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Long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated intramucosal gastric cancer regardless of size

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World Journal of Gastroenterology 2022年第8期28卷 840-852页

作者： Gil Ho Lee Eunyoung Lee Bumhee Park Jin Roh Sun Gyo Lim Sung jae Shin Kee Myung Lee Choong-kyun Noh Department of Gastroenterology Ajou University School of MedicineSuwon 16499South Korea Department of Biomedical Informatics Ajou University School of MedicineSuwon 16499South Korea Department of Pathology Ajou University School of MedicineSuwon 16499South Korea

BACKGROUND The clinical outcomes of endoscopic submucosal dissection(ESD)for undifferentiated(UD)intramucosal early gastric cancer(EGC)compared with those of surgery,regardless of lesion size,are not well ***,there is a concern regarding the treatment plan before and after ESD in cases of UD intramucosal EGC within expanded *** To evaluate clinical outcomes of ESD compared with those of surgery in UD intramucosal EGC patients regardless of tumor *** We enrolled patients with UD intramucosal EGC after ESD with complete resection or surgery from January 2005 to August 2020 who met the within or beyond expanded indications with lesion size>2 cm(the only non-curative factor).Overall,123 and 562 patients underwent ESD and surgery,*** propensity-score matching,clinical and long-term outcomes,i.e.,recurrencefree survival(RFS)and overall survival(OS),were *** multivariable Cox proportional hazard model with treatment modality and ESD indication was used to evaluate the recurrence *** After matching,119 patients each were finally enrolled in the ESD and surgery *** median length of hospital stay was shorter in the ESD group than surgery group(4.0 vs 9.0 days,P<0.001).Four cases of recurrence after ESD were local recurrences,all of which occurred within 1 *** recurrence was seven(5.9%)and two(1.7%)in the ESD and surgery groups,*** difference was observed between the two groups with respect to OS(P=0.948).However,the ESD group had inferior RFS compared with the surgery group(P=0.031).ESD was associated with the risk of recurrence after initial treatment in all enrolled patients(hazard ratio,5.2;95%confidence interval:1.0-25.8,P=0.045).CONCLUSION Although OS was similar between the two groups,surveillance endoscopy was important for the ESD than for the surgery group because RFS was inferior and local recurrence was an issue.

关键词： Early gastric cancer Undifferentiated cancer Expanded indication Endoscopic submucosal dissection Surgery

Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord

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Neural Regeneration Research 2020年第11期15卷 2162-2168页

作者： ju-Young Oh Tae-Yeon Hwang jae-Hwan Jang Ji-Yeun Park Yeonhee Ryu Hyejung Lee Hi-Joon Park Acupuncture and Meridian Science Research Center Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoulRepublic of Korea Department of Korean Medical Science Graduate School of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea BK21 PLUS Korean Medicine Science Center College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea College of Korean Medicine Daejeon UniversityDaejeonRepublic of Korea Korean Institute of Oriental Medicine DaejeonRepublic of Korea

Despite numerous efforts to overcome neuropathic pain,various pharmacological drugs often fail to meet the needs and have many side *** is an aluminosilicate mineral that has been reported to have an anti-inflammatory effect,but the efficacy of muscovite for neuropathic pain has not been ***,we assessed whether muscovite nanoparticles can reduce the symptoms of pain by controlling the inflammatory process observed in neuropathic *** analgesic effects of muscovite nanoparticles were explored using partial sciatic nerve ligation model of neuropathic pain,in which one-third to onehalf of the nerve trifurcation of the sciatic nerve was tightly tied to the dorsal *** nanoparticles(4 mg/100μL)was given intramuscularly to evaluate its effects on neuropathic pain(3 days per week for 4 weeks).The results showed that the muscovite nanoparticle injections significantly alleviated partial sciatic nerve ligation-induced mechanical and cold *** the spinal cord,the muscovite nanoparticle injections exhibited inhibitory effects on astrocyte and microglia activation and reduced the expression of pro-inflammatory cytokines,such as interleukin-1β,tumor necrosis factor-α,interleiukin-6 and monocyte chemoattractant protein-1,which were upregulated in the partial sciatic nerve ligation ***,the muscovite nanoparticle injections resulted in a decrease in activating transcription factor 3,a neuronal injury marker,in the sciatic *** results suggest that the analgesic effects of muscovite nanoparticle on partial sciatic nerve ligation-induced neuropathic pain may result from inhibiting activation of astrocytes and microglia as well as pro-inflammatory *** propose that muscovite nanoparticle is a potential anti-nociceptive candidate for neuropathic *** experimental protocols in this study were approved by the Institutional Animal Ethics Committee(IACUC)at Dongguk University,South Korea(approval No.2017-022-1)

