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Major gastrointestinal bleeding and antithrombotics: Characteristics and management

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World Journal of Gastroenterology 2020年第36期26卷 5463-5473页

作者： jacques Bouget Damien Viglino Quentin Yvetot Emmanuel Oger EA 7449 REPERES Pharmacoepidemiology and Health Services ResearchUniv RennesRennes 35000France Emergency Department and Mobile Intensive Care Unit-HP2 Laboratory INSERM U1042 University Grenoble AlpsLa Tronche 38700France Emergency Department CHU RennesRennes 3500France EA 7449 REPERES Universitéde Rennes 1Rennes 35000France

BACKGROUND There are few reports on major gastrointestinal(GI)bleeding among patients receiving an *** To describe clinical characteristics,bleeding locations,management and inhospital mortality related to these *** Over a three-year period,we prospectively identified 1080 consecutive adult patients admitted in two tertiary care hospitals between January 1,2013 and December 31,2015 for major GI bleeding while receiving an *** bleeding events were medically *** characteristics,causative lesions,management and fatalities were *** distribution of antithrombotics prescribed was compared across the bleeding lesions *** Of 576 patients had symptoms of upper GI bleeding and 504 symptoms of lower GI *** cause was identified for 383(35.5%)***-duodenal ulcer was the first causative lesion in the upper tract(209 out of 408)and colonic diverticulum the first causative lesion in the lower tract(120 out of 289).There was a larger proportion of direct oral anticoagulant use among patients with lower GI than among those with upper GI lesion locations(P=0.03).There was an independent association between gastro-duodenal ulcer and antithrombotic use(P=0.03),taking account of confounders and proton pump inhibitor *** wise comparisons pointed to a difference between vitamin K antagonist,direct oral anticoagulants,and antiplatelet agents in monotherapy vs dual antiplatelet *** We showed a higher rate of bleeding lesion identification and suggested a different pattern of antithrombotic exposure between upper and lower GI lesion locations and between gastro-duodenal ulcer and other identified upper GI causes of *** was similar across antithrombotics and in-hospital mortality was low(5.95%).

关键词： Real-world setting Emergency Bleeding Mortality Antithrombotics Management

Chaos in DNA evolution

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International Journal of Biomathematics 2016年第5期9卷 199-215页

作者： jacques M. Bahi Christophe Guyeux Antoine Perasso Institut FEMTO-ST Universitg Bourgogne Franche-Comtd 25000 Besancon France UMR Chrono-Environnement Universite Bourgogne Franche-Comte 25000 Besancon France

In this paper, we explain why the chaotic mutation （CM） model of J. M. Bahi and C. Michel （2008） simulates the genes mutations over time with good accuracy. It is firstly shown that the CM model is a truly chaotic one, as it is defined by Devaney. Then, it is established that mutations occurring in genes mutations have indeed a same chaotic dynamic, thus making relevant the use of chaotic models for genomes evolution. Transposition and inversion dynamics are finally investigated.

关键词： Genomes evolution models mutations inversions transpositions mathema- tical topology Devaney's chaos.

Dawn of ocular gene therapy:implications for molecular diagnosis in retinal disease

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Science China(Life Sciences) 2013年第2期56卷 125-133页

作者： ZANEVELD jacques WANG Feng WANG Xia CHEN Rui Human Genome Sequencing Center Department of Molecular and Human GeneticsBaylor College of Medicine

Personalized medicine aims to utilize genomic information about patients to tailor treatment. Gene replacement therapy for ra- re genetic disorders is perhaps the most extreme form of personalized medicine, in that the patients＇ genome wholly determines their treatment regimen. Gene therapy for retinal disorders is poised to become a clinical reality. The eye is an optimal site for gene therapy due to the relative ease of precise vector delivery, immune system isolation, and availability for monitoring of any potential damage or side effects. Due to these advantages, clinical trials for gene therapy of retinal diseases are currently underway. A necessary precursor to such gene therapies is accurate molecular diagnosis of the mutation（s） underlying disease. In this review, we discuss the application of Next Generation Sequencing （NGS） to obtain such a diagnosis and identify disease causing genes, using retinal disorders as a case study. After reviewing ocular gene therapy, we discuss the application of NGS to the identification of novel Mendelian disease genes. We then compare current, array based mutation detection methods against next NGS-based methods in three retinal diseases： Leber＇s Congenital Amaurosis, Retinitis Pigmentosa, and Stargardt＇s disease. We conclude that next-generation sequencing based diagnosis offers several advantages over array based methods, including a higher rate of successful diagnosis and the ability to more deeply and efficiently assay a broad spectrum of mutations. However, the relative difficulty of interpreting sequence results and the development of standardized, reliable bioinforrnatic tools remain outstanding concerns. In this review, recent advances NGS based molecular diagnoses are discussed, as well as their implications for the development of personalized medicine.

