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New oral pharmacotherapeutic agents for venous thromboprophylaxis after total hip arthroplasty

World Journal of Orthopedics 2014年第3期5卷 188-203页

作者： Garrett B Aikens jacob r osmundson Michael P rivey Department of Pharmacy Central Alabama Veterans Health Care SystemMontgomeryAL 36109United States Department of Pharmacy Practice Auburn University Harrison School of Pharmacy Auburn University AuburnAL 36849United States Department of Pharmacy Practice University of Montana Skaggs School of PharmacyMissoulaMT 59812United States Department of Pharmacy Community Medical CenterMissoulaMT 59804United States

Patients undergoing total hip arthroplasty(THA)are at high risk for developing venous thromboembolism and,therefore,require short term prophylaxis with antithrombotic ***,target specific oral anticoagulants(TSOA)including the direct thrombin inhibitor,dabigatran,and the factorⅩa inhibitors rivaroxaban,apixaban,and edoxaban have been approved for THA thrombopropylaxis in various *** TSOAs provide a rapid acting,oral alternative to parenteral agents including low-molecular weight heparins(LMWH)and fondaparinux;and compared to warfarin,they do not require routine laboratory monitoring and possess much fewer drug-drug *** on phaseⅢclinical studies,TSOAs have established themselvesas an effective and safe option for thromboprophylaxis after THA compared to LMWH,particularly enoxaparin,but require additional evaluation in specific populations such as the renally impaired or *** ability to monitor and reverse these TSOAs in the case of bleeding complications or suspected sub-or supra-therapeutic anticoagulation is of importance,but remains *** review will focus on the drug-specific characteristics,efficacy,safety,and economic impact of the TSOAs for thromboprophylaxis following THA,as well as the aspects of therapeutic monitoring and anticoagulation reversal in the event of bleeding complications or a need for urgent reversal.

关键词： Oral Thromboprophylaxis Venous thromboembolism Hip Arthroplasty

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