关键词： astrocyte microglia muscovite nanoparticle neuropathic pain partial sciatic nerve ligation pharmacopuncture pro-inflammatory cytokine spinal cord

Highly efficient and stable solid-state fiber dye-sensitized solar cells with Ag-decorated SiO_(2) nanoparticles

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Nano Research 2021年第8期14卷 2728-2734页

作者： jae Ho Kim Seok-ju Yoo Daseul Lee Jin Woo Choi Sang-Cheol Han Tae In Ryu Hyung Woo Lee Myunghun Shin Myungkwan Song Materials Center for Energy Convergence Korea Institute of Materials Science(KIMS)797Changwon-daeroSungsan-guChangwonGyeongsangnam-do51508Republic of Korea CEN Nano.Co.Ltd. Nano Convergence CenterMuan-roBuduk-myeonMiryang-siGyeongsangnam-do50404Republic of Korea Accident Coordination and Training Division National Institute of Chemical Safety(NICS)90Gajeongbuk-roYuseong-guDaejeon34114Republic of Korea Department of Nanoenergy Engineering and Research Center of Energy Convergence Technology Pusan National UniversityBusandaehak-ro 63-2Geumjeong-guBusan 46241Republic of Korea School of Electronics and Information Engineering Korea Aerospace University Goyang-cityGyeonggi-do10540Republic of Korea

Fiber-shaped dye-sensitized solar cells(FDSSCs)represent promising futuristic flexible or wearable power sources,owing to their simple fabrication process,light weight,weavability,and *** with strategies on changing the properties of semiconductor materials,the effects of incorporating silver-embedded SiO_(2) nanoparticles(Ag@SiO_(2)NPs)on the photoanodes of solid-state FDSSCs(SS-FDSSCs)are *** power conversion efficiency(PCE)of SS-FDSSCs with Ag@SiO_(2) NPs reaches 5.38%,which is comparable to the reference(3.98%).The PCEs remain at 95%between-16.9 and 91.7℃,indicating the operational stability of SS-FDSSCs within this temperature *** fabricated SS-FDSSCs,whose radii were 2 mm,maintains more than 90%of their efficiency over 500 bending cycles and 10 washing cycles.

关键词： dye-sensitized solar cells fiber-shaped solar cells SiO_(2)nanoparticles plasmonic effect solid-state electrolyte

Cystic Brunner's gland hamartoma in the duodenum:A case report

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World Journal of Gastroenterology 2009年第39期15卷 4980-4983页

作者： Beom Jin Park Min ju Kim Jeong Hyeon Lee Sung-Soo Park Deuk jae Sung Sung Bum Cho Department of Radiology Korea UniversityCollege of MedicineAnam Hospital Department of Pathology Korea UniversityCollege of MedicineAnam Hospital Department of Surgery Korea UniversityCollege of MedicineAnam Hospital

Cystic Brunner's gland hamartoma in the duodenum is exceedingly rare,although microscopic examination may sometimes reveal a Brunner's gland hamartoma containing dilated ducts in the *** present a case of large cystic Brunner's gland hamartoma in the duodenum with a long stalk,which is described in light of multidetector-row computed tomography,magnetic resonance imaging,and a modified small bowel series,together with pathologic correlation and differential diagnosis.

