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Molecular targeted therapy for hepatocellular carcinoma:Current and future

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World Journal of Gastroenterology 2013年第37期19卷 6144-6155页

作者： Jung Woo shin young-Hwa Chung Department of Internal Medicine University of Ulsan College of Medicine Ulsan University Hospital Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center

Hepatocellular carcinoma(HCC)is one of the most frequent tumors *** majority of HCC cases occur in patients with chronic liver *** regular surveillance to detect small HCC in these patients,HCC is often diagnosed at an advanced *** HCC is highly resistant to conventional systemic therapies,the prognosis for advanced HCC patients remains *** introduction of sorafenib as the standard systemic therapy has unveiled a new direction for future research regarding HCC ***,given the limited efficacy of the drug,a need exists to look beyond *** molecular targeted agents that inhibit different pathways involved in hepatocarcinogenesis are under various phases of clinical development,and novel targets are being assessed in *** review aims to summarize the efforts to target molecular components of the signaling pathways that are responsible for the development and progression of HCC and to discuss perspectives on the future direction of research.

关键词： Hepatocellular carcinoma Targeted therapy Molecular agents Sorafenib

Landscapes of SARS-CoV-2-reactive CD8^(+)T cells:heterogeneity of host immune responses against SARS-CoV-2

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1399-1401页

作者： June-young Koh Eui-Cheol shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea The Center for Epidemic Preparedness KAISTDaejeonRepublic of Korea

In a recent study published in Science Immunology,^Kusnadi et *** single-cell RNA sequencing(scRNA-seq)of SARS-CoV-2-reactive CD8^(+)T cells and reported ***-CoV-2 infection causes COVID-19,which is an ongoing pandemic disease threatening public *** virology of SARS-CoV-2 and immune responses against the virus have been urgently investigated to develop effective measures against *** viral infection,CD84 T cells contribute to elimination of the virus by exerting cytotoxicity against virus-infected cells and producing effector cytokines,whereas neutralizing antibodies interfere with viral entry of host cells.

关键词： al. infection Immunology

Mechanical and electrochemical characteristics evaluation in annealing treatment for ship material

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中国有色金属学会会刊：英文版 2009年第B09期19卷 40-44页

作者： Seok-Ki JANG young-jae JEONG Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Jeonnam Techno Park

The effect of heat treatment on the electrochemical and mechanical properties of SS400 steel was investigated, and the effects of annealing conditions on notched specimens subjected to the slow strain rate test (SSRT) were studied. The results show that no correlations are observed among the maximum tensile strength, yield strength, and stress corrosion cracking. In contrast, the elongation and time-to-fracture are improved with stress-relieving annealing compared with the as-received condition. The elongation, time-to-fracture, and number of dimples increase with annealing heat treatment.

关键词：退火处理电化学船舶材料特性评价机械 SS400钢应力腐蚀开裂消除应力退火

Rhabdomyolysis following severe hypokalemia caused by familial hypokalemic periodic paralysis

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World Journal of Clinical Cases 2017年第2期5卷 56-60页

作者： young-Lee Jung jae-young Kang Division of Nephrology Department of Internal Medicine Sejong General Hospital

Rhabdomyolysis continues to appear with increasing frequency and represents a medical emergency requiring rapid appropriate treatment. One of the unusual causes of nontraumatic rhabdomyolysis is hypokalemic periodic paralysis without secondary causes. Primary hypokalemic periodic paralysis is a rare genetic disease characterized by episodic attacks of muscle weakness due to decreases in serum potassium. A 30-year-old woman who had 3 episodic attacks of hypokalemic periodic paralysis was admitted in emergency room with sudden onset symmetrical muscle weakness. After several hours, she started to complain myalgia and severe ache in both calves without any changes. Laboratory test showed markedly elevated creatine phosphokinase, lactic dehydrogenase levels with hypokalemia, rhabdomyolysis resulting from hypokalemia was diagnosed. Here, we report an unusual case of rhabdomyolysis caused by severe hypokalemia, which was suggested a result of familial hypokalemic periodic paralysis.

