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Serum prostate-specific antigen as a predictor of prostate volume and lower urinary tract symptoms in acommunity-based cohort： a large-scale Korean screening study

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Asian Journal of Andrology 2013年第2期15卷 249-253,I0008页

作者： Dong Soo Park Jong Jin Oh jae yup hong Young Kwon hong Don Kyung Choi In Hyuck Gong Jin HoHwang Sung Won Kwon Department of Urology CHA Bundang Medical Center CHA University Seongnam 463-712 Korea CHA Cancer Research Center Seou1135-081 Korea Department of Urology CHA Gangnam Medical Center CHA University Seou1135-081 Korea Korea Prostate Health Council Seou1137-070 Korea

The aim of this study is to assess the ability of serum prostate-specific antigen （PSA） to predict prostate volume （PV） and lower urinary tract symptoms （LUTS） represented by the international prostate symptom score （IPSS）. From January 2001 to December 2011, data were collected from men who first enrolled in the Korean Prostate Health Council Screening Program. Patients with a serum PSA level of 10 ng ml^-1 or age 〈40 years were excluded. Accordingly, a total of 34 857 men were included in our study, and serum PSA, PV and the IPSS were estimated in all patients. Linear and age-adjusted multivariate logistic analyses were used to assess the potential association between PSA and PV or IPSS. The predictive value of PSA for estimating PV and IPSS was assessed based on the receiver operating characteristics-derived area under the curve （AUC）. The mean PV was 29.9 ml, mean PSA level was 1.49 ng ml^-1 and mean IPSS was 15.4. A significant relationship was shown between PSA and PV, and the IPSS and PSA were also significantly correlated after adjusting by age. The AUCs of PSA for predicting PV ~20 ml, 〉25 ml and 〉35 ml were 0.722, 0.728 and 0.779, respectively. The AUCs of PSA for predicting IPSS 〉 7, 〉 13 and 〉 19 were 0. 548, 0.536 and 0. 537, respectively. Serum PSA was a strong predictor of PV in a community-based cohort in a large-scale screening study. Although PSA was also significantly correlated with IPSS, predictive values of PSA for IPSS above the cutoff levels were not excellent. Further investigations are required to elucidate the exact interactions between PSA and LUTS and between PSA and PV in prospective controlled studies. Such studies may suggest how PSA can be used to clinically predict PV and the IPSS.

关键词： lower urinary tract symptoms (LUTS) prostate prostate-specific antigen (PSA) prostate volume (PV)

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Application of Transformed Two-Stage Network DEA to Strategic Design of Biofuel Supply Chain Network

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Journal of Systems Science and Systems Engineering 2023年第2期32卷 129-151页

作者： jae-Dong hong Industrial Engineering Program South Carolina State UniversityOrangeburgSCUSA

This paper proposes an innovative procedure for designing efficient biomass-biofuel logistics networks(BBLNs).This procedure is based on the two-stage network data envelopment analysis(TSN-DEA)models that have been developed to provide specific process guidance for the managers to improve the efficiency of the decision-making unit(DMU)with the TSN *** crucial issue of the TSN-DEA is that the overall efficiency score depends on the DMUs under ***,the rankings for the DMUs generated by the TSN-DEA model are *** a result,the TSN-DEA-based ranking methods are *** TSN-DEA’s inconsistency frequently makes it difficult for decision-makers to select the top-rated *** develop the transformed TSN(T-TSN)DEA method by applying the multi-criteria DEA model to overcome this *** proposed method transforms the DMUs with any number of inputs,intermediate measures,and outputs in the TSN process,through the multi-objective programming model with a minimax objective approach,into the DMUs with two inputs and one output in the single-stage network(SSN)***,the well-known DEA methods for the SSN,such as the cross-efficiency and super-efficiency DEA methods,can be applied to evaluate and rank the transformed DMUs more *** exhibit the applicability of the proposed approach for the BBLN design problem.A case study of South Carolina in the USA demonstrates that the proposed method performs well in identifying efficient BBLN schemes more consistently than the traditional TSN-DEA.

