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Protective effects of Ecklonia cava extract on the toxicity and oxidative stress induced by hair dye in in-vitro and in-vivo models

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Journal of Oceanology and Limnology 2019年第3期37卷 909-917页

作者： OH jae-Young RYU Bo-Mi YANG Hye-won KIM Eun-A lee Jung-Suck JEON You-Jin Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Jeju International Marine Science Center for Research & Education Korea Institute of Ocean Science and TechnologyJeju 63349Republic of Korea Research Center for Industrial Development of Seafood Gyeongsang National UniversityTongyeong 53064Republic of Korea

Oxidative hair dyes containingρ-phenylenediamine(PPD)are reported to induce an allergic reaction by promoting oxidative stress when absorbed through the *** the associated risk,these hair dyes remain popular owing to their convenience and sharpness of *** makes it important to minimize the cytotoxicity and oxidative stress induced by PPD-containing hair *** cava extract has been evaluated in different studies for its protective effects against external stress in fibroblasts and *** study was aimed at using in-vitro and in-vivo models to investigate the extract’s effects on cytotoxicity of and oxidative stress induced by PPD-containing hair *** of CIEL*a*b*Color space was first used to determine the range of *** extract that would not interfere with the coloring ability of the dye upon ***,the set ranges of *** extract(5% and 7%)were added to the hair dye and their toxicity assessed by evaluating the viability of fibroblasts and *** effects on developmental phenotypes and induction of oxidative stress by hair dye were evaluated and compared with those of hair dyes containing different contents of *** extract using an in-vivo zebrafish *** results showed that *** extract in hair dye could significantly decrease the cytotoxicity and levels of oxidative stress caused by hair dyes containing PPD in both in-vitro and in-vivo *** results suggest that the addition of 7% *** extract to 250μg/mL hair dye does not interfere with the coloring ability of the dye while showing significant protective eff ects against the hair *** study proposes that the use of *** extract as an adduct to hair dyes containing PPD reduces the cytotoxicity and oxidative stress induced by these hair dyes.

关键词： hair dye Ecklonia cava cytotoxicity oxidative stress in-vitro and in-vivo models

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Is mannitol combined with furosemide a new treatment for refractory lymphedema?A case report

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World Journal of Clinical Cases 2021年第29期9卷 8804-8811页

作者： Hyeon Seong Kim jae Young lee Ji won Jung Kyu Hoon lee Mi Jung Kim Si-Bog Park Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea

BACKGROUND Mannitol is a hyperosmolar agent and the combination of mannitol and furosemide is a widely used treatment for intracranial pressure *** the hypertonic properties of mannitol to move water out of intracellular spaces,we hypothesized that mannitol combined with furosemide could relieve focal tissue swelling in refractory *** SUMMARY A 90-year-old female had been diagnosed with intracranial hemorrhage and received a combination of mannitol and furosemide for intracranial pressure *** of the intracranial hemorrhage,she had refractory lymphedema of the left lower extremity since ***,after receiving the mannitol and furosemide,the patient’s lower extremity lymphedema improved *** the mannitol and furosemide were discontinued,the lymphedema worsened in spite of complete decongestive therapy(CDT)and intermittent pneumatic compression treatment(IPC).To identify the presumed effect of mannitol and furosemide on the lymphedema,these agents were resumed,and the lymphedema improved *** The present case raises the possibility that a combination of mannitol and furosemide might be considered another effective therapeutic option for refractory lymphedema when CDT and IPC are ineffective.

关键词： Lymphedema Mannitol Furosemide Rehabilitation Intermittent pneumatic compression Case report

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Optimal biliary drainage for inoperable Klatskin's tumor based on Bismuth type

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World Journal of Gastroenterology 2007年第29期13卷 3948-3955页

作者： Sang Hyub lee Joo Kyung Park won jae Yoon Jun Kyu lee Ji Kon Ryu Yong Bum Yoon Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul South Korea

