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Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel

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Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 786-796页

作者： Jigar Shah Anroop B.Nair Hiral Shah Shery jacob Tamer m.Shehata mohamed Aly morsy Institute of Pharmacy Nirma UniversityAhmedabad 382481India College of Clinical Pharmacy King Faisal UniversityAl-Ahsa 31982Saudi Arabia Arihant School of Pharmacy&BRI Gandhinagar 382421India College of Pharmacy Gulf Medical UniversityAjman 4184United Arab Emirates Faculty of Pharmacy University of ZagazigZagazig 44519Egypt Faculty of medicine Minia UniversityEl-Minia 61511Egypt

Oral therapy of tramadol,an opiate analgesic,undergoes extensive hepatic metabolism and requires frequent *** therapy by virtue can overcome these issues and can improve the efficacy and reduce abuse liability of *** aim of this research was to investigate the possibility of transdermal delivery of tramadol by formulating proniosome gel and evaluate its therapeutic potential in *** effect of formulation composition as well as amount of drug on physicochemical characteristics of prepared proniosomes were *** proniosome gel(F4)was selected and evaluated for drug release,stability and transdermal efficacy by ex vivo and in vivo *** vesicles demonstrated optimal properties including spherical shape,nanosize with good entrapment efficiency,adequate zeta potential,higher stability and greater transdermal *** amorphization and dispersion of tramadol in the aqueous core of proniosome vesicles was confirmed by differential scanning *** profile of F4 was distinct(Pm control and displayed steady and prolonged tramadol release by Fickian *** therapy of F4 showed prominent reduction of induced twitches(Pmice and edema(Pmpared to oral *** improvement in clinical efficacy of tramadol in transdermal therapy is correlated with the pharmacokinetic data *** conclusion,the observed improvement in antinociceptive and anti-inflammatory effects from proniosome carriers signifies its potential to be a suitable alternative to oral therapy of tramadol with greater efficacy.

关键词： Tramadol Proniosomes Flux Edema Pharmacokinetics Rats

Effect of a 26-month floorball training on male elderly's cardiovascular fitness, glucose control, body composition, and functional capacity

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Journal of Sport and Health Science 2018年第2期7卷 149-158页

作者： mogens Theisen Pedersen jacob Vorup Jens Bangsbo Copenhagen Centre of Team Sport and Health Department of NutritionExercise and SportsSection of Integrated PhysiologyUniversity of Copenhagen Health Science Research Center University College Lillebaelt

Background: Floorball training offers a motivating and socially stimulating team activity for older adults, and 12 weeks of floorball training twice a week among men aged 65—76 years have been shown to have positive effects on a number of physiological parameters important for health. However, the effect of long-term participation in floorball training among male elderly has not been investigated. The aim of the present study was to examine the effect of 26-month self-organized regular participation in floorball training on cardiovascular fitness, body composition, blood lipids, glucose control, and physical function among recreationally active men aged 66—78 ***: After completing a 12-week randomized and controlled intervention with floorball and petanque training in the autumn 2014 or spring2015, 15 subjects chose to participate in floorball training(floorball group, FG), whereas 16 subjects resumed their usual lifestyle(control group,CG). FG took part in self-organized floorball training 1.7 sessions of 40 min/week, and CG continued their normal recreationally active lifestyle during a 26-month follow-up period. At baseline and after the follow-up period subjects were tested for cardiovascular fitness, glucose control(resting blood samples), body composition dual-energy X-ray absorptiometry(DXA-scanning), and functional ***: In FG, the decline in maximal oxygen uptake(VO_(2max)) during the follow-up period was lower(242 ± 379 mL/min, p = 0.01), blood glycosylated hemoglobin(HbA1c) increased less(—1.6 ± 2.9 mmol/L, p = 0.02), and leg bone mineral density increased more(0.03 ± 0.05 g/cm^2,p = 0.02) than those in CG. The effects on body mass, total lean body mass, fat mass, blood lipids, and physical function were similar in FG and ***: Approximately twice weekly floorball sessions with 40 min/session over 26-month appear to reduce age-related decline in cardiovascular fitness and glucose control and improve leg bone mineral density,

关键词： Bone mineral density Elderly Floorball Glucose control VO2max

Navigated laser in diabetic macular edema: the impact of reduced injection burden on patients and physicians-who wins and who loses?

