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Growth inhibition of colon cancer cells by compounds affecting AMPK activity

World Journal of Gastrointestinal Oncology 2014年第7期6卷 244-252页

作者： Michael A Lea jacob pourat Rupali Patel Charles desBordes Department of Biochemistry and Molecular Biology New Jersey Medical School Rutgers University Newark NJ 07103 United States Department of Biology Medgar Evers Col-lege-City University of New York Brooklyn NY 11225 United States

AIM:To determine if other molecules reported to modulate AMP-dependent protein kinase(AMPK)activ-ity would have effects resembling those of metformin and phenformin on colon cancer cell proliferation and ***:Studies were performed with four hu-man colon cancer cell lines,Caco-2,HCT116,HT29 and *** compounds that were studied included A-769662,5-aminoimidazole-4-carboxamide-1-ribofu-ranoside,butyrate,(-)-epigallocatechin gallate(EGCG),KU-55933,quercetin,resveratrol and *** parameters that were measured were cell proliferation and viability,glucose uptake,lactate production and acidification of the incubation ***:Investigations with several molecules that have been reported to be associated with AMPK activa-tion(A-769662,5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside,EGCG,KU-55933,quercetin,resve-ratrol and salicylates)or AMPK inhibition(compound C)failed to reveal increased medium acidification and increased glucose uptake in colon cancer cells as previ-ously established with metformin and *** only exception was 5-aminosalicylic acid with which there were apparently lower glucose levels in the me-dium after incubation for 72 *** study in the absence of cells revealed that the effect was an artifact due to inhibition of the enzyme-linked glucose *** compounds were studied at concentrations that inhibited cell ***:It was concluded that treatment with several agents that can affect AMPK activity resulted in the inhibition of the proliferation of colon cancer cells under conditions in which glucose metabolism is not enhanced,in contrast to the effect of biguanides.

关键词： Colon cancer cells Proliferation AMP-dependent protein kinase Glucose metabolism

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