AIM： To investigate differences in the effects of biliary drainage procedures in patients with inoperable Klatskin＇s tumor based on Bismuth type, considering endoscopic retrograde biliary drainage （ERBD）, external percutaneous transhepatic biliary drainage （EPTBD） and internal biliary stenting via the PTBD tract （IPTBD）. METHODS： The initial success rate, cumulative patency rate, and complication rate were compared retrospectively, according to the Bismuth type and ERBD, EPTBD, and IPTBD. Patency was defined as the duration for adequate initial bile drainage or to the point of the patient＇s death associated with inadequate drainage. RESULTS： One hundred thirty-four patients （93 men, 41 women; 21 Bismuth type Ⅱ, 47Ⅲ, 66 Ⅳ; 34 ERBD, 66 EPTBD, 34 IPTBD） were recruited. There were no differences in demographics among the groups. Adequate initial relief of jaundice was achieved in 91% of patients without a significant difference in the results among different procedures or Bismuth types. The cumulative patency rates for ERBD and IPTBD were better than those for EPTBD with Bismuth type Ⅲ. IPTBD provided an excellent response for Bismuth type IV. However, there was no difference in the patency rate among drainage procedures for Bismuth type Ⅱ. Procedure-related cholangitis occurred less frequently with EPTBD than with ERBD and IPTBD. CONCLUSION： ERBD is recommended as the firstline drainage procedure for the palliation of jaundice in patients with inoperable Klatskin＇s tumor of Bismuth type Ⅱ or Ⅲ, but IPTBD is the best option for Bismuth type Ⅳ.

关键词： Klatskin's tumor Palliation Drainage Bile ducts Intervention

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Abrupt visual loss during anti-vascular endothelial growth factor treatment for type 3 neovascularization

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 480-487页

作者： jae Hui Kim Young Suk Chang Jong Woo Kim Chul Gu Kim Dong won lee Department of Ophthalmology Kim's Eye Hospital Konyang University College of Medicine Department of Ophthalmology Konyang University College of Medicine

AIM: To investigate the incidence of abrupt visual loss and its associated factors, during anti-vascular endothelial growth factor(VEGF) treatment for type 3 ***: This retrospective study included 137 eyes that were newly diagnosed with type 3 neovascularization. All eyes were treated with anti-VEGF therapy. Abrupt visual loss was defined as loss of 5 or more lines in best-corrected visual acuity(BCVA) in comparison to the previous visit. The incidence and timing of abrupt visual loss as well as the factors associated with it, were determined. In addition, the BCVA at the final follow-up was compared between the eyes with and those without abrupt visual ***: The mean follow-up period was 42.4±18.9 mo after diagnosis, and abrupt visual loss was noted in 22 eyes(16.1%) at a mean of 19.6±13.9 mo. Abrupt visual loss was found to be associated with subretinal hemorrhage in 11 eyes(50.0%), development of or increase in the height of pigment epithelial detachment with fluid in 8 eyes(36.4%), and tears in the retinal pigment epithelium in 3 eyes(13.6%). The logarithm of minimum angle of resolution(logMAR) mean BCVA at the final follow-up was 2.07±0.67(Snellen equivalents: 20/2349) and 1.00±0.55(20/200) in eyes with and without abrupt visual loss, respectively. BCVA was significantly worse in the eyes with abrupt visual loss(P<0.001).CONCLUSION: Abrupt visual loss is noted in 16.1% of patients with type 3 neovascularization and is associated with poor visual outcome. Additional studies are needed to determine how abrupt visual loss can be prevented.

关键词： age-related macular degeneration type 3 neovascularization retinal angiomatous proliferation hemorrhage tear in retinal pigment epithelium pigment epithelial detachment

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Prognostic factors in patients with middle and distal bile duct cancers

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World Journal of Gastroenterology 2014年第21期20卷 6658-6665页

作者： Hyung Jun Kwon Sang Geol Kim jae Min Chun won Kee lee Yoon Jin Hwang Department of Surgery Kyungpook National University Medical CenterDaegu 702-210South Korea Department of Surgery School of MedicineKyungpook National UniversityDaegu 700-422South Korea Department of Preventive Medicine School of Medicine Kyungpook National University Daegu 700-422South Korea

AIM: To identify the influence of the surgery type and prognostic factors in middle and distal bile duct cancers.

关键词： Distal extrahepatic bile duct cancer Lymphovascular invasion Tumor node metastasis Pancreaticoduodenectomy Bile duct resection Prognostic factor

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Segmental artery injury during transforaminal percutaneous endoscopic lumbar discectomy:Two case reports

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World Journal of Clinical Cases 2022年第33期10卷 12345-12351页

作者： Wan-jae Cho Ki-won Kim Hyung-Youl Park Bo-Hyoung Kim Jun-Seok lee Department of Orthopedic Surgery Yeouido St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 07345South Korea Department of Orthopedic Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 03312South Korea

