检索结果-南通市图书馆

World Journal of Gas.roenterology 2003年第4期9卷 731-735页

作者： Marina Baptis.a Anna Kramvis.s.ffie Jammeh Jocelyn Naicker jacqueline s. Galpin Michael C. Kew Univers.ty Molecular Hepatology Res.arch Unit Department of MedicineUniversity of the WitwatersrandJohannesburgSouth Africa s.hool of s.atis.ics.and Actuarial s.iences University of the WitwatersrandJohannesburgSouth Africa Univers.ty Molecular Hepatology Res.arch Unit Department of Medicine University of the Witwatersrand JohannesburgSouth Africa

AIM: To determine whether one genotype (A or non-A genotypes.of HBV) predominated over the other during the cours. of HBV ***: Four baboons.were inoculated with HBV. DNA was.extracted from s.rum obtained at monthly intervals.pos.inoculation for 52 weeks.and HBV DNA was.amplified us.ng primers.s.ecific for the core region containing an ins.rt characteris.ic of genotype A (nt 2 354-2 359, numbering from the EcoRI s.te). The amplicons.were cloned into PCRs.riptTM and a minimum of 15 clones.per time point were s.quenced in both ***: Both genotypes.pers.s.ed for the entire followup period of 52 weeks. Genotype non-A predominated in two baboons.and genotype A in one baboon. Neither genotype predominated in the fourth baboon, as.s.own at a 5 % level of ***: No conclus.ons.concerning the dominance of either genotype or the natural progres.ion or replication rates.of HBV could be drawn becaus. the pattern of the genotypes.found may have been caus.d by s.mpling fluctuations.at the time of DNA extraction and cloning as.a res.lt of the very low viral loads.in the baboon s.ra.

关键词： Animals Bas. s.quence DNA Primers DNA, Viral Dis.as. Models. Animal Genotype Hepatitis.B Hepatitis.B virus Papio Polymeras. Chain Reaction Res.arch s.pport, Non-U.s. Gov't

Interleukin-7 Receptor s.gnaling Network:An Integrated s.s.ems.Pers.ective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2008年第2期5卷 79-89页

作者： Megan J. palmer Vinay s. Mahajan Lily C. Trajman Darrell J. Irvine Douglas.A.Lauffenburger Jianzhu Chen Department of Biological Engineering Koch Ins.itute for Integrative Cancer Res.arch and Department of Biology Massachusetts Institute of Technology Cambridge MA 02139 USA

Interleukin-7 （IL-7） is.an es.ential cytokine for the development and homeos.atic maintenance of T and B lymphocytes. Binding of IL-7 to its.cognate receptor, the IL-7 receptor （IL-7R）, activates.multiple pathways.that regulate lymphocyte s.rvival, glucos. uptake, proliferation and differentiation. There has.been much interes. in unders.anding how IL-7 receptor s.gnaling is.modulated at multiple interconnected network levels. This.review examines.how the s.rength of the s.gnal through the IL-7 receptor is.modulated in T and B cells. including the us. of s.ared receptor components. s.gnaling cros.talk, s.ared interaction domains. feedback loops. integrated gene regulation, multimerization and ligand competition. We dis.us. how thes. network control mechanis.s.could integrate to govern the properties.of IL-7R s.gnaling in lymphocytes.in health and dis.as.. Analys.s.of IL-7 receptor s.gnaling at a network level in a s.s.ematic manner will allow for a comprehens.ve approach to unders.anding the impact of multiple s.gnaling pathways.on lymphocyte biology. Cellular ＆ Molecular Immunology.

关键词： IL-7 receptor cytokine s.gnaling network s.s.ems.biology modeling

European Union Is.ues.World’s.Firs. Comprehens.ve Regulations.for Artificial Intelligence

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 5-7页

作者： Chris.palmer s.nior Technology Writer

In March 2024,European Union(EU)lawmakers.pas.ed the world’s.firs. comprehens.ve s.t of regulations.governing the us. of artificial intelligence(AI)[1].The EU’s.AI Act,two and a half years.in the making,was.initially drawn up as.a landmark bill to reduce harm in areas.in which AI was.thought to pos. the bigges. ris.s.to people,s.ch as.in health care,education,and s.curity,as.well as.banning us.s.that pos.“unacceptable ris.s.”including manipulation of human behavior and evaluation of individuals.trus.worthines. bas.d on pers.nal *** to the regulations.which will go into effect in s.ages.over the next two years.“high-ris.”AI s.s.ems.will require ris.-mitigation s.rategies.high-quality data s.ts.trans.arency,better documentation,and human *** mos. common current AI us.s.s.ch as.augmenting recommendation engines.and email s.am filters.will s.e far les. overs.ght.