关键词： Biomass-biofuel logistics network two-stage network data envelopment analysis efficiency score decision-making unit multiple criteria

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Application of Integrated Multiple Criteria Data Envelopment Analysis to Humanitarian Logistics Network Design

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Journal of Systems Science and Systems Engineering 2020年第6期29卷 709-729页

作者： jae-Dong hong Industrial Engineering Program South Carolina State UniversityOrangeburgSCUSA

This paper considers a humanitarian logistics network(HTLN)design problem,including the emergency relief facilities(ERFs)location-allocation decision for the efficient distribution of emergency supplies from the ERFs to the affected areas.A goal programming(GP)approach is applied to consider the multiple objectives *** the GP model with a given weight assigned to each goal yields a single HTLN scheme,so there will be various schemes available by solving the GP with multiple values of the *** evaluating these schemes and identifying the most efficient one,we apply the data envelopment analysis(DEA)methods considering each scheme as a decision-making unit(DMU).Since the classical DEA(C-DEA)intrinsically aims to identify efficient DMUs and the efficient frontier,the use of C-DEA may not lead to a full ranking in many *** are several independent evaluation approaches to increasing discriminating *** them,this study integrates the multiple criteria DEA(MC-DEA)with the following three DEA methods,(i)stratification DEA(S^DEA),(ii)cross-efficiency DEA(CE-DEA),and(iii)super-efficiency DEA(SE-DEA),to make the most use of each method's *** a case study of designing the HTLN system for South Carolina,the procedure of implementing the integrated multiple criteria DEA(IMC-DEA)method is *** is observed that the IMCDEA method performs well in terms of designing the HTLN system and would help the decision-makers consider more efficient options and make a final decision.

关键词： Humanitarian logistics network goal programming decision-making unit data envelopment analysis(DEA) stratification DEA cross efficiency DEA super-efficiency DEA multiple-criteria DEA

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Effects of structure and electronic properties of D-π-A organic dyes on photovoltaic performance of dye-sensitized solar cells

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Journal of Energy Chemistry 2021年第3期30卷 208-216页

作者： Min-Woo Lee jae-yup Kim Hyung-Geun Lee Hyun Gil Cha Duck-Hyung Lee Min jae Ko Bio-Based Chemistry Research Center Advanced Convergent Chemistry DivisionKorea Research Institute of Chemical Technology(KRICT)Ulsan 44429Republic of Korea Department of Chemical Engineering Dankook UniversityYongin 16890Republic of Korea Department of Chemistry Sogang UniversitySeoul 04107Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul 04763Republic of Korea

Herein,we examine the performance of dye-sensitized solar cells containing five D-π-A organic dyes designed by systematic modification of π-bridge size and geometric *** dye has a simple push-pull structure with a triarylamino group as an electron donor,bithiophene-4,4-dimethyl-4 H-cyclopenta 1,2-b:5,4-b’]dithiophene(M11),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophenethiophene(M12),thiophene-4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M13),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene-benzene(M14),and 4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M15)units asπ-bridges,and cyanoacrylic acid as an electron acceptor/*** extension of theπ-bridge linkage favors wide-range absorption but,because of the concomitant molecular volume increase,hinders the efficient adsorption of dyes on the TiO_(2) film ***,higher loadings are achieved for smaller dye molecules,resulting in(i)a shift of the TiO_(2) conduction band edge to more negative values,(ii)a greater photocurrent,and(iii)suppressed charge recombination between the photoanode and the redox couple in the ***,under one-sun equivalent illumination(AM 1.5 G,100 mW/cm^(2)),the highest photovoltage,photocurrent,and conversion efficiency(η=7.19%)are observed for M15,which has the smallest molecular volume among M series dyes.

