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One-step method to enhance biotribological properties and biocompatibility of DLC coating by ion beam irradiation

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Friction 2022年第7期10卷 1114-1126页

作者： Yuzhen LIU Kelun ZhaNG jae-Ho haN Youn-Hoo hwang Shusheng XU Dae-Eun KIM Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of MedicineSeoul 03722Republic of Korea State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

A one-step method was developed to create a highly biocompatible micropatterned surface on a diamond-like carbon(DLC)through irradiation with a nitrogen ion beam and thus enhance the biocompatibility of osseointegrated surfaces and biotribological performance of articular *** biocompatibility and biotribological mechanisms were analyzed in terms of the structure and morphology of *** was demonstrated that a layer enriched in sp^(3) C-N bonds was formed on the surface of the DLC after nitrogen ion beam ***,with an increase in the radiation dose,the content of sp^(3) C-N on the DLC surface increased significantly,and the biocompatibility was positively correlated with *** adhesion of the MC3T3 osteoblasts increased significantly from 32%to 86%under an irradiation dose of 8×10^(15) ions/cm^(2).In contrast,the micropattern had a significant negative effect on the adhesion of the osteoblasts as it physically hindered cell expansion and *** micropattern with a depth of 37 nm exhibited good friction properties,and the coefficient of friction was reduced by 21%at relatively high speeds.

关键词： ion beam irradiation biocompatibility diamond-like carbon(DLC) in-vivo micropattern biotribological performance

Room-temperature lasing from nanophotonic topological cavities

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Light(Science & Applications) 2020年第1期9卷 823-830页

作者： Daria Smirnova Aditya Tripathi Sergey Kruk Min-Soo hwang ha-Reem Kim Hong-Gyu Park Yuri Kivshar Nonlinear Physics Center Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia Institute of Applied Physics Russian Academy of ScienceNizhny Novgorod 603950Russia Department of Physics Indian Institute of TechnologyDelhi 110016India Department of Physics Korea UniversitySeoul 02841Republic of Korea

The study of topological phases of light underpins a promising paradigm for engineering disorder-immune compact photonic devices with unusual *** with an optical gain,topological photonic structures provide a novel platform for micro-and nanoscale lasers,which could benefit from nontrivial band topology and spatially localized gap ***,we propose and demonstrate experimentally active nanophotonic topological cavities incorporating Ⅲ-Ⅴ semiconductor quantum wells as a gain medium in the *** observe room-temperature lasing with a narrow spectrum,high coherence,and threshold *** emitted beam hosts a singularity encoded by a triade cavity mode that resides in the bandgap of two interfaced valley-hall periodic photonic lattices with opposite parity *** findings make a step towards topologically controlled ultrasmall light sources with nontrivial radiation characteristics.

关键词： lasing singularity narrow

Long-type double-balloon enteroscopy-assisted ERCP using hand-made accessories in Roux-en-Y hepaticojejunostomy(with video)

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 407-408页

作者： Min jae Yang Ah Reum Kim jae Chul hwang Byung Moo Yoo Jin Hong Kim Department of Gastroenterology Ajou University School of MedicineSuwonSouth Korea

To the Editor:Short-type balloon enteroscope-assisted endoscopic retrograde cholangiopancreatography(BE-ERCP)is becoming the procedure of choice for biliopancreatic disease treatment in patients with postoperative anatomy^([1,2]).However,it has not yet been available in many *** a long-type balloon enteroscope with a200-cm working length has been widely used for small bowel endoscopy,its use for ERCP was limited by the lack of commercially available extra-long accessories^([3]).

关键词： balloon anatomy ERCP

Derivation of Regression Coefficients for Sea Surface Temperature Retrieval over East Asia

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Advances in Atmospheric Sciences 2006年第3期23卷 474-486页

作者： Myoung-Hwan AHN Eun-ha SOHN Byong-Jun hwang Chu-Yong CHUNG Xiangqian WU Remote Sensing Research Laboratory/Meteorological Research Institute Seoul Korea Office of Research and Applications National Environmental Satellite Data and Information Service National Oceanic and Atmospheric Administration

Among the regression-based algorithms for deriving SST from satellite measurements, regionally optimized algorithms normally perform better than the corresponding global algorithm. In this paper, three algorithms are considered for SST retrieval over the East Asia region （15°-55°N, 105°-170°E）, including the multi-channel algorithm （MCSST）, the quadratic algorithm （QSST）, and the Pathfinder algorithm （PFSST）. All algorithms are derived and validated using collocated buoy and Geostationary Meteorological Satellite （GMS-5） observations from 1997 to 2001. An important part of the derivation and validation of the algorithms is the quality control procedure for the buoy SST data and an improved cloud screening method for the satellite brightness temperature measurements. The regionally optimized MCSST algorithm shows an overall improvement over the global algorithm, removing the bias of about -0.13℃ and reducing the root-mean-square difference （rmsd） from 1.36℃ to 1.26℃. The QSST is only slightly better than the MCSST. For both algorithms, a seasonal dependence of the remaining error statistics is still evident. The Pathfinder approach for deriving a season-specific set of coefficients, one for August to October and one for the rest of the year, provides the smallest rmsd overall that is also stable over time.