关键词： Brunner's gland Hamartoma Duodenum Multidetector-row computed tomography Magnetic resonance imaging

Management of complications following endoscopic submucosal dissection for gastric cancer

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World Journal of Gastrointestinal Endoscopy 2011年第4期3卷 67-70页

作者： Yoon jae Kim Dong kyun Park Department of Gastroenterology Gachon University of Medicine and ScienceGachon University Gil HospitalIncheon 405-760South Korea

Endoscopic treatment should be considered for early gastric cancer(EGC)and gastric precancerous *** submucosal dissection(ESD)was developed for en bloc removal of a large gastric neoplasm and has been developed following improvements in electrical equipment for hemostasis and dissection and with advances in various knives,hemostatic forceps and endoscopic *** is currently the treatment of choice for precancerous lesions or EGC showing mucosal *** and perforation are major complications of ESD for *** describe the complication of ESD procedures in gastric lesions for endoscopists who are relatively inexperienced in ESD and who may lack optimal access to ESD education and facilities.

关键词： Endoscopic submucosal dissection Gastric cancer,Perforation Bleeding

Tailored eradication strategy vs concomitant therapy for Helicobacter pylori eradication treatment in Korean patients

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World Journal of Gastroenterology 2021年第31期27卷 5247-5258页

作者： Youn I Choi jun-Won Chung Kyoung Oh Kim Kwang An Kwon Yoon jae Kim jung Ho Kim Ja Young Seo Dong kyun Park Division of Internal Medicine Department of GastroenterologyGachon University College of MedicineGil Medical CenterInchoen 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityInchoen 21565South Korea Health IT Research Center Gachon University Gil HospitalIncheon 21565South Korea

BACKGROUND Antibiotic resistance to Helicobacter pylori(***)infection,which ultimately results in eradication failure,has been an emerging issue in the clinical ***,to overcome this problem,an antibiotic sensitivity-based tailored therapy(TT)for *** infection has received *** To investigate the efficacy and safety profiles of TT for *** infection treatment compared to a non-bismuth quadruple therapy,concomitant therapy(CT)*** We included patients(>18 years)with an *** infection and without a history of Helicobacter eradication who visited the Gil Medical Center between March 2016 and October *** being randomly assigned to either the TT or CT treatment group in 1 to 1 manner,patient compliance,eradication success rate(ESR),and patient-reported side effects profiles were assessed and compared between the two *** infection was diagnosed using a rapid urease test,Giemsa stain,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR).Tailored eradication strategy based through the presence of a 23S ribosomal RNA point *** the TT group,a DPO-PCR test,which detected A2142G and/or A2143G point mutations,and a clarithromycin resistance test were *** in the clarithromycin-resistant group were treated with a bismuth-containing quadruple combination therapy,while those with sensitive results were treated with the standard triple *** Of the 217 patients with a treatment naive *** infection,110 patients[mean age:58.66±13.03,men,n=55(50%)]were treated with TT,and 107 patients[mean age:56.67±10.88,men,n=52(48.60%)]were treated with *** compliance(TT vs CT,100%vs 98.13%,P=0.30),and follow-up loss rates(8.18%vs 9.35%,P=0.95)were not significantly different between the *** ESR after treatment was also not statistically different between the groups(TT vs CT,82.73%vs 82.24%,P=0.95).However,the treatment-related and patient-reported side effects were signifi

关键词： Helicobacter pylori Eradication Tailored therapy Conco-mitant therapy regimen

Adult intussusception caused by colonic anisakis: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2536-2541页

作者： Youn I Choi Dong kyun Park Hyun Yee Cho Seung Joon Choi jun-Won Chung kyung Oh Kim Kwang An Kwon Yoon jae Kim Department of Gastroenterology Gachon UniversityGil Medical CenterIncheon 21565South Korea Department of Pathology Gachon University Gil Medical CenterIncheon 21565South Korea