关键词： Dye-sensitized solar cells Donor-acceptor dyes Electron-rich unit Wide-range absorption Impedance spectroscopy

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Delayed-onset micrococcus luteus-induced postoperative endophthalmitis several months after cataract surgery:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6592-6596页

作者： Ki-yup Nam hong-Won Lee Department of Ophthalmology Chungnam National UniversityCollege of MedicineDaejeon 35015South Korea Department of Ophthalmology Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Micrococcus luteus(***)-induced endophthalmitis is very rare and and may present as either acute or chronic postoperative *** aim of this study was to report a case of delayed-onset ***-induced endophthalmitis that occurred several months after cataract *** SUMMARY A 78-year-old man presented with decreased vision,pain and redness in the right eye that had begun 3 days *** had undergone cataract surgery 4 mo *** acuity was counting fingers;slit-lamp examination revealed conjunctival injection,posterior corneal precipitates,anterior chamber inflammation(cell 4+),and *** examination revealed moderate vitreous *** vitrectomy was performed for suspected infectious endophthalmitis,followed by vitreous irrigation with injections of *** the postoperative day 1,anterior chamber cell decreased to 2+and hypopyon was not observed on slit lamp *** days postoperatively,the patient had recurrent eye pain,and the anterior chamber cell grade increased to 4+;hypopyon recurred in the anterior chamber,and whitish plaque was observed in the lens ***,the patient underwent intraocular lens(IOL)and lens capsule removal,followed by vitreous irrigation,antibiotics injection,and *** was identified from a lens capsule *** In cases of delayed-onset ***-induced endophthalmitis,early vitrectomy and removal of the IOL and lens capsule may be necessary.

关键词： Micrococcus luteus Chronic endophthalmitis Postoperative endophthalmitis Case report

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Effect of CaF2 content in refining slag on formation behavior of spinel inclusion in Ni-Cr-V-alloyed special steel

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Journal of Iron and Steel Research International 2018年第2期25卷 157-163页

作者： jae-hong Shin Joo-hyun Park Department of Materials Engineering Hanyang UniversityAnsan 426-791 Korea

The influence of CaF2 content on the formation behavior of spinel inclusions in the Ni-Cr-V-alloyed special steel was presented. The spinel was not formed at CaF2 content lower than 10 wt%. However, it was formed at early stage when the CaF2 content was greater than 30 wt%, followed by a modification to the aluminosilicate-type inclusions. Because the slag was saturated by MgO, the activity of MgO was unity irrespective of CaF2 content in the slag. Thus, Mg was transferred from slag to metal phase. Mg transferred to molten steel reacted with Al2O3-rich inclusions to form ***2O3 spinel. However, the spinel inclusion was modified to aluminosilicate-type inclusions by the reaction with Si and Ca transferred from slag to molten steel about 2-3 h later.

关键词： Spinel inclusion Refining slag CaF2 content Ni-Cr-V-alloyed special steel

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Adsorption properties of polycarboxylate ether-based superplasticizer on cement particles and their resultant dispersion

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Frontiers of Structural and Civil Engineering 2022年第4期16卷 506-514页

作者： Jinyoung YOON Byoung Il CHOI jae hong KIM Department of Structural Engineering Research Korea Institute of Civil Engineering and Building Technology(KICT)Goyang 10223Republic of Korea System Safety Research Department Korea Shipbuilding and Offshore EngineeringSeongnam 13591Republic of Korea Department of Civil and Environmental Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

The cement dispersion performance of a polycarboxylate(PCE)-based superplasticizer is highly related to their adsorption behaviors as a function of *** study evaluated effects of PCEs on rheological properties of cementitious ***,characteristics of PCEs were characterized via permeation chromatography(GPC)and Fourier-transform infrared spectrometry(FT-IR).The adsorption behavior of single and blended PCEs on cementitious composites was identified using total organic carbon analyzer(TOC).Based on the measurement of PCE adsorption,the changes of rheological properties of cementitious materials as well as the number of dispersed cement particles were characterized using a rheometer and laser spectroscopy,*** experimental results support the systematic mechanism of PCE adsorption,cement dispersion,and the decrease in viscosity of cementitious materials.