BACKGROUND Since Kambin experimentally induced arthroscopy to treat herniated nucleus pulposus,percutaneous endoscopic lumbar discectomy(PELD)has been *** branch of the segmental artery around the neural foramen may be damaged during PELD using the transforaminal *** report 2 rare cases in which segmental artery injury that occurred during PELD was treated with emergency *** SUMMARY In case 1,a 31-year-old man was transferred to our emergency department with left lower quadrant abdominal pain after PELD at a local *** spine magnetic resonance imaging after the surgery showed a hematoma of the left retroperitoneal area and the psoas muscle *** suspicion of vascular injury,arteriography was *** and blood leakage from the left 4th lumbar segmental artery into the abdominal cavity were *** transarterial embolization was performed using fibered microcoils for bleeding of the segmental *** case 2,a 75-year-old woman was transferred to our emergency department with low blood pressure,right flank pain,and drowsy mental status after PELD at a local *** the patient arrived at the emergency room,the blood pressure decreased from 107/55 mmHg to 72/47 *** blood pressure *** suspicion of vessel injury,arteriography was performed,and the right 4th lumbar segmental artery rupture was *** transarterial embolization was performed for bleeding of segmental *** We were able to find the bleeding focus by angiography and treat the injury of the segmental artery successfully through emergency transarterial embolization.

关键词： Percutaneous endoscopic lumbar discectomy Segmental artery injury Transarterial embolization Angiography Case report

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Utility of a deep learning model and a clinical model for predicting bleeding after endoscopic submucosal dissection in patients with early gastric cancer

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World Journal of Gastroenterology 2022年第24期28卷 2721-2732页

作者： Ji Eun Na Yeong Chan lee Tae Jun Kim Hyuk lee Hong-Hee won Yang won Min Byung-Hoon Min Jun Haeng lee Poong-Lyul Rhee jae J Kim Department of Internal Medicine Inje University Haeundae Paik HospitalBusan 48108South Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan UniversitySeoul 06351South Korea

BACKGROUND Bleeding is one of the major complications after endoscopic submucosal dissection(ESD)in early gastric cancer(EGC)*** are limited studies on estimating the bleeding risk after ESD using an artificial intelligence *** To derivate and verify the performance of the deep learning model and the clinical model for predicting bleeding risk after ESD in EGC *** Patients with EGC who underwent ESD between January 2010 and June 2020 at the Samsung Medical Center were enrolled,and post-ESD bleeding(PEB)was investigated *** split the entire cohort into a development set(80%)and a validation set(20%).The deep learning and clinical model were built on the development set and tested in the validation *** performance of the deep learning model and the clinical model were compared using the area under the curve and the stratification of bleeding risk after *** A total of 5629 patients were included,and PEB occurred in 325 *** area under the curve for predicting PEB was 0.71(95%confidence interval:0.63-0.78)in the deep learning model and 0.70(95%confidence interval:0.62-0.77)in the clinical model,without significant difference(P=0.730).The patients expected to the low-(leeding rate of 2.2%,3.9%,and 11.6%,respectively,in the deep learning model;4.0%,8.8%,and 18.2%,respectively,in the clinical *** A deep learning model can predict and stratify the bleeding risk after ESD in patients with EGC.

关键词： Clinical model Deep learning model Post-endoscopic submucosal dissection bleeding Stratification of bleeding risk

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Effects of structure and electronic properties of D-π-A organic dyes on photovoltaic performance of dye-sensitized solar cells

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Journal of Energy Chemistry 2021年第3期30卷 208-216页

作者： Min-Woo lee jae-Yup Kim Hyung-Geun lee Hyun Gil Cha Duck-Hyung lee Min jae Ko Bio-Based Chemistry Research Center Advanced Convergent Chemistry DivisionKorea Research Institute of Chemical Technology(KRICT)Ulsan 44429Republic of Korea Department of Chemical Engineering Dankook UniversityYongin 16890Republic of Korea Department of Chemistry Sogang UniversitySeoul 04107Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul 04763Republic of Korea

Herein,we examine the performance of dye-sensitized solar cells containing five D-π-A organic dyes designed by systematic modification of π-bridge size and geometric *** dye has a simple push-pull structure with a triarylamino group as an electron donor,bithiophene-4,4-dimethyl-4 H-cyclopenta 1,2-b:5,4-b’]dithiophene(M11),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophenethiophene(M12),thiophene-4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M13),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene-benzene(M14),and 4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M15)units asπ-bridges,and cyanoacrylic acid as an electron acceptor/*** extension of theπ-bridge linkage favors wide-range absorption but,because of the concomitant molecular volume increase,hinders the efficient adsorption of dyes on the TiO_(2) film ***,higher loadings are achieved for smaller dye molecules,resulting in(i)a shift of the TiO_(2) conduction band edge to more negative values,(ii)a greater photocurrent,and(iii)suppressed charge recombination between the photoanode and the redox couple in the ***,under one-sun equivalent illumination(AM 1.5 G,100 mW/cm^(2)),the highest photovoltage,photocurrent,and conversion efficiency(η=7.19%)are observed for M15,which has the smallest molecular volume among M series dyes.

