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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele l Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

Towards an l^p Potential Theory for Sub-markovian Semigroups:Kernels and Capacities

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Acta mathematica Sinica,English Series 2006年第4期22卷 1227-1250页

作者： Niels jacob Renél.SCHIllING Department of mathematics University of Wales SwanseaSingleton ParkSwansea SA 2 8 PP.United Kinadom FB 12-mathematik Philipps-Universitat MarburgD-35032 MarburgGermany

We study in fairly general measure spaces （X,μ） the （non-linear） potential theory of l^p sub-markovian semigroups which are given by kernels having a density with respect to the underlying measure. In terms of mapping properties of the operators we provide sufficient conditions for the existence （and regularity） of such densities. We give various （dual） representations for several associated capacities and, in the corresponding abstract Bessel potential spaces, we study the role of the truncation property. Examples are discussed in the case of R^n where abstract Bessel potential spaces can be identified with concrete function spaces.

关键词： nonlinear potential theory (r,p)-capacity Bessel potential space gamma.transform sub-markovian semigroup

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

An evaluation of a catch and release trout regulation in Rapid Creek,South Dakota

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Aquaculture and Fisheries 2023年第5期8卷 558-563页

作者： jacob l.Davis South Dakota Department of Game Fish and Parks4130 Adventure TrailRapid CitySD57702USA

Often,catch and release regulations are meant to maximize a fisheries potential to create trophy fish.I evaluated adult Brown Trout populations at five locations within Rapid Creek within Rapid City,SD over a two-year *** each year,one of these locations was within a catch and release area,while two were *** 2012,density and biomass estimates were higher in a site located outside of the catch and release ***,size structure within the catch and release area was only significantly larger than one of the two sites outside of the regulation *** relative weight values were inversely related to density estimates,with the lowest density sites having the highest mean relative ***,a site outside of the catch and release area had the highest abundance and biomass estimates in *** cumulative length distribution was significantly different between the site within the catch and release area and the two located *** weight was significantly higher in the catch and release area than the two sites *** population characteristics within the catch and release area were not consistently better than outside,it is more likely that factors such as habitat and density dependence are impacting the Brown Trout population more than the regulation itself.

关键词： Trout Regulations Catch and release

Endocannabinoids are potential inhibitors of glioblastoma multiforme proliferation

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Journal of Integrative medicine 2023年第2期21卷 120-129页

作者： Ashraf Duzan Desiree Reinken Timothy l.mcGomery Nicholas m.Ferencz jacob m.Plummer mufeed m.Basti School of Pharmacy Wingate UniversityWingateNC 28174USA Applied Science and Technology Department North Carolina State University of Agriculture and TechnologyGreensboroNC 27411USA College of Nursing University of Colorado Anschutz Medical CampusAuroraCO 80045USA Collage of Arts and Science Department of Chemistry and PhysicsWingate UniversityWingateNC 28174USA

Globally,it is evident that glioblastoma multiforme(GBm)is an aggressive malignant cancer with a high mortality rate and no effective treatment *** is classified as the stage-four progression of a glioma tumor,and its diagnosis results in a shortened life *** options for GBm include chemotherapy,immunotherapy,surgical intervention,and conventional pharmacotherapy;however,at best,they extend the patient’s life by a maximum of 5 *** are considered incurable due to their high recurrence rate,despite various aggressive therapeutic approaches which can have many serious adverse ***,classified as endocannabinoids,offer a promising novel therapeutic approach for *** may enhance the apoptosis of GBm cells but have no effect on normal healthy neural *** promote atypical protein kinase C,deactivate fatty acid amide hydrolase enzymes,and activate transient receptor potential vanilloid 1(TRPV1)and TRPV2 to induce pro-apoptotic signaling pathways without increasing endogenous *** previous in vivo studies,endocannabinoids,chemically classified as amide formations of oleic and palmitic acids,have been shown to increase the pro-apoptotic activity of human cancer cells and inhibit cell migration and *** review focuses on the biological synthesis and pharmacology of endogenous cannabinoids for the enhancement of cancer cell apoptosis,which have potential as a novel therapy for GBm.

关键词： Glioblastoma Endocannabinoids Ceramide Apoptosis Chemotherapy Cancer

management of symptomatic ureteric stumps laparoscopically

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Asian Journal of Andrology 2001年第2期3卷 147-150页

作者： A.m.Khan S.jacob Department of Surgery King George Hospital Ilford Essex IG1 2HL UKDepartment of Surgery King George Hospital Ilford Essex IG1 2HL UK

Aim: To study the advantage of excision of the distal symptomatic ureteric stumps with the retroperitoneal laparo-scopic approach. methods: Four patients who had failed to settle their symptoms with the initial conservative man-agement were included in the study. All underwent excision of the distal symptomatic ureteric stumps with the retroperi-toneal laparoscopic approach and then received prophylactic antibiotics. Results: We have achieved better resultsthan those reported in the literature in terms of operating time (mean 1 h 45 min), blood loss ( ml), postopera-tive recovery (within 12 h) and hospital stay ( lusion; Retroperitoneal laparoscopic excision is asafe, simple and effective method in the management of symptomatic ureteric stumps.