关键词： Rhabdomyolysis Hypokalemia Familial hypokalemic periodic paralysis

Fabrication and Mechanical Properties of Sm2O3 Doped CeO2 Reinforced Ti3AlC2 Nano Composite

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Journal of Rare Earths 2004年第z2期22卷 85-88页

作者： jae Ho Han Sang Whan Park young Do Kim Division of Materials Science & Engineering Hanyang UniversitySeoul133-791Korea Korea Institute of Science and TechnologyMulti-Functional Ceramics Research CenterSeoul136-791Korea Division of Materials Science & EngineeringHanyang UniversitySeoul133-791Korea

The fabrication process of Sm2O3 doped CeO2 reinforced Ti3AlC2 nano composites including the nano particle dispersion process by a hetero-coagulation process was developed using in-situ synthesis and densification process of Ti3AlC2. The effects of Sm2O2 doped CeO2 nano particles on mechanical properties of Ti3AlC2 were investigated. It was found that the presence of 20SDC nano particles in Ti3AlC2 was very effective to improve the mechanical properties of Ti3AlC2 without spoiling the unique characteristics of Ti3AlC2temary carbide.

关键词： nano ceramic composite Ti3AlC2 CeO2 fabrication rare earths

Performance of the EDACS-ADP incorporating high-sensitivity troponin assay:Do components of major adverse cardiac events matter?

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World Journal of Emergency Medicine 2024年第3期15卷 175-180页

作者： Yedalm Yoo shin Ahn Bora Chae Won young Kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea

BACKGROUND:The accelerated diagnostic protocol(ADP)using the Emergency Department Assessment of Chest pain Score(EDACS-ADP),a tool to identify patients at low risk of a major adverse cardiac event(MACE)among patients presenting with chest pain to the emergency department,was developed using a contemporary troponin *** study was performed to validate and compare the performance of the EDACS-ADP incorporating high-sensitivity cardiac troponin I between patients who had a 30-day MACE with and without unstable angina(MACE I and II,respectively).METHODS:A single-center prospective observational study of adult patients presenting with chest pain suggestive of acute coronary syndrome was *** performance of EDACS-ADP in predicting MACE was assessed by calculating the sensitivity and negative predictive ***:Of the 1,304 patients prospectively enrolled,399(30.6%;95%confidence interval[95%CI]:27.7%–33.8%)were considered low-risk using the *** them,the rates of MACE I and II were 1.3%(5/399)and 1.0%(4/399),*** EDACS-ADP showed sensitivities and negative predictive values of 98.8%(95%CI:97.2%–99.6%)and 98.7%(95%CI:97.0%–99.5%)for MACE I and 98.7%(95%CI:96.8%–99.7%)and 99.0%(95%CI:97.4%–99.6%)for MACE II,***:EDACS-ADP could help identify patients as safe for early ***,when unstable angina was added to the outcome,the 30-day MACE rate among the designated lowrisk patients remained above the level acceptable for early discharge without further evaluation.

关键词： Chest pain Major adverse cardiac event Acute coronary syndrome Emergency department

Remote induction of in situ hydrogelation in a deep tissue,using an alternating magnetic field and superparamagnetic nanoparticles

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Nano Research 2018年第11期11卷 5997-6009页

作者： Hwangjae Lee Guru Karthikeyan Thirunavukkarasu Semin Kim jae young Lee School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 51005 Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology Gwangju 61005 Repubfic of Korea

In situ hydrogelation systems, such as transdermal polymerization, allow for external control over the gelation processes in a minimally invasive way. Recently, a novel system consisting of near-infrared (NIR) light and plasmonic nanomaterials was demonstrated to cause in vivo transdermal gelation. However, NIR light is not sufficient for gelation induction in deep tissues owing to its limited penetration into tissues. To overcome this problem, here we developed an alternating magnetic field (AMF)-inducible hydrogelation system with superparamagnetic iron oxide nanoparticles (SPIONs), by which a deep-tissue-penetrating AMF can induce heat generation in the SPIONs and temperature elevation ( 43 degrees C), leading to initiation of thermal polymerization of poly(ethylene glycol) diacrylate. The feasibility of our AMF-inducible hydrogelation was successfully demonstrated using thick porcine muscle tissues (> 2 cm), whereas the NIR light-based hydrogelation system could induce gelation only in tissues thinner than several millimeters. Cell viability assays indicated cytocompatibility of the AMF-inducible hydrogelation for cell encapsulation and delivery. In vivo hydrogelation in rat muscle tissues further validated in situ hydrogelation in deep muscle tissues of a living animal. This AMF-inducible hydrogelation system may overcome the conventional problems of depth limitation and should extend the applicable area of on-demand injectable hydrogel systems for tissue engineering and drug delivery applications.

