by the upwind and downwind buildings but decreases in the lower region of the streamwise street canyon. The increase in momentum due to buoyancy force intensifies mechanically induced flow in the spanwise street canyon. The vorticity in the spanwise street canyon strengthens. The temperature increase is not large because relatively cold above-roof-level air comes into the spanwise street canyon. In the presence of both street-bottom and building-roof heating, the mean kinetic energy rather decreases in the spanwise street canyon. This is caused by the decrease in horizontal flow speed at the roof level, which results in the weakening of the mean flow circulation in the spanwise street canyon. It is found that the vorticity in the spanwise street canyon weakens. The temperature increase is relatively large compared with that in the street-bottom heating case, because relatively warm above-roof-level air comes into the spanwise street canyon.

关键词： street canyon flow CFD model street-bottom heating building-roof heating mean kineticenergy vorticity

Effects of Wind Fences on the Wind Environment around Jang Bogo Antarctic Research Station

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Advances in Atmospheric Sciences 2017年第12期34卷 1404-1414页

作者： Jang-Woon WANG jae-jin kim Wonsik CHOI Da-Som MUN Jung-Eun KANG Hataek KWON jin-Soo kim Kyung-Soo HAN Department of Environmental Atmospheric Sciences Pukyong National University 45Yongso-ro Korea Polar Research Institute 26 Songdomirae-ro Yeonsu-gu Department of Spatial Information Engineering Pukyong National University 45Yongso-ro

This study investigated the flow characteristics altered by Jang Bogo Antarctic Research Station using computational fluid dynamics(CFD) modeling. The topography and buildings around Jang Bogo Station were constructed with computeraided-design data in the CFD model domain. We simulated 16 cases with different inflow directions, and compared the flow characteristics with and without Jang Bogo Station for each inflow direction. The wind data recorded by the site’s automatic weather station(AWS) were used for comparison. Wind rose analysis showed that the wind speed and direction after the construction of Jang Bogo Station were quite different from those before construction. We also investigated how virtual wind fences would modify the flow patterns, changing the distance of the fence from the station as well as the porosity of the fence. For westerly inflows, when the AWS was downwind of Jang Bogo Station, the decrease in wind speed was maximized(-81% for west-northwesterly). The wind speed reduction was also greater as the distance of the fence was closer to Jang Bogo Station. With the same distance, the fence with medium porosity(25%–33%) maximized the wind speed *** results suggest that the location and material of the wind fence should be selected carefully, or AWS data should be interpreted cautiously, for particular prevailing wind directions.

关键词： Jang Bogo Antarctic Research Station CFD model observation environment wind fence porosity

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-Hong kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul C.Khot Chenjie Yao Nahyun kim Tae Geun kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory