检索结果-南通市图书馆

出口商品包装 1996年第4期 4-5,20页

作者： jacob.,m

management of symptomatic ureteric stumps laparoscopically

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2001年第2期3卷 147-150页

作者： A.m.Khan S.jacob Department of Surgery King George Hospital Ilford Essex IG1 2HL UKDepartment of Surgery King George Hospital Ilford Essex IG1 2HL UK

Aim: To study the advantage of excision of the distal symptomatic ureteric stumps with the retroperitoneal laparo-scopic approach. methods: Four patients who had failed to settle their symptoms with the initial conservative man-agement were included in the study. All underwent excision of the distal symptomatic ureteric stumps with the retroperi-toneal laparoscopic approach and then received prophylactic antibiotics. Results: We have achieved better resultsthan those reported in the literature in terms of operating time (mean 1 h 45 min), blood loss ( mL), postopera-tive recovery (within 12 h) and hospital stay ( mple and effective method in the management of symptomatic ureteric stumps.

关键词： ureter laparoscopy retroperitoneal space

Targeting sepsis through inflammation and oxidative metabolism

在线全文

学校读者我要写书评

暂无评论

World Journal of Critical Care medicine 2025年第1期14卷 69-81页

作者： Salena jacob.Sanjana Ann jacob.Joby Thoppil Halmos College of Arts and Sciences Nova Southeastern UniversityFort LauderdaleFL 33328United States Dell School of medicine University of Texas at Austin Medical SchoolAustinTX 78712United States Emergency medicine UT Southwestern Medical CenterDallasTX 75390United States

Infection is a public health problem and represents a spectrum of disease that can result in sepsis and septic *** is characterized by a dysregulated immune response to *** shock is the most severe form of sepsis which leads to distributive shock and high mortality *** have been significant advances in sepsis management mainly focusing on early identification and ***,complicating matters is the lack of reliable diagnostic tools and the poor specificity and sensitivity of existing scoring tools i.e.,systemic inflammatory response syndrome criteria,sequential organ failure assessment(SOFA),or quick *** limitations have underscored the modest progress in reducing sepsis-related *** review will focus on novel therapeutics such as oxidative stress targets,cytokine modulation,endothelial cell modulation,etc.,that are being conceptualized for the management of sepsis and septic shock.

关键词： Sepsis Inflammation Oxidative metabolism Infection Reactive oxygen species

Inhibition of FLT3:A Prototype for molecular Targeted Therapy in Acute myeloid Leukemia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2021年第10期7卷 1354-1368页

作者： meira Yisraeli Salman jacob.m.Rowe Nir Weigert Department of Hematology Shaare Zedek Medical CenterJerusalem 9103102Israel Department of Hematology and Bone marrow Transplantation Rambam Medical CenterHaifa 3109601Israel Technion—Israel Institute of Technology Haifa 3200003Israel

modern therapy of acute myeloid leukemia(AmL)began in 1973 with the first report of the successful combination of daunorubicin and cytarabine,which led to complete remission in approximately 45%of *** AmL diagnosis was dependent on morphology,aided initially only by *** acute lymphoblastic leukemia(ALL),immunophenotyping offered little in the diagnosis of AmL,at least during the 1970s and *** advent of reliable cytogenetics changed the entire prognostic outlook of *** karyotypic analysis,different groups of AmL could be classified and stratified for various *** mutational profiling was a major advance in further categorizing AmL patients,aided by the immunophenotypic identification of antigenic markers on the *** these advances were occurring as the understanding of the importance of the tumor burden—known as minimal residual disease(mRD)—became crucial for the management of AmL *** efficacy of mRD has rapidly progressed in the past decade,from a specificity of 103 with immunophenotyping to 104 with polymerase chain reaction(PCR),which is only appropriate for some patients with AmL,and finally to 105 or even 106 cells with the extraordinary sensitivity of next-generation sequencing(NGS).All of these advances have promoted the concept of personalized medicine,which has led to the advent of targeted agents that can accurately be used for specific diagnostic *** can be predicted and measured *** targeted agents have now become a cornerstone in the management of AmL,increasing effi-cacy and dramatically reducing *** focus of this review is on one of the most well-studied targeted agents in AmL:the FmS-like tyrosine kinase 3(FLT3)inhibitors,which have impacted the prognostication and therapeutics of *** review selectively discusses the FLT3 inhibitors in detail,as a model for the other burgeoning targeted agents that have already been approved,as well as tho

关键词： AmL Targeted therapy FLT3 inhibitors midostaurin Gilteritinib Quizartinib Sorafenib

在线全文

学校读者我要写书评

暂无评论

金属切削中滞积区的一种新的分类方法

国外金属加工 1991年第5期12卷 1-7页

作者： jacob.,S 刘彩

VOLUmE SEGmENTATION BY POST-PROCESSING DATA FROm SImULATION OF SOLIDIFICATION IN THE mETAL CASTING PROCESS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of modeling, Simulation, and Scientific Computing 2013年第S01期4卷 128-141页

作者： ELIZABETH jacob.m.mANOJ ROSCHEN SASIKUmAR Computational modeling and Simulation Unit National Institute for Interdisciplinary Science and Technology Council of Scientific and Industrial Research Trivandrum–695019 India

In the process of interpreting simulation results,new post-processing techniques are *** work presents a post-processing method that analyzes the solidification pattern formed by simulation of the solidification process of molten metal in a mold to produce shaped *** generally involve numerical solutions of differential equations which are discretized by dividing the three-dimensional computational domain into small finite volume elements using a 3D *** locations of the grid points and values of the solidification time at these locations are used to divide the spatial data into 3D sections such that starting from a hotspot location within the section that has high solidification time,there is a gradient outwards with lower values of solidification *** section is assumed to be fed by one or more feeders that must freeze only after the section has solidified *** volume of a feeder can be determined from the volume of the section it is supposed to *** volume and surface area of sections are determined approximately to calculate feeder size and *** post-processing algorithm is a simulation-based quantitative approach to feeder design which in conventional foundry practice has been more of an art than *** is also general enough for use in other 3D segmentation applications.

关键词： metal casting simulation solidification pattern volume segmentation feeder design.

A balancing act between IFITm3 and IRF3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & molecular Immunology 2018年第10期15卷 873-874页

作者： Temet m mcmichael mahesh Chemudupati jacob.S Yount Department of microbial Infection and Immunity Center for Microbial Interface BiologyThe Ohio State UniversityColumbusOH 43210USA

Interferon(IFN)-induced transmembrane protein 3(IFITm3)is a potent antiviral factor capable of restricting numerous virus infections.1 Viruses inhibited by IFITm3 generally enter cells via endocytosis,and are trafficked to IFITm3-positive intracellular membrane compartments.1,2 IFITm3-positive compartments are acidic and stain positive for a variety of endosomal,lysosomal and autophagosomal markers.2,3 Although the membrane fusion of many endocytic viruses,such as influenza virus,is triggered by acidic pH,fusion is blocked in the presence of IFITm3,and virions are degraded2,4,5(Figure 1).It has been proposed that IFITm3 alters membrane properties,including rigidity and curvature,to inhibit virus membrane fusion.5 The molecular mechanism underlying these IFITm3-induced membrane alterations is not well characterized,and whether IFITm3 has other cellular functions is also not known.

关键词： IFITm3 inhibited alterations

Sulfurized-polyacrylonitrile in lithium-sulfur batteries:Interactions between undercoordinated carbons and polymer structure under low lithiation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第3期31卷 587-596,I0016页

作者： Samuel Bertolini Timo jacob Institute of Electrochemistry Ulm UniversityAlbert-Einstein-Allee 4789081 UlmGermany Helmholtz-Institute Ulm(HIU) Electrochemical Energy StorageHelmholtzstr.1189081 UlmGermany Karlsruhe Institute of Technology(KIT) P.O.Box 364076021 KarlsruheGermany

Lithium-sulfur battery(LSB)represents an important candidate to be used in energy storage applications,due to its high specific ***-polyacrylonitrile(SPAN)is a candidate as a host material in LSB to replace graphite,due to its ability to chemisorb polysulfides(PSs).The sulfur chains attached to the polymer can reversibly form Li2S,and SPAN indicates to have a good cyclability and better performance than graphite,thus,SPAN acts partially as an active and also as a host *** this study,we investigated the capacity of the solvent or the SPAN to lose a hydrogen atom from the backbone,to predict possible anodic reactions between solvent and host *** simulation suggests that the photophilic salts may preferentially react with the solvent,and possibly building a cathode electrolyte interphase(CEI).We observed that an undercoordinated carbon(C_(uc))can be thermodynamically created,due to *** Cuccan react with the solvent on the polymer backbone through different mechanisms,however,the simulations indicated that the reaction should be affected by the interaction between the solvent and C_(uc),according to SPAN’s ***,C_(uc)reacts with long sulfur chains attached to SPAN,capturing sulfur and forming a C-S bond.A sulfur chain from one SPAN can connect to another polymer backbone,however,this process is affected by lithiation and ***,this work also investigates the formation of interconnected SPAN structures and the multiple C_(uc)effects.

关键词： Density functional theory Ab initio molecular dynamics Lithium-sulfur batteries Sulfurized-polyacrylonitrile

Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam-mai jacob.m.Samuel Boone m.Prentice Department of Neurology University of FloridaGainesvilleFLUSA Department of Chemistry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only composed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the misfolding of α-syn.

关键词： lipids species folding

Distributed media cooperation for enhanced video communication

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 773-783页

作者： CHAKARESKI jacob Ecole Polytechnique Fédérale de Lausanne

The author designed two algorithms for distributed cooperation among multiple video streams sharing common communication resources. The algorithms take advantage of an optimization framework that characterizes video packets such that joint resource allocation can be implemented not only over the packets of a single stream, but also across packets of different streams. The first algorithm enables collaboration among multiple video senders in an 802.11 CSmA/CA wireless network such that their joint performance is maximized. Via the algorithm, the users cooperatively establish transmission priorities based on the assigned characterizations of their video packets. The second technique allows for low-complexity joint bandwidth adaptation of multiple video streams at intermediate network nodes in the Internet in order to maximize the overall network performance. The author analyzes the advantages of the proposed algorithms over conventional solutions employed in such scenarios. It is shown that depending on system parameters such as available network data rate the proposed techniques can provide substantial gains in end-to-end performance.

关键词： media cooperation, Distributed video streaming, Wireless networks, Resource allocation, Rate-quality optimization