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Unilateral versus bilateral Y-type stent-in-stent metal stent insertions in inoperable malignant hilar biliary strictures:A multicenter retrospective study

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 561-567页

作者： Ik hyun Jo Chang-Nyol Paik Dae Bum Kim jaesin Lee Jong Yul Lee jae Hyuck Chang Kyu-hyun Paik Won-Suk Park Department of Internal Medicine College of MedicineSt.Vincent’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineIncheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineBucheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineDaejeon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea

Background:To date,there is controversy regarding unilateral versus bilateral stent placement in patients with malignant hilar biliary strictures(MHBSs).The aim of this study was to compare the clinical outcomes and complications of unilateral and bilateral(stent-in-stent method)stent placements for these ***:We conducted a multicenter retrospective analysis of patients with inoperable MHBS who underwent endoscopic self-expandable metal stent(SEMS)placement from January 2009 to December *** groups classified according to the stent procedure method were compared for demographic,procedural,and postprocedure *** analysis for patency loss and overall survival was also ***:A total of 236 subjects were included.A superior technical success rate was found in the unilateral stent group(98.8%vs.82.5%,P<0.001),whereas the clinical success rate was higher in the bilateral group(85.7%vs.70.5%,P=0.028).There was no significant difference with respect to complications or patency loss,and the bilateral group had better overall survival(P<0.01).In the Cox proportional hazard model,MHBSs from lymph node compression were associated with a higher risk of death(HR=9.803,P=0.003).In contrast,bilateral SEMS insertion showed reduced postprocedural mortality(HR=0.316,P=0.001).Conclusions:Y-type stent-in-stent bilateral SEMSs are technically difficult but demonstrated more favorable overall survival for palliative bile drainage of inoperable MHBS patients compared to unilateral insertions.

关键词： Cholestasis Extrahepatic neoplasm Cholangiopancreatography Endoscopy Self-expandable metal stents

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Antimelanogenic effects of Inula britannica flower petal extract fermented by Lactobacillus plantarum KCCM 11613P

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 816-824页

作者： Eun-hye PARK Won-young BAE jae-yeon KIM Kee-tae KIM hyun-dong PAIK Department of Food Science and Biotechnology of Animal Resources Konkuk University Bio/Molecular Informatics Center Konkuk University

The inhibitory effects of Lactobacillus plantarum-fermented and non-fermented Inula britannica extracts on the tyrosinase activity were comparatively investigated to examine whether and how they improve the whitening activity, and the contents of total flavonoids and polyphenolics as bioactive compounds were determined. The skin whitening activity using in vitro or ex vivo tyrosinase and L-3,4-dihydroxyphenylalanine(L-DOPA) staining was examined. The total flavonoid content(TFC) was increased by 13.4% after 72h-fermentation. The viabilities of the B16F10 cells treated with the fermented and non-fermented control extracts were 100.26% and 92.15% at 500μg/ml, respectively. In addition, the inhibition of tyrosinase activity was increased by the fermented samples from 29.33% to 41.74% following fermentation for up to 72h. The tyrosinase activity of the untreated control group was increased to 145.69% in B16F10 cells. The results showed that I. britannica fermented by L. plantarum dose-dependently inhibited tyrosinase activity, which was stimulated by α-melanocyte stimulating hormone. These results suggest that lactic fermented I. britannica extracts can be used as effective skin-whitening materials.

关键词： Inula britannica Flavonoid Lactobacillus plantarum Antioxidant Tyrosinase inhibitor

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Presence of CCK-A, B receptors and effect of gastrin and cholecystokinin on growth of pancreatobiliary cancer cell lines

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World Journal of Gastroenterology 2005年第6期11卷 803-809页

作者： Jin-Young Jang Sun-Whe Kim Ja-Lok Ku Yong-hyun Park jae-Gahb Park Department of Surgery

AIM: To investigate the effects of gastrin and cholecystokinin (CCK) and their specific antagonists on the growth of pancreatic and biliary tract cancer cell lines. METHODS: Five pancreatic and 6 biliary cancer cell lines with 2 conrtol cells were used in this study. Cell proliferation study was done using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) test and direct cell count method. Reverse transcription-polymerase chain reaction (RT-PCR) and slot blot hybridization were performed to examine and quantify the expression of hormonal receptors in these cell lines. RESULTS: SNU-308 showed a growth stimulating effect by gastrin-17, as did SNU-478 by both gastrin-17 and CCK-8. The trophic effect of these two hormones was completely blocked by specific antagonists (L-365, 260 for gastrin and L-364, 718 for CCK). Other cell lines did not respond to gastrin or CCK. In RT-PCR, the presence of CCK-A receptor and CCK-B/gastrin receptor mRNA was detected in all biliary and pancreatic cancer cell lines. In slot blot hybridization, compared to the cell lines which did not respond to hormones, those that responded to hormones showed high expression of receptor mRNA. CONCLUSION: Gastrin and CCK exert a trophic action on some of the biliary tract cancers.