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 342-345页

作者： jacob menzler Aljoscha Neubauer Focke Ziemssen Institute for Health and Pharmacoeconomics Private Practice Ophthalmology Center for Ophthalmology Eberhard-Karls University

We inquired the impact of reduced therapy discontinuation in diabetic macular edema(DmE) on physician's revenue considering anti-vascular endothelial growth factor(VEGF) monotherapy and its combination with Navilas treatment. Data were collected on injection frequency, treatment discontinuation and reimbursement fees for DmE treatment with anti-VEGF compared to anti-VEGF in combination with navigated laser. Based on these data an economic model was built to compare physicians revenue over a 5y period using either therapy for 4 European countries and the USA. Due to patients' higher therapy adherence, physicians using navigated laser therapy with anti-VEGF generate similar or higher revenues compared to VEGF monotherapy in all analyzed countries. The use of Navilas decreases the patient's injection burden at the same clinical outcome, while the physician's revenue remained stable or increased. Therewith, therapy discontinuation in DmE can be reduced using the combination therapy with Navilas.

关键词： diabetic macular edema laser therapy Navilas cost-effectiveness injection burden adherence

Epidemiology and genetics of ventricular fibrillation during acute myocardial infarction

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Journal of Geriatric Cardiology 2016年第9期13卷 789-797页

作者： Charlotte Glinge Stefan Sattler Reza Jabbari jacob Tfelt-Hansen Department of Cardiology Heart Centre Copenhagen University Hospital Rigshospitalet Copenhagen Denmark

Sudden cardiac death （SCD） from ventricular fibrillation （VF） during coronary artery disease （CAD） is a leading cause of total and cardiovascular mortality, and in more than half of SCD cases VF occurs as the first symptom of CAD. Several epidemiological studies have shown that sudden death of a family member is a risk factor for SCD and VF during acute myocardial infarction （mI）, independent of traditional risk factors including family history of mI, suggesting a genetic component in the susceptibility to VF. To prevent SCD and VF due to mI, we need a better understanding of the genetic and molecular mechanisms causing VF in this apparently healthy population. Even though new insights and technologies have become available, the genetic predisposition to VF during mI remains poorly understood. Findings from a variety of different genetic studies have failed to reach reproducibility, although several genetic variants, both common and rare variants, have been associated to either VF or SCD. For this review, we searched Pubmed for potentially relevant articles, using the following meSH-terms：＂sudden cardiac death＂, ＂ventricular fibrillation＂, ＂out-of-hospital cardiac arrest＂, ＂myocardial infarction, myocardial ische- mia＂, ＂coronary artery disease＂, and ＂genetics＂. This review describes the epidemiology and evidence for genetic susceptibility to VF due to mI.

关键词： Family history Genetics myocardial infarction Sudden cardiac death Ventricular fibrillation

Overview of Activities:ARES-III and LEARN Analog missions in the LunAres Hab

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Space(Science & Technology) 2022年第1期2022卷 64-82页

作者： Simon Bouriat matej Poliaček jacob Smith SpaceAble France Aerospace Industry Professional and Independent Reseacher Slovakia UK Students for the Exploration and Development of Space(UKSEDS) UK

Progress is being made on human Lunar and martian missions by space agencies and private organisations around the world,with the aims of establishing reliable long-duration *** this,research is being carried out under controlled and isolated conditions within simulated space habitats,to gain insights into the effects of such conditions on the research subjects and their impacts on crews’wellbeing and *** paper provides an overview of the experiments conducted during two separate 15-day missions—one martian and one Lunar—conducted in the LunAres Research Base in Piła,Poland,in *** activities were common between the two crews;others were only carried out by *** the same methodology,both collected cognitive function,environmental,physiological,and inventory data,resulting in a larger dataset allowing comparisons between the two missions in terms of varying human *** conducted by the Lunar crew included the following:effects of consuming lyophilised food on oral health and saliva production,influence of isolation on hearing capability,feelings on security in the isolated habitat,and research into earthworm growth in different soil *** mars mission analysed physical performances of the crew and compared them to performances realised during similar activities in mars Research Desert Station missions and the impact of confinement on their efficiency performing a remote operation of a *** each piece of research,an overview of the background,methodology,results,and conclusions is given,referencing the resulting *** addition,nonresearch activities are included for completeness and context.

关键词： Desert habitat consuming

Effects of rodent abundance and richness on cache pilfering

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Integrative Zoology 2018年第3期13卷 331-338页

作者： jacob W.DITTEL Stephen B.VANDER WALL Department of Fisheries and Wildlife Oregon State UniversityCorvallisOregonUSA Department of Biology and the Program in Ecology Evolutionand Conservation BiologyUniversity of NevadaRenoNevadaUSA

Scatterhoarding is a common behavioral strategy to conserve food during periods of scarcity,but this type of food storage is vulnerable to theft or pilferage.A variety of environmental factors and cache characteristics influence the rate of *** we investigate 2 environmental factors,which heretofore have not received much attention:the abundance and species richness of scatterhoarding animals in the vicinity of scatterhoarded *** measured the rate of cache pilferage at 7 sites that differed in the number and species composition of granivorous rodents in western Nevada using local native seeds and sunflower *** found that there was no difference between the pilferage rate of native seeds and sunflower seeds,but that sites with different rodent abundances had different pilferage *** rates were proportional to the abundance of scatterhoarding *** rodents removed seeds at the rate of 1.3%/day/rodent *** richness of scatterhoarding rodents was not correlated with rates of *** results suggest that density-dependent competition for scatterhoarded seeds is a strong determinant of pilferage rates.