关键词： Regional SST algorithm GMS-5 Data quality control cloud detection

Treatment and prognosis of hepatic epithelioid hemangioendothelioma based on SEER data analysis from 1973 to 2014

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 29-35页

作者： O Kyu Noh Soon Sun Kim Min jae Yang Sun Gyo Lim jae Chul hwang Hyo Jung Cho jae Youn Cheong Sung Won Cho Department of Radiation Oncology Ajou University School of MedicineSuwonKorea Department of Biomedical Informatics Ajou University School of MedicineSuwonKorea Office of Biostatistics Ajou Research Institute for Innovative MedicineAjou University Medical CenterSuwonKorea Department of Gastroenterology Ajou University School of MedicineSuwonKorea

Background: Hepatic epithelioid hemangioendothelioma (HEH) is a rare tumor of vascular origin with an unknown etiology, a low incidence, and a variable natural course. We evaluated the management and prognosis of HEH from the Surveillance, Epidemiology and End Results (SEER) program and changes in treatment modalities of HEH over 30 years. Methods: From 1973 to 2014 in the SEER database, we selected patients diagnosed with HEH. We analyzed the clinical characteristics, patterns of management, and clinical outcomes of patients with HEH. Results: We identi ed 79 patients with HEH (median age: 54.0 years;male to female ratio: 1:2.6). The initial extent of disease was local in 22 (27.8%) patients, regional metastasis in 22 (27.8%), distant metas-tasis in 31 (39.2%) and unknown in 4 (5.1%). The median size of primary tumor was 3.85 cm (interquartile range, 2.50 7.93 cm). Among 74 patients with available management data, the most common manage-ment was no treatment (29/74, 39.2%), followed by chemotherapy only (22/74, 29.7%), liver resection-based (13/74, 17.6%), and transplantation-based therapy (6/74, 8.1%). The 5-year cancer-speci c survival rate was 57.8%. Patients who underwent surgical treatment had signi cantly higher survival than those who underwent non-surgical treatment (5-year survival;88% vs. 49%, P=0.019). Multivariate analysis revealed that surgical therapy was the only independent prognostic factor for survival (hazard ratio: 0.20, P=0.040). Conclusions: Resection or liver transplantation is worth considering for treatment of patients with HEH.

关键词： Hemangioendothelioma Epithelioid SEER program Liver transplantation Hepatectomy Liver neoplasms

Flexible electronics based on one-dimensional and two-dimensional hybrid nanomaterials

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InfoMat 2020年第1期2卷 33-56页

作者： Jihun Park jae Chul hwang Gon Guk Kim Jang-Ung Park Department of Materials Science and Engineering Nano Science Technology InstituteYonsei UniversitySeoulRepublic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Yonsei-IBS InstituteSeoulRepublic of Korea

Research on flexible or wearable electronics has been grown remarkably due to the advent of nanomaterials,such as metal nanowires,graphene,or transition metal *** each nanomaterial has mechanical and electrical characteristics that can be applied into flexible electronics,the limitations of each nanomaterial are also *** order to overcome the limitations of these nanomaterials,research on the hybrid structures of nanomaterials has been extensively *** this study,we introduce the properties of one-dimensional nanomaterials,twodimensional nanomaterials,and their hybrid *** then,we provide information concerning various flexible electronics based on these nanomaterials.

