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Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

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Asian Journal of Andrology 2012年第4期14卷 612-615页

作者： Byoung-Jin Park jae-Yong Shim Yong-jae lee Jung-Hyun lee Hye-Ree lee Department of Family Medicine Yonsei University College of Medicine Seou1135-720 Korea Department of Health Promotion Center Gangnam Severance Hospita Yonsei University College of Medicine Seou1135-720 Korea

Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.

关键词： bioavailable testosterone cardiovascular disease coronary calcium score male sex hormone subclinical coronary arterydisease testosterone

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Stochastic rules for predator and prey hunting and escape behavior in a lattice-based model

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International Journal of Biomathematics 2016年第6期9卷 181-190页

作者： Wonju Jeon Sang-hee lee Department of Mechanical Engineering Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea Division of Integrated Mathematics National Institute for Mathematical Sciences Daejeon 34047 Republic of Korea

Understanding of ecosystem resilience and stability requires comprehending predator- prey dynamics because ecosystems consist of dynamically interacting subsystems that include predator-prey relationships. This relationship is closely related to the hunting- escaping strategies employed by the predator and prey. Therefore, understanding the effects of hunting and escaping strategies on ecosystems will lead to a better under- standing of these systems. As an approach for describing the predator-prey interaction, lattice-based models have been adopted because this approach has strong advantages for simulating various dynamical processes of individual-individual interaction. In the models, each lattice cell is either considered as an attractive/repulsive cell, or an indi- vidual cell, or else it is empty. The attractive （or repulsive cell） can be interpreted as the prey （or predator） of the individual. These states allow us to incorporate the ecological processes of local antagonistic interactions, namely the spread of disturbances （by the predator） and regrowth or recovery （by the prey）. These processes are directly related to the strategic behavior of individuals, such as hunting and escaping. In this study, we suggest a simple and effective mapping formula as a stochastic rule to describe the hunt- ing and escaping behavior. This formula could be widely used not only in the behavior but also in competitive and cooperative relationships.

关键词： Hunting and escaping behavior strategic behavior predator-prey interaction individual-based model.

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Association between metabolic syndrome and agerelated cataract

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 804-811页

作者： Sangshin Park Eun-hee lee Center for International Health Research Rhode Island Hospital The Warren Alpert Medical School of Brown University Department of Visual Optics and Graduate School of Health Science Far East University

·AIM: To determine the effect of metabolic syndrome on age-related cataract formation.·METHODS: We analyzed data for 2852 subjects [41.8%men and 58.2% women; mean(±SD) age, 52.9 ±13.9y],taken from the Korea National Health and Nutrition Examination Survey 2008. Metabolic syndrome was diagnosed by criteria proposed by the Joint Interim Societies. Cataract was diagnosed by using the Lens Opacities Classification System III. The association between metabolic syndrome and cataract was determined using age-adjusted and multivariable logistic regression analyses.· RESULTS: In multivariable analyses, men with metabolic syndrome had a 64% increased risk of nuclear cataract [odds ratio(OR), 1.64; 95% confidence interval(CI), 1.12-2.39]. Women with metabolic syndrome had a56% increased risk of cortical cataract(OR, 1.56; 95% CI,1.06-2.30). Men and women with metabolic syndrome had a 46%(OR, 1.46; 95% CI, 1.01-2.12) and 49%(OR,1.49; 95% CI, 1.07-2.08) increased risk of any cataract,respectively. The prevalence of nuclear and any cataract significantly increased with an increasing number of disturbed metabolic components in men, and prevalence of all types of cataracts increased in women. Men using hypoglycemic medication had an increased risk of nuclear(OR, 2.62; 95% CI, 1.41-4.86) and any(OR, 2.27;95% CI, 1.14-4.51) cataract, and women using antidyslipidemia medication had an increased risk of cortical(OR, 2.18; 95% CI, 1.12-4.24) and any(OR, 2.21;95% CI, 1.14-4.26) cataract.·CONCLUSION: Metabolic syndrome and its components,such as abdominal obesity, high blood pressure, andimpaired fasting glucose, are associated with age-related cataract formation in the Korean population.

