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Treatment and prognosis of hepatic epithelioid hemangioendothelioma based on SEER data analysis from 1973 to 2014

Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 29-35页

作者： O Kyu Noh Soon Sun Kim Min jae Yang Sun Gyo Lim jae Chul Hwang Hyo Jung Cho jae youn cheong Sung Won Cho Department of Radiation Oncology Ajou University School of MedicineSuwonKorea Department of Biomedical Informatics Ajou University School of MedicineSuwonKorea Office of Biostatistics Ajou Research Institute for Innovative MedicineAjou University Medical CenterSuwonKorea Department of Gastroenterology Ajou University School of MedicineSuwonKorea

Background: Hepatic epithelioid hemangioendothelioma (HEH) is a rare tumor of vascular origin with an unknown etiology, a low incidence, and a variable natural course. We evaluated the management and prognosis of HEH from the Surveillance, Epidemiology and End Results (SEER) program and changes in treatment modalities of HEH over 30 years. Methods: From 1973 to 2014 in the SEER database, we selected patients diagnosed with HEH. We analyzed the clinical characteristics, patterns of management, and clinical outcomes of patients with HEH. Results: We identi ed 79 patients with HEH (median age: 54.0 years;male to female ratio: 1:2.6). The initial extent of disease was local in 22 (27.8%) patients, regional metastasis in 22 (27.8%), distant metas-tasis in 31 (39.2%) and unknown in 4 (5.1%). The median size of primary tumor was 3.85 cm (interquartile range, 2.50 7.93 cm). Among 74 patients with available management data, the most common manage-ment was no treatment (29/74, 39.2%), followed by chemotherapy only (22/74, 29.7%), liver resection-based (13/74, 17.6%), and transplantation-based therapy (6/74, 8.1%). The 5-year cancer-speci c survival rate was 57.8%. Patients who underwent surgical treatment had signi cantly higher survival than those who underwent non-surgical treatment (5-year survival;88% vs. 49%, P=0.019). Multivariate analysis revealed that surgical therapy was the only independent prognostic factor for survival (hazard ratio: 0.20, P=0.040). Conclusions: Resection or liver transplantation is worth considering for treatment of patients with HEH.

关键词： Hemangioendothelioma Epithelioid SEER program Liver transplantation Hepatectomy Liver neoplasms

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Impact of guideline adherence on the prognosis of Barcelona clinic liver cancer stage B hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第47期29卷 6122-6137页

作者： Ji Eun Han Hyo Jung Cho jae youn cheong Sun Gyo Lim Min jae Yang Choong-Kyun Noh Gil Ho Lee Soon Sun Kim Department of Gastroenterology Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BACKGROUND Patients with Barcelona clinic liver cancer(BCLC)stage B hepatocellular carcinoma(HCC)are considerably heterogeneous in terms of tumor burden,liver function,and performance *** improve the poor survival outcomes of these patients,treatment approaches other than transarterial chemoembolization(TACE),which is recommended by HCC guidelines,have been adopted in realworld clinical *** hypothesize that this non-adherence to treatment guidelines,particularly with respect to the use of liver resection,improves survival in patients with stage B *** To assess guideline adherence in South Korean patients with stage B HCC and study its impact on *** A retrospective analysis was conducted using data from 2008 to 2016 obtained from the Korea Central Cancer *** with stage B HCC were categorized into three treatment groups,guideline-adherent,upward,and downward,based on HCC guidelines recommended by the Asian Pacific Association for the Study of the Liver(APASL),the European Association for the Study of the Liver(EASL),and the American Association for the Study of Liver Diseases(AASLD).The primary outcome was HCC-related deaths;tumor recurrence served as the secondary *** among the groups was compared using the Kaplan-Meier method and the log-rank *** of survival outcomes were identified using multivariable Cox regression *** In South Korea, over the study period from 2008 to 2016, a notable trend was observed in adherence to HCCguidelines. Adherence to the EASL guidelines started relatively high, ranging from 77% to 80% between 2008 and2012, but it gradually declined to 58.8% to 71.6% from 2013 to 2016. Adherence to the AASLD guidelines began at71.7% to 75.9% from 2008 to 2010, and then it fluctuated between 49.2% and 73.8% from 2011 to 2016. In contrast,adherence to the APASL guidelines remained consistently high, staying within the range of 90.14% to 94.5%throughout the entire study per

关键词： Hepatocellular carcinoma Barcelona clinic liver cancer stage B Guideline adherence Liver neoplasms Transarterial chemoembolization Liver resection

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Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib

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Cancer Communications 2023年第4期43卷 455-479页

作者： JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho jae youn cheong Department of Gastroenterology Ajou University School of MedicineSuwonSouth Korea Department of Pathology College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedical Sciences AjouUniversity Graduate School of MedicineSuwonSouth Korea Department of Pathology Ajou University School of MedicineSuwonSouth Korea Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea The Moagen IncDaejeonSouth Korea

Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of *** study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to *** then performed in vitro and in vivo experiments to validate selected targets and related *** associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression ***:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI ***1 inhibitors reversed CAF-induced TKI resistance in vitro and in ***-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI ***:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT *** inhibition represents a promising therapeutic strategy against TKI resistance ***,plasma SPP1 level before TKI treatment represents a potential biomar

关键词： drug resistance epithelial-to-mesenchymal transition hepatocellular carcinoma secreted phosphoprotein 1

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Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women

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World Journal of Gastroenterology 2005年第34期11卷 5314-5321页

作者： Hyeon Chang Kim Sung Hee Choi Hae Won Shin jae youn cheong Kwan Woo Lee Hyun Chul Lee Kap Bum Huh Dae Jung Kim Department of Preventive Medicine Yonsei University College of Medicine Seoul South Korea Department of Internal Medicine Seoul National University College of Medicine Seongnam South Korea Department of Public Health Graduate School of Yonsei University Seoul South Korea Department of Gastroenterology Ajou University School of Medicine Suwon South Korea Department of Endocrinology and Metabolism Ajou University School of Medicine Suwon South Korea Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea Huh's Diabetes Center and the 21~(st) Century Diabetes and Vascular Research Institute Seoul South Korea

AIM：To evaluate the association between the severity of liver steatosis and metabolic syndrome in apparently healthy Korean adults. METHODS： We examined 1022 men and women, aged 30-79 years, who participated in a health screening test. A standard interview, anthropometrics, biochemical studies, and abdominal ultrasonography were conducted for each participant. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel Ⅲ, with a modification for the waist circumference cut-off level. The severity of liver steatosis was evaluated using liver ultrasonography, and serum aspartate aminotransferase（AST）, alanine aminotransferase （ALT）, and γ-glutamyl transferase （γ-GT） levels were determined. RESULTS： Ultrasonographic liver steatosis was strongly associated with metabolic syndrome and common metabolic abnormalities. Compared with people without steatosis, people with mild, moderate, and severe steatosis had adjusted odds ratios for metabolic syndrome of 2.72 （95% CI, 1.01-2.94）, 2.89 （1.75-4.76） and 3.53 （1.25-9.98） in men, and 2.86 （1.64-5.01）, 3.19 （1.80-5.65） and 3.70 （0.82-16.73） in women, respectively. The serum AST level was not associated with metabolic syndrome. The serum ALT and γ-GT levels were significantly associated with metabolic syndrome in men but not in women.CONCLUSION： The occurrence of metabolic syndrome shows a stronger association with the severity of ultrasonographic steatosis than with the serum liver enzyme levels. The degree of fatty infiltration detected on ultrasonography can be used as an indicator of liver dysfunction attributable to metabolic abnormalities.

关键词： Metabolic syndrome Liver steatosis Nonalcoholic fatty liver disease Ultrasonography

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Decomposition kinetics of dimethyl methylphospate(chemical agent simulant) by supercritical water oxidation

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Journal of Environmental Sciences 2006年第1期18卷 13-16页

作者： Bambang VERIANSYAH jae-Duck KIM youn-Woo LEE Supercritical Fluid Research Laboratory Korea Institute of Science and Technology(KIST) 39-1 Hawolgok-dong Seoungbuk-gu Seoul 136-791 Korea. School of Chemical and Biological Engineering Seoul National University(SNU) San 56-1 Sillim-dong Gwanak-gu Seoul 151-744 Korea

Supercritical water oxidation （SCWO） has been drawing much attention due to effectively destroy a large variety of high-risk wastes resulting from munitions demilitarization and complex industrial chemical. An important design consideration in the development of supercritical water oxidation is the information of decomposition rate. In this paper, the decomposition rate of dimethyl methylphosphonate（DMMP）, which is similar to the nerve agent VX and GB（Sarin） in its structure, was investigated under SCWO conditions. The experiments were performed in an isothermal tubular reactor with a H2O2 as an oxidant. The reaction temperatures were ranged from 398 to 633℃ at a fixed pressure of 24 MPa. The conversion of DMMP was monitored by analyzing total organic carbon （TOC） on the liquid effluent samples. It is found that the oxidative decomposition of DMMP proceeded rapidly and a high TOC decomposition up to 99.99% was obtained within 11 s at 555℃. On the basis of data derived from experiments, a global kinetic equation for the decomposition of DMMP was developed. The model predictions agreed well with the experimental data.

关键词： supercritical water oxidation kinetics chemical agent DMMP

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Improvement of uniformity in cultivation environment and crop growth rate by hybrid control of air flow devices

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Journal of Central South University 2015年第12期22卷 4702-4708页

作者： BAEK Min-Seon KWON Sook-youn LIM jae-Hyun Department of Computer Science and Engineering Kongju National University Green Energy Technology Research Center Kongju National University

A complete control type plant factory has high efficiency in terms of cultivation area by constructing vertical multiple layered cultivation ***,it has a problem of irregular crop growth due to temperature deviation at upper and lower beds and increases in energy consumption by a prolonged cultivation *** this work,air flow rate inside a facility was improved by a hybrid control of air flow devices like air conditioning and air circulation fan with an established wireless sensor network to minimize temperature deviations between upper and lower beds and to promote crop *** performance of proposed system was verified with an experimental environment or Case A wherein air conditioning device was operated without a control algorithm and Case B wherein air conditioning and circulation fans were alternatively operated based on the hybrid control *** planting leafy vegetables under each experimental condition,crops were cultivated for 21 *** a result,Case B wherein AC(air conditioning) and ACF(air-circulation fan) were alternatively operated based on the hybrid control algorithm showed that fresh mass,number of leaves,and leaf length for the crops grown were increased by 40.6%,41.1%,and 11.1%,respectively,compared to Case A.

关键词： air flow devices hybrid control cultivation environment uniformity growth rate

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Improvement of light uniformity by lighting arrangement for standardized crop production

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Journal of Central South University 2014年第11期21卷 4311-4319页

作者： Lee Hwa-Soo Kwon Sook-youn Lim jae-Hyun Department of Computer Science and Engineering Kongju National UniversityCheonan 331-717 Korea

In a commercialized, fully artificial plant factory, artificial luminaire is arranged in a unified way using a general illumination theory, an actual measurement, or an empirical methodology. However, with these methods, lightings are implemented without considering specific optical characteristics of lighting or material characteristics of each component that constructs a cultivation system, resulting in an amount of light that becomes irregular. The amount of lighting is closely related with the growth and quality of crops, and the deviation between points where cultivated crops are located causes quality difference in the produced crops, thus impairing the economic feasibility of a plant factory. In this regard, a simulation to figure out an optimum lighting layout was performed. Arrangements based on the spectrum distribution of light source and reflector materials were implemented to ascertain the distance between lighting and height of lighting and gather information in the pre-treatment process to improve the uniformity of light in the plant cultivation system. Improvement of around 15% in light uniformity is achieved compared with the existing system after the simulation is carried out. This result would reduce the deviation in crop growth to make uniform quality crop production possible.

关键词： high-quality crop light uniformity improvement optimal lighting layout fully artificial plant factory Relux simulation

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Intercellular communications and metabolic reprogramming as new predictive markers for immunotherapy responses in gastric cancer

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Cancer Communications 2022年第6期42卷 572-575页

作者： Ji-Yong Sung jae-Ho cheong Department of Laboratory Medicine Yonsei University College of MedicineSeoul 03722Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Korea Yonsei Biomedical Research Institute Yonsei University College of MedicineSeoul 03722Korea Department of Biochemistry&Molecular Biology Yonsei University College of MedicineSeoul 03722Korea

Dear Editor,Immune-directed therapeutic approaches have changed the paradigm of cancer *** tumor-immune microenvironment[1]is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxygen,nutrient deficiency,acidity,and interactions between multiple cell *** particular,immune cells in the tumor microenvironment are vulnerable to cellular dysfunctions(because of metabolic reprogramming[2])and engage in intercellular communications with neighboring cells.