关键词： next-generation sequencing (NGS) retinal disease molecular diagnosis Leber's Congenital Amarosis (LCA) Retinitus Pigmentosa (RP) Stargardt disease APEX personal medicine

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A time fractional model to represent rainfall process

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Water Science and Engineering 2014年第1期7卷 32-40页

作者： jacques GOLDER Maminirina JOELSON Marie-Christine NEEL Liliana DI PIETRO Department of Physics University of Avignon Mediterranean Environment and Agro-Hydro System Modelisation Laboratory French National Institute for Agricultural Research

This paper deals with a stochastic representation of the rainfall process. The analysis of a rainfall time series shows that cumulative representation of a rainfall time series can be modeled as a non-Gaussian random walk with a log-normal jump distribution and a time-waiting distribution following a tempered a-stable probability law. Based on the random walk model, a fractional Fokker-Planck equation （FFPE） with tempered a-stable waiting times was obtained. Through the comparison of observed data and simulated results from the random walk model and FFPE model with tempered a-stable waiting times, it can be concluded that the behavior of the rainfall process is globally reproduced, and the FFPE model with tempered a-stable waiting times is more efficient in reproducing the observed behavior.

关键词： rainfall process heavy-tailed probability distribution tempered a-stable probability law log-normal law Hurst exponent continuous time random walk model fractional Fokker-Planck equation

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Integrating fossils in a molecular-based phylogeny and testing them as calibration points for divergence time estimates in Menispermaceae

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Journal of Systematics and Evolution 2011年第1期49卷 25-49页

作者： Frdric M.B. jacques Rosa Del C. ORTIZ Department of Biodiversity and Biogeography Kunming Institute of Botany Chinese Academy of Sciences State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Missouri Botanical Garden St. Louis MO 63166-0299 USA

The phylogeny of extant Menispermaceae (Ranunculales) is reconstructed based on DNA sequences of two chloroplast genes (rbcL and atpB) from 94 species belonging to 56 genera. Fossilized endocarps represent 34 genera. The positions of these are inferred using 30 morphological characters and the molecular phylogeny as a backbone constraint. Nine of the thirteen nodes that are each dated by a fossil are used as calibration points for the estimates of molecular divergence times. BEAST is used to estimate stem age (121.2 Myr) and crown age (105.4 Myr) for Menispermaceae. This method does not require an input tree topology and can also account for rate heterogeneity among lineages. The sensitivity of these estimates to fossil constraints is then evaluated by a cross-validation procedure. The estimated origin for Menispermaceae is dated to the mid-Jurassic if the customary maximum age of 125 Myr for eudicots is not implemented. All constraints when used alone failed to estimate node ages in some parts of the tree. Fossils from the Palaeocene and Eocene impose strict constraints. Likewise, the use of Prototinomiscium as a dating constraint for Menispermaceae appears to be a conservative approach.

关键词： age calibration cross-validation fossil Menispermaceae molecular scaffold phylogeny.

ASSESSMENT OF OPTICAL CLEARING AGENTS USING REFLECTANCE-MODE CONFOCAL SCANNING LASER MICROSCOPY

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Journal of Innovative Optical Health Sciences 2010年第3期3卷 183-188页

作者： RAVIKANT SAMATHAM KEVIN G.PHILLIPS STEVEN L.jacques Departments of Dermatology and Biomedical Engineering Oregon Health and Science University 3303 SW Bond Avenue PortlandOR 97239USA

The mechanism of action of clearing agents to improve optical imaging of mouse skin during reflectance-mode confocal microscopy was *** dermal side of excised dorsal mouse skin was exposed for one hour to saline,glycerin,or 80% DMSO,then the clearing agent was removed and the dermis placed against a glass cover slip through which a confocal microscope measured reflectance at 488 nm *** untreated control was also *** axial attenuation of reflectance signal,R(z_(f))versus increasing depth of focus zf behaved as R=ρexp(−μz_(f) 2G),where ρ is tissue reflectivity and μ is attenuation[cm^(−1)].The factor 2G accounts for the in/out path of photons,and the numerical aperture of the *** ρ,μ data were mapped to values of scattering coefficient(μ_(s)[cm^(−1)])and anisotropy of scattering(g).Images showed that glycerin significantly increased the g of dermis from about 0.7 to about 0.99,with little change in the μ_(s) of dermis at about 300cm^(−1).DMSO and saline had only slight and inconsistent effects on g and μ_(s).