关键词： cataract metabolic syndrome obesity diabetes mellitus hypertension

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Proximate and mineral components of Viscum album var. coloratum grown on eight different host tree species

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Journal of Forestry Research 2019年第4期30卷 1245-1253页

作者： Chul-Woo Kim Chan-Hoon An Hyun-Seok lee jae-Seon Yi Eun Ju Cheong Sang-Hyun Lim hee-Yeon Kim Forest Bioresources Department National Institute of Forest Science39 OnjeongroGwonseon-guSuwon 16631Republic of Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceSobaek-ro 2009PunggiYoungjuGyungsangbuk-do 36040Republic of Korea Program of Forest Resources Division of Forest ScienceCollege of Forest and Environmental SciencesKangwon National UniversityChuncheon 24341Republic of Korea Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment ServicesChuncheon 24203Republic of Korea

Mistletoes are parasite plants growing on various tree species,taking nutrients from the *** compounds of mistletoe were used in medicine and these mistletoes were commonly collected from oak species that were not well *** analyzed the nutritional value by measuring proximate and mineral components of Korean mistletoe(Viscum album ***)from various host *** was the most proximate component in both leaves and twigs followed crude protein,crude fiber,crude ash and crude *** the contents of the proximate components and minerals varied among hosts and between plant parts,leaves contained higher crude protein and ash,and more minerals except for magnesium than twigs,although no significant difference was found inmistletoe grown on Prunus *** were significant differences of proximate and mineral contents depending on the host *** grown on Chaenomeles sinensis contained higher levels of carbohydrates,crude fat,crude ash,magnesium,calcium,sodium,iron,and zinc than mistletoe grown on other *** grown on *** contained high mineral levels of potassium,copper and *** nutritional value of mistletoes were greatly influenced by the host species but among the hosts,specific nutrients accumulated in leaves more than in twigs,and vice *** on the analysis,Korean mistletoe contains relatively good quality of nutrients and has high potential for dietary supplements as well as for medicinal compounds.

关键词： Mistletoe Viscum album var coloratum Proximate compositions Mineral contents Nutritional value Host species

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Origin of superior low-cycle fatigue resistance of an interstitial metastable high-entropy alloy

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Journal of Materials Science & Technology 2022年第20期115卷 115-128页

作者： Seyed Amir Arsalan Shams jae Wung Bae jae Nam Kim Hyoung Seop Kim Taekyung lee Chong Soo lee Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea

In this study, the deformation behaviors and related microstructural evolutions were investigated in either monotonic or cyclic deformation modes in an interstitial metastable high-entropy alloy. These investigations aimed to reveal the mechanisms underlying the superior low-cycle fatigue(LCF) life of this alloy.A thermomechanical process was applied to induce fine-grained(FG) and coarse-grained(CG) microstructures in Fe–30Mn–10Co–10Cr–0.4C(atomic percentage) alloy. Their superior combination of strength and ductility was attributed to the appearance of deformation-induced ε-martensite and the presence of carbon. The CG alloy showed a greater volume fraction of ε-martensite than the FG alloy in the monotonic deformation mode, and vice versa in the cyclic mode. Such a disparity was interpreted in light of the back-stress effect of the relaxed γ-grain boundaries in the latter mode. Meanwhile, the γ-to-ε phase transformation under cyclic loading at low strain amplitudes(0.4%) barely led to an improved fatigue life as compared with that at higher strain amplitudes(≥ 0.55%). The high reversibility of partial dislocation motions under cyclic loading and delaying the formation of dislocation cells through the martensitic transformation could explain why the alloys investigated in this study exhibited a superior LCF life compared with high-entropy alloys reported in previous studies.

关键词： High-entropy alloy Transformation-induced plasticity Monotonic deformation Cyclic deformation Low-cycle fatigue Stacking faults

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Development of Non-Dissipative Direct Time Integration Method for Structural Dynamics Application

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Computer Modeling in Engineering & Sciences 2019年第1期118卷 41-89页

作者： Sun-Beom Kwon jae-Myung lee Department of Naval Architecture and Ocean Engineering Pusan National UniversityJangjeon-DongGeumjeong-GuBusan 609-735Korea.

A direct time integration scheme based on Gauss-Legendre quadrature is proposed to solve problems in linear structural *** proposed method is a oneparameter non-dissipative *** stability,accuracy,and dispersion characteristics are achieved using appropriate values of the *** proposed scheme has second-order accuracy with and without physical ***,its stability,accuracy,and dispersion are *** addition,its performance is demonstrated by the two-dimensional scalar wave problem,the single-degree-of-freedom problem,two degrees-of-freedom spring system,and beam with boundary *** wave propagation problem is solved in the high frequency wave regime to demonstrate the advantage of the proposed *** the proposed scheme is applied to solve the wave problem,more accurate solutions than those of other methods are obtained by using the appropriate value of the *** the single-degree-offreedom system,two degrees-of-freedom system,and the time responses of beam,the proposed scheme can be used effectively owing to its high accuracy and lower computational cost.