关键词： Bile duct cancer Gallbladder cancer Pancreatic cancer Gastrin Cholecystokinin

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Nanostructured hafnium-doped strontium oxide film for homeotropic/homogeneous convertible liquid crystal alignment depending on the curing temperature

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International Journal of Smart and Nano Materials 2022年第4期13卷 597-611页

作者： Dong hyun Kim Dong Wook Lee Jin Young Oh Jonghoon Won Hae-Chang Jeong Dae-Shik seo IT Nano Electronic Device Laboratory Department of Electrical and Electronic EngineeringYonsei UniversitySeoulRepublic of Korea Department of Smart Manufacturing Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea Department of Electrical Electronic and Control Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea

A hafnium strontium oxide(HfSrO)liquid crystal(LC)alignment film was efficiently created through brush coating,and its ability to change the LC alignment direction was confirmed.A brush was applied to HfSrO sol coated on an indium-tin oxide substrate,after which the coating was solidified at var-ious curing *** was confirmed that a directional micro/nanostructure was formed above 280°C due to the shear stresses caused by the movement of the brush *** chemical changes were analyzed by using X-ray photoelectron spectroscopy and contact angle *** the curing temperature increased,the prevalence of oxygen bonds increased and the contact angle decreased,thereby increasing the surface *** anisotropic boundary of the micro-grooves and the van der Waals forces due to an increase in surface energy changed the alignment direction of LC mole-cules from vertical to horizontal,as verified through polarized optical microscopy and pretilt angle ***,the efficiency of the brush-coating method,which dramatically simplifies the LC alignment film process,was *** homeotropic/homogeneous LC alignment property of the HfSrO film produced through brush coating depending on the curing temperature provides an innovative approach for LC alignment.

关键词： Brush coating nanostructure solution process liquid crystal alignment

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Improved MIMO Signal Detection Based on DNN in MIMO-OFDM System

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Computers, Materials & Continua 2022年第2期70卷 3625-3636页

作者： jae-hyun Ro Jong-Gyu Ha Woon-Sang Lee Young-Hwan You Hyoung-Kyu Song Department of Convergence Engineering for Intelligent Drone Sejong UniversitySeoul05006Korea Department of Information and Communication Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea Department of Computer Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea

This paper proposes the multiple-input multiple-output(MIMO)detection scheme by using the deep neural network(DNN)based ensemble machine learning for higher error performance in wireless communication *** the MIMO detection based on the ensemble machine learning,all learning models for the DNN are generated in offline and the detection is performed in online by using already learned *** the offline learning,the received signals and channel coefficients are set to input data,and the labels which correspond to transmit symbols are set to output *** the online learning,the perfectly learned models are used for signal detection where the models have fixed bias and *** performance improvement,the proposed scheme uses the majority vote and the maximum probability as the methods of the model combinations for obtaining diversity gains at the MIMO *** simulation results show that the proposed scheme has improved symbol error rate(SER)performance without additional receive antennas.

关键词： MIMO DNN ensemble machine learning ML

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Mechanical characteristics of tensile strength ratio method compared to other parameters used for moisture susceptibility evaluation of asphalt mixtures

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 621-630页

作者： Thanh Chung Do Van Phuc Tran Van Phuc Le hyun Jong Lee Won jae Kim Department of Civil and Environmental Engineering Sejong UniversitySeoul 143-747South Korea Faculty of Civil Engineering University of Transport and CommunicationsHo Chi Minh CityVietnam

In this study,mechanical characteristics of tensile strength ratio(TSR)were evaluated by comparing it to other methods in evaluating moisture sensitivity of asphalt *** types of asphalt mixtures with and without anti-stripping additives were prepared and tested in the *** compressive strength(UCS)and indirect tensile(IDT)testing were conducted to determine the mixture’s tensile strength ratio and cohesion ratio(CR).Determining TSR alone was found to be insufficient when evaluating moisture *** is a need to consider both TSR and wet IDT strength to properly evaluate moisture behavior of asphalt ***,it was found that the cohesion and the IDT strength have a good relation in which the minimum condition of the slope,must be ***,it was observed thatβvalues change depending on material type and ***,there is a need to evaluate theseβvalues for varying material and testing *** addition,it was found that the TSR and CR results are highly correlated with an average difference of 1.5%.Furthermore,other tests such as Marshall stability and dynamic immersion were also *** was found that Marshall stability ratio(MSR)and Marshall stability to flow ratio(MSFR)values are less sensitive to moisture effect when measuring moisture resistance compared to TSR ***,the 48 h testing result of the dynamic immersion test showed better correlation with TSR values.

