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Social media growth of orthopaedic surgery residency programs in response to the COVID-19 pandemic

World Journal of Orthopedics 2022年第8期13卷 693-702页

作者： Joseph S Geller Dustin H Massel Michael G Rizzo Ean Schwartz jacob eric milner Chester J Donnally III Department of Orthopaedic Surgery University of Miami Miller School of MedicineMiamiFL 33136United States Department of Orthopedics University of Miami Miller School of MedicineMiamiFL 33136United States University of Miami Leonard M.Miller School of Medicine University of Miami Miller School of MedicineMiamiFL 33136United States Miller School of Medicine University of MiamiMiamiFL 33136United States Texas Spine Consultants Texas Spine ConsultantsAddisonTX 75001United States

BACKGROUND In the Spring of 2020,residency programs across the country experienced rapid and drastic changes to their application process as a result of the coronavirus disease 2019(COVID-19)*** response,residency programs shifted to virtual events and began harnessing social media to communicate with *** To analyze the changes in social media usage by orthopaedic surgery programs in response to the COVID-19 *** Based on the 2019 residency and fellowship electronic database,accredited US orthopaedic surgery programs were reviewed for social media presence on Instagram and *** 47000 tweets from 2011-2021 were extracted through the Twitter application programming *** extracted:Total number of followers,accounts following,tweets,likes,date of account creation,hashtags,and *** language processing was utilized for tweet sentiment analysis and classified as positive,neutral,or *** data was collected and deemed current as of August 11,*** account foundation date analysis was based on the date recognized as the start of the COVID-19 outbreak in the United States,before or after March 1,*** A total of 85(42.3%)orthopaedic surgery residency program Twitter handles were ***-five(41.2%)programs joined Twitter in the nine months after the 2020 covid *** 2020,there was a 126.6%increase in volume of tweets by orthopaedic surgery residency accounts as compared to *** median number of followers was 474.5(interquartile range 205.0-796.5).The account with the highest number of tweets was Hospital for Special Surgery(@HSpecialSurgery)with 13776 tweets followed by University of Virginia(@UVA_Ortho)with 5063 and Yale(@OrthoAtYale)with *** analysis before 2020 revealed 30.4%positive,60.8%neutral,and 8.8%negative sentiments across ***,the positive sentiment percentage increased in 2020 from 30.4%to 34.5%.Of the 201 ACGME-accredited ortho

关键词： Social media COVID-19 Orthopaedic surgery Residency

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Bilateral nephrolithiasis and upper tract transitional cell carcinoma in horseshoe kidney

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Current Urology 2024年第3期18卷 247-249页

作者： jacob M.Gaines eric J.Macdonald Arun Rai David Hoenig Arthur Smith Zeph Okeke Tareq Aro The Smith Institute for Urology Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellLake SuccessNYUSA

Nephroureterectomy is currently the criterion-standard treatment for high-grade upper tract urothelial carcinoma(UTUC).Current guidelines and expert opinions propose some exceptions to this approach based on patient characteristics,disease status,and function of the contralateral *** present a rare case of a patient with horseshoe kidney,bilateral large nephrolithiasis,high-grade UTUC in one moiety,and relative parenchymal thinning of the contralateral *** patient was treated with a percutaneous,minimally invasive,nephron sparing *** patient also had intracollecting system instillations of gemcitabine and *** invasive percutaneous resection of high-grade UTUC is a safe procedure in select *** guidelines may not apply to all patients;unique scenarios with UTUC may require personalized decision-making and treatment at specialized centers.

关键词： Upper tract urothelial cancer Percutaneous resection Horseshoe kidney Nephrolithiasis

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Aging impairs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha Dole Nadja M.Maldonado Luna Natalia Castillo Ryan Potter jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Simon Melov Simon Tang eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

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Biomechanics associated with tibial stress fracture in runners:A systematic review and meta-analysis

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Journal of Sport and Health Science 2023年第3期12卷 333-342页

作者： Clare E.milner eric Foch Joseph M.Gonzales Drew Petersen Department of Physical Therapy and Rehabilitation Sciences Drexel UniversityPhiladelphiaPA 19102USA Department of Health Sciences Central Washington UniversityEllensburgWA 98926USA

