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Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type

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World Journal of Gastroenterology 2008年第37期14卷 5723-5729页

作者： jae Hyuck Chang Jong Young Choi hyun Young Woo Jung hyun Kwon Chan Ran You Si hyun Bae Seung Kew Yoon Myung-Gyu Choi In-Sik Chung Dong Goo Kim Department of Internal Medicine College of Medicine the Catholic University of Korea505 Banpo-Dong Seocho-Gu Seoul 137-040 Korea Department of Surgery College of Medicine the Catholic University of Korea505 Banpo-Dong Seocho-Gu Seoul 137-040 Korea

AIM： To compare the recovery of thrombocytopenia and splenomegaly during long-term follow-up after liver transplantation in patients receiving a living donor transplant or a cadaveric donor transplant. METHODS： This was a retrospective cohort study of 216 consecutive liver transplant patients who survived for 〉 6 mo after transplantation; 169 received a liver transplant from a living donor and 47 from a cadaveric donor. The platelet counts or spleen volumes were examined before transplant, i, 6, and 12 mo after transplant, and then annually until 5 years after transplant. RESULTS： The mean follow-up period was 49 mo （range, 21-66）. Platelet counts increased continuously for 5 years after orthotopic liver transplant. The restoration of platelet counts after transplant was significantly slower in patients with severe pretransplant thrombocytopenia （〈 50000/μL） until 4 years after transplant （P = 0.005）. Donor type did not significantlyaffect the recovery of platelet count and spleen volume in either patient group. In multivariate analysis, pretransplant severe thrombocytopenia （〈 50000/μL） was an independent factor associated with sustained thrombocytopenia （P 〈 0.001, odds ratio 6.314; confidence interval, 2.828-14.095）. Thrombocytopenia reappeared after transplant in seven patients with portal flow disturbance near the anastomosis site. CONCLUSION： Our study suggests that severe thrombocytopenia before transplant is closely associated with delayed recovery of platelet count after transplant and donor type did not affect the recovery of thrombocytopenia. The reappearance of thrombocytopenia after transplant should be considered a possible indicator of flow disturbance in the portal vein.

关键词： Liver transplantation Thrombocytopenia Splenomegaly Hypersplenism

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Synchronous quintuple primary gastrointestinal tract malignancies: Case report

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World Journal of Gastroenterology 2017年第1期23卷 173-177页

作者： Soo-Hong Kim Byung-Soo Park hyun Sung Kim jae Hun Kim Department of Surgery Pusan National University Yangsan Hospital Department of Surgery Pusan National University Hospital

Multiple primary malignancy is defined as two or more malignancies detected in an individual person. In particular, synchronous quintuple primary malignancy is extremely rare. A 52-year-old male with anal pain and intermittent blood-tinged stool was diagnosed with malignancies in the stomach, jejunum, ascending colon, transverse colon and rectum. He underwent a subtotal gastrectomy, segmental resection of the jejunum and total protocolectomy with end ileostomy. The postoperative pathologic findings were moderate differentiated gastric adenocarcinoma (pT1bN0M0, pStageIA), combined adenocarcinoma and neuroendocrine carcinoma of the jejunum (pT3N0M0, pStageIIA), three mucinous adenocarcinoma of the ascending colon (pT3N0M0, pStageIIA), transverse colon (pT1N0M0, pStageI) and rectum (pT3N1aM0, pStageIIIB). The tumors did not lack MLH-1 and MSH-2 expression, as the markers (bat26, D5S346, bat25, D2S123) suggest MSI-H presence. Adjuvant chemoradiotherapy was started according to regimen, FOLFOX 4 for advanced rectal cancer. Six years post-operation, the patient is currently attending regular follow-ups without recurrence or metastasis.

关键词： Small bowel neoplasm Stomach neoplasm Synchronous quintuple primary cancer Colon neoplasm

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New Diarylheptanoid from the Barks of Alnus japonica Steudel

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Chinese Chemical Letters 2005年第10期16卷 1337-1340页

作者： hyun Jung KIM Kwang Ho KIM Seung Hwan YEOM Min Kee KIM jae Geul SHIM hyun Woo LIM Min Won LEE College of Pharmacy Chung Ang Univ. Seoul 156-756 KoreaKwang Ho KIMCollege of Pharmacy Chung Ang Univ. Seoul 156-756 KoreaKwang Ho KIMCollege of Pharmacy Chung Ang Univ. Seoul 156-756 KoreaKwang Ho KIMCollege of Pharmacy Chung Ang Univ. Seoul 156-756 KoreaKwang Ho KIMCollege of Pharmacy Chung Ang Univ. Seoul 156-756 KoreaKwang Ho KIMCollege of Pharmacy Chung Ang Univ. Seoul 156-756 KoreaKwang Ho KIMCollege of Pharmacy Chung Ang Univ. Seoul 156-756 KoreaKwang Ho KIM

A new diarylheptanoid glycoside, 1,7-bis-（3,4-dihydroxyphenyl）-5-hydroxyheptane- 3-O-β-D-xylopyranoside （1）, together with nine known diarylheptanoids （2-10） were isolated from the fresh bark of Alnus japonica ... 详细信息

关键词： Alnus japonica Betulaceae diarylheptanoid.

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White luminescence of Ho^(3+)/Tm^(3+)/Yb^(3+)-codoped CaWO_4 synthesized via citrate complex route assisted by microwave irradiation

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 134-140页

作者： hyun CHO seok Min HWANG jae Bin LEE Dong hyun KA Tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong Ho RYU Department of Nanomechatronics Engineering Pusan National University50 Cheonghak-ri Miryang Gyeongnam 627-706 Korea Department of Materials Science and Engineering Korea National University of Transportation Chungju Chungbuk 380-702 Korea

The nanocrystalline Ho3+/Tm3+/Yb3+ co-doped CaWO4 upconversion(UC) phosphors were successfully synthesized by a modified citrate complex method using microwave irradiation. The citrate complex precursors were heat-treated at temperature ranging from 300 to 700 °C for 3 h. Crystallization of the Ho3+/Tm3+/Yb3+ co-doped CaWO4 was detected at 400 °C, and entirely completed at 600 °C. The Ho3+/Tm3+/Yb3+ co-doped CaWO4 heat-treated at 600 °C showed primarily spherical and homogeneous morphology. Under the laser excitation of 980 nm, Ho3+/Tm3+/Yb3+ co-doped CaWO4 shows the bright white upconversion(UC) emission visible to the naked eye, which is composed of a blue emission at 475 nm from Tm3+, and green and red emissions at 543 and 651 nm respectively from Ho3+. The coordinates of Ho3+/Tm3+/Yb3+ co-doped CaWO4 in the Commission International De'eclairage(CIE) chromaticity diagram could be controlled from a cool to a warm white color depending on the Tm3+ and Ho3+ concentrations. The UC luminescent properties on Tm3+ and Ho3+ concentrations and related mechanism based on laser pump power were discussed in detail.

关键词： upconversion CaWO4 microwave irradiation white luminescence

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Tailoring uniform γ-MnO2 nanosheets on highly conductive three-dimensional current collectors for high-performance supercapacitor electrodes

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Nano Research 2015年第3期8卷 990-1004页

作者： Sangbaek Park hyun-Woo Shim Chan Woo Lee Hee Jo Song Ik jae Park jae-Chan Kim Kug Sun Hong Dong-Wan Kim Department of Materials Science and Engineering Seoul National University Seou1151-744 R. O. Korea School of Civil Environmental and Architectural Engineering Korea University Seou1136-713 R. O. Korea

Recent efforts have focused on the fabrication and application of three- dimensional （3-D） nanoarchitecture electrodes, which can exhibit excellent electrochemical performance. Herein, a novel strategy towards the design and synthesis of size- and thickness-tunable two-dimensional （2-D） MnO2 nanosheets on highly conductive one-dimensional （l-D） backbone arrays has been developed via a facile, one-step enhanced chemical bath deposition （ECBD） method at a low temperature （-50 ℃）. Inclusion of an oxidizing agent, BrO3-, in the solution was crucial in controlling the heterogeneous nucleation and growth of the nanosheets, and in inducing the formation of the tailored and uniformly arranged nanosheet arrays. We fabricated supercapacitor devices based on 3-D MnO2 nanosheets with conductive Sb-doped SnO2 nanobelts as the backbone. They achieved a specific capacitance of 162 F·g-1 at an extremely high current density of 20 A·g% and good cycling stability that shows a capacitance retention of -92% of its initial value, along with a coulombic efficiency of almost 100% after 5,000 cycles in an aqueous solution of I M Na2SO4. The results were attributed to the unique hierarchical structures, which provided a short diffusion path of electrolyte ions by means of the 2-D sheets and direct electrical connections to the current collector by 1-D arrays as well as the prevention of aggregation by virtue of the well-aligned 3-D structure.

关键词： nanosheets manganese oxide chemical bath deposition SnO2 nanobelts supercapacitor

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Memory-centric neuromorphic computing for unstructured data processing

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Nano Research 2021年第9期14卷 3126-3142页

作者： Sang hyun Sung Tae Jin Kim Hera Shin Hoon Namkung Tae Hong Im Hee Seung Wang Keon jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

The unstructured data such as visual information,natural language,and human behaviors opens up a wide array of opportunities in the field of artificial intelligence(Al).The memory-centric neuromorphic computing(MNC)has been proposed for the efficient processing of unstructured data,bypassing the von Neumann bottleneck of current computing *** development of MNC would provide massively parallel processing of unstructured data,realizing the cognitive Al in edge and wearable *** this review,recent advances in memory-centric neuromorphic devices are discussed in terms of emerging nonvolatile memories,volatile switches,synaptic plasticity,neuronal models,and memristive neural network.

关键词： neuromorphic computing memory-centric memristor artificial synapses artificial neurons memristive neural network

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Case of inappropriate ADH syndrome:Hyponatremia due to polyethylene glycol bowel preparation

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World Journal of Gastroenterology 2014年第34期20卷 12350-12354页

作者： Sun-Hye Ko Chul-hyun Lim jae-Young Kim Seung Hun Kang Myong Ki Baeg hyun Jin Oh Division of Endocrinology and Metabolism Department of Internal MedicineCollege of MedicineThe Catholic UniversitySeoul 137-701South Korea Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Colonoscopic screening has been reported to reduce deaths from colorectal *** bowel preparation is essential for this and safety is an important issue in choosing the *** glycol(PEG)is regarded as a safe method for cleansing,especially compared with oral sodium ***,we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone(ADH)syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures.A 62-year-old women had ingested PEG for precolonoscopic bowel *** waiting for the colonoscopy,she developed a stuporous mentality and generalized tonic-clonic seizures,which did not correlate with brain magnetic resonance *** serum sodium level was 113 mEq per liter and laboratory analyses were consistent with inappropriate ADH *** thyroid and adrenal functions were *** were no malignancies,infections,respiratory disorders or central nervous disorders and she had no history of taking either diuretics or other medications,which might have caused inappropriate ADH *** was treated with 3%hypertonic saline and showed a complete neurological recovery as her sodium levels ***-up visits showed the patient to have a normal sodium level without neurologic *** case shows that inappropriate ADH syndrome can be caused by PEG preparation,which implies that physicians have to be aware of the possible side effects of this colonic cleansing approach and mindful of the possible ensuing symptoms.

关键词： Inappropriate antidiuretic hormone syndrome Colonoscopy Polyethyelene glycol Hyponatremia Seizure

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Seroepidemiology of echovirus 30 in Korean children

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World Journal of Pediatrics 2017年第6期13卷 611-614页

作者： Joo Young Lee Yumi seo Ui Yoon Choi Jong-hyun Kim Jin Han Kang Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type *** current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus ***:Two hundred and fifty residual serum samples were collected at ***'s *** were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were ***:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) *** rates were 23%,48%,55% and 73% in groups 1-4,*** antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and *** the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,***:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age *** findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years *** 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.

关键词： echovirus 30 Korea seroepidemiology

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Removal of press-through-packs impacted in the upper esophagus using an overtube

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World Journal of Gastroenterology 2006年第36期12卷 5909-5912页

作者： Yeon seok seo Jong-jae Park Ji Hoon Kim Jin Yong Kim Jong Eun Yeon jae seon Kim Kwan Soo Byun Young-Tae Bak Department of Internal Medicine Korea University Medical Center Guro Hospital Seoul Korea Department of Internal Medicine Sungkyunkwan University School of Medicine Seoul Korea

Foreign bodies in the upper esophagus should be re-moved as soon as possible to avoid serious complica-tions. However, removals of foreign bodies in the upper esophagus are very difficult, especially if they have sharp edges, such as press-through-packs (PTPs). We expe-rienced four cases of the impacted PTPs in the upper esophagus which was successfully extracted endoscopi-cally with the overtube. Because two edges of PTPs were so firmly impacted in the esophageal wall in all cases, the PTPs were not movable in the upper esophagus. However, after insertion of the overtube, PTPs became movable and were successfully extracted and no serious complications occurred after extraction of PTPs. In one case, insertion of the overtube rapidly expanded the up-per esophagus and PTP progressed to the gastric cavity and it could be extracted with the endoscopic protector hood. The endoscopic removal with the overtube was a simple, safe and effective technique for the removal of the impacted PTPs in upper esophagus.

关键词： Esophagus Foreign body Endoscopy

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Effects of lysophosphatidic acid on human periodontal ligament stem cells from teeth extracted from dental patients

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The Journal of Biomedical Research 2019年第2期33卷 122-130页

作者： Byung Cheol Kim jae-In Song Kyoung-Ha So Sang-Hwan hyun Laboratory of Veterinary Embryology and Biotechnology Veterinary Medical Center and College of Veterinary MedicineChungbuk National University Institute of Stem Cell & Regenerative Medicine Chungbuk National University

Despite their potential applications in future regenerative medicine, periodontal ligament stem cells(PDLSCs) are difficult to obtain in large amounts from patients. Therefore, maintaining sternness while expanding the cell numbers for medical use is the key to transitioning PDLSCs from the bench to the clinic. Lysophosphatidic acid(LPA), which is present in the human body and saliva, is a signaling molecule derived from phospholipids. In this study, we examined the effects of LPA on sternness maintenance in human PDLSCs. Several spindle-shaped and fibroblast-like periodontal ligament stem-like cell lines were established from PDLSC isolation. Among these cell lines, the most morphologically appropriate cell line was characterized. The expression levels of OCT4, NANOG(a stem cell marker), and CD90(a mesenchymal stem cell marker) were high. However, CD73(a negative marker of mesenchymal stem cells) expression was not observed. Notably, immunofluorescence analysis identified the expression of STRO-1, CD146(a mesenchymal stem cell marker), and sex determining region Y-box 2 at the protein level. In addition, lipid droplets were stained by Oil red O after the induction of adipogenesis for 21 days, and mineralized nodules were stained by Alizarin Red S after the induction of osteogenesis for 14 days. Alkaline phosphate staining also demonstrated the occurrence of osteogenesis. In summary, we established a human PDLSC line, which could be applied as a cell source for tissue regeneration in dental patients. However, further studies are needed to determine the detailed effects of LPA on PDLSCs.

关键词： periodontal ligament stem cell lysophosphatidic acid stemness primary cell culture

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