关键词： Structural dynamics finite elements direct time integration Gauss-Legendre quadrature non-dissipative scheme.

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Development of two-axis control index table driven by direct drive motors

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Journal of Central South University 2011年第6期18卷 1962-1968页

作者： KIM jae-hyun lee Choon-man School of Mechatronics Changwon National University

The stability and reliability of a tilting index table should be considered at the design stage. A design method for the lightweight and improvement of the stability of the structure in a tilting index table was proposed using a commercial analysis program, ANSYS Workbench 12, by analyzing the static-thermal characteristics of the developed high-accuracy tilting index table at its design stage. The results of the performed structural analysis show that the maximum stress is generated at the stock tail part. An optimum design for the stock tail part was carried out to reduce the maximum stress and deformation. Also, the design variables were determined by considering the support of the stock tail part for the C-axis body. In the comparison of the results before and after the optimization, the maximum deformation and stress are improved by 2.8% and 8%, respectively.

关键词： tilting index table structural analysis modal analysis thermal analysis optimum design

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Prothrombin kringle-2, a mediator of microglial activation: new insight in Alzheimer’s disease pathogenesis

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Neural Regeneration Research 2022年第12期17卷 2675-2676页

作者： jae Man lee Sang Ryong Kim Department of Biochemistry and Cell Biology Cell and Matrix Research InstituteSchool of MedicineKyungpook National UniversityDaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea School of Life Sciences BK21 FOUR KNU Creative BioResearch GroupInstitute of Life Science and BiotechnologyKyungpook National UniversityDaeguKorea

Microglial activation in Alzheimer’s disease(AD):In 1907,*** Alzheimer,a Bavarian-born German psychiatrist and neuropathologist,published an article describing the clinical and neuropathological features of an unclassified psychiatric *** disorder was later named AD and is currently the most common brain disorder(Takata et al.,2021).AD involves the accumulation of amyloid-β(Aβ)and hyperphosphorylated tau proteins in the brain,which are associated with senile plaques and neurofibrillary tangles,respectively(Vergara et al.,2019;Takata et al.,2021).AD is characterized by cognitive impairment and memory loss with hippocampal neurodegeneration(Kim et al.,2021).

关键词： Alzheimer Aβ tau

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Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms

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Journal of Environmental Sciences 2015年第9期27卷 115-127页

作者： Jin Wuk lee Eun-Ji Won Sheikh Raisuddin jae-Seong lee Department of Biological Science College of Science Sungkyunkwan University Department of Medical Elementology and Toxicology Hamdard University

In environmental risk assessments（ERA）, biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes（e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function）. To mitigate these limitations, the concept of adverse outcome pathways（AOPs） was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event（MIE） to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo（a）pyrene（Ba P）, silver nanoparticles（Ag NPs）, and selenium（Se）. Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population ***, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural *** development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem.

关键词： Adverse outcome pathway Biomarker Omics Environmental risk assessment Aquatic organisms Interspecific difference

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Potholeeye^(+): Deep-Learning Based Pavement Distress Detection System toward Smart Maintenance

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Computer Modeling in Engineering & Sciences 2021年第6期127卷 965-976页

作者： Juyoung Park Jung hee lee Junseong Bang Korea Expressway Corporation 77Hyeoksin8-roGimcheon-siKorea Electronics and Telecommunications Research Institute(ETRI) 218 Gajeong-roYuseong-guDaejun-siKorea University of Science&Technology(UST) 217 Gajeong-roYuseong-guDaejun-siKorea

We propose a mobile system,called Potholeeye+,for automatically monitoring the surface of a roadway and detecting the pavement distress in real-time through analysis of a ***+pre-processes the images,extracts features,and classifies the distress into a variety of types,while the road manager is *** day for a year,we have tested Potholeeye+on real highway involving real settings,a camera,a mini computer,a GPS receiver,and so ***,Potholeeye+detected the pavement distress with accuracy of 92%,precision of 87%and recall 74%averagely during driving at an average speed of 110 km/h on a real highway.

关键词： Pavement distress detection classification convolutional neural network deep learning video analysis

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