关键词： cache pilfering competition food hoarding heteromyids rodent abundance scatter hoarding sciurids

Food-delivery behavior under crowd sourcing mobility services

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第4期9卷 676-691页

作者： Jianqiang Fan Xiaoxia Yao Luhao Zhou jacob Wood Chao Wang School of Economics and management Chang'an UniversityXi'an 710064China The Youth Innovation Team of Shaanxi Universities Chang’an UniversityXi’an 710064China Department of Business James Cook University SingaporeSingapore 387380Singapore

The rapid development of the online food-delivery industry,has led to not only increases in the number of the crowd-sourced shared food-delivery service drivers on our roads,but also growing urban traffic safety management *** study investigates the decision-making behaviors that exist between delivery drivers,their food-delivery platform and their potential impact on traffic *** the evolutionary game theory,stakeholder decision-making behaviors involving traffic safety within the food-delivery industry were *** our analysis,several behavioral influencers were identified,including penalties for traffic violations,the opportunity cost of delivery drivers complying with traffic rules,the costs associated with risk and strict management approaches,reputation incentives,costs related to the delivery platform being punished,the probability of compliance with traffic rules,and the probability of adopting a strict management approach by the delivery *** study demonstrates that stabilization strategies used by the food service industry differ when the types of government control measures also *** the government takes a more aggressive approach to regulation and control,compliance with the traffic rules and the adoption of strict enforcement measures by management are the only evolutionary stability strategies available to food-delivery *** part of a strict management strategy,appropriate compensation or incentive measures should be provided by the distribution ***,the fines given for traffic violations should be increased to create a safer road environment that has fewer traffic accidents involving food-delivery drivers.

关键词： Crowd sourcing mobility services Shared food-delivery Evolutionary game Behavior analysis Traffic safety

Spectroscopic studies of gel-grown lanthanum malonate crystals

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Journal of Rare Earths 2012年第3期30卷 245-249页

作者： Varghese mathew Sabu jacob Lizymol Xavier K.E.Abraham Department of Physics St.Aloysius'CollegeEdathua-689573India Department of Physics S.B.CollegeChanganacherry-686101India

Lanthanum malonate crystals were grown by single tube ionic diffusion through silica gel. The crystallinity of the grown crystals was analyzed by powder X-ray diffraction studies. Fourier transform infrared spectroscopy （FTIR） and fourier transform （FT） Raman studies confirmed the presence of functional groups in the title compound. The optical band gap energy of the material was extracted from diffuse reflectance spectrum.

关键词： lanthanum malonate crystal growth X-ray diffraction analysis DRS studies FTIR and FT Raman studies rare earths

minor fibrillar collagens,variable regions alternative splicing,intrinsic disorder,and tyrosine sulfation

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Protein & Cell 2012年第6期3卷 419-433页

作者： ming Fang Reed jacob Owen mcDougal Julia Thom Oxford Department of Biological Sciences Boise State UniversityBoiseID 83725USA Department of Chemistry and Biochemistry Boise State UniversityBoiseID 83725USA Biomolecular Research Center Boise State UniversityBoiseID 83725USA

minor fibrillar collagen types V and XI,are those less abundant than the fibrillar collagen types I,II and *** alpha chains share a high degree of similarity with respect to protein sequence in all domains except the variable *** variation and,in some cases,extensive alternative splicing contribute to the unique sequence characteristics of the variable *** unique expression patterns in tissues exist,the functions and biological relevance of the variable regions have not been *** this review,we summarize the existing knowledge about expression patterns and biological functions of the collagen types V and XI alpha *** of biochemical similarities among the peptides encoded by each exon of the variable region suggests the potential for a shared *** alternative splicing,conservation of biochemical characteristics in light of low sequence conservation,and evidence for intrinsic disorder,suggest modulation of binding events between the surface of collagen fibrils and surrounding extracellular molecules as a shared function.

关键词： minor fibrillar collagens variable regions alternative splicing fibrillogenesis heparan sulfate binding sites intrinsic disorder tyrosine sulfation