Background:Tibial stress fracture(TSF)is an overuse running injury with a long recovery *** many running studies refer to biomechanical risk factors for TSF,only a few have compared biomechanics in runners with TSF to *** aim of this systematic review and meta-analysis was to evaluate biomechanics in runners with TSF compared to ***:Electronic databases PubMed,Web of Science,SPORTDiscus,Scopus,Cochrane,and CINAHL were *** of bias was assessed and meta-analysis conducted for variables reported in 3 or more ***:The search retrieved 359 unique records,but only the 14 that compared runners with TSF to controls were included in the *** studies were retrospective,2 were prospective,and most had a small sample size(5-30 per group).Many variables were not significantly different between ***-analysis of peak impact,active,and braking ground reaction forces found no significant differences between *** studies found larger tibial peak anterior tensile stress,peak posterior compressive stress,peak axial acceleration,peak rearfoot eversion,and hip adduction in the TSF ***:Meta-analysis indicated that discrete ground reaction force variables were not statistically significantly different in runners with TSF compared to *** individual included studies,many biomechanical variables were not statistically significantly different between ***,many were reported by only a single study,and sample sizes were *** encourage additional studies with larger sample sizes of runners with TSF and controls and adequate statistical power to confirm or refute these findings.

关键词： Bone stress injury Gait Kinematics Kinetics Tibial acceleration

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无线（限）升温

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国外职业教育 2006年第4期 30-33页

作者： jacob milner[美] 陶嘉（译）

在无线技术引领各大校区之际，当务之急便是如何让教师采纳该技术，把学生的学习提高到一个新水平--jacob

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海滨拱顶别墅

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设计 2014年第5期27卷 54-55页

作者： jacob eric Staudenmaier

这是位于南加州一个高密度海滩的一栋别墅，地形狭窄。建筑由一系列拱形空间嵌套并列在一起，装进方形的外壳中。一系列透明的室内空间不仅能够提供单一的海景，而且提供了多种斜向的视线，并通过多种角度捕捉自然光线。根据法规要求，... 详细信息

这是位于南加州一个高密度海滩的一栋别墅，地形狭窄。建筑由一系列拱形空间嵌套并列在一起，装进方形的外壳中。一系列透明的室内空间不仅能够提供单一的海景，而且提供了多种斜向的视线，并通过多种角度捕捉自然光线。根据法规要求，该建筑的主生活区需要抬升高出沙地2米，避免海啸灾害。建筑的剖面呈不对称，一层、夹层、二层都围绕着一个庭院布局，这个庭院不仅作为住宅的主入口，还作为中央室外区。

关键词： Vault House 别墅拱顶海滨室内空间自然光线海啸灾害

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Using cfRNA as a tool to evaluate clinical treatment outcomes in patients with metastatic lung cancers and other tumors

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Cancer Drug Resistance 2021年第4期4卷 1061-1071页

作者： Luis E.Raez Kathleen Danenberg Daniel Sumarriva Joshua Usher jacob Sands Aurelio Castrellon Pablo Ferraro Adriana Milillo eric Huang Patrick Soon-Shiong Sandeep Reddy Peter Danenberg Thoracic Oncology Program Memorial Cancer Institute/Memorial Healthcare SystemFlorida International UniversityMiamiFL 33199USA Nant Health Culver City2040 E Mariposa AveEl SegundoCA 90245USA Thoracic Oncology Program Dana Farber Cancer InstituteHarvard Medical SchoolBostonMA 02215USA Burning Rock Beijing 100022China Department of Biochemistry and Molecular Medicine University of Southern CaliforniaLos AngelesCA 90089USA

Aim:We report an exploratory analysis of cfRNA as a biomarker to monitor clinical responses in non-small cell lung cancer(NSCLC),breast cancer,and colorectal cancer(CRC).An analysis of cfRNA as a method for measuring PD-L1 expression with comparison to clinical responses was also performed in the NSCLC ***:Blood samples were collected from 127 patients with metastatic disease that were undergoing therapy,52 with NSCLC,50 with breast cancer,and 25 with *** was purified from fractionated plasma,and following reverse transcription(RT),total cfRNA and gene expression of PD-L1were analyzed by real-time polymerase chain reaction(qPCR)using beta-actin expression as a surrogate for relative amounts of cfDNA and *** the concordance study of liquid biopsies and tissue biopsies,the isolated RNA was analyzed by RNAseq for the expressions of 13 *** had to close the study early due to a lack of follow-up during the Covid-19 ***:We collected a total of 373 blood *** cfRNA PCR signals after RT were about 50-fold higher than those of *** was detected in all patients,while cfDNA was detected in 88%of them.A high concordance was found for the expression levels of 13 genes between blood and solid tumor *** in cfRNA levels followed over the course of treatments were associated with response to therapy,increasing in progressive disease(PD)and falling when a partial response(PR)*** expression of PD-L1 over time in patients treated with immunotherapy decreased with PR but increased with ***-treatment levels of PD-L1 were predictive of response in patients treated with ***:Changes in cfRNA correlate with clinical response to the *** cfRNA may be useful in predicting clinical ***-L1 gene expression may provide a biomarker to predict response to PD-L1 inhibition.

关键词： cfRNA cfDNA liquid biopsies NSCLC PD-L1

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用EPDM双峰聚合物加工EPDM海绵胶料的进展

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世界橡胶工业 2013年第6期40卷 5-12页

作者： Sunny jacob eric P Jourdain 刘霞

三元乙丙橡胶因其优异的耐候性和耐热性而成为汽车风雨密封条的主要备选聚合物。汽车密封系统结构复杂,特别是门用密封件是密封系统最复杂的部件之一,通常由低密度海绵共挤到密实金属架上制成,作为车身的连接件。门(或风雨)密封条可隔... 详细信息

三元乙丙橡胶因其优异的耐候性和耐热性而成为汽车风雨密封条的主要备选聚合物。汽车密封系统结构复杂,特别是门用密封件是密封系统最复杂的部件之一,通常由低密度海绵共挤到密实金属架上制成,作为车身的连接件。门(或风雨)密封条可隔绝水、振动和气动噪音,因而使车厢具有舒适的环境。近年来,为改善总体密封性能,海绵的结构变得日益复杂。它控制了关门力(有负荷变形测试评定)和长期密封性能(经过1 000h压缩永久变形试验评定)。近十年来,使用了双峰EPDM品级生产海绵已明显增多,这有助于提高门密封系统的生产率。综述了使用双峰EPDM聚合物进行胶料混炼和海绵挤出的最新进展。说明了这类技术在没有对基本OEM技术要求(如表面形态、力学性能、压缩负荷变形和永久变形)产生不利影响的条件下可以降低总成本,提高生产效率。

关键词： EPDM海绵胶密封件(条) 双峰聚合物

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Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon:cross-sectional study

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Infectious Diseases of Poverty 2017年第1期6卷 1205-1214页

作者： Tobias O.Apinjoh Regina N.Mugri Olivo Miotto Hanesh F.Chi Rolland B.Tata Judith K.Anchang-Kimbi Eleanor M.Fon Delphine A.Tangoh Robert V.Nyingchu Christopher jacob Roberto Amato Abdoulaye Djimde Dominic Kwiatkowski eric A.Achidi Alfred Amambua-Ngwa Department of Biochemistry and Molecular Biology University of BueaBueaCameroon Department of Microbiology and Parasitology University of BueaBueaCameroon Mahidol-Oxford Research Unit Faculty of Tropical MedicineMahidol UniversityBangkokThailand Department of Zoology and Animal Physiology University of BueaBueaCameroon Department of Medical Laboratory Science University of BueaBueaCameroon Wellcome Trust Sanger Institute HinxtonCambridge CB101SAUK Malaria Research and Training Centre BamakoMali MRC Unit FajaraThe Gambia

Background:Drug resistance is one of the greatest challenges of malaria control programmes,with the monitoring of parasite resistance to artemisinins or to Artemisinin Combination Therapy(ACT)partner drugs critical to elimination *** of resistance to a wide panel of antimalarials were assessed in natural parasite populations from southwestern ***:Individuals with asymptomatic parasitaemia or uncomplicated malaria were enrolled through crosssectional surveys from May 2013 to March 2014 along the slope of mount *** falciparum malaria parasitaemic blood,screened by light microscopy,was depleted of leucocytes using CF11 cellulose columns and the parasite genotype ascertained by sequencing on the Illumina HiSeq ***:A total of 259 participants were enrolled in this study from three different *** some alleles associated with drug resistance in pfdhfr,pfmdr1 and pfcrt were highly prevalent,less than 3%of all samples carried mutations in the pfkelch13 gene,none of which were amongst those associated with slow artemisinin parasite clearance rates in Southeast *** most prevalent haplotypes were triple mutants PfdhfrI51R59N108I164(99%),pfcrt-C72V73I74E75T76(47.3%),and single mutants PfdhpsS_(436)G_(437)K_(540)A_(581)A_(613)(69%)and Pfmdr1 N_(86)F)(184)D_(1246)(53.2%).Conclusions:The predominance of the Pf pfcrt CVIET and Pf dhfr IRN triple mutant parasites and absence of pfkelch13 resistance alleles suggest that the amodiaquine and pyrimethamine components of AS-AQ and SP may no longer be effective in their role while chloroquine resistance still persists in southwestern Cameroon.

关键词： Molecular markers Drug resistance Plasmodium falciparum

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美国股市一路上涨投资者却不高兴

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商业周刊（中文版） 2014年第14期 46-47页

作者： Nick Summers jacob Barach Joseph Ciolli eric Lam 小本

美国股市过去五年中上涨了近两倍。

关键词：美国股市投资者华尔街

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