关键词： flexible electronics hybrid nanomaterials one-dimensional nanomaterials two-dimensional nanomaterials wearable electronics

Controlling a lithium surface with an alkyl halide nucleophile exchange

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Journal of Energy Chemistry 2021年第11期30卷 617-626,I0015页

作者： Jung-Hun Lee Thuy Hoai Linh Vuong Soo Min hwang jae-Hun Kim Young-Jun Kim SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Nano Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea

Despite its high theoretical energy density, lithium metal faces huge challenges in its implementation as an anode for Li secondary batteries because of its uncontrollable dendritic growth and large volume change during plating/stripping processes. These geometric changes cause degradation in a cell’s cycle life and performance and can lead to short-circuits and explosions. Here, we report a new approach to producing a LiF-rich phase on the lithium anode surface by employing a “bi-phase” separator. We fabricated it by coating polyvinylidene fluoride-co-hexafluoropropylene (PVDF-HFP) onto a cellulose separator. The coverage of coating was adjusted by varying its concentration in the coating solution. The combination of cellulose and PVDF-HFP produced a LiF-rich solid-electrolyte interphase layer on the Li metal surface via an alkyl halide nucleophile exchange in contact with the bi-phase separator during plating. Symmetric cell tests show that the bi-phase separator extends the cycle life by more than 300 h, with overpotentials of less than 100 mV under plating/stripping at 2 mA cm^(−2) for a capacity of 2 mAh cm^(−2). The formation mechanism of the LiF-rich phase is suggested from spectroscopic analyses.

关键词： Li metal anode PVDF-HFP Cellulose LiF Phase inversion

Fiber-based quantum-dot pulse oximetry for wearable health monitoring with high wavelength selectivity and photoplethysmogram sensitivity

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npj Flexible Electronics 2023年第1期7卷 413-424页

作者： Ho Seung Lee Byeongju Noh Seong Uk Kong Yong ha hwang ha-Eun Cho Yongmin Jeon Kyung Cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Biomedical Engineering Gachon UniversitySeongnamRepublic of Korea

Increasing demand for real-time healthcare monitoring is leading to advances in thin and flexible optoelectronic device-based wearable pulse *** previous studies have used OLEDs for this purpose,but did not consider the side effects of broad full-width half-maximum(FWHM)characteristics and single *** this study,we performed SpO_(2)measurement using a fiber-based quantum-dot pulse oximetry(FQPO)system capable of mass production with a transferable encapsulation technique,and a narrow FWHM of about 30 *** on analyses we determined that uniform angular narrow FWHM-based light sources are important for accurate SpO_(2)measurements through multi-layer structures and human skin *** FQPO was shown to have improved photoplethysmogram(PPG)signal sensitivity with no waveguide-mode noise signal,as is typically generated when using a single substrate(30–50%).We successfully demonstrate improved SpO_(2)measurement accuracy as well as all-in-one clothing-type pulse oximetry with FQPO.

关键词： pulse waveguide quantum

Expression of prothymosin α predicts early recurrence and poor prognosis of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 171-177页

作者： Sang Yun ha Dae Hyun Song Soo Hyun hwang Soo Youn Cho Cheol-Keun Park Department of Pathology Samsung Medical CenterSungkyunkwan University School of Medicine

BACKGROUND：Prothymosinα（PTMA）is a nuclear oncoprotein-transcription factor essential for cell cycle progression and *** was overexpressed in several human malignancies including hepatocellular carcinoma（HCC）.However,the prognostic significance of PTMA protein expression in HCC remains *** the present study,we evaluated PTMA protein expression by immunohistochemistry in order to elucidate the prognostic roles of PTMA in HCC ***： By immunohistochemistry, we investigated the expression of PTMA protein in tumor tissue from 226 HCC patients who underwent curative hepatectomy. Univariate and multivariate analyses were performed to evaluate its predic- tive value for tumor recurrence and survival of patients. The median follow-up period was 120 months. RESULTS： PTMA expression was observed in 162 （71.7%） of the 226 HCC patients and was significantly associated with higher Edmondson grade, microvascular invasion, intrahe- patic metastasis, higher American Joint Committee on Cancer （AJCC） T-stage, and lower albumin level. PTMA expression was an independent predictor of early recurrence （P=0.001）. PTMA expression showed an unfavorable influence on recurrence- free survival （RFS）（P〈0.001）. Subgroup analysis showed that among patients with tumor size _〈5.0 cm （140 patients）, patients at AJCC T-stage I （95 patients） and patients with a-fetoprotein ≤20 ng/mL （83 patients）, the differences in RFS between PTMA- positive and PTMA-negative groups were also statistically sig- nificant （P=0.017, P=0.002 and P=0.002, respectively）. In addi- tion, PTMA expression was an independent predictor of shorter RFS （P=0.011）. PTMA expression showed an unfavorable influ- ence on overall survival （P=0.014）, but was not an independent predictor of shorter overall survival （P=0.161）. CONCLUSIONS： PTMA protein expression might be a novel predictor of early recurrence and RFS in HCC patients, even those at early stage or with a-fetoprotein-negative after curative hep

关键词： prothymosin a hepatocellular carcinoma recurrence