关键词： cancer programming immunotherapy

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Endoscopic removal of gastric ectopic pancreas:An initial experience with endoscopic submucosal dissection

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World Journal of Gastroenterology 2010年第36期16卷 4589-4593页

作者： Dong Yup Ryu Gwang Ha Kim Do youn Park Bong Eun Lee jae Hoon cheong Dong Uk Kim Hyun young Woo Jeong Heo Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Medical Research InstitutePusan National University HospitalBusan 602-739South Korea Department of Pathology Pusan National University School of MedicineBusan 602-739South Korea

AIM:To evaluate the therapeutic usefulness and safety of endoscopic resection in patients with gastric ectopic ***:A total of eight patients with ectopic pancreas were *** of them underwent endoscopic ultrasonography before endoscopic ***-scopic resection was performed by two methods:endo-scopic mucosal resection(EMR)by the injection-and-cut technique or endoscopic mucosal dissection(ESD).RESULTS:We planned to perform EMR in all eight cases but EMR was successful in only four *** the other four cases,saline spread into surrounding normal tissues and the lesions becameattened,which made it impossible to remove them by *** four cases,we performed ESD and removed the lesions without any ***:If conventional EMR is difficult to remove gastric ectopic pancreas,ESD is a feasible alternative method for successful removal.

关键词： Ectopic pancreas Endoscopic resection Endoscopic ultrasonography

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Lithospheric thinning and ignition of a Cordilleran magmatic flare-up:Geochemical and O-Hf isotopic constraints from Cretaceous plutons in southern Korea

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Geoscience Frontiers 2023年第1期14卷 327-345页

作者： Albert Chang-sik cheong Min-Ji Jung Hui JeJo Jeongmin Kim Shinae Lee youn-Joong Jeong Korea Basic Science Institute Ochang Center Cheongju 28119Republic of Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 34134Republic of Korea Korea Institute of Geoscience and Mineral Resources Daejeon 34132Republic of Korea

Northeast Asian continental margins contain the products of magma emplacement driven by prolonged subduction of the(paleo-)Pacific *** observed in many Cordilleran arcs,magmatic evolution in this area was punctuated by high-volume pulses amid background *** present study investigates the early evolution of the Cretaceous magmatic flare-up using new and published geochronological,geochemical,and O-Hf isotope data from plutonic rocks in the southern Korean *** a long(~50 m.y.)magmatic hiatus and the development of the Honam Shear Zone through flat-slab subduction,the Cretaceous flare-up began with the intrusion of monzonites,granodiorites,and granites in the inboard Gyeonggi Massif and the intervening Okcheon *** to Jurassic granitoids formed during the former flare-up,Albian(~111 Ma)monzonites found in the Eopyeong area of the Okcheon Belt have distinctly higher zirconε_(Hf)(t)(-7.5±1.3)andδ^(18)O(7.78‰±0.25‰)values and lower wholerock La/Yb and Sr/Y *** voluminous coeval granodiorite and granite plutons in the Gyeonggi Massif are further reduced in Sr/Y and to a lesser extent,in La/Yb,and have higher zirconε_(Hf)(t)values(-13 to-19)than the Precambrian basement(ca.-30).These chemical and isotopic features indicate that Early Cretaceous lithospheric thinning,most likely resulting from delamination of tectonically and magmatically overthickened lithospheric keel that was metasomatized during prior subduction episodes,and consequent asthenospheric upwelling played vital roles in igniting the magmatic *** O-Hf isotopic ranges of synmagmatic zircons from the Albian plutons and their Paleoproterozoic and Jurassic inheritance attest to the involvement of lithospheric mantle and crustal basement in magma generation during this decratonization *** magmatism then migrated trenchward and culminated in the Late Cretaceous,yielding widespread granitoid rocks emplaced at shallow crustal *** early Late Cretaceous(94-8

关键词： Cordilleran arc Cretaceous flare-up Korean Peninsula Lithospheric thinning Crustal rejuvenation

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