关键词： Asphalt mixtures Moisture damage Anti-stripping additives Tensile strength ratio Cohesion strength ratio

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A Strategy of Signal Detection for Performance Improvement in Clipping Based OFDM System

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Computers, Materials & Continua 2020年第7期64卷 181-191页

作者： jae-hyun Ro Won-seok Lee Min-Goo Kang Dae-Ki Hong Hyoung-Kyu Song Department of Information and Communication Engineering Sejong UniversitySeoulKorea Department of IT Contents Hanshin UniversityOsan-siKorea Department of System Semiconductor Engineering SangMyung UniversityCheonan-si31066Korea

In this paper,the supervised Deep Neural Network(DNN)based signal detection is analyzed for combating with nonlinear distortions efficiently and improving error performances in clipping based Orthogonal Frequency Division Multiplexing(OFDM)*** of the main disadvantages for the OFDM is the high Peak to Average Power Ratio(PAPR).The clipping is a simple method for the PAPR ***,an effect of the clipping is nonlinear distortion,and estimations for transmitting symbols are difficult despite a Maximum Likelihood(ML)detection at the *** DNN based online signal detection uses the offline learning model where all weights and biases at fully-connected layers are set to overcome nonlinear distortions by using training data ***,this paper introduces the required processes for the online signal detection and offline learning,and compares error performances with the ML detection in the clipping-based OFDM *** simulation results,the DNN based signal detection has better error performance than the conventional ML detection in multi-path fading wireless *** performance improvement is large as the complexity of system is increased such as huge Multiple Input Multiple Output(MIMO)system and high clipping rate.

关键词： Clipping DNN ML nonlinear distortion OFDM

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Weighted Gauss-Seidel Precoder for Downlink Massive MIMO Systems

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Computers, Materials & Continua 2021年第5期67卷 1729-1745页

作者： Jun-Yong Jang Won-seok Lee jae-hyun Ro Young-Hawn You Hyoung-Kyu Song Department of Information and Communication Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea Department of Computer Engineering Sejong UniversitySeoul05006Korea

In this paper,a novel precoding scheme based on the Gauss-Seidel(GS)method is proposed for downlink massive multiple-input multiple-output(MIMO)*** GS method iteratively approximates the matrix inversion and reduces the overall complexity of the precoding *** addition,the GS method shows a fast convergence rate to the Zero-forcing(ZF)method that requires an exact invertible ***,to satisfy demanded error performance and converge to the error performance of the ZF method in the practical condition such as spatially correlated channels,more iterations are necessary for the GS method and increase the overall *** efficient approximation with fewer iterations,this paper proposes a weighted GS(WGS)method to improve the approximation accuracy of the GS *** optimal weights that accelerate the convergence rate by improved accuracy are computed by the least square(LS)*** the computation of weights,the different weights are applied for each iteration of the GS *** addition,an efficient method of weight computation is proposed to reduce the complexity of the LS *** simulation results show that bit error rate(BER)performance for the proposed scheme with fewer iterations is better than the GS method in spatially correlated channels.

关键词： Massive MIMO GS matrix inversion complexity weight

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Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction

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Neural Regeneration Research 2015年第8期10卷 1251-1257页

作者： Ji Yun Ahn hyun-Jin Tae Jeong-Hwi Cho In Hye Kim Ji Hyeon Ahn Joon Ha Park Dong Won Kim Jun Hwi Cho Moo-Ho Won seongkweon Hong jae-Chul Lee Jeong Yeol seo Department of Emergency Medicine Sacred Heart Hospital College of Medicine Hallym University Department of Emergency Medicine School of Medicine Kangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Neurobiology School of Medicine Kangwon National University Department of Emergency Medicine Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Surgery School of Medicine Kangwon National University

c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. Neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, Neu N immunohistochemistry and Fluoro-Jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction.

关键词： nerve regeneration paralimbic cortices myocardial infarction c-Fos cingulate cortex piriform cortex immunohistochemistry western analysis neural regeneration

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Successful endoscopic treatment of biliary stricture following mesenteric tear caused by blunt abdominal trauma

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World Journal of Gastroenterology 2008年第14期14卷 2277-2279页

作者： Dong O Kang Tae Hyo Kim Seung Suk You hyun Ju Min hyun Jin Kim Woon Tae Jung Ok jae Lee Department of Internal Medicine Institute of Health Science Gyeongsang National University School of Medicine Jinju 660-702 Korea

Biliary duct injuries are frequently iatrogenic, being associated with surgery for gallbladder stones. However, blunt abdominal trauma such as a motor vehicle crash is a rare cause of extrahepatic biliary stricture. A few reports have been published on biliary strictures treated with endoscopic therapy. In the present study, we describe a suprapancreatic biliary stricture associated with mesenteric tear following road traffic accident. We performed endoscopic stent placement, which was successful in relieving the biliary stricture.

关键词： Biliary stricture Blunt abdominal trauma Mesenteric tear Endoscopic stent treatment

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