BACKGROUND Colo-colonic intussusception is an uncommon phenomenon in an *** intussusception accounts for < 5% of total cases,and the colo-colonic type is < 30% of *** surgical management has been the treatment of choice for intestinal intussusception in adults,because most frequent causes for adult intussusception are malignant in origin,the importance of the roles of preoperative colonoscopic evaluation has recently been *** SUMMARY We report an extremely rare case of adult colo-colonic intussusception caused by colonic anisakiasis and successfully treated by endoscopic removal of the Anisakis body.A 59-year-old man visited the emergency department due to 1 day of lower abdominal colicky *** computed tomography (APCT) revealed the presence of mid-transverse colon intussusception without definite necrosis,which was possibly related with colorectal *** there was no evidence of necrosis at the intussusception site,a colonoscopy was performed to target the colonic lesion and obtain tissue for a histopathological *** Anisakis body was found when inspecting the suspicious colonic lesion recorded by *** Anisakis body was removed with forceps assisted by *** patient’s symptoms improved dramatically after removing the Anisakis.A reduced colon without any pathological findings was seen on the follow-up *** any further treatment,the patient was discharged 5 d after the *** When colonic intussusception without necrosis occurs in an adult,physician should consider a colonoscopy to exclude causes cured by endoscopy.

关键词： Intussusception Anisakis Colonoscopy Case report

Comparative Study of Visual and Instrumental Analyses of Shade Selection

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Journal of Wuhan University of Technology(Materials Science) 2010年第1期25卷 62-67页

作者： Jee-Ha Choi ju-Mi Park Seung-Geun Ahn Kwang-Yeob Song Min-Ho Lee jae-Youn jung Xinyu Wang Department of Prosthodontics and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Department of Dental Biomaterials and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Division of Mechanical & Aerospace System Engineering and RCIT Chonbuk National University Jeonju Republic of Korea Biomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070 China

The difference between visual and instrumental analyses of a shade selection on natural teeth was investigated. With visual analysis, five prosthodontist examined the middle third of the unrestored maxillary right central incisor of a patient using VITAPEN classical and Vita Toothguide 3D-MASTER tooth shade guide. In instrumental analysis, one prosthodontist examined the same teeth using a spectrophotometer （ShadepilotTM, Degudent, Hanau-Wolfgang, Germany, software 2.40）. Overall, instrumental analysis is more accurate and reproducible than a visual assessment. However, the difference is clinically acceptable.

关键词： shade selection visual analysis instrumental analysis spectrophotometer

Proximate and mineral components of Viscum album var. coloratum grown on eight different host tree species

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Journal of Forestry Research 2019年第4期30卷 1245-1253页

作者： Chul-Woo Kim Chan-Hoon An Hyun-Seok Lee jae-Seon Yi Eun ju Cheong Sang-Hyun Lim Hee-Yeon Kim Forest Bioresources Department National Institute of Forest Science39 OnjeongroGwonseon-guSuwon 16631Republic of Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceSobaek-ro 2009PunggiYoungjuGyungsangbuk-do 36040Republic of Korea Program of Forest Resources Division of Forest ScienceCollege of Forest and Environmental SciencesKangwon National UniversityChuncheon 24341Republic of Korea Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment ServicesChuncheon 24203Republic of Korea

Mistletoes are parasite plants growing on various tree species,taking nutrients from the *** compounds of mistletoe were used in medicine and these mistletoes were commonly collected from oak species that were not well *** analyzed the nutritional value by measuring proximate and mineral components of Korean mistletoe(Viscum album ***)from various host *** was the most proximate component in both leaves and twigs followed crude protein,crude fiber,crude ash and crude *** the contents of the proximate components and minerals varied among hosts and between plant parts,leaves contained higher crude protein and ash,and more minerals except for magnesium than twigs,although no significant difference was found inmistletoe grown on Prunus *** were significant differences of proximate and mineral contents depending on the host *** grown on Chaenomeles sinensis contained higher levels of carbohydrates,crude fat,crude ash,magnesium,calcium,sodium,iron,and zinc than mistletoe grown on other *** grown on *** contained high mineral levels of potassium,copper and *** nutritional value of mistletoes were greatly influenced by the host species but among the hosts,specific nutrients accumulated in leaves more than in twigs,and vice *** on the analysis,Korean mistletoe contains relatively good quality of nutrients and has high potential for dietary supplements as well as for medicinal compounds.

关键词： Mistletoe Viscum album var coloratum Proximate compositions Mineral contents Nutritional value Host species