关键词： Optical properties skin anisotropy

Carbon dioxide for gut distension during digestive endoscopy:Technique and practice survey

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World Journal of Gastroenterology 2009年第12期15卷 1475-1479页

作者： Filip Janssens jacques Deviere Pierre Eisendrath Jean-Marc Dumonceau Division of Gastroenterology and Hepatology Geneva University HospitalsMicheli-du-Crest street241205 GenevaSwitzerland Medical-Surgical Department of Gastroenterology and Hepato-Pancreatology Erasme HospitalUniversité Libre de BruxellesBrusselsBelgium

AIM:To assess the adoption of Carbon dioxide(CO2)insufflation by endoscopists from various European countries,and its ***:A survey was distributed to 580 endoscopists attending a live course on digestive ***:The response rate was 24.5%.Fewer than half the respondents(66/142,46.5%)were aware of the fact that room air can be replaced by CO2 for gut distension during endoscopy,and 4.2%of respondents were actually using CO2 as the insufflation *** aware of the possibility of CO2 insufflation mentioned technical difficulties in implementing the system and the absence of significant advantages of CO2 in comparison with room air as barriers to adoption in daily practice(84%and 49%of answers,respectively;two answers were permitted for this item).CONCLUSION:Based on this survey,adoption of CO2 insufflation during endoscopy seems to remain relatively exceptional.A majority of endoscopists were not aware of this possibility,while others were not aware of recent technical developments that facilitate CO2 implementation in an endoscopy suite.

关键词： Colonoscopy Practice survey Carbondioxide Digestive endoscopy

Nodular fasciitis of the external auditory canal: Clinical case report and review of the literature

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中华耳科学杂志:英文版 2023年第4期18卷 240-245页

作者： Adrien Philippart Jean-Christophe Degols jacques Vilain Department of Oto-Rhino-Laryngology-Head and Neck Surgery Saint-Luc University HospitalCatholic University of LouvainAvenue Hippocrate 101200BrusselsBelgium Chief of Department of Oto-Rhino-Laryngology-Head and Neck Surgery Saint-Pierre Clinic OttigniesAvenue Reine Fabiola 91340Ottignies-Louvain-la-NeuveBelgium Department of Oto-Rhino-Laryngology-Head and Neck Surgery Saint-Pierre Clinic Ottignies Avenue Reine Fabiola 91340Ottignies-Louvain-la-NeuveBelgium

Nodular fasciitis is a benign reactive soft tissue tumor arising from fibroblasts and *** incidence is low and misdiagnosis is frequent especially for malignant *** can lead to inappropriate and unnecessary invasive *** fasciitis of the external auditory canal is extremely *** far,around fifteen cases have been *** present here the case of a 90-year-old patient with nodular fasciitis of the right external auditory *** lesion extends anteriorly for 6.5 cm and reaches the posterior wall of the maxillary *** our knowledge,this is the first case in the literature of an external auditory canal nodular fasciitis presenting as an inflammatory ear polyp with such a wide extension.

关键词： Nodular fasciitis External ear canal Polyp

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Leadership and Burundi-rwanda’s Unstable Relations(2000-2020)

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Leadership and Burundi-rwanda’s Unstable Relations(2000-202...

作者： MAGABO jacques 华中师范大学

学位级别：硕士

历史告诉我们,布隆迪与卢旺达两国之间的关系很不稳定。这两个国家通常被认为是孪生国家,这是因为两国几乎具有相同的历史和语言,相同的文化习俗、社会和政治结构。这两个前比利时殖民地国家,都经历了类似的种族灭绝和叛军领导的过渡时... 详细信息

历史告诉我们,布隆迪与卢旺达两国之间的关系很不稳定。这两个国家通常被认为是孪生国家,这是因为两国几乎具有相同的历史和语言,相同的文化习俗、社会和政治结构。这两个前比利时殖民地国家,都经历了类似的种族灭绝和叛军领导的过渡时期。然而,两国的过渡以截然不同的方式发生。由图西人统治的卢旺达爱国阵线(RPF)通过军事胜利掌权,建立起一个强大的、受捐助者青睐的国家。由胡图人领导的布隆迪捍卫民主全国委员会(CNDD-FDD)迫使图西人控制的军队就权力分享协议进行谈判,而其领导的政府权力分裂,对其境外的国家几乎没有影响力。本文认为,这些截然不同的转变不仅仅是某些偶然和特殊因素的结果,例如战争、种族灭绝、冲突的结束、外部影响或个别统治者。在捍卫民主全国委员会(CNDD-FDD)上台之前,布隆迪与卢旺达的关系很好。但是在其执政期间,情况发生了变化。本论文解释并论证了领导力为何以及如何与这种不稳定性联系在一起。该论据主要基于三个论点:第一,如果布隆迪和卢旺达两国领导人属于同一种族,那么布隆迪与卢旺达的关系仍然良好;第二,如果布隆迪和卢旺达领导人属于不同种族,一方对另一方发动侵略时另一方保持冷静,那么布隆迪-卢旺达将保持良好关系;第三,如果卢旺达和布隆迪领导人属于不同种族,一方对另一方发动侵略时另一方采取报复行动,那么布隆迪-卢旺达关系将会恶化。

关键词：愿景领导力布隆迪-卢旺达关系