关键词： Dye-sensitized solar cells Donor-acceptor dyes Electron-rich unit Wide-range absorption Impedance spectroscopy

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Unilateral versus bilateral Y-type stent-in-stent metal stent insertions in inoperable malignant hilar biliary strictures:A multicenter retrospective study

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 561-567页

作者： Ik Hyun Jo Chang-Nyol Paik Dae Bum Kim jaesin lee Jong Yul lee jae Hyuck Chang Kyu-Hyun Paik won-Suk Park Department of Internal Medicine College of MedicineSt.Vincent’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineIncheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineBucheon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea Department of Internal Medicine College of MedicineDaejeon St.Mary’s HospitalThe Catholic University of KoreaSeoulKorea

Background:To date,there is controversy regarding unilateral versus bilateral stent placement in patients with malignant hilar biliary strictures(MHBSs).The aim of this study was to compare the clinical outcomes and complications of unilateral and bilateral(stent-in-stent method)stent placements for these ***:We conducted a multicenter retrospective analysis of patients with inoperable MHBS who underwent endoscopic self-expandable metal stent(SEMS)placement from January 2009 to December *** groups classified according to the stent procedure method were compared for demographic,procedural,and postprocedure *** analysis for patency loss and overall survival was also ***:A total of 236 subjects were included.A superior technical success rate was found in the unilateral stent group(98.8%vs.82.5%,P<0.001),whereas the clinical success rate was higher in the bilateral group(85.7%vs.70.5%,P=0.028).There was no significant difference with respect to complications or patency loss,and the bilateral group had better overall survival(P<0.01).In the Cox proportional hazard model,MHBSs from lymph node compression were associated with a higher risk of death(HR=9.803,P=0.003).In contrast,bilateral SEMS insertion showed reduced postprocedural mortality(HR=0.316,P=0.001).Conclusions:Y-type stent-in-stent bilateral SEMSs are technically difficult but demonstrated more favorable overall survival for palliative bile drainage of inoperable MHBS patients compared to unilateral insertions.

关键词： Cholestasis Extrahepatic neoplasm Cholangiopancreatography Endoscopy Self-expandable metal stents

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Characteristics of bifurcation and buckling load of space truss in consideration of initial imperfection and load mode

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 206-218页

作者： Su-deok SHON Seung-jae lee Kang-guk lee School of Architectural Engineering Korea University of Technology and Education1800 ChungjeolroCheonan ChungnamRepublic of Korea Research Center for Urban Affair Kyungil UniversityGyeongsan-city GyeongbukRepublic of Korea

This study investigated characteristics of bifurcation and critical buckling load by shape imperfection of space truss,which were sensitive to initial *** critical point and buckling load were computed by the analysis of the eigenvalues and determinants of the tangential stiffness *** two-free-nodes example and star dome were selected for the case study in order to examine the nodal buckling and global buckling by the sensitivity to the eigen buckling mode and the analyses of the influence,and characteristics of the parameters as defined by the load ratio of the center node and surrounding node,as well as rise-span ratio were *** sensitivity to the imperfection of the initial shape of the two-free-nodes example,which occurs due to snapping at the critical point,resulted in bifurcation before the limit point due to the buckling mode,and the buckling load was reduced by the increase in the amount of *** two sensitive buckling patterns of the numerical model are established by investigating the displaced position of the free nodes,and the asymmetric eigenmode greatly influenced the behavior of the imperfection shape whether it was at limit point or ***,the sensitive mode of the two-free-nodes example was similar to the in-extensional basis mechanism of a simplified *** star dome,which was used to examine the influence among several nodes,indicated that the influence of nodal buckling was greater than that of global buckling as the rise-span ratio was ***,global buckling is occurred with reaching bifurcation point as the value of load ratio was higher,and the buckling load level was about 50%-70% of load level at limit point.

关键词： Space truss Geometric nonlinearity Initial imperfection Snap-through Bifurcation Global buckling

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