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Genetic factors for differentiated thyroid cancer in French Polynesia:new candidate loci

Precision Clinical Medicine 2023年第2期6卷 57-66页

作者： Monia Zidane Marc Haber Thérèse Truong Frédérique Rachédi Catherine Ory Sylvie Chevillard Hélène Blanché Robert Olaso Anne Boland Éric Conte Mojgan Karimi Yan Ren Constance Xhaard Vincent Souchard jacques gardon Marc Taquet André Bouville Jean-François Deleuze Vladimir Drozdovitch Florent de Vathaire Jean-Baptiste Cazier University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Radiations Epidemiology"Villejuif 94805France Centre for Computational Biology University of BirminghamBirmingham B152TTUK Institute of Cancer and Genomic Sciences University of BirminghamBirmingham B152TTUK University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Exposome and Heredity"Villejuif 94805France Endocrinology Unit Territorial Hospital TaaoneF-98713PapeeteTahiti 98713French Polynesia CEA Laboratoire de Cancérologie FondamentaleInstitut de Biologie François JacobiRCMSREITLaboratoire de Cancérologie Expérimentale(LCE)UniversitéParis-SaclayFontenay aux Roses 92265France Fondation Jean Dausset-Centre d’Etude du Polymorphisme Humain Paris 75010France UniversitéParis-Saclay CEACentre National de Recherche en Génomique HumaineEvry 91057France U.S.R.2003(CNRS/UPF) Faa’aTahiti 98702France University of Lorraine INSERM CIC 1433Nancy CHRUINSERM U1116Nancy 54500France Hydrosciences Montpellier Research Institute for DevelopmentCNRSUniversity of MontpellierMontpellier 62307France Research Institute for Development Center IRD on TahitiArueTahiti 98713French Polynesia National Cancer Institute(retired) BethesdaMD 20892USA Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Background:Populations of French Polynesia(FP),where France performed atmospheric tests between 1966 and 1974,experience a high incidence of differentiated thyroid cancer(DTC).However,up to now,no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive *** research aimed to analyze the genetic factors of DTC risk among the native FP ***:We analyzed more than 300000 single nucleotide polymorphisms(SNPs)genotyped in 283 DTC cases and 418 matched controls born in FP,most being younger than 15 years old at the time of the first nuclear *** analyzed the genetic profile of our cohort to identify population *** then completed a genome-wide analysis study on the whole ***:We identified a specific genetic structure in the FP population reflecting admixture from Asian and European *** identified three regions associated with increased DTC risk at 6q24.3,10p12.2,and *** lead SNPs at these loci showed respective p-values of 1.66×10^(−7),2.39×10^(−7),and 7.19×10^(−7) and corresponding odds ratios of 2.02,1.89,and ***:Our study results suggest a role of the loci 6q24.3,10p12.2 and 17q21.32 in DTC ***,a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian ***,the functional impact of these three new loci needs to be further explored and validated.

关键词： differentiated thyroid cancer population genetics genetic susceptibility

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