关键词： hydrogelation alternating magnetic field superparamagnetic nanoparticles hydrogel tissue engineering cell delivery

Efficacy of 14-d vs 7-d moxifloxacin-based triple regimens for second-line Helicobacter pylori eradication

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World Journal of Gastroenterology 2015年第18期21卷 5568-5574页

作者： jae Jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk Yoon Cheol Min shin young Soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital Gyeonggi-do 463-707 South Korea

AIM: To evaluate the efficacy of the 14-d moxifloxacinbased triple therapy for the second-line eradication of Helicobacter pylori(H. pylori) ***: Between 2011 and 2013, we conducted a retrospective review of the medical records of 160 patients who had experienced failure of their first-line proton pump inhibitor-based eradication therapy and subsequently received the moxifloxacin-based triple therapy as a second-line eradication treatment regimen. The patients who were treated with the moxifloxacinbased triple therapy(oral 20 mg rabeprazole b.i.d., 1000 mg amoxicillin b.i.d., and 400 mg moxifloxacin q.d.) for 7 d were assigned to the RAM-7 group(n = 79) while those who took them for 14 days were assigned to RAM-14 group(n = 81). The eradication rates for both groups were determined by intentionto-treat(ITT) and per-protocol(PP) analyses. ITT analysis compared the treatment groups as originally allocated while the PP analysis including only those patients who had completed the treatment as originally allocated. Successful eradication therapy for H. pylori infection was defined as the documentation of a negative 13C-urea breath test 4 wk after the end of the eradication ***: The overall ITT eradication rate was 76.2%(122/160). The final ITT eradication rates were 70.8%(56/79; 95%CI: 63.3%-77.1%) in the RAM-7 group and 81.4%(66/81; 95%CI: 74.6%-88.3%) in the RAM-14 group(P = 0.034). The overall PP eradication rate was 84.1%(122/145), and the final PP eradication rates were 77.7%(56/72; 95%CI: 70.2%-85.3%) in the RAM-7 group and 90.4%(66/73; 95%CI: 82.8%-98.1%) in the RAM-14 group(P = 0.017). The H. pylori-eradication rates in the RAM-14 group were significantly higher compared with that of the RAM-7 group according to both the ITT(P = 0.034) and the PP analyses(P = 0.017). Both groups exhibited good treatment compliance(RAM-7/RAM-14 group: 100%/100%). The adverse event rates were19.4%(14/72)and 20.5%(15/73)in the RAM-7 and RAM-14 groups,resp

关键词： Helicobacter pylori Treatment failure Second-line treatment Moxifloxacin Eradication rate

Improved thermal performance of a hydronic radiant panel heating system by the optimization of tube shapes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第6期12卷 428-437页

作者： young T.CHAE Kwang Ho LEE jae Sung PARK School of Architecture University of Illinois at Urbana-Champaign Department of Architectural Engineering Hanbat National University Department of Mechanical Engineering University of Illinois at Urbana-Champaign

The thermal performance enhancement of the hydronic radiant floor heating system by tube shape refinements is investigated in this *** analytical and detailed numerical modelings are carried out to predict the performance of the radiant *** the simple analytical model briefly investigates the possibility of the effect of the tube shape improvement with the parametric analysis,the commercial computational fluid dynamics(CFD) code(Ansys/CFX) is used to perform the detailed 3D analysis under different tube shape *** fin thickness,the number of fins,and the tube thermal conductivity turn out to have significant effects on the radiant system *** potential energy saving impacts of the tube shape refinements are also *** tube shape improvement turns out to increase the floor surface temperature and to decrease the hot water temperature drop across the system,resulting in heating energy savings.

关键词： Radiant panel system Analytical modeling Computational fluid dynamics(CFD) Tube shape Energy saving