关键词： adsorption polycarboxylate superplasticizer rheology dispersion

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Grade-4 commercially pure titanium with ultrahigh strength achieved by twinning-induced grain refinement through cryogenic deformation

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Journal of Materials Science & Technology 2021年第7期66卷 193-201页

作者： Seong-Woo Choi jae Sukjeong Jong Woo Won jae Keun hong Yoon Suk Choi Titanium Department.Korea Institute of Materials Science Changwon51508Republic of Korea School of Materials Science and Engineering Pusan National UniversityPusan.46241Republic of Korea Materials and Manufacturing Development Team Doosan Heavy Industries and ConstructionChangwon51711Republic of Korea

The yield strength of commercially pure(CP) Ti of ASTM grade 4, the strongest among all the CP-Ti grades, is too low for structural applications that require high-strength materials. Here, we demonstrate the strengthening of grade-4 CP Ti by cryogenic-temperature rolling(CTR), which enables deformation twinning in grade-4 CP Ti to achieve twinning-induced grain refinement. CTR activated {11.22} twinning and {10.12} twinning, which are the most common twinning systems in pure Ti, whereas room-temperature rolling(RTR) did not activate any twinning system. CTR with imposing an area reduction of just 30% significantly increased the yield strength of the CP Ti to 946 MPa, which is not achievable through typical processes performed at or above room temperature and is comparable to that of commercial Ti-6 Al-4 V. The significant increase in strength was due to microstructural strengthening caused by twinning-induced grain refinement, combined with dislocation accumulation. In contrast to RTR, CTR greatly increased the stress concentration at grain boundaries(GBs), which caused the unusual activation of twinning in the grade-4 CP Ti by facilitating twin nucleation at GBs. The stress concentration increased because CTR activated the slip to a lesser extent compared to RTR, thereby reducing the strain compatibility between neighboring grains. These results will contribute to development of ultrahigh-strength CP Ti and may thereby extend its use to structural applications that require high-strength materials.

关键词： Titanium Twinning Cryogenic deformation Grain refinement Tensile properties

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Study on adhesively-bonded surface of tapered double cantilever specimen made of aluminum foam affected with shear force

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Journal of Central South University 2015年第12期22卷 4521-4527页

作者：孙洪鹏 CHO jae-ung Division of Mechanical Engineering Graduate School Kongju National University Division of Mechanical and Automotive Engineering Kongju National University

Aluminum foam is widely used in diverse areas to minimize the weight and maximize the absorption of shock energy in lightweight structures and various *** presents a number of advantages,such as low density,incombustibility,non-rigidity,excellent energy absorptivity,sound absorptivity and low heat *** aluminum foam with an air cell structure was placed under the TDCB Mode II tensile load by using Landmark equipment manufactured by MTS to examine the shear failure *** angle of the tapered adhesively-bonded surfaces of specimens was designated as a variable,and three models were developed with the inclined angles differing from one another at 6°,8° and 10°.The specimens with the inclined angles of 6°,8° and 10° have the maximum reaction forces of 168 N,194 N when the forced displacements are 6,5 and 4.2 mm *** are three specimens with the inclined angles of 10°,8° and 6° in the order of maximum reaction *** the analysis result,the maximum equivalent stresses of 0.813 MPa and 0.895 MPa happened when the forced displacements of 6 mm and 5 mm proceeded at the models of 6° and 8°,respectively.A simulation was carried out on the basis of finite element method and the experimental *** results of the experiment and the simulation analysis are shown not different from each other ***,only a simulation could be confirmed to be performed in substitution of an experiment,which is costly and time-consuming in order to determine the shearing properties of materials made of aluminum foam with artificial data.

关键词： adhesive displacement force reaction shearing fracture characteristic tapered double cantilever beam(TDCB)

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