关键词： ureter laparoscopy retroperitoneal space

Pullthrough pitfalls in treating Hirschsprung disease

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World Journal of Pediatric Surgery 2024年第3期7卷 237-241页

作者： Kristy l Rialon jacob C langer Pediatric Surgery Texas Children's HospitalHoustonTexasUSA Surgery Baylor College of MedicineHoustonTexasUSA General and Pediatric Surgery The Hospital for Sick ChildrenToronto0ntarioCanada

INTRODUCTION Complications after a pullthrough for Hirschsprung disease can occur either early or late in the postoperative period.A small number of these patients may require reoper-ation,with rates varying from 3%to 28%at a large volume colorectal center.12 Indications for reoperation include stricture,leak,fistula,transition zone pullthrough or retained agan-glionosis,retained Soave cuff,or a Duhamel *** of these may manifest as obstruc-tive symptoms or constipation,which can be seen in 11%to 42%of patients.

关键词： patients Hirschsprung colorectal

Inhibition of FlT3:A Prototype for molecular Targeted Therapy in Acute myeloid leukemia

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Engineering 2021年第10期7卷 1354-1368页

作者： meira Yisraeli Salman jacob m.Rowe Nir Weigert Department of Hematology Shaare Zedek Medical CenterJerusalem 9103102Israel Department of Hematology and Bone marrow Transplantation Rambam Medical CenterHaifa 3109601Israel Technion—Israel Institute of Technology Haifa 3200003Israel

modern therapy of acute myeloid leukemia(Aml)began in 1973 with the first report of the successful combination of daunorubicin and cytarabine,which led to complete remission in approximately 45%of *** Aml diagnosis was dependent on morphology,aided initially only by *** acute lymphoblastic leukemia(All),immunophenotyping offered little in the diagnosis of Aml,at least during the 1970s and *** advent of reliable cytogenetics changed the entire prognostic outlook of *** karyotypic analysis,different groups of Aml could be classified and stratified for various *** mutational profiling was a major advance in further categorizing Aml patients,aided by the immunophenotypic identification of antigenic markers on the *** these advances were occurring as the understanding of the importance of the tumor burden—known as minimal residual disease(mRD)—became crucial for the management of Aml *** efficacy of mRD has rapidly progressed in the past decade,from a specificity of 103 with immunophenotyping to 104 with polymerase chain reaction(PCR),which is only appropriate for some patients with Aml,and finally to 105 or even 106 cells with the extraordinary sensitivity of next-generation sequencing(NGS).All of these advances have promoted the concept of personalized medicine,which has led to the advent of targeted agents that can accurately be used for specific diagnostic *** can be predicted and measured *** targeted agents have now become a cornerstone in the management of Aml,increasing effi-cacy and dramatically reducing *** focus of this review is on one of the most well-studied targeted agents in Aml:the FmS-like tyrosine kinase 3(FlT3)inhibitors,which have impacted the prognostication and therapeutics of *** review selectively discusses the FlT3 inhibitors in detail,as a model for the other burgeoning targeted agents that have already been approved,as well as tho

关键词： Aml Targeted therapy FlT3 inhibitors midostaurin Gilteritinib Quizartinib Sorafenib

VOlUmE SEGmENTATION BY POST-PROCESSING DATA FROm SImUlATION OF SOlIDIFICATION IN THE mETAl CASTING PROCESS

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International Journal of modeling, Simulation, and Scientific Computing 2013年第S01期4卷 128-141页

作者： ElIZABETH jacob m.mANOJ ROSCHEN SASIKUmAR Computational modeling and Simulation Unit National Institute for Interdisciplinary Science and Technology Council of Scientific and Industrial Research Trivandrum–695019 India

In the process of interpreting simulation results,new post-processing techniques are *** work presents a post-processing method that analyzes the solidification pattern formed by simulation of the solidification process of molten metal in a mold to produce shaped *** generally involve numerical solutions of differential equations which are discretized by dividing the three-dimensional computational domain into small finite volume elements using a 3D *** locations of the grid points and values of the solidification time at these locations are used to divide the spatial data into 3D sections such that starting from a hotspot location within the section that has high solidification time,there is a gradient outwards with lower values of solidification *** section is assumed to be fed by one or more feeders that must freeze only after the section has solidified *** volume of a feeder can be determined from the volume of the section it is supposed to *** volume and surface area of sections are determined approximately to calculate feeder size and *** post-processing algorithm is a simulation-based quantitative approach to feeder design which in conventional foundry practice has been more of an art than *** is also general enough for use in other 3D segmentation applications.

关键词： metal casting simulation solidification pattern volume segmentation feeder design.