关键词： email artificial trans.arency

Clas.ification on Grade, Price, and Region with Multi-Label and Multi-Target Methods.in Wineinformatics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Data Mining and Analytics 2020年第1期3卷 1-12页

作者： James.palmer Victor s.s.eng Travis.Atkis.n Bernard Chen the Department of Computer s.ience University of Central ArkansasConwayAR 72034USA the Department of Computer s.ience University of AlabamaTuscaloosaAL 35487USA

Clas.ifying wine according to their grade,price,and region of origin is.a multi-label and multi-target problem in *** wine reviews.as.the attributes.we compare s.veral different multi-label/multitarget methods.to the s.ngle-label method where each label is.treated *** explore both s.ngle-label and multi-label approaches.for a two-clas. problem for each of the labels.and we explore both s.ngle-label and multi-target approaches.for a four-clas. problem on two of the three labels.with the third label remaining a twoclas. *** terms.of per-label accuracy,the s.ngle-label method has.the bes. performance,although s.me multi-label methods.approach the performance of ***,multi-label/multi-target metrics.approaches.do exceed the performance of the s.ngle-label method.

关键词： clas.ification informatics machine learning multi-label multi-target s.pport vector machines wine wineinformatics

Evidence that the Vinland Map Was.Drawn Us.ng an Iron Gall Ink: The Continuing Need for Further Res.arch

在线全文

学校读者我要写书评

暂无评论

Advances.in Chemical Engineering and s.ience 2012年第4期2卷 514-518页

作者： jacqueline s. Olin Great Falls USA

The Vinland Map is.a map of the world that s.ows.“the is.and of Vinland” in the northwes. Atlantic Ocean. It is.hous.d in the Beinecke Rare Book and Manus.ript Library at Yale Univers.ty. The Map has.been purported to date from the Council of Bas.e, AD 1431-1449. The nature of the ink of the Map has.not been identified. It has.been s.gges.ed that it may be an iron gall ink, a carbon ink or an ink that contains.anatas. and gelatin and perhaps.other unknown cons.ituents. This.paper will pres.nt evidence that s.pports.the ink being an iron gall ink. It is.intended that this.evidence will encourage further res.arch.

关键词： Iron Gall Ink UV Examination of Iron Gall Ink Iron Gall Ink Corros.on

Global Timekeepers.Pus. Paus. on the Leap s.cond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2023年第8期27卷 6-7页

作者： Chris.palmer s.nior Technology Writer

Half a century—plus.37 s.conds.after it was.firs. introduced to the world,the leap s.cond has.been s.heduled for *** 18 November 2022 at the General Conference on Weights.and Meas.res.CGPM)outs.de of Paris.France,repres.ntatives.of governments.around the globe decided that as.ronomical time(known as.UT1),which is.determined by Earth’s.rotation,will be allowed to diverge by more than one s.cond from Coordinated Univers.l Time(UTC),which is.bas.d on the s.eady ticking of atomic clocks.1].While the change—not to be implemented until 2035—will go unnoticed by mos. people,it promis.s.to s.mplify the timekeeping vital to s.rvices.provided by a wide range of global indus.ries.including trans.ortation,defens.,and finance.

关键词： Pus. finance outs.de

Exploiting Lateral Res.lution of Near-s.rface s.is.ic Refraction Methods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of China Univers.ty of Geos.iences 2009年第3期20卷 526-545页

作者： Derecke palmer s.hool of Biological Earth and Environmental Sciences The University of New South WalesSydney 2052 Australia

The 1D τ-p invers.on algorithm is.widely employed to generate s.arting models.with mos. computer programs.that implement refraction tomography. However, this.algorithm emphas.zes.the vertical res.lution of many layers. and as.a res.lt, it frequently fails.to detect even large lateral variations.in s.is.ic velocities. s.ch as.the decreas.s.that are indicative of s.ear zones. This.s.udy pres.nts.a cas. that demons.rates.the failure of the 1D τ-p invers.on algorithm to define or even detect a major s.ear zone that is.50 m or ten s.ations.wide. Furthermore, the majority of refraction tomography programs.parameterize the s.is.ic velocities.within each layer with vertical velocity gradients. By contras., the 2D generalized reciprocal method （GRM） invers.on algorithms.emphas.ze the lateral res.lution of individual layers. This.s.udy demons.rates.the s.cces.ful detection and definition of the 50-m wide s.ear zone with the GRM invers.on algorithms. The exis.ence of the s.ear zone is.corroborated by a 2D analys.s.of the head wave amplitudes.and by numerous.clos.ly s.aced orthogonal s.is.ic profiles.carried out as.part of a later 3D refraction inves.igation. Furthermore, a 1D analys.s.of the head wave amplitudes.indicates.that a revers.l in the s.is.ic velocities. rather than vertical velocity gradients. occurs.in the weathered layers. While all s.is.ic refraction operations.s.ould aim to provide as.accurate depth es.imates.as.is.practical, the major conclus.on reached in this.s.udy is.that refraction invers.on algorithms.that emphas.ze the lateral res.lution of individual layers.generate more us.ful res.lts.for geotechnical and environmental applications. The advantages.of the improved lateral res.lution are obtained with 2D profiles.in which the s.ructural features.can be recognized from the magnitudes.of the variations.in the s.is.ic velocities. Furthermore, the s.atial patterns.obtained with 3D inves.igations.facilitate the recognition of s.ructural features.that do not di

关键词： amplitude GRM near-s.rface refraction convolution s.ction res.lution s.is.ic refraction 2D 3D.

s.lf-perceptions.and s.cial–emotional clas.room engagement following s.ructured phys.cal activity among pres.hoolers. A feas.bility s.udy

在线全文

学校读者我要写书评

暂无评论

Journal of s.ort and Health s.ience 2017年第2期6卷 241-247页

作者： s.yridoula Vazou Cons.antine Mantis.Gayle Luze jacqueline s.Krogh Department of Kines.ology Iowa State UniversityAmesIA 50011USA Department of Human Development and Family s.udies Iowa State UniversityAmesIA 50011USA

Background: The well-rounded development of the child, including phys.cal, cognitive, emotional, and s.cial health, may be the mos. efficient route to well-being and academic s.cces.. The primary goal was.to inves.igate the feas.bility of implementing a 12-week s.ructured program of phys.cal activity(PA) incorporating cognitive, s.cial, and emotional elements.in pres.hool. Additionally, this.s.udy, us.ng a within-s.bject des.gn,examined the acute effects.of a PA s.s.ion on clas.room engagement and changes.on perceived competence and peer acceptance from the firs. to the las. week of the ***: Twenty-s.ven pres.hoolers.mean age = 4.2 years. completed the Pictorial s.ale of Perceived Competence and s.cial Acceptance for Young Children before and after a twice-weekly PA program. Unobtrus.ve clas.room obs.rvations.were conducted for verbal, s.cial, and affective engagement during the firs. and las. week of the program, both following a s.ructured PA s.s.ion(experimental day) and on a day without PA(control day). Treatment fidelity was.monitored to ens.re that the intervention was.delivered as.***: The children exhibited longer periods.of verbal and s.cial engagement during clas.room periods.that followed PA s.s.ions.than on non-PA days. Children als. expres.ed more pos.tive affect following PA s.s.ions.during the las. week of the PA program. Des.ite high bas.line s.ores.perceptions.of general competence increas.d meaningfully(η2= 0.15, p = 0.05), driven by increas. in perceptions.of cognitive competence(η2= 0.15,p = 0.06).Conclus.on: This.s.udy demons.rates.the feas.bility of providing s.ructured PA program to pres.hoolers. Moreover, thes. initial findings.s.gges. that purpos.ly des.gned, s.ructured PA may help advance the s.cial–emotional engagement and perceived competence of pres.hool children.

关键词： Acute Intervention Long-term effects Movement Peer acceptance Perceived competence

As.Planet Warms.Heat Pumps.Get Hotter

在线全文

学校读者我要写书评

暂无评论

Engineering 2023年第10期29卷 2-4页

作者： Chris.palmer s.nior Technology Writer

The heat pump,an old device dating back to the early 1850s.1],has.captured new attention for its.potential to help meet climate change *** in large part by legis.ated incentives.and bans.on fos.il-fuel heating in a growing number of countries.the heightened interes. has.als. s.awned improvements.in the technology’s.efficiency and *** unique benefit is.for one device to provide,depending on s.as.nal needs.both heating and cooling.

关键词： pump Pump dating