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Cold plumes trigger contamination of oceanic mantle wedges with continental crust-derived sediments:Evidence from chromitite zircon grains of eastern Cuban ophiolites

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Geoscience Frontiers 2018年第6期9卷 1921-1936页

作者： J.A.Proenza J.M.González-Jiménez A.Garcia-Casco E.Belousova W.L.Griffin C.talavera Y.Rojas-Agramonte t.Aiglsperger D.Navarro-Ciurana N.Pujol-Solà F.Gervilla S.Y.O’Reilly D.E.jacob Departament de Mineralogia Petrologia i Geologia AplicadaUniversitat de BarcelonaC/Martíi Franquès s/n08028BarcelonaSpain Departamento de Mineralogía y Petrología Universidad de GranadaFacultad de CienciasFuentenueva s/n 18002GranadaSpain Instituto Andaluz de Ciencias de la tierra(CSIC-UGR) Avda.de las Palmeras 4E-18100ArmillaGranadaSpain ARC Centre of Excellence for Core to Crust Fluid Systems(CCFS) GEMOC National Key CentreDepartment of Earth and Planetary SciencesMacquarie UniversitySydneyNSW 2109Australia John de Laeter Centre Curtin UniversityPerthWA 6102Australia Geocycles-Earth System Research Center Institut fur GeowissenschaftenJohannes Gutenberg-UniversitatBecherweg 21D-55099 MainzGermany Departamento de Geociencias Universidad de los AndesBogotáColombia

the origin of zircon grains, and other exotic minerals of typical crustal origin, in mantle-hosted ophiolitic chromitites are hotly debated. We report a population of zircon grains with ages ranging from Cretaceous(99 Ma) to Neoarchean(2750 Ma), separated from massive chromitite bodies hosted in the mantle section of the supra-subduction(SSZ)-type Mayari-Baracoa Ophiolitic Belt in eastern Cuba. Most analyzed zircon grains(n = 20, 287 ± 3 Ma to 2750 ± 60 Ma) are older than the early Cretaceous age of the ophiolite body, show negativeε_(Hf)(t)(-26 to-0.6) and occasional inclusions of quartz, K-feldspar,biotite, and apatite that indicate derivation from a granitic continental crust. In contrast, 5 mainly rounded zircon grains(297±5 Ma to 2126±27 Ma) show positive εHf(t)(+0.7 to +13.5) and occasional apatite inclusions, suggesting their possible crystallization from melts derived from juvenile(mantle)sources. Interestingly, younger zircon grains are mainly euhedral to subhedral crystals, whereas older zircon grains are predominantly rounded grains. A comparison of the ages and Hf isotopic compositions of the zircon grains with those of nearby exposed crustal terranes suggest that chromitite zircon grains are similar to those reported from terranes of Mexico and northern South America. Hence, chromitite zircon grains are interpreted as sedimentary-derived xenocrystic grains that were delivered into the mantle wedge beneath the Greater Antilles intra-oceanic volcanic arc by metasomatic fluids/melts during subduction processes. thus, continental crust recycling by subduction could explain all populations of old xenocrystic zircon in Cretaceous mantle-hosted chromitites from eastern Cuba *** integrate the results of this study with petrological-thermomechanical modeling and existing geodynamic models to propose that ancient zircon xenocrysts, with a wide spectrum of ages and Hf isotopic compositions, can be transferred to the mantle wedge above subducting slabs by

关键词： Zircon U-Pb geochronology Chromitites Cold plumes Ophiolites Cuba

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不同距离观看3D影像后视光学参数和视力疲劳症状分析（英文）

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国际眼科杂志 2018年第5期18卷 769-774页

作者： Oleeviya Joseph Lavanya Kalikivayi Sajeev Cherian jacob Venkataramana Kalikivayi Ahvliv视光学院视光科印度伯拉卡德678557 Ahvliv基础眼科医院青光眼科印度伯拉卡德678557

目的:不同距离观看3D影像后调节幅度、集合近点(NPC)及近隐斜视和视力疲劳的症状分析。方法:前瞻性研究,包括30例青年。每人每天三次分别在特定距离和不同距离观看3D影像,并连续三天进行观察,每一距离使用相同视频,相同的时间和不同的... 详细信息

目的:不同距离观看3D影像后调节幅度、集合近点(NPC)及近隐斜视和视力疲劳的症状分析。方法:前瞻性研究,包括30例青年。每人每天三次分别在特定距离和不同距离观看3D影像,并连续三天进行观察,每一距离使用相同视频,相同的时间和不同的屏幕大小。使用K-multimedia player 3D播放器。观看3D影响后立即记录立体视觉、调节幅度、调节近点及近隐斜视和视力疲劳症状等相关变量。分别使用tNO测量视功能,RAF尺测量调节幅度和集合近点,棱镜杆测量近隐斜视,封闭式问卷调查视力疲劳症状的发生情况。用描述性统计和配对t检验进行数据分析,定性数据采用卡方检测。结果:在40 cm,3 m和6 m处调节幅度分别减少了0.66 D,1.12 D和1.44 D,集合近点显著降低了0.63 cm,0.93 cm和1.23 cm,近隐斜视分别增加了0.87,2.74和2.2棱镜度。结果发现,大多数受试者在每一距离处都出现眼周疼痛,头痛和刺激等反应。在家庭环境中,头痛、盗汗、疲劳、刺激和恶心等症状会显著增加,此外,通过使用笔记本电脑观看3D可能会引起头痛和盗汗等相关不适症状。结论:观看3D前后、在三种不同距离处,调节幅度、集合近点及近隐斜视和视力疲劳的症状显著不同。在不同距离观看3D影像后,视力疲劳为主要症状。

关键词：调节幅度集合近点近隐斜视视疲劳 3D视频与立体视觉

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New US device versus imaging US to assess tumor-in-brain

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Chinese Neurosurgical Journal 2020年第4期6卷 211-223页

作者： jacob Halevy-Politch Menashe Zaaroor Alon Sinai Marius Constantinescu Aerospace Eng. Technion CityHaifaIsrael School of Medicine Technion I.I.T.HaifaIsrael Department of Neurosurgery Rambam HCCHaifaIsrael

Background:Applying ultrasonic imaging system during surgery requires the poring of saline,performing the measurement,and acquiring data from its display—which requires time and is highly“performer dependent,”i.e.,the measure is of a subjective nature.A new ultrasonic device was recently developed that overcomes most of these drawbacks and was successfully applied during tumor-in-brain *** purpose of this study was to compare the two types of US devices and demonstrate their ***:the study was performed in the following stages:(i)an ex vivo experiment,where slices of the muscle and brain of a young porcine were laid one on top the *** and border depths were measured and compared,using the two types of US instruments.(ii)During human clinical neurosurgeries,tumor depth was compared by measuring it with both devices.(iii)Following the success of stages(i)and(ii),using solely the new US device,the tumor thickness was monitored while its ***,Pearson’s coefficient,average,mean,and standard deviation were applied for statistical ***:A high correlation was obtained for the distances of tissue borders and for their respective *** these ultrasonic devices during neurosurgeries,tumor depths were monitored with high similarity(87%),which was also obtained by Pearson’s correlation coefficient(0.44).the new US device,thanks to its small footprint,its remote measurement,and the capability of monitoring intraoperatively and in real-time,provides the approach to tumor’s border before its complete ***:the new US device provides better accuracy than an ultrasonic imaging system;its data is objective;it enables to control the residual tumor thickness during its resection,and it is especially useful in restricted *** features were found of great help during a tumor-in-brain surgery and especially in the final stages of tumor’s resection.

关键词： Neurosurgery tumor Ultrasound Pulse-echo Residual thickness

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Distribution and effects of polymorphic RANtES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study

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World Journal of Gastroenterology 2005年第48期11卷 7631-7638页

作者： Golo Ahlenstiel Agathe Iwan jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled tilman Sauerbruch Ulrich Spengler Rainer P Woitas Department of Internal Medicine 1 Institute of Experimental Hematology Institute of Medical Microbiology and Immunology tIB MOLBIOL Synthesis Laboratory Goldyne Savad Institute of Gene therapy

AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANtES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. therefore,these mutations may also affect the course of HIV/HCV ***: We determined allele frequencies of RANtES-403 (G→A), RANtES-28 (C→G) and RANtESIN1.1 (t→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANtES ***: Frequencies of RANtES-403 A, RANtES-28 G and RANtES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANtES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy ***: All three RANtES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. the finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection.

关键词： RANtES polymorphism HIV/HCV-coinfectJon HCV

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thymosinβ4 Impeded Murine Stem Cell Proliferation with an Intact Cardiovascular Differentiation

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Journal of Huazhong University of Science and technology(Medical Sciences) 2016年第3期36卷 328-334页

作者：聂丽高仕君赵亚楠 jacob Masika 骆红艳胡新武张亮品曾莹 Jürgen Hescheler 梁华敏 Department of Physiology Chinese-German Stem Cell Centerthe Key Laboratory of Drug Target Research and Pharmacodynamic EvaluationHubei Province School of Basic Medicine Huazhong University of Science and Technology Institute of Brain Research Huazhong University of Science and Technology College of Pharmacy Wuhan Institute of Bioengineering Department of Medical Physiology Faculty of Health SciencesEgerton University Union Hospital Huazhong University of Science and Technology Institute of Neurophysiology University of Cologne

thymosin β4（tβ4） is a key factor in cardiac development, growth, disease, epicardial integrity, blood vessel formation and has cardio-protective properties. However, its role in murine embryonic stem cells（m ESCs） proliferation and cardiovascular differentiation remains unclear. thus we aimed to elucidate the influence of tβ4 on m ESCs. target genes during m ESCs proliferation and differentiation were detected by real-time PCR or Western blotting, and patch clamp was applied to characterize the m ESCs-derived cardiomyocytes. It was found that tβ4 decreased m ESCs proliferation in a partial dose-dependent manner and the expression of cell cycle regulatory genes c-myc, c-fos and c-jun. However, m ESCs self-renewal markers Oct4 and Nanog were elevated, indicating the maintenance of self-renewal ability in these m ESCs. Phosphorylation of StAt3 and Akt was inhibited by tβ4 while the expression of RAS and phosphorylation of ERK were enhanced. No significant difference was found in BMP2/BMP4 or their downstream protein smad. Wnt3 and Wnt11 were remarkably decreased by tβ4 with upregulation of tcf3 and constant ？-catenin. Under m ESCs differentiation, tβ4 treatment did not change the expression of cardiovascular cell markers α-MHC, PECAM, and α-SMA. Neither the electrophysiological properties of m ESCs-derived cardiomyocytes nor the hormonal regulation by Iso/Cch was affected by tβ4. In conclusion, tβ4 suppressed m ESCs proliferation by affecting the activity of StAt3, Akt, ERK and Wnt pathways. However, tβ4 did not influence the in vitro cardiovascular differentiation.

关键词： thymosin β4 murine embryonic stem cells proliferation cardiogenesis patch clamp

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非酒精性脂肪肝病的Ct与PEt/Ct心肌灌注影像冠状动脉微血管功能异常两者之间的相关性

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国际医学放射学杂志 2019年第4期 478-479页

作者：吴酥 t.Vita D.J.Murphy M.t.Osborne N.S.Bajaj A.Keraliya S.jacob Cardiovascular Imaging Program Departments of Medicine and Radiology Division of Nuclear Medicine and Molecular Imaging Department of Radiology and Cardiovascular Division Brigham and Women's Hospital

摘要非酒精性脂肪肝病(NAFLD)病人死亡的主要原因是心血管疾病。但NAFLD与冠状动脉微血管功能异常之间的关系尚不清楚。目的确定冠状动脉微血管功能障碍是否

关键词：非酒精性脂肪肝病冠状动脉微血管功能障碍 Ct NAFLD 冠状动脉功能异常微血管心肌灌注 PEt/Ct

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Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation

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Zoological Research 2022年第2期43卷 184-187页

作者： Kai Song Bin Gao Peter Halvarsson Yun Fang Siegfried Klaus Ying-Xin Jiang Jon E.Swenson Zhi-Ming Han Yue-Hua Sun jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityUppsala 75236Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesUppsala 75007Sweden Lindenhöhe 5 Jena D-07749Germany Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesAs NO-1432Norway State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

the Chinese Grouse(tetrastes sewerzowi) and Hazel Grouse(t. bonasia) are sibling species that are well-adapted to harsh high-altitude and latitude habitats. In the current study, we sampled and sequenced 29 Chinese Grouse(n=16) and Hazel Grouse(n=13) from eight locations in China, Sweden,Germany, and northeast Poland to analyze population genetic diversity and structure, introgression, and local adaptation.

关键词： northeast adapted controlling

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A Histogram-Based Static Error Correction technique for Flash ADCs: Implementation

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ZtE Communications 2012年第1期10卷 63-70页

作者： J jacob Wikner Armin Jalili Sayed Masoud Sayedi Rasoul Dehghani Department of Electrical Engineering Linkping University Department of Electrical and Computer Engineering Isfahan University of Technology

In this paper, we focus on practical issues in implementing a calibration technique for medium-resolution, highspeed flash analogtodigital converters （ADCs）. In [1], we theoretically describ the calibration technique and perform a behaviorallevel simulation to test its functionality [1]. In this work, we discuss some issues in transistorlevel implementation. the predominant factors that contribute to static errors such as reference generator mismatch and trackandhold （t/H） gain error can be treated as inputreferred offsets of each comparator. Using the proposed calibration technique, these errors can be calibrated with minimal detriment to the dynamic performance of the converter. We simulate a transistorlevel implementation of a 5-bit, 1 GHz ADC in a 1.2 V, 65 nm CMOS process. the results show that DNL can be improved from 2.5 LSB to below 0.7 LSB after calibration, and INL can be improved from 1.6 LSB to below 0.6 LSB after calibration.

关键词： Calibration chopping flash ADC PDF generator referencegenerator circuit track and hold circuit

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高产植酸酶乳酸菌发酵对黑豆面包蛋白质品质及烘焙特性的影响

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食品科学 2021年第6期42卷 111-117页

作者：罗昆曹伟超马子琳武盟 Omedi jacob OJOBI 郑建仙黄卫宁李宁 Filip ARNAUt 江南大学食品科学与技术国家重点实验室江苏无锡214122 华南理工大学食品科学与工程学院广东广州510641 广州焙乐道食品有限公司广东广州511400 焙乐道食品集团比利时布鲁塞尔1201

从实验室获得1株高产植酸酶乳酸菌(L-19)并应用于黑豆酸面团面包,同时选用不产植酸酶的乳酸菌(K-12)作为对照。通过分析面包氨基酸组成和营养指标、蛋白质体外消化率、质构特性、超微结构和感官评定,研究其对黑豆酸面团面包蛋白质营养... 详细信息

从实验室获得1株高产植酸酶乳酸菌(L-19)并应用于黑豆酸面团面包,同时选用不产植酸酶的乳酸菌(K-12)作为对照。通过分析面包氨基酸组成和营养指标、蛋白质体外消化率、质构特性、超微结构和感官评定,研究其对黑豆酸面团面包蛋白质营养及烘焙学特性的影响。结果表明:添加乳酸菌黑豆酸面团后,面包蛋白营养和烘焙品质都得到了明显改善,其中L-19酸面团面包(L-19SDB)效果最显著。与黑豆面包(BB)相比,L-19SDB植酸含量下降60.68%,蛋白质体外消化率由64.70%升高至73.93%,总氨基酸含量提高73%。同时与其他3组相比,L-19SDB有更好的氨基酸特征:其必需氨基酸与总氨基酸之比、必需氨基酸指数和生物价均为最高。面包烘焙品质方面,相比黑豆面包BB,L-19SDB和K-12SDB比容分别提高了31.45%和23.59%,硬度降低了68.79%和56.59%。通过ImageJ分析发现,L-19SDB芯囊组织更加均匀,感官评价总体可接受度最高(7.72分)。

关键词：植酸酶氨基酸组成蛋白质体外消化率黑豆酸面团烘焙品质

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Enhancement in the Electrical and thermal Properties of Ethylene Vinyl Acetate (EVA) Co-Polymer by Zinc Oxide Nanoparticles

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Open Journal of Composite Materials 2015年第3期5卷 79-91页

作者： Jose Sebastian Eby t. thachil Jobin Job Mathen Joseph Madhavan Prince thomas jacob Philip M. S. Jayalakshmy Shahrom Mahmud Ginson P. Joseph Department of Polymer Science and Rubber technology Cochin University of Science and Technology Kerala India Department of Physics Loyola College Chennai India Department of Physics St. Thomas College Palai India Department of Instrumentation Cochin University of Science and Technology Kerala India School of Physics Universiti Sains Malaysia Minden Malaysia

EVA/ZnO nanocomposites of 1%, 2% and 4% ZnO were fabricated by direct probe sonicator method. the ZnO nanopowders were prepared by solvothermal method. As the particle size of the filler incorporated to the polymer matrix decreases, the properties of the polymer-filler interface show dominance over its bulk properties. the dielectric constant and dielectric loss of the composites at ambient temperatures are found to decrease with increasing frequency. the thermal analysis using tGA-DtA is also performed and it is found that the thermal stability of the nanocomposites increases with increasing the filler concentrations. the thermal parameters such as thermal diffusivity (α) and thermal effusivity (e), the thermal conductivity (k) and heat capacity (Cp) were studied using photopyroelectric technique. the band gap of the samples was also determined and found to decrease with increasing filler concentrations. the tensile strength and peel strength of the samples were also investigated and it is found to increase with small inclusion of filler material.

关键词： Composite Materials Polymers Differential thermal Analysis